Oncotarget

Vol 6, No 40

December 15, 2015

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Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model. See Duquette et al.

Table of Contents

Editorial: Immunology

How lung infection leads to gut injury

How lung infection leads to gut injury

https://doi.org/10.18632/oncotarget.6470

Jian Wang,  and Zhigang Tian
42394-42395
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Priority Research Papers

Potent efficacy of metronomic topotecan and pazopanib combination therapy in preclinical models of primary or late stage metastatic triple-negative breast cancer

Potent efficacy of metronomic topotecan and pazopanib combination therapy in preclinical models of primary or late stage metastatic triple-negative breast cancer

https://doi.org/10.18632/oncotarget.6377

Teresa Di Desidero, Ping Xu, Shan Man, Guido Bocci,  and Robert S. Kerbel
42396-42410
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Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents

Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents

https://doi.org/10.18632/oncotarget.6389

Vit Sestak, Jan Stariat, Jolana Cermanova, Eliska Potuckova, Jaroslav Chladek, Jaroslav Roh, Jan Bures, Hana Jansova, Petr Prusa, Martin Sterba, Stanislav Micuda, Tomas Simunek, Danuta S. Kalinowski, Des R. Richardson,  and Petra Kovarikova
42411-42428
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Genomic landscape of liposarcoma

Genomic landscape of liposarcoma

https://doi.org/10.18632/oncotarget.6464

Deepika Kanojia, Yasunobu Nagata, Manoj Garg, Dhong Hyun Lee, Aiko Sato, Kenichi Yoshida, Yusuke Sato, Masashi Sanada, Anand Mayakonda, Christoph Bartenhagen, Hans-Ulrich Klein, Ngan B. Doan, Jonathan W. Said, S. Mohith, Swetha Gunasekar, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Satoru Miyano, Ola Myklebost, Henry Yang, Martin Dugas, Leonardo A. Meza-Zepeda, Allan W. Silberman, Charles Forscher, Jeffrey W. Tyner, Seishi Ogawa,  and H. Phillip Koeffler
42429-42444
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Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model

Metastasis-associated MCL1 and P16 copy number alterations dictate resistance to vemurafenib in a BRAFV600E patient-derived papillary thyroid carcinoma preclinical model

https://doi.org/10.18632/oncotarget.6442

Mark Duquette, Peter M. Sadow, Amjad Husain, Jennifer N. Sims, Zeus A. Antonello, Andrew H. Fischer, Chen Song, Elena Castellanos-Rizaldos, G. Mike Makrigiorgos, Junichi Kurebayashi, Vania Nose, Paul Van Hummelen, Roderick T. Bronson, Michelle Vinco, Thomas J. Giordano, Dora Dias-Santagata, Pier Paolo Pandolfi,  and Carmelo Nucera
42445-42467
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Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk

Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk

https://doi.org/10.18632/oncotarget.6468

Kyle M. Walsh, Veryan Codd, Terri Rice, Christopher P. Nelson, Ivan V. Smirnov, Lucie S. McCoy, Helen M. Hansen, Edward Elhauge, Juhi Ojha, Stephen S. Francis, Nils R. Madsen, Paige M. Bracci, Alexander R. Pico, Annette M. Molinaro, Tarik Tihan, Mitchel S. Berger, Susan M. Chang, Michael D. Prados, Robert B. Jenkins, Joseph L. Wiemels, ENGAGE Consortium Telomere Group, Nilesh J. Samani, John K. Wiencke,  and Margaret R. Wrensch
42468-42477
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Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB

Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-κB

https://doi.org/10.18632/oncotarget.6478

Ying Hu, Wenjie Ge, Xingwen Wang, Gopinath Sutendra, Kunming Zhao, Zinaida Dedeić, Elizabeth A. Slee, Caroline Baer,  and Xin Lu
42478-42490
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Research Papers: Pathology

Aberrant modulation of the BRCA1 and G1/S cell cycle pathways in alcoholic hepatitis patients with Mallory Denk Bodies revealed by RNA sequencing

