Oncotarget

Vol 6, No 39

December 8, 2015

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Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex. See Fischer et al.

Table of Contents

Editorial

SnoRNPs, ZNHIT proteins and the R2TP pathway

SnoRNPs, ZNHIT proteins and the R2TP pathway

https://doi.org/10.18632/oncotarget.6388

Céline Verheggen, Bérengère Pradet-Balade,  and Edouard Bertrand
41399-41400
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Editorial: Chromosome

Active transcription without histone modifications

Active transcription without histone modifications

https://doi.org/10.18632/oncotarget.6437

Sílvia Pérez-Lluch, Roderic Guigó,  and Montserrat Corominas
41401-41401
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Priority Research Papers

Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex

Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex

https://doi.org/10.18632/oncotarget.6356

Martin Fischer, Marianne Quaas, Annina Nickel,  and Kurt Engeland
41402-41417
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Research Papers: Gerotarget (Focus on Aging)

Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans

Genome-wide endogenous DAF-16/FOXO recruitment dynamics during lowered insulin signalling in C. elegans

https://doi.org/10.18632/oncotarget.6282

Neeraj Kumar, Vaibhav Jain, Anupama Singh, Urmila Jagtap, Sonia Verma,  and Arnab Mukhopadhyay
41418-41433
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Research Papers: Pathology

LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease

LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease

https://doi.org/10.18632/oncotarget.5163

Sara Ceccarelli, Nadia Panera, Marco Mina, Daniela Gnani, Cristiano De Stefanis, Annalisa Crudele, Chiara Rychlicki, Stefania Petrini, Giovannella Bruscalupi, Laura Agostinelli, Laura Stronati, Salvatore Cucchiara, Giovanni Musso, Cesare Furlanello, Gianluca Svegliati-Baroni, Valerio Nobili,  and Anna Alisi
41434-41452
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

VE1 immunohistochemistry predicts BRAF V600E mutation status and clinical outcome in colorectal cancer

VE1 immunohistochemistry predicts BRAF V600E mutation status and clinical outcome in colorectal cancer

https://doi.org/10.18632/oncotarget.6162

Christian Schafroth, José A. Galván, Irene Centeno, Viktor H. Koelzer, Heather E. Dawson, Lena Sokol, Gregor Rieger, Martin D. Berger, Marion Hädrich, Robert Rosenberg, Ulrich Nitsche, Beat Schnüriger, Rupert Langer, Daniel Inderbitzin, Alessandro Lugli,  and Inti Zlobec
41453-41463
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Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro

Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro

https://doi.org/10.18632/oncotarget.6203

Abdo Mahli, Wolfgang E. Thasler, Eleonora Patsenker, Sebastian Müller, Felix Stickel, Martina Müller, Helmut K. Seitz, Arthur I. Cederbaum,  and Claus Hellerbrand
41464-41478
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Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis

Myristic acid potentiates palmitic acid-induced lipotoxicity and steatohepatitis associated with lipodystrophy by sustaning de novo ceramide synthesis

https://doi.org/10.18632/oncotarget.6286

Laura Martínez, Sandra Torres, Anna Baulies, Cristina Alarcón-Vila, Montserrat Elena, Gemma Fabriàs, Josefina Casas, Joan Caballeria, Jose C. Fernandez-Checa,  and Carmen García-Ruiz
41479-41496
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Donor-derived stem-cells and epithelial mesenchymal transition in squamous cell carcinoma in transplant recipients

Donor-derived stem-cells and epithelial mesenchymal transition in squamous cell carcinoma in transplant recipients

https://doi.org/10.18632/oncotarget.6359

Laurence Verneuil, Christophe Leboeuf, Guilhem Bousquet, Charlotte Brugiere, Morad Elbouchtaoui, Louis-François Plassa, Marie-Noelle Peraldi, Celeste Lebbé, Philippe Ratajczak,  and Anne Janin
41497-41507
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Research Papers: Immunology

4-Hydroxynonenal regulates mitochondrial function in human small airway epithelial cells

4-Hydroxynonenal regulates mitochondrial function in human small airway epithelial cells

https://doi.org/10.18632/oncotarget.6131

Lakshmi Galam, Athena Failla, Ramani Soundararajan, Richard F. Lockey,  and Narasaiah Kolliputi
41508-41521
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Research Papers: Autophagy and Cell Death

