Oncotarget

Vol 6, No 38

December 1, 2015

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Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras. See Sung et al.

Table of Contents

Editorial

Immune evasion mechanisms of arenaviruses

Immune evasion mechanisms of arenaviruses

https://doi.org/10.18632/oncotarget.6367

Hinh Ly,  and Yuying Liang
40386-40387
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Priority Research Papers

A new class of small molecule estrogen receptor-alpha antagonists that overcome anti-estrogen resistance

A new class of small molecule estrogen receptor-alpha antagonists that overcome anti-estrogen resistance

https://doi.org/10.18632/oncotarget.6323

Yongxian Ma, Anju Preet, York Tomita, Eliseu De Oliveira, Li Zhang, Yumi Ueda, Robert Clarke, Milton Brown,  and Eliot M. Rosen
40388-40404
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Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras

Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras

https://doi.org/10.18632/oncotarget.6334

Suhyun Sung, Jungwon Choi,  and Heesun Cheong
40405-40417
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Genomic binding and regulation of gene expression by the thyroid carcinoma-associated PAX8-PPARG fusion protein

Genomic binding and regulation of gene expression by the thyroid carcinoma-associated PAX8-PPARG fusion protein

https://doi.org/10.18632/oncotarget.6340

Yanxiao Zhang, Jingcheng Yu, Chee Lee, Bin Xu, Maureen A. Sartor,  and Ronald J. Koenig
40418-40432
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Research Papers: Pathology

In vivo regeneration of renal vessels post whole decellularized kidneys transplantation

In vivo regeneration of renal vessels post whole decellularized kidneys transplantation

https://doi.org/10.18632/oncotarget.6321

JianSe Zhang, ZhiBin Wang, KeZhi Lin, YaLing Yu, LiNa Zhao, TingGang Chu, LiZhi Wu, Ali Alkhawaji, MiaoZhong Li, YingKuan Shao, Ting Li, XinFa Lou, ShiXin Chen, MaoLin Tang,  and Jin Mei
40433-40442
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Research Papers: Immunology

Linking estrogen receptor β expression with inflammatory bowel disease activity

Linking estrogen receptor β expression with inflammatory bowel disease activity

https://doi.org/10.18632/oncotarget.6217

Marina Pierdominici, Angela Maselli, Barbara Varano, Cristiana Barbati, Paola Cesaro, Cristiano Spada, Angelo Zullo, Roberto Lorenzetti, Marco Rosati, Gabriella Rainaldi, Maria Rosaria Limiti, Luisa Guidi, Lucia Conti,  and Sandra Gessani
40443-40451
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Myelin oligodendrocyte glycoprotein (MOG35-55)-induced experimental autoimmune encephalomyelitis is ameliorated in interleukin-32 alpha transgenic mice

Myelin oligodendrocyte glycoprotein (MOG35-55)-induced experimental autoimmune encephalomyelitis is ameliorated in interleukin-32 alpha transgenic mice

https://doi.org/10.18632/oncotarget.6306

Jaesuk Yun, Sun Mi Gu, Hyung Mun Yun, Dong Ju Son, Mi Hee Park, Moon Soon Lee,  and Jin Tae Hong
40452-40463
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Research Papers: Chromosome

Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells

Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells

https://doi.org/10.18632/oncotarget.6342

Maciej Kliszczak, Hana Sedlackova, Ganesha P. Pitchai, Werner W. Streicher, Lumir Krejci,  and Ian D. Hickson
40464-40479
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Reviews

Deconvoluting the complexity of autophagy and Parkinson’s disease for potential therapeutic purpose

Deconvoluting the complexity of autophagy and Parkinson’s disease for potential therapeutic purpose

https://doi.org/10.18632/oncotarget.5803

Jingjing Li, Sijia Li, Lan Zhang, Liang Ouyang,  and Bo Liu
40480-40495
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Cancer stem cells are the cause of drug resistance in multiple myeloma: fact or fiction?