Aberrant modulation of the BRCA1 and G1/S cell cycle pathways in alcoholic hepatitis patients with Mallory Denk Bodies revealed by RNA sequencing

https://doi.org/10.18632/oncotarget.6382

Hui Liu, Ming Gong, Barbara A. French, Guanghong Liao, Jun Li, Brittany Tillman,  and Samuel W. French
42491-42503
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Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer’s disease in Caribbean Hispanic individuals

Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer’s disease in Caribbean Hispanic individuals

https://doi.org/10.18632/oncotarget.6391

Zhenwei Shang, Hongchao Lv, Mingming Zhang, Lian Duan, Situo Wang, Jin Li, Guiyou Liu, Zhang Ruijie,  and Yongshuai Jiang
42504-42514
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Antihypertensive treatments in adult autosomal dominant polycystic kidney disease: network meta-analysis of the randomized controlled trials

Antihypertensive treatments in adult autosomal dominant polycystic kidney disease: network meta-analysis of the randomized controlled trials

https://doi.org/10.18632/oncotarget.6452

Cheng Xue, Chenchen Zhou, Bing Dai, Shengqiang Yu, Chenggang Xu, Zhiguo Mao, Chaoyang Ye, Dongping Chen, Xuezhi Zhao, Jun Wu, Wansheng Chen,  and Changlin Mei
42515-42529
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Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells

Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells

https://doi.org/10.18632/oncotarget.6466

Ling Chen, Long Li, Junde Chen, Lei Li, Zihan Zheng, Jie Ren,  and Yan Qiu
42530-42540
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Research Papers: Immunology

Saikosaponin A inhibits influenza A virus replication and lung immunopathology

Saikosaponin A inhibits influenza A virus replication and lung immunopathology

https://doi.org/10.18632/oncotarget.6448

Jianxin Chen, Mubing Duan, Yaqin Zhao, Fangfang Ling, Kun Xiao, Qian Li, Bin Li, Chunni Lu, Wenbao Qi, Zhenling Zeng, Ming Liao, Yahong Liu,  and Weisan Chen
42541-42556
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Plasma microRNA expression profiles in Chinese patients with rheumatoid arthritis

Plasma microRNA expression profiles in Chinese patients with rheumatoid arthritis

https://doi.org/10.18632/oncotarget.6449

Wenhong Wang, Yingying Zhang, Bo Zhu, Tanghai Duan, Qiugui Xu, Rui Wang, Liwei Lu,  and Zhijun Jiao
42557-42568
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NK cell expression of natural cytotoxicity receptors may determine relapse risk in older AML patients undergoing immunotherapy for remission maintenance

NK cell expression of natural cytotoxicity receptors may determine relapse risk in older AML patients undergoing immunotherapy for remission maintenance

https://doi.org/10.18632/oncotarget.5559

Anna Martner, Anna Rydström, Rebecca E. Riise, Johan Aurelius, Mats Brune, Robin Foà, Kristoffer Hellstrand,  and Fredrik B. Thorén
42569-42574
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Research Papers: Chromosome

Hormone stimulation of androgen receptor mediates dynamic changes in DNA methylation patterns at regulatory elements

Hormone stimulation of androgen receptor mediates dynamic changes in DNA methylation patterns at regulatory elements

https://doi.org/10.18632/oncotarget.6471

Vineet K. Dhiman, Kristopher Attwood, Moray J. Campbell,  and Dominic J. Smiraglia
42575-42589
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Reviews

The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications

The role and mechanism of CRL4 E3 ubiquitin ligase in cancer and its potential therapy implications

https://doi.org/10.18632/oncotarget.6052

Youzhou Sang, Fan Yan,  and Xiubao Ren
42590-42602
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The double face of Morgana in tumorigenesis

The double face of Morgana in tumorigenesis

https://doi.org/10.18632/oncotarget.6058

Mara Brancaccio, Stefania Rocca, Laura Seclì, Elena Busso,  and Federica Fusella
42603-42612
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Non-coding RNAs in cardiac regeneration