Differential role of RIP1 in Smac mimetic-mediated chemosensitization of neuroblastoma cells

Differential role of RIP1 in Smac mimetic-mediated chemosensitization of neuroblastoma cells

https://doi.org/10.18632/oncotarget.6308

Sebastian Czaplinski, Behnaz Ahangarian Abhari, Alica Torkov, Dominik Seggewiß, Manuela Hugle,  and Simone Fulda
41522-41534
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Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells

Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells

https://doi.org/10.18632/oncotarget.6365

Kaitlyn M. Dykstra, Cheryl Allen, Ella J. Born, Huaxiang Tong,  and Sarah A. Holstein
41535-41549
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Research Papers: Chromosome

ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments

ASPP1/2-PP1 complexes are required for chromosome segregation and kinetochore-microtubule attachments

https://doi.org/10.18632/oncotarget.6355

Pingzhao Zhang, Yuanyuan Zhang, Kun Gao, Yuqi Wang, Xiaofeng Jin, Youheng Wei, Heige Saiyin, Dejie Wang, Jintao Peng, Jian Ma, Yan Tang, Reziya Wumaier, Hongxiu Yu, Yimin Dong, Haojie Huang, Long Yu,  and Chenji Wang
41550-41565
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Reviews

The dark side of ZNF217, a key regulator of tumorigenesis with powerful biomarker value

The dark side of ZNF217, a key regulator of tumorigenesis with powerful biomarker value

https://doi.org/10.18632/oncotarget.5893

Pascale A. Cohen, Caterina F. Donini, Nhan T. Nguyen, Hubert Lincet,  and Julie A. Vendrell
41566-41581
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Decoding Warburg’s hypothesis: tumor-related mutations in the mitochondrial respiratory chain

Decoding Warburg’s hypothesis: tumor-related mutations in the mitochondrial respiratory chain

https://doi.org/10.18632/oncotarget.6057

Jose M. Garcia-Heredia,  and Amancio Carnero
41582-41599
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Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: impact on clinical studies and considerations for combined therapies

Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: impact on clinical studies and considerations for combined therapies

https://doi.org/10.18632/oncotarget.6113

Simon Gebremeskel,  and Brent Johnston
41600-41619
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Research Papers

MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells

MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells

https://doi.org/10.18632/oncotarget.5871

Xing Guo, Hao Xue, Xiaofan Guo, Xiao Gao, Shugang Xu, Shaofeng Yan, Xiao Han, Tong Li, Jie Shen,  and Gang Li
41620-41637
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-1 down-regulates proliferation and migration of breast cancer stem cells by inhibiting the Wnt/β-catenin pathway

MicroRNA-1 down-regulates proliferation and migration of breast cancer stem cells by inhibiting the Wnt/β-catenin pathway

https://doi.org/10.18632/oncotarget.5873

Tong Liu, Kebang Hu, Zuowei Zhao, Guanglei Chen, Xunyan Ou, Hao Zhang, Xin Zhang, Xiaofei Wei, Dan Wang, Meizi Cui,  and Caigang Liu
41638-41649
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The proinflammatory LTB4/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region

The proinflammatory LTB4/BLT1 signal axis confers resistance to TGF-β1-induced growth inhibition by targeting Smad3 linker region

https://doi.org/10.18632/oncotarget.6146

Woo-Kwang Jeon, Jiyeon Choi, Seong Ji Park, Eun Ji Jo, Young K. Lee, Seunghwan Lim, Jae-Hong Kim, John J. Letterio, Fang Liu, Seong-Jin Kim,  and Byung-Chul Kim
41650-41666
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Eribulin targets a ch-TOG-dependent directed migration of cancer cells

Eribulin targets a ch-TOG-dependent directed migration of cancer cells

https://doi.org/10.18632/oncotarget.6147

Brice Chanez, Anthony Gonçalves, Ali Badache,  and Pascal Verdier-Pinard
41667-41678
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-κB pathway

Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-κB pathway

https://doi.org/10.18632/oncotarget.6149

Li Xu, Huan Ning, Ling Gu, Qinghong Wang, Wenbao Lu, Hui Peng, Weiguang Cui, Baoling Ying, Christina R. Ross, Gerald M. Wilson, Lin Wei, William S.M. Wold,  and Jianguo Liu
41679-41691
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mutant p53 confers chemoresistance in non-small cell lung cancer by upregulating Nrf2