Cancer stem cells are the cause of drug resistance in multiple myeloma: fact or fiction?

https://doi.org/10.18632/oncotarget.5800

Reinaldo Franqui-Machin, Erik B. Wendlandt, Siegfried Janz, Fenghuang Zhan,  and Guido Tricot
40496-40506
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Vascular heterogeneity and targeting: the role of YKL-40 in glioblastoma vascularization

Vascular heterogeneity and targeting: the role of YKL-40 in glioblastoma vascularization

https://doi.org/10.18632/oncotarget.5943

Rong Shao, Sherry L. Taylor, Dennis S. Oh,  and Lawrence M. Schwartz
40507-40518
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Research Papers

Identification of short-form RON as a novel intrinsic resistance mechanism for anti-MET therapy in MET-positive gastric cancer

Identification of short-form RON as a novel intrinsic resistance mechanism for anti-MET therapy in MET-positive gastric cancer

https://doi.org/10.18632/oncotarget.5816

Zheng Wu, Zhe Zhang, Xiaoxiao Ge, Ying Lin, Congqi Dai, Jinjia Chang, Xinyang Liu, Ruixuan Geng, Chenchen Wang, Huan Chen, Menghong Sun, Weijian Guo,  and Jin Li
40519-40534
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Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma

Overexpression of Mcl-1 confers resistance to BRAFV600E inhibitors alone and in combination with MEK1/2 inhibitors in melanoma

https://doi.org/10.18632/oncotarget.5755

Neel M. Fofaria, Dennie T. Frederick, Ryan J. Sullivan, Keith T. Flaherty,  and Sanjay K. Srivastava
40535-40556
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Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA

Efficacy of CDK4 inhibition against sarcomas depends on their levels of CDK4 and p16ink4 mRNA

https://doi.org/10.18632/oncotarget.5829

Marco Perez, Sandra Muñoz-Galván, Manuel P. Jiménez-García, Juan J. Marín,  and Amancio Carnero
40557-40574
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Exosomes enriched in stemness/metastatic-related mRNAS promote oncogenic potential in breast cancer

Exosomes enriched in stemness/metastatic-related mRNAS promote oncogenic potential in breast cancer

https://doi.org/10.18632/oncotarget.5818

Marta Rodríguez, Javier Silva, Alberto Herrera, Mercedes Herrera, Cristina Peña, Paloma Martín, Beatriz Gil-Calderón, María Jesús Larriba, Mª José Coronado, Beatriz Soldevilla, Víctor S. Turrión, Mariano Provencio, Antonio Sánchez, Félix Bonilla,  and Vanesa García-Barberán
40575-40587
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Whole-exome sequencing and genome-wide methylation analyses identify novel disease associated mutations and methylation patterns in idiopathic hypereosinophilic syndrome

Whole-exome sequencing and genome-wide methylation analyses identify novel disease associated mutations and methylation patterns in idiopathic hypereosinophilic syndrome

https://doi.org/10.18632/oncotarget.5845

Christen Lykkegaard Andersen, Helene Myrtue Nielsen, Lasse Sommer Kristensen, Alexandra Søgaard, Jonas Vikeså, Lars Jønson, Finn Cilius Nielsen, Hans Hasselbalch, Ole Weis Bjerrum, Vasu Punj,  and Kirsten Grønbæk
40588-40597
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Novel C6-substituted 1,3,4-oxadiazinones as potential anti-cancer agents

Novel C6-substituted 1,3,4-oxadiazinones as potential anti-cancer agents

https://doi.org/10.18632/oncotarget.5839

Maqusood Md. Alam, Su-Chan Lee, Yujin Jung, Hye Jeong Yun, Hye-Young Min, Ho Jin Lee, Phuong Chi Pham, Jayoung Moon, Dah In Kwon, Bumhee Lim, Young-Ger Suh, Jeeyeon Lee,  and Ho-Young Lee
40598-40610
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Identification of specific DNA methylation sites on the Y-chromosome as biomarker in prostate cancer