Non-coding RNAs in cardiac regeneration

https://doi.org/10.18632/oncotarget.6073

Lichan Tao, Yihua Bei, Yanli Zhou, Junjie Xiao,  and Xinli Li
42613-42622
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Research Papers

Diagnosis of skin cancer by correlation and complexity analyses of damaged DNA

Diagnosis of skin cancer by correlation and complexity analyses of damaged DNA

https://doi.org/10.18632/oncotarget.6003

Hamidreza Namazi, Vladimir V. Kulish, Fatemeh Delaviz,  and Ali Delaviz
42623-42631
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Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer

Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer

https://doi.org/10.18632/oncotarget.5822

Ulises D. Orlando, Ana F. Castillo, Melina A. Dattilo, Angela R. Solano, Paula M. Maloberti,  and Ernesto J. Podesta
42632-42650
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EMT-induced metabolite signature identifies poor clinical outcome

EMT-induced metabolite signature identifies poor clinical outcome

https://doi.org/10.18632/oncotarget.4765

Salil Kumar Bhowmik, Esmeralda Ramirez-Peña, James Michael Arnold, Vasanta Putluri, Nathalie Sphyris, George Michailidis, Nagireddy Putluri, Stefan Ambs, Arun Sreekumar,  and Sendurai A. Mani
42651-42660
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Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population

Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population

https://doi.org/10.18632/oncotarget.6124

Li-Xin Qiu, Jing He, Lei Cheng, Fei Zhou, Meng-Yun Wang, Meng-Hong Sun, Xiao-Yan Zhou, Jin Li, Wei-Jian Guo, Ya-Nong Wang, Ya-Jun Yang, Jiu-Cun Wang, Li Jin, Xiao-Dong Zhu,  and Qing-Yi Wei
42661-42666
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The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells

The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells

https://doi.org/10.18632/oncotarget.5626

Donatella Malanga, Carmela De Marco, Ilaria Guerriero, Fabiana Colelli, Nicola Rinaldo, Marianna Scrima, Teresa Mirante, Claudia De Vitis, Pietro Zoppoli, Michele Ceccarelli, Miriam Riccardi, Maria Ravo, Alessandro Weisz, Antonella Federico, Renato Franco, Gaetano Rocco, Rita Mancini, Antonia Rizzuto, Elio Gulletta, Gennaro Ciliberto,  and Giuseppe Viglietto
42667-42686
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ILs-3, 6 and 11 increase, but ILs-10 and 24 decrease stemness of human prostate cancer cells in vitro

ILs-3, 6 and 11 increase, but ILs-10 and 24 decrease stemness of human prostate cancer cells in vitro

https://doi.org/10.18632/oncotarget.5883

Dan-Dan Yu, Ya-Li Zhong, Xiao-Ran Li, Ya-Qing Li, Xiao-Li Li, Jing Cao, Hui-Jie Fan, Yuan Yuan, Zhen-Yu Ji, Bao-Ping Qiao, Jian-Guo Wen, Ming-Zhi Zhang, Gunnar Kvalheim, Jahn M. Nesland,  and Zhen-He Suo
42687-42703
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Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis

Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis

https://doi.org/10.18632/oncotarget.5678

Xiangjian Luo, Lifang Yang, Lanbo Xiao, Xiaofeng Xia, Xin Dong, Juanfang Zhong, Ying Liu, Namei Li, Ling Chen, Hongde Li, Wei Li, Wenbin Liu, Xinfang Yu, Hanyong Chen, Min Tang, Xinxian Weng, Wei Yi, Ann Bode, Zigang Dong, Jikai Liu,  and Ya Cao
42704-42716
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NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor

NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor

https://doi.org/10.18632/oncotarget.3956

Elena Galvani, Jing Sun, Leticia G. Leon, Rocco Sciarrillo, Ravi S. Narayan, Robert Tjin Tham Sjin, Kwangho Lee, Kadoaki Ohashi, Daniëlle A.M. Heideman, Roberta R. Alfieri, Guus J. Heynen, René Bernards, Egbert F. Smit, William Pao, Godefridus J. Peters,  and Elisa Giovannetti
42717-42732
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Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis

Identification of a novel platelet antagonist that binds to CLEC-2 and suppresses podoplanin-induced platelet aggregation and cancer metastasis

https://doi.org/10.18632/oncotarget.5811

Yao-Wen Chang, Pei-Wen Hsieh, Yu-Tsui Chang, Meng-Hong Lu, Tur-Fu Huang, Kowit-Yu Chong, Hsiang-Ruei Liao, Ju-Chien Cheng,  and Ching-Ping Tseng
42733-42748
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Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability

Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability

https://doi.org/10.18632/oncotarget.5722

Ignacio Niechi, Eduardo Silva, Pablo Cabello, Hernan Huerta, Valentina Carrasco, Paulina Villar, Luis Rodrigo Cataldo, Katherine Marcelain, Ricardo Armisen, Manuel Varas-Godoy, Cristina Fernandez,  and Julio C. Tapia
42749-42760
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MiR-542-5p is a negative prognostic factor and promotes osteosarcoma tumorigenesis by targeting HUWE1

MiR-542-5p is a negative prognostic factor and promotes osteosarcoma tumorigenesis by targeting HUWE1

https://doi.org/10.18632/oncotarget.6199

Dong-dong Cheng, Tao Yu, Tu Hu, Ming Yao, Cun-yi Fan,  and Qing-cheng Yang
42761-42772
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Predictive significance of DNA damage and repair biomarkers in triple-negative breast cancer patients treated with neoadjuvant chemotherapy: An exploratory analysis

Predictive significance of DNA damage and repair biomarkers in triple-negative breast cancer patients treated with neoadjuvant chemotherapy: An exploratory analysis

https://doi.org/10.18632/oncotarget.6001

Patrizia Vici, Anna Di Benedetto, Cristiana Ercolani, Laura Pizzuti, Luigi Di Lauro, Domenico Sergi, Francesca Sperati, Irene Terrenato, Rosanna Dattilo, Claudio Botti, Alessandra Fabi, Maria Teresa Ramieri, Lucia Mentuccia, Camilla Marinelli, Laura Iezzi, Teresa Gamucci, Clara Natoli, Ilio Vitale, Maddalena Barba, Marcella Mottolese, Ruggero De Maria,  and Marcello Maugeri-Saccà
42773-42780
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A functional variant in miR-155 regulation region contributes to lung cancer risk and survival

A functional variant in miR-155 regulation region contributes to lung cancer risk and survival

https://doi.org/10.18632/oncotarget.5840

Kaipeng Xie, Hongxia Ma, Cheng Liang, Cheng Wang, Na Qin, Wei Shen, Yayun Gu, Caiwang Yan, Kai Zhang, Ningbin Dai, Meng Zhu, Shuangshuang Wu, Hui Wang, Juncheng Dai, Guangfu Jin, Hongbing Shen,  and Zhibin Hu
42781-42792
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Genetic and epigenetic characterization of hypodiploid acute lymphoblastic leukemia

Genetic and epigenetic characterization of hypodiploid acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.6000

Setareh Safavi, Linda Olsson, Andrea Biloglav, Srinivas Veerla, Molly Blendberg, Johnbosco Tayebwa, Mikael Behrendtz, Anders Castor, Markus Hansson, Bertil Johansson,  and Kajsa Paulsson
42793-42802
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Iron deficient erythropoiesis might play key role in development of anemia in cancer patients

Iron deficient erythropoiesis might play key role in development of anemia in cancer patients

https://doi.org/10.18632/oncotarget.5658

Silvia Park, Chul Won Jung, Kihyun Kim, Seok Jin Kim, Won Seog Kim,  and Jun Ho Jang
42803-42812
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway

LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway

https://doi.org/10.18632/oncotarget.5970

Jie Ji, Junwei Tang, Lei Deng, Yu Xie, Runqiu Jiang, Guoqiang Li,  and Beicheng Sun
42813-42824
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Bone marrow-derived mesenchymal stem cell-secreted IL-8 promotes the angiogenesis and growth of colorectal cancer