Mutant p53 confers chemoresistance in non-small cell lung cancer by upregulating Nrf2

https://doi.org/10.18632/oncotarget.6150

Min-Che Tung, Po-Lin Lin, Yao-Chen Wang, Tsung-Ying He, Ming-Ching Lee, Sauh-Der Yeh, Chih-Yi Chen,  and Huei Lee
41692-41705
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits

5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits

https://doi.org/10.18632/oncotarget.5991

Corti Denise, Paolo Paoli, Maura Calvani, Maria Letizia Taddei, Elisa Giannoni, Scott Kopetz, Syed Mohammad Ali Kazmi, Morelli Maria Pia, Piergiorgio Pettazzoni, Elena Sacco, Anna Caselli, Marco Vanoni, Matteo Landriscina, Paolo Cirri,  and Paola Chiarugi
41706-41721
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Suppression of ATAD2 inhibits hepatocellular carcinoma progression through activation of p53- and p38-mediated apoptotic signaling

Suppression of ATAD2 inhibits hepatocellular carcinoma progression through activation of p53- and p38-mediated apoptotic signaling

https://doi.org/10.18632/oncotarget.6152

Wen-Jing Lu, Mei-Sze Chua,  and Samuel K. So
41722-41735
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway

A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway

https://doi.org/10.18632/oncotarget.6153

Azadeh Cheraghchi-Bashi, Christine A. Parker, Ed Curry, Jean-Frederic Salazar, Hatice Gungor, Azeem Saleem, Paula Cunnea, Nona Rama, Cristian Salinas, Gordon B. Mills, Shannon R. Morris, Rakesh Kumar, Hani Gabra,  and Euan A. Stronach
41736-41749
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation

A novel prohibitin-binding compound induces the mitochondrial apoptotic pathway through NOXA and BIM upregulation

https://doi.org/10.18632/oncotarget.6154

Cristina Moncunill-Massaguer, José Saura-Esteller, Alba Pérez-Perarnau, Claudia Mariela Palmeri, Sonia Núñez-Vázquez, Ana M. Cosialls, Diana M. González-Gironès, Helena Pomares, Anne Korwitz, Sara Preciado, Fernando Albericio, Rodolfo Lavilla, Gabriel Pons, Thomas Langer, Daniel Iglesias-Serret,  and Joan Gil
41750-41765
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EBV-miR-BART10-3p facilitates epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC

EBV-miR-BART10-3p facilitates epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC

https://doi.org/10.18632/oncotarget.6155

Qijia Yan, Zhaoyang Zeng, Zhaojian Gong, Wenling Zhang, Xiayu Li, Baoyu He, Yali Song, Qiao Li, Yong Zeng, Qianjin Liao, Pan Chen, Lei Shi, Songqing Fan, Bo Xiang, Jian Ma, Ming Zhou, Xiaoling Li, Jianbo Yang, Wei Xiong,  and Guiyuan Li
41766-41782
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells

Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells

https://doi.org/10.18632/oncotarget.6157

Christian Holzmann, Sven Kappel, Tatiana Kilch, Marcus Martin Jochum, Sabine Katharina Urban, Volker Jung, Michael Stöckle, Karen Rother, Markus Greiner,  and Christine Peinelt
41783-41793
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-Jun/COX-2 signaling pathway

Palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-Jun/COX-2 signaling pathway

https://doi.org/10.18632/oncotarget.5993

Ge Qin, Fei Xu, Tao Qin, Qiufan Zheng, Dingbo Shi, Wen Xia, Yun Tian, Yanlai Tang, Jingshu Wang, Xiangshen Xiao, Wuguo Deng,  and Shusen Wang
41794-41808
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model

Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model

https://doi.org/10.18632/oncotarget.6166

Xuesen Li, Noriko N. Yokoyama, Saiyang Zhang, Lina Ding, Hong-min Liu, Michael B. Lilly, Dan Mercola,  and Xiaolin Zi
41809-41824
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combination of circulating tumor cell enumeration and tumor marker detection in predicting prognosis and treatment effect in metastatic castration-resistant prostate cancer