Identification of specific DNA methylation sites on the Y-chromosome as biomarker in prostate cancer

https://doi.org/10.18632/oncotarget.6141

Lushuai Yao, Shancheng Ren, Minjie Zhang, Fengxia Du, Yasheng Zhu, Hui Yu, Chenyu Zhang, Xiaohua Li, Caiyun Yang, Huixian Liu, Dong Wang, Hao Meng, Shuang Chang, Xiao Han, Yinghao Sun,  and Yingli Sun
40611-40621
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Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma

Ack1 overexpression promotes metastasis and indicates poor prognosis of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.5872

Xiong Lei, Yun-feng Li, Guo-dong Chen, Di-peng Ou, Xiao-xin Qiu, Chao-hui Zuo,  and Lian-Yue Yang
40622-40641
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Personalized comprehensive molecular profiling of high risk osteosarcoma: Implications and limitations for precision medicine

Personalized comprehensive molecular profiling of high risk osteosarcoma: Implications and limitations for precision medicine

https://doi.org/10.18632/oncotarget.5841

Vivek Subbiah, Michael J. Wagner, Mary F. McGuire, Nawid M. Sarwari, Eswaran Devarajan, Valerae O. Lewis, Shanon Westin, Shumei Kato, Robert E. Brown,  and Pete Anderson
40642-40654
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Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2

Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2

https://doi.org/10.18632/oncotarget.5821

Daibiao Xiao, Ping Ren, Hexiu Su, Ming Yue, Ruijuan Xiu, Yufeng Hu, Hudan Liu,  and Guoliang Qing
40655-40666
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Doxycycline reverses epithelial-to-mesenchymal transition and suppresses the proliferation and metastasis of lung cancer cells

Doxycycline reverses epithelial-to-mesenchymal transition and suppresses the proliferation and metastasis of lung cancer cells

https://doi.org/10.18632/oncotarget.5842

Yuan Qin, Qiang Zhang, Shan Lee, Wei-long Zhong, Yan-rong Liu, Hui-juan Liu, Dong Zhao, Shuang Chen, Ting Xiao, Jing Meng, Xue-shuang Jing, Jing Wang, Bo Sun, Ting-ting Dai, Cheng Yang, Tao Sun,  and Hong-gang Zhou
40667-40679
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Effects of curcumin in pediatric epithelial liver tumors: inhibition of tumor growth and alpha-fetoprotein in vitro and in vivo involving the NFkappaB- and the beta-catenin pathways

Effects of curcumin in pediatric epithelial liver tumors: inhibition of tumor growth and alpha-fetoprotein in vitro and in vivo involving the NFkappaB- and the beta-catenin pathways

https://doi.org/10.18632/oncotarget.5673

Nicola Bortel, Sorin Armeanu-Ebinger, Evi Schmid, Bettina Kirchner, Jan Frank, Alexa Kocher, Christina Schiborr, Steven Warmann, Jörg Fuchs,  and Verena Ellerkamp
40680-40691
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A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1

A novel chemical, STF-083010, reverses tamoxifen-related drug resistance in breast cancer by inhibiting IRE1/XBP1

https://doi.org/10.18632/oncotarget.5827

Jie Ming, Shengnan Ruan, Mengyi Wang, Dan Ye, Ningning Fan, Qingyu Meng, Bo Tian,  and Tao Huang
40692-40703
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression

UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression

https://doi.org/10.18632/oncotarget.5727

Sajjad Hussain, Tibor Bedekovics, Marta Chesi, P. Leif Bergsagel,  and Paul J. Galardy
40704-40718
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Interleukin 6 trigged ataxia-telangiectasia mutated activation facilitates lung cancer metastasis via MMP-3/MMP-13 up-regulation