Bone marrow-derived mesenchymal stem cell-secreted IL-8 promotes the angiogenesis and growth of colorectal cancer

https://doi.org/10.18632/oncotarget.5739

Jiancheng Wang, Yingnan Wang, Shaochuan Wang, Jianye Cai, Jiangqiang Shi, Xin Sui, Yong Cao, Weijun Huang, Xiaoyong Chen, Zijie Cai, Hongyu Li, Adham Sameer A. Bardeesi, Bin Zhang, Muyun Liu, Wu Song, Maosheng Wang,  and Andy Peng Xiang
42825-42837
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HOXB9 induction of mesenchymal-to-epithelial transition in gastric carcinoma is negatively regulated by its hexapeptide motif

HOXB9 induction of mesenchymal-to-epithelial transition in gastric carcinoma is negatively regulated by its hexapeptide motif

https://doi.org/10.18632/oncotarget.5814

Qing Chang, Li Zhang, Changyu He, Baogui Zhang, Jun Zhang, Bingya Liu, Naiyan Zeng,  and Zhenggang Zhu
42838-42853
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation

HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation

https://doi.org/10.18632/oncotarget.5733

Yue-Mei Xu, Hong-Jiang Wang, Fang Chen, Wan-Hua Guo, Yan-Yang Wang, Hang-Yu Li, Jin-Hai Tang, Ying Ding, Ya-Chen Shen, Min Li, Wen-Ying Xuan, Lin-Hui Liu, Jia Wang, Xue-Rong Wang, Ze-Jun Gao, Xiu-Bin Liang,  and Dong-Ming Su
42854-42867
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HER3 over-expression and overall survival in gastrointestinal cancers

HER3 over-expression and overall survival in gastrointestinal cancers

https://doi.org/10.18632/oncotarget.5998

Yadong Wang, Haiyan Yang,  and Guangcai Duan
42868-42878
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Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells

Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells

https://doi.org/10.18632/oncotarget.6002

Mingzhu Fang, Wei-Ren Guo, Yongil Park, Hwan-Goo Kang,  and Helmut Zarbl
42879-42891
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Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis

Involvement of MBD4 inactivation in mismatch repair-deficient tumorigenesis

https://doi.org/10.18632/oncotarget.5740

Rossella Tricarico, Salvatore Cortellino, Antonio Riccio, Shantie Jagmohan-Changur, Heleen van der Klift, Juul Wijnen, David Turner, Andrea Ventura, Valentina Rovella, Antonio Percesepe, Emanuela Lucci-Cordisco, Paolo Radice, Lucio Bertario, Monica Pedroni, Maurizio Ponz de Leon, Pietro Mancuso, Karthik Devarajan, Kathy Q. Cai, Andres J.P. Klein-Szanto, Giovanni Neri, Pål Møller, Alessandra Viel, Maurizio Genuardi, Riccardo Fodde,  and Alfonso Bellacosa
42892-42904
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Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAK, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells

Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAK, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells

https://doi.org/10.18632/oncotarget.5466

Han Ie Kim, Hyun Sung Lee, Tae Hyun Kim, Ju-Seog Lee, Seung-Taek Lee,  and Seo-Jin Lee
42905-42922
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Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer

Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer

https://doi.org/10.18632/oncotarget.5976

Wei-Ching Chen, Yung-Sheng Chang, Hui-Ping Hsu, Meng-Chi Yen, Hau-Lun Huang, Chien-Yu Cho, Chih-Yang Wang, Tzu-Yang Weng, Po-Ting Lai, Ching-Shih Chen, Yih-Jyh Lin,  and Ming-Derg Lai
42923-42937
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Phenotypic profile of expanded NK cells in chronic lymphoproliferative disorders: a surrogate marker for NK-cell clonality