Combination of circulating tumor cell enumeration and tumor marker detection in predicting prognosis and treatment effect in metastatic castration-resistant prostate cancer

https://doi.org/10.18632/oncotarget.6167

Kun Chang, Yun-Yi Kong, Bo Dai, Ding-Wei Ye, Yuan-Yuan Qu, Yue Wang, Zhong-Wei Jia,  and Gao-Xiang Li
41825-41836
Abstract  |  PDF  |  HTML  |  Order a Reprint

Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1

Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1

https://doi.org/10.18632/oncotarget.5995

Yi-Chen Yen, Jenn-Ren Hsiao, Shih Sheng Jiang, Jeffrey S. Chang, Ssu-Han Wang, Ying-Ying Shen, Chung-Hsing Chen, I-Shou Chang, Jang-Yang Chang,  and Ya-Wen Chen
41837-41855
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model

Adjuvant treatment with tumor-targeting Salmonella typhimurium A1-R reduces recurrence and increases survival after liver metastasis resection in an orthotopic nude mouse model

https://doi.org/10.18632/oncotarget.6170

Takashi Murakami, Yukihiko Hiroshima, Ming Zhao, Yong Zhang, Takashi Chishima, Kuniya Tanaka, Michael Bouvet, Itaru Endo,  and Robert M. Hoffman
41856-41862
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Inhibition of iNOS activity enhances the anti-tumor effects of alpha-galactosylceramide in established murine cancer model

Inhibition of iNOS activity enhances the anti-tumor effects of alpha-galactosylceramide in established murine cancer model

https://doi.org/10.18632/oncotarget.6172

Hiroyasu Ito, Tatsuya Ando,  and Mitsuru Seishima
41863-41874
Abstract  |  PDF  |  HTML  |  Order a Reprint

The demographic features, clinicopathologic characteristics, treatment outcome and disease-specific prognostic factors of solitary fibrous tumor: a population-based analysis

The demographic features, clinicopathologic characteristics, treatment outcome and disease-specific prognostic factors of solitary fibrous tumor: a population-based analysis

https://doi.org/10.18632/oncotarget.6174

Alimujiang Wushou, Yi-Zhou Jiang, Yi-Rong Liu,  and Zhi-Ming Shao
41875-41883
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties

Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties

https://doi.org/10.18632/oncotarget.6099

Alain C. Jung, Anne-Marie Ray, Ludivine Ramolu, Christine Macabre, Florian Simon, Fanny Noulet, Anne-Florence Blandin, Guillaume Renner, Maxime Lehmann, Laurence Choulier, Horst Kessler, Joseph Abecassis, Monique Dontenwill,  and Sophie Martin
41884-41901
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL

Bcl-xL inhibition by molecular-targeting drugs sensitizes human pancreatic cancer cells to TRAIL

https://doi.org/10.18632/oncotarget.5881

Yoko Hari, Nanae Harashima, Yoshitsugu Tajima,  and Mamoru Harada
41902-41915
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GalNAc-T14 promotes metastasis through Wnt dependent HOXB9 expression in lung adenocarcinoma

GalNAc-T14 promotes metastasis through Wnt dependent HOXB9 expression in lung adenocarcinoma

https://doi.org/10.18632/oncotarget.6019

Ok-Seon Kwon, Ensel Oh, Jeong-Rak Park, Ji-Seon Lee, Gab-Yong Bae, Jae-Hyung Koo, Hyungbum Kim, Yoon-La Choi, Young Soo Choi, Jhingook Kim,  and Hyuk-Jin Cha
41916-41928
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

(E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol inhibits growth of colon tumors in mice

(E)-4-(3-(3,5-dimethoxyphenyl)allyl)-2-methoxyphenol inhibits growth of colon tumors in mice

https://doi.org/10.18632/oncotarget.5861

Jie Zheng, Mi Hee Park, Dong Ju Son, Min Gi Choi, Jeong Soon Choi, Kyung Tak Nam, Hae Deun Kim, Kevin Rodriguez, Benjamin Gann, Young Wan Ham, Sang Bae Han,  and Jin Tae Hong
41929-41943
Abstract  |  PDF  |  HTML  |  Order a Reprint

STAT3 blockade enhances the efficacy of conventional chemotherapeutic agents by eradicating head neck stemloid cancer cell