Interleukin 6 trigged ataxia-telangiectasia mutated activation facilitates lung cancer metastasis via MMP-3/MMP-13 up-regulation

https://doi.org/10.18632/oncotarget.5825

Yi Na Jiang, Hong Qiong Yan, Xiao Bo Huang, Yi Nan Wang, Qing Li,  and Feng Guang Gao
40719-40733
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Molecular mechanisms of cisplatin cytotoxicity in acute promyelocytic leukemia cells

Molecular mechanisms of cisplatin cytotoxicity in acute promyelocytic leukemia cells

https://doi.org/10.18632/oncotarget.5754

Sanjay Kumar,  and Paul B. Tchounwou
40734-40746
Abstract  |  PDF  |  HTML  |  Order a Reprint

IL-32θ gene expression in acute myeloid leukemia suppresses TNF-α production

IL-32θ gene expression in acute myeloid leukemia suppresses TNF-α production

https://doi.org/10.18632/oncotarget.5688

Man Sub Kim, Jeong-Woo Kang, Jae-Sik Jeon, Jae Kyung Kim, Jong Wan Kim, Jintae Hong,  and Do-Young Yoon
40747-40761
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A biotherapy based on PSCs-in-3D spheroid-ameliorated biologics depletes in vivo cancer-sustaining stem cells

A biotherapy based on PSCs-in-3D spheroid-ameliorated biologics depletes in vivo cancer-sustaining stem cells

https://doi.org/10.18632/oncotarget.5691

Wenhui Zhang, Huanhuan Yang, Yanna Zhang, Yanan Lu, Tianlin Zhou, Meng Li, Yanjun Wen, Xiaojuan Lin, Rong Xiang,  and Xiancheng Chen
40762-40774
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc

CUDR promotes liver cancer stem cell growth through upregulating TERT and C-Myc

https://doi.org/10.18632/oncotarget.5805

Hu Pu, Qidi Zheng, Haiyan Li, Mengying Wu, Jiahui An, Xin Gui, Tianming Li,  and Dongdong Lu
40775-40798
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-29B (mir-29b) regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3

MicroRNA-29B (mir-29b) regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3

https://doi.org/10.18632/oncotarget.5695

Yue Teng, Yan Zhang, Kai Qu, Xinyuan Yang, Jing Fu, Wei Chen,  and Xu Li
40799-40814
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A set of defined oncogenic mutation alleles seems to better predict the response to cetuximab in CRC patient-derived xenograft than KRAS 12/13 mutations

A set of defined oncogenic mutation alleles seems to better predict the response to cetuximab in CRC patient-derived xenograft than KRAS 12/13 mutations

https://doi.org/10.18632/oncotarget.5886

Dawei Chen, Xuesong Huang, Jie Cai, Sheng Guo, Wubin Qian, Jean-Pierre Wery,  and Qi-Xiang Li
40815-40821
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122

Active glycolytic metabolism in CD133(+) hepatocellular cancer stem cells: regulation by MIR-122

https://doi.org/10.18632/oncotarget.5812

Kyoungsub Song, Hyunjoo Kwon, Chang Han, Jinqiang Zhang, Srikanta Dash, Kyu Lim,  and Tong Wu
40822-40835
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Distribution and prognostic relevance of tumor-infiltrating lymphocytes (TILs) and PD-1/PD-L1 immune checkpoints in human brain metastases

Distribution and prognostic relevance of tumor-infiltrating lymphocytes (TILs) and PD-1/PD-L1 immune checkpoints in human brain metastases

https://doi.org/10.18632/oncotarget.5696

Patrick N. Harter, Simon Bernatz, Alexander Scholz, Pia S. Zeiner, Jenny Zinke, Makoto Kiyose, Stella Blasel, Rudi Beschorner, Christian Senft, Benjamin Bender, Michael W. Ronellenfitsch, Harriet Wikman, Markus Glatzel, Matthias Meinhardt, Tareq A. Juratli, Joachim P. Steinbach, Karl H. Plate, Jörg Wischhusen, Benjamin Weide,  and Michel Mittelbronn
40836-40849
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cetuximab enhanced the efficacy of chemotherapeutic agent in ABCB1/P-glycoprotein-overexpressing cancer cells