Phenotypic profile of expanded NK cells in chronic lymphoproliferative disorders: a surrogate marker for NK-cell clonality

https://doi.org/10.18632/oncotarget.5480

Paloma Bárcena, María Jara-Acevedo, María Dolores Tabernero, Antonio López, María Luz Sánchez, Andrés C. García-Montero, Noemí Muñoz-García, María Belén Vidriales, Artur Paiva, Quentin Lecrevisse, Margarida Lima, Anton W. Langerak, Sebastian Böttcher, Jacques J.M. van Dongen, Alberto Orfao,  and Julia Almeida
42938-42951
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Hepatitis B virus (HBV) receptors: Deficiency in tumor results in scant HBV infection and overexpression in peritumor leads to higher recurrence risk

Hepatitis B virus (HBV) receptors: Deficiency in tumor results in scant HBV infection and overexpression in peritumor leads to higher recurrence risk

https://doi.org/10.18632/oncotarget.5518

Ying-Ying Jing, Wen-Ting Liu, Shi-Wei Guo, Fei Ye, Qing-Min Fan, Guo-Feng Yu, Dan-Dan Yu, Lu Gao, Kai Sun, Zhi-Peng Han, Rong Li, Yang Yang, Qiu-Dong Zhao, Meng-Chao Wu, Hong-Yang Wang,  and Li-Xin Wei
42952-42962
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Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2

Chemopreventive effect of resveratrol and apocynin on pancreatic carcinogenesis via modulation of nuclear phosphorylated GSK3β and ERK1/2

https://doi.org/10.18632/oncotarget.5981

Akihisa Kato, Aya Naiki-Ito, Takahiro Nakazawa, Kazuki Hayashi, Itaru Naitoh, Katsuyuki Miyabe, Shuya Shimizu, Hiromu Kondo, Yuji Nishi, Michihiro Yoshida, Shuichiro Umemura, Yasuki Hori, Toshio Mori, Masahiro Tsutsumi, Toshiya Kuno, Shugo Suzuki, Hiroyuki Kato, Hirotaka Ohara, Takashi Joh,  and Satoru Takahashi
42963-42975
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Cancer metastasis and EGFR signaling is suppressed by amiodarone-induced versican V2

Cancer metastasis and EGFR signaling is suppressed by amiodarone-induced versican V2

https://doi.org/10.18632/oncotarget.5621

Hung-Chieh Lee, Mai-Yan Su, Hao-Chan Lo, Chin-Chieh Wu, Jia-Rung Hu, Dao-Ming Lo, Tsu-Yi Chao, Huai-Jen Tsai,  and Ming-Shen Dai
42976-42987
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Statin use and breast cancer survival and risk: a systematic review and meta-analysis

Statin use and breast cancer survival and risk: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.5557

Qi-Jun Wu, Chao Tu, Yuan-Yuan Li, Jingjing Zhu, Ke-Qing Qian, Wen-Jing Li,  and Lang Wu
42988-43004
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TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner

TGF-β blockade depletes T regulatory cells from metastatic pancreatic tumors in a vaccine dependent manner

https://doi.org/10.18632/oncotarget.5656

Kevin C. Soares, Agnieszka A. Rucki, Victoria Kim, Kelly Foley, Sara Solt, Christopher L. Wolfgang, Elizabeth M. Jaffee,  and Lei Zheng
43005-43015
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Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis

Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis

https://doi.org/10.18632/oncotarget.5513

Letícia F. Leal, Ana Carolina Bueno, Débora C. Gomes, Rafael Abduch, Margaret de Castro,  and Sonir R. Antonini
43016-43032
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miR-150 inhibits terminal erythroid proliferation and differentiation

miR-150 inhibits terminal erythroid proliferation and differentiation

https://doi.org/10.18632/oncotarget.5824

Zhiwei Sun, Ye Wang, Xu Han, Xielan Zhao, Yuanliang Peng, Yusheng Li, Minyuan Peng, Jianhui Song, Kunlu Wu, Shumin Sun, Weihua Zhou, Biwei Qi, Chufan Zhou, Huiyong Chen, Xiuli An,  and Jing Liu
43033-43047
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Stromal cell-mediated mitochondrial redox adaptation regulates drug resistance in childhood acute lymphoblastic leukemia