STAT3 blockade enhances the efficacy of conventional chemotherapeutic agents by eradicating head neck stemloid cancer cell

https://doi.org/10.18632/oncotarget.5986

Lin-Lin Bu, Zhi-Li Zhao, Jian-Feng Liu, Si-Rui Ma, Cong-Fa Huang, Bing Liu, Wen-Feng Zhang,  and Zhi-Jun Sun
41944-41958
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cullin3 promotes breast cancer cells metastasis and epithelial-mesenchymal transition by targeting BRMS1 for degradation

Cullin3 promotes breast cancer cells metastasis and epithelial-mesenchymal transition by targeting BRMS1 for degradation

https://doi.org/10.18632/oncotarget.5999

Xiongwei Huo, Suoni Li, Tingting Shi, Aili Suo, Zhiping Ruan, Hui Guo,  and Yu Yao
41959-41975
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reciprocal feedback inhibition of the androgen receptor and PI3K as a novel therapy for castrate-sensitive and -resistant prostate cancer

Reciprocal feedback inhibition of the androgen receptor and PI3K as a novel therapy for castrate-sensitive and -resistant prostate cancer

https://doi.org/10.18632/oncotarget.5659

Wenqing Qi, Carla Morales, Laurence S. Cooke, Benny Johnson, Bradley Somer,  and Daruka Mahadevan
41976-41987
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mitochondrial DNA copy number in peripheral blood leukocytes and the aggressiveness of localized prostate cancer

Mitochondrial DNA copy number in peripheral blood leukocytes and the aggressiveness of localized prostate cancer

https://doi.org/10.18632/oncotarget.5889

Huakang Tu, Jian Gu, Qing H. Meng, Jeri Kim, John W. Davis, Yonggang He, Elizabeth A. Wagar, Timothy C. Thompson, Christopher J. Logothetis,  and Xifeng Wu
41988-41996
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance

Oncogenic Ras suppresses ING4-TDG-Fas axis to promote apoptosis resistance

https://doi.org/10.18632/oncotarget.6015

Jie Sun, Qi Shen, Haiqi Lu, Zhinong Jiang, Wenxia Xu, Lifeng Feng, Ling Li, Xian Wang, Xiujun Cai,  and Hongchuan Jin
41997-42007
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma

Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma

https://doi.org/10.18632/oncotarget.5788

Elin S. Gray, Helen Rizos, Anna L. Reid, Suzanah C. Boyd, Michelle R. Pereira, Johnny Lo, Varsha Tembe, James Freeman, Jenny H.J. Lee, Richard A. Scolyer, Kelvin Siew, Chris Lomma, Adam Cooper, Muhammad A. Khattak, Tarek M. Meniawy, Georgina V. Long, Matteo S. Carlino, Michael Millward,  and Melanie Ziman
42008-42018
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD133 overexpression correlates with clinicopathological features of gastric cancer patients and its impact on survival: a systematic review and meta-analysis

CD133 overexpression correlates with clinicopathological features of gastric cancer patients and its impact on survival: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.5714

Li Yiming, Guo Yunshan, Ma Bo, Zang Yu, Wei Tao, Liang Gengfang, Fan Dexian, Cui Shiqian, Jiang Jianli, Tang Juan,  and Chen Zhinan
42019-42027
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E

Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E

https://doi.org/10.18632/oncotarget.5973

Jiaqing Hao, Xiao Song, Jingjing Wang, Chengli Guo, Yan Li, Bing Li, Yu Zhang,  and Yanhui Yin
42028-42039
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma

Comprehensive profiling of novel microRNA-9 targets and a tumor suppressor role of microRNA-9 via targeting IGF2BP1 in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.5969

Jiangbo Zhang, Jin Cheng, Zhenzhen Zeng, Yongfeng Wang, Xiaojun Li, Qing Xie, Junqiao Jia, Ying Yan, Zhengyang Guo, Jian Gao, Mingjie Yao, Xiangmei Chen,  and Fengmin Lu
42040-42052
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MDM2 and HIF1alpha expression levels in different histologic subtypes of malignant pleural mesothelioma: correlation with pathological and clinical data