Cetuximab enhanced the efficacy of chemotherapeutic agent in ABCB1/P-glycoprotein-overexpressing cancer cells

https://doi.org/10.18632/oncotarget.5813

Fang Wang, Yifan Chen, Lihua Huang, Tao Liu, Yue Huang, Jianming Zhao, Xiaokun Wang, Ke Yang, Shaolin Ma, Liyan Huang, Kenneth Kin Wah To, Yong Gu,  and Liwu Fu
40850-40865
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Bis-cyclopropane analog of disorazole C1 is a microtubule-destabilizing agent active in ABCB1-overexpressing human colon cancer cells

Bis-cyclopropane analog of disorazole C1 is a microtubule-destabilizing agent active in ABCB1-overexpressing human colon cancer cells

https://doi.org/10.18632/oncotarget.5885

Shaoyu Wu, Zhijian Guo, Chad D. Hopkins, Ning Wei, Edward Chu, Peter Wipf,  and John C. Schmitz
40866-40879
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Amphiregulin enhances intercellular adhesion molecule-1 expression and promotes tumor metastasis in human osteosarcoma

Amphiregulin enhances intercellular adhesion molecule-1 expression and promotes tumor metastasis in human osteosarcoma

https://doi.org/10.18632/oncotarget.5679

Ju-Fang Liu, Ya-Ting Tsao,  and Chun-Han Hou
40880-40895
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IDH mutation and MGMT promoter methylation in glioblastoma: results of a prospective registry

IDH mutation and MGMT promoter methylation in glioblastoma: results of a prospective registry

https://doi.org/10.18632/oncotarget.5683

Pei Yang, Wei Zhang, Yinyan Wang, Xiaoxia Peng, Baoshi Chen, Xiaoguang Qiu, Guilin Li, Shouwei Li, Chenxing Wu, Kun Yao, Wenbin Li, Wei Yan, Jie Li, Yongping You, Clark C. Chen,  and Tao Jiang
40896-40906
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway

Disulfiram inhibits TGF-β-induced epithelial-mesenchymal transition and stem-like features in breast cancer via ERK/NF-κB/Snail pathway

https://doi.org/10.18632/oncotarget.5723

Dan Han, Gang Wu, Chan Chang, Fang Zhu, Yin Xiao, Qiuhui Li, Tao Zhang,  and Liling Zhang
40907-40919
Abstract  |  PDF  |  HTML  |  Order a Reprint

Overexpression of WWP1 promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma

Overexpression of WWP1 promotes tumorigenesis and predicts unfavorable prognosis in patients with hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.5712

Xiao-Fei Zhang, Jie Chao, Qiu-Zhong Pan, Ke Pan, De-Sheng Weng, Qi-Jing Wang, Jing-Jing Zhao, Jia He, Qing Liu, Shan-Shan Jiang, Chang-Long Chen, Hong-Xia Zhang,  and Jian-Chuan Xia
40920-40933
Abstract  |  PDF  |  HTML  |  Order a Reprint

Whole transcriptome sequencing identifies BCOR internal tandem duplication as a common feature of clear cell sarcoma of the kidney

Whole transcriptome sequencing identifies BCOR internal tandem duplication as a common feature of clear cell sarcoma of the kidney

https://doi.org/10.18632/oncotarget.5882

Annalisa Astolfi, Fraia Melchionda, Daniela Perotti, Maura Fois, Valentina Indio, Milena Urbini, Chiara Giusy Genovese, Paola Collini, Nunzio Salfi, Marilina Nantron, Paolo D’Angelo, Filippo Spreafico,  and Andrea Pession
40934-40939
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutual regulation between CHD5 and EZH2 in hepatocellular carcinoma