Stromal cell-mediated mitochondrial redox adaptation regulates drug resistance in childhood acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.5528

Jizhong Liu, Ashish Masurekar, Suzanne Johnson, Sohini Chakraborty, John Griffiths, Duncan Smith, Seema Alexander, Clare Dempsey, Catriona Parker, Stephanie Harrison, Yaoyong Li, Crispin Miller, Yujun Di, Zhumur Ghosh, Shekhar Krishnan,  and Vaskar Saha
43048-43064
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mitochondrial oncobioenergetic index: A potential biomarker to predict progression from indolent to aggressive prostate cancer

Mitochondrial oncobioenergetic index: A potential biomarker to predict progression from indolent to aggressive prostate cancer

https://doi.org/10.18632/oncotarget.5487

Praveen K. Vayalil,  and Aimee Landar
43065-43080
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Infiltrating neutrophils increase bladder cancer cell invasion via modulation of androgen receptor (AR)/MMP13 signals

Infiltrating neutrophils increase bladder cancer cell invasion via modulation of androgen receptor (AR)/MMP13 signals

https://doi.org/10.18632/oncotarget.5638

ChangYi Lin, WanYing Lin, Shuyuan Yeh, Lei Li,  and Chawnshang Chang
43081-43089
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Clinical Research Papers

Aspartate aminotransferase-lymphocyte ratio index and systemic immune-inflammation index predict overall survival in HBV-related hepatocellular carcinoma patients after transcatheter arterial chemoembolization

Aspartate aminotransferase-lymphocyte ratio index and systemic immune-inflammation index predict overall survival in HBV-related hepatocellular carcinoma patients after transcatheter arterial chemoembolization

https://doi.org/10.18632/oncotarget.5719

Zongguo Yang, Jianliang Zhang, Yunfei Lu, Qingnian Xu, Bozong Tang, Qiang Wang, Wensi Zhang, Shishi Chen, Lingqing Lu,  and Xiaorong Chen
43090-43098
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Dietary fat and fatty acid intake and epithelial ovarian cancer risk: evidence from epidemiological studies

Dietary fat and fatty acid intake and epithelial ovarian cancer risk: evidence from epidemiological studies

https://doi.org/10.18632/oncotarget.5525

Rui Hou, Qi-Jun Wu, Ting-Ting Gong,  and Luo Jiang
43099-43119
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Clinical analysis of intraoperative radiotherapy during breast-conserving surgery of early breast cancer in the Chinese Han population

Clinical analysis of intraoperative radiotherapy during breast-conserving surgery of early breast cancer in the Chinese Han population

https://doi.org/10.18632/oncotarget.5716

Xin Wang, Jiaqi Liu, Wenyan Wang, Qinfu Feng,  and Xiang Wang
43120-43126
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Phase 1b study of lenvatinib (E7080) in combination with temozolomide for treatment of advanced melanoma

Phase 1b study of lenvatinib (E7080) in combination with temozolomide for treatment of advanced melanoma

https://doi.org/10.18632/oncotarget.5756

David S. Hong, Razelle Kurzrock, Gerald S. Falchook, Corina Andresen, Jennifer Kwak, Min Ren, Lucy Xu, Goldy C. George, Kevin B. Kim, Ly M. Nguyen, James P. O’Brien,  and John Nemunaitis
43127-43134
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chemotherapy of metastatic triple negative breast cancer: Experience of using platinum-based chemotherapy

Chemotherapy of metastatic triple negative breast cancer: Experience of using platinum-based chemotherapy

https://doi.org/10.18632/oncotarget.5654

Jian Zhang, Minhao Fan, Jie Xie, Zhonghua Wang, Biyun Wang, Sheng Zhang, Leiping Wang, Jun Cao, Zhonghua Tao, Ting Li,  and Xichun Hu
43135-43143
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