MDM2 and HIF1alpha expression levels in different histologic subtypes of malignant pleural mesothelioma: correlation with pathological and clinical data

https://doi.org/10.18632/oncotarget.5974

Giulia Pasello, Loredana Urso, Manlio Mencoboni, Federica Grosso, Giovanni Luca Ceresoli, Francesca Lunardi, Stefania Edith Vuljan, Roberta Bertorelle, Valeria Sacchetto, Vincenzo Ciminale, Federico Rea, Adolfo Favaretto, PierFranco Conte,  and Fiorella Calabrese
42053-42066
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PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPα axis in HPV negative head and neck squamous cell carcinoma

PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPα axis in HPV negative head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.5955

Guang-Tao Yu, Lin-Lin Bu, Cong-Fa Huang, Wen-Feng Zhang, Wan-Jun Chen, J. Silvio Gutkind, Ashok B. Kulkarni,  and Zhi-Jun Sun
42067-42080
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Imaging the distribution of an antibody-drug conjugate constituent targeting mesothelin with 89Zr and IRDye 800CW in mice bearing human pancreatic tumor xenografts

Imaging the distribution of an antibody-drug conjugate constituent targeting mesothelin with 89Zr and IRDye 800CW in mice bearing human pancreatic tumor xenografts

https://doi.org/10.18632/oncotarget.5877

Eva J. ter Weele, Anton G.T. Terwisscha van Scheltinga, Jos G.W. Kosterink, Linda Pot, Silke R. Vedelaar, Laetitia E. Lamberts, Simon P. Williams, Marjolijn N. Lub-de Hooge,  and Elisabeth G.E. de Vries
42081-42090
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nucleolin antagonist triggers autophagic cell death in human glioblastoma primary cells and decreased in vivo tumor growth in orthotopic brain tumor model

Nucleolin antagonist triggers autophagic cell death in human glioblastoma primary cells and decreased in vivo tumor growth in orthotopic brain tumor model

https://doi.org/10.18632/oncotarget.5990

Elisabetta Benedetti, Andrea Antonosante, Michele d’Angelo, Loredana Cristiano, Renato Galzio, Damien Destouches, Tiziana Marilena Florio, Anne Chloé Dhez, Carlo Astarita, Benedetta Cinque, Alessia Fidoamore, Floriana Rosati, Maria Grazia Cifone, Rodolfo Ippoliti, Antonio Giordano, José Courty,  and Annamaria Cimini
42091-42104
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis

Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis

https://doi.org/10.18632/oncotarget.5870

Xudong Jiang, Wenjuan Mao, Ziyi Yang, Jia Zeng, Yi Zhang, Yang Song, Ying Kong, Shuangyi Ren,  and Yunfei Zuo
42105-42117
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LRG1 expression indicates unfavorable clinical outcome in hepatocellular carcinoma

LRG1 expression indicates unfavorable clinical outcome in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.5967

Chun-Hua Wang, Min Li, Li-Li Liu, Ruo-Yao Zhou, Jia Fu, Chris Zhiyi Zhang,  and Jing-Ping Yun
42118-42129
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Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival

Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival

https://doi.org/10.18632/oncotarget.6239

Valentina Trimarco, Elisa Ave, Monica Facco, Giorgia Chiodin, Federica Frezzato, Veronica Martini, Cristina Gattazzo, Federica Lessi, Carlo Alberto Giorgi, Andrea Visentin, Monica Castelli, Filippo Severin, Renato Zambello, Francesco Piazza, Gianpietro Semenzato,  and Livio Trentin
42130-42149
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Co-delivery of cisplatin and paclitaxel by folic acid conjugated amphiphilic PEG-PLGA copolymer nanoparticles for the treatment of non-small lung cancer

Co-delivery of cisplatin and paclitaxel by folic acid conjugated amphiphilic PEG-PLGA copolymer nanoparticles for the treatment of non-small lung cancer

https://doi.org/10.18632/oncotarget.6243

Zelai He, Jingwen Huang, Yuanyuan Xu, Xiangyu Zhang, Yanwei Teng, Can Huang, Yufeng Wu, Xi Zhang, Huijun Zhang,  and Wenjie Sun
42150-42168
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Correlation of clinical features and genetic profiles of stromal interaction molecule 1 (STIM1) in colorectal cancers

Correlation of clinical features and genetic profiles of stromal interaction molecule 1 (STIM1) in colorectal cancers

https://doi.org/10.18632/oncotarget.5888

Henry Sung-Ching Wong,  and Wei-Chiao Chang
42169-42182
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutant HRAS as novel target for MEK and mTOR inhibitors