Mutual regulation between CHD5 and EZH2 in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.5724

Cheng-Rong Xie, Zhao Li, Hong-Guang Sun, Fu-Qiang Wang, Yu Sun, Wen-Xiu Zhao, Sheng Zhang, Wen-Xing Zhao, Xiao-Min Wang,  and Zhen-Yu Yin
40940-40952
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

­­Prevalence of deleterious ATM germline mutations in gastric cancer patients

­­Prevalence of deleterious ATM germline mutations in gastric cancer patients

https://doi.org/10.18632/oncotarget.5944

Dong-Sheng Huang, Hou-Quan Tao, Xu-Jun He, Ming Long, Sheng Yu, Ying-Jie Xia, Zhang Wei, Zikai Xiong, Sian Jones, Yiping He, Hai Yan,  and Xiaoyue Wang
40953-40958
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PTTG regulates the metabolic switch of ovarian cancer cells via the c-myc pathway

PTTG regulates the metabolic switch of ovarian cancer cells via the c-myc pathway

https://doi.org/10.18632/oncotarget.5726

Xiu Wang, Wanxing Duan, Xuqi Li, Jiangbo Liu, Donghong Li, Lianhong Ye, Lu Qian, Aijun Yang, Qinhong Xu, Han Liu, Qiaoshan Fu, Erxi Wu, Qingyong Ma,  and Xin Shen
40959-40969
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Design of a peptidic inhibitor that targets the dimer interface of a prototypic galectin

Design of a peptidic inhibitor that targets the dimer interface of a prototypic galectin

https://doi.org/10.18632/oncotarget.5403

Maria Claudia Vladoiu, Marilyne Labrie, Myriam Létourneau, Philippe Egesborg, Donald Gagné, Étienne Billard, Andrée-Anne Grosset, Nicolas Doucet, David Chatenet,  and Yves St-Pierre
40970-40980
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia

The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia

https://doi.org/10.18632/oncotarget.5715

Kimberley L. Kaufman, Yiping Jenkins, Munther Alomari, Mehdi Mirzaei, O.Giles Best, Dana Pascovici, Swetlana Mactier, Stephen P. Mulligan, Paul A. A. Haynes,  and Richard I. Christopherson
40981-40997
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heterogeneous glioblastoma cell cross-talk promotes phenotype alterations and enhanced drug resistance

Heterogeneous glioblastoma cell cross-talk promotes phenotype alterations and enhanced drug resistance

https://doi.org/10.18632/oncotarget.5701

Helena Motaln, Ana Koren, Kristina Gruden, Živa Ramšak, Christian Schichor,  and Tamara T. Lah
40998-41017
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anti-cancer efficacy of SREBP inhibitor, alone or in combination with docetaxel, in prostate cancer harboring p53 mutations

Anti-cancer efficacy of SREBP inhibitor, alone or in combination with docetaxel, in prostate cancer harboring p53 mutations

https://doi.org/10.18632/oncotarget.5879

Xiangyan Li, Jason Boyang Wu, Leland W.K. Chung,  and Wen-Chin Huang
41018-41032
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The copy number of Epstein-Barr virus latent genome correlates with the oncogenicity by the activation level of LMP1 and NF-κB

The copy number of Epstein-Barr virus latent genome correlates with the oncogenicity by the activation level of LMP1 and NF-κB

https://doi.org/10.18632/oncotarget.5708

Lielian Zuo, Haibo Yu, Lingzhi Liu, Yunlian Tang, Hongzhuan Wu, Jing Yang, Meijuan Zhu, Shujuan Du, Lian Zhao, Li Cao, Guiyuan Li,  and Jianhong Lu
41033-41044
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LncRNA MALAT1 enhances oncogenic activities of EZH2 in castration-resistant prostate cancer