Mutant HRAS as novel target for MEK and mTOR inhibitors

https://doi.org/10.18632/oncotarget.5619

Michael K. Kiessling, Alessandra Curioni-Fontecedro, Panagiotis Samaras, Kirstin Atrott, Jesus Cosin-Roger, Silvia Lang, Michael Scharl,  and Gerhard Rogler
42183-42196
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sense-antisense gene-pairs in breast cancer and associated pathological pathways

Sense-antisense gene-pairs in breast cancer and associated pathological pathways

https://doi.org/10.18632/oncotarget.6255

Oleg V. Grinchuk, Efthymios Motakis, Surya Pavan Yenamandra, Ghim Siong Ow, Piroon Jenjaroenpun, Zhiqun Tang, Aliaksandr A. Yarmishyn, Anna V. Ivshina,  and Vladimir A. Kuznetsov
42197-42221
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

New tumor regression grade for rectal cancer after neoadjuvant therapy and radical surgery

New tumor regression grade for rectal cancer after neoadjuvant therapy and radical surgery

https://doi.org/10.18632/oncotarget.6008

Jun Li, Hao Liu, Junjie Hu, Sai Liu, Jie Yin, Feng Du, Jiatian Yuan,  and Bo Lv
42222-42231
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Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma

Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma

https://doi.org/10.18632/oncotarget.6273

Daniel Nagel, Miriam Bognar, Andrea C. Eitelhuber, Kerstin Kutzner, Michelle Vincendeau,  and Daniel Krappmann
42232-42242
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Molecular characterization of metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) beyond KIT/PDGFRα genotype evaluated by next generation sequencing (NGS)

Molecular characterization of metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) beyond KIT/PDGFRα genotype evaluated by next generation sequencing (NGS)

https://doi.org/10.18632/oncotarget.6278

Maristella Saponara, Milena Urbini, Annalisa Astolfi, Valentina Indio, Giorgio Ercolani, Massimo Del Gaudio, Donatella Santini, Maria Giulia Pirini, Michelangelo Fiorentino, Margherita Nannini, Cristian Lolli, Anna Mandrioli, Lidia Gatto, Giovanni Brandi, Guido Biasco, Antonio Daniele Pinna,  and Maria Abbondanza Pantaleo
42243-42257
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A Polycomb-mir200 loop regulates clinical outcome in bladder cancer

A Polycomb-mir200 loop regulates clinical outcome in bladder cancer

https://doi.org/10.18632/oncotarget.5546

Mónica Martínez-Fernández, Marta Dueñas, Andrew Feber, Cristina Segovia, Ramón García-Escudero, Carolina Rubio, Fernando F. López-Calderón, Claudio Díaz-García, Felipe Villacampa, José Duarte, María J. Gómez-Rodirguez, Daniel Castellano, José L. Rodriguez-Peralto, Federico de la Rosa, Stephan Beck,  and Jesus M. Paramio
42258-42275
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Involvement of Wnt/β-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma

Involvement of Wnt/β-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma

https://doi.org/10.18632/oncotarget.5514

Weiwei Wang, Wei Zhong, Jiahui Yuan, Congcong Yan, Shaoping Hu, Yinping Tong, Yubin Mao, Tianhui Hu, Bing Zhang,  and Gang Song
42276-42289
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Controllable permeability of blood-brain barrier and reduced brain injury through low-intensity pulsed ultrasound stimulation

Controllable permeability of blood-brain barrier and reduced brain injury through low-intensity pulsed ultrasound stimulation

https://doi.org/10.18632/oncotarget.5978

Wei-Shen Su, Min-Lan Tsai, Sin-Luo Huang, Shing-Hwa Liu,  and Feng-Yi Yang
42290-42299
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Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia

Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.5982

Zheng Ge, Xing Guo, Jianyong Li, Melanie Hartman, Yuka Imamura Kawasawa, Sinisa Dovat,  and Chunhua Song
42300-42311
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Germline HOXB13 p.Gly84Glu mutation and cancer susceptibility: a pooled analysis of 25 epidemiological studies with 145,257 participates

Germline HOXB13 p.Gly84Glu mutation and cancer susceptibility: a pooled analysis of 25 epidemiological studies with 145,257 participates

https://doi.org/10.18632/oncotarget.5994

Qiliang Cai, Xinpeng Wang, Xiaodong Li, Rui Gong, Xuemei Guo, Yang Tang, Kuo Yang, Yuanjie Niu,  and Yan Zhao
42312-42321
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Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5

Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5

https://doi.org/10.18632/oncotarget.5996

Ying Gu, Mansoureh Barzegar, Xin Chen, Yang Wu, Chaowei Shang, Elahe Mahdavian, Brian A. Salvatore, Shanxiang Jiang,  and Shile Huang
42322-42333
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mutational profiling of colorectal cancers with microsatellite instability

Mutational profiling of colorectal cancers with microsatellite instability

https://doi.org/10.18632/oncotarget.5997

Elaine I. Lin, Li-Hui Tseng, Christopher D. Gocke, Stacy Reil, Dung T. Le, Nilofer S. Azad,  and James R. Eshleman
42334-42344
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Clinical Research Papers

IDH1/2 but not DNMT3A mutations are suitable targets for minimal residual disease monitoring in acute myeloid leukemia patients: a study by the Acute Leukemia French Association

IDH1/2 but not DNMT3A mutations are suitable targets for minimal residual disease monitoring in acute myeloid leukemia patients: a study by the Acute Leukemia French Association

https://doi.org/10.18632/oncotarget.5645

Houria Debarri, Delphine Lebon, Christophe Roumier, Meyling Cheok, Alice Marceau-Renaut, Olivier Nibourel, Sandrine Geffroy, Nathalie Helevaut, Philippe Rousselot, Bérengère Gruson, Claude Gardin, Marie-Lorraine Chretien, Shéhérazade Sebda, Martin Figeac, Céline Berthon, Bruno Quesnel, Nicolas Boissel, Sylvie Castaigne, Hervé Dombret, Aline Renneville,  and Claude Preudhomme
42345-42353
Abstract  |  PDF  |  HTML  |  Order a Reprint

Wait-and-see or radical surgery for rectal cancer patients with a clinical complete response after neoadjuvant chemoradiotherapy: a cohort study

Wait-and-see or radical surgery for rectal cancer patients with a clinical complete response after neoadjuvant chemoradiotherapy: a cohort study

https://doi.org/10.18632/oncotarget.6093

Jun Li, Hao Liu, Jie Yin, Sai Liu, Junjie Hu, Feng Du, Jiatian Yuan, Bo Lv, Jun Fan, Shusheng Leng,  and Xin Zhang
42354-42361
Abstract  |  PDF  |  HTML  |  Order a Reprint

High incidence of MYC and BCL2 abnormalities in mantle cell lymphoma, although only MYC abnormality predicts poor survival

High incidence of MYC and BCL2 abnormalities in mantle cell lymphoma, although only MYC abnormality predicts poor survival

https://doi.org/10.18632/oncotarget.5705

Shuhua Yi, Dehui Zou, Chengwen Li, Shizhen Zhong, Weiwei Chen, Zengjun Li, Wenjie Xiong, Wei Liu, Enbin Liu, Rui Cui, Kun Ru, Peihong Zhang, Yan Xu, Gang An, Rui Lv, Junyuan Qi, Jianxiang Wang, Tao Cheng,  and Lugui Qiu
42362-42371
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identifying the optimal criteria of radiotherapeutic parameters for patients with unresectable locally advanced hepatocellular carcinoma

Identifying the optimal criteria of radiotherapeutic parameters for patients with unresectable locally advanced hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.5713

Seok Hyun Son, Hong Seok Jang, Soo Yoon Sung, Hye Jin Kang, Sojung Lee,  and Chul Seung Kay
42372-42379
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Diffusion kurtosis imaging can efficiently assess the glioma grade and cellular proliferation

Diffusion kurtosis imaging can efficiently assess the glioma grade and cellular proliferation

https://doi.org/10.18632/oncotarget.5675

Rifeng Jiang, Jingjing Jiang, Lingyun Zhao, Jiaxuan Zhang, Shun Zhang, Yihao Yao, Shiqi Yang, Jingjing Shi, Nanxi Shen, Changliang Su, Ju Zhang,  and Wenzhen Zhu
42380-42393
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


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