LncRNA MALAT1 enhances oncogenic activities of EZH2 in castration-resistant prostate cancer

https://doi.org/10.18632/oncotarget.5728

Dejie Wang, Liya Ding, Liguo Wang, Yu Zhao, Zhifu Sun, R.Jeffrey Karnes, Jun Zhang,  and Haojie Huang
41045-41055
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YpT1-2N0 rectal cancer after neoadjuvant chemoradiation has lower survival compared with pT1-2N0 rectal cancer

YpT1-2N0 rectal cancer after neoadjuvant chemoradiation has lower survival compared with pT1-2N0 rectal cancer

https://doi.org/10.18632/oncotarget.5379

Jue-feng Wan, Ji Zhu, Gui-chao Li, Wen-jie Sun,  and Zhen Zhang
41056-41062
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Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice

Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice

https://doi.org/10.18632/oncotarget.5729

Hironobu Takano, Toru Nakamura, Takahiro Tsuchikawa, Toshihiro Kushibiki, Kouji Hontani, Kazuho Inoko, Mizuna Takahashi, Shoki Sato, Hirotake Abe, Shintaro Takeuchi, Nagato Sato, Kei Hiraoka, Hiroshi Nishihara, Toshiaki Shichinohe,  and Satoshi Hirano
41063-41076
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Epigenetic downregulation of the ISG15–conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma

Epigenetic downregulation of the ISG15–conjugating enzyme UbcH8 impairs lipolysis and correlates with poor prognosis in nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.6218

Xiaoying Zhou, Jiazhang Wei, Fu Chen, Xue Xiao, Tingting Huang, Qian He, Shumin Wang, Chunping Du, Yingxi Mo, Longde Lin, Ying Xie, Lili Wei, Ying Lan, Mairiko Murata, Guangwu Huang, Ingemar Ernberg, Liudmila Matskova,  and Zhe Zhang
41077-41091
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation

CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation

https://doi.org/10.18632/oncotarget.5732

Baocai Liu, Yu Su, Ting Li, Wanqiong Yuan, Xiaoning Mo, Henan Li, Qihua He, Dalong Ma,  and Wenling Han
41092-41107
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Germ-line variants identified by next generation sequencing in a panel of estrogen and cancer associated genes correlate with poor clinical outcome in Lynch syndrome patients

Germ-line variants identified by next generation sequencing in a panel of estrogen and cancer associated genes correlate with poor clinical outcome in Lynch syndrome patients

https://doi.org/10.18632/oncotarget.5694

Balazs Jóri, Rick Kamps, Sofia Xanthoulea, Bert Delvoux, Marinus J. Blok, Koen K. Van de Vijver, Bart de Koning, Felicia Trups Oei, Carli M. Tops, Ernst J. M. Speel, Roy F. Kruitwagen, Encarna B. Gomez-Garcia,  and Andrea Romano
41108-41122
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Chemical probing of HER2-amplified cancer cells identifies TORC2 as a particularly effective secondary target for combination with lapatinib

Chemical probing of HER2-amplified cancer cells identifies TORC2 as a particularly effective secondary target for combination with lapatinib

https://doi.org/10.18632/oncotarget.5660

Dhara N. Amin, Ana Ruiz-Saenz, Nathaniel Gulizia,  and Mark M. Moasser
41123-41133
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Ki67/SATB1 ratio is an independent prognostic factor of overall survival in patients with early hormone receptor-positive invasive ductal breast carcinoma

Ki67/SATB1 ratio is an independent prognostic factor of overall survival in patients with early hormone receptor-positive invasive ductal breast carcinoma

https://doi.org/10.18632/oncotarget.5838

Arvydas Laurinavicius, Andrew R. Green, Aida Laurinaviciene, Giedre Smailyte, Valerijus Ostapenko, Raimundas Meskauskas,  and Ian O. Ellis
41134-41145
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Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth

Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth

https://doi.org/10.18632/oncotarget.5843

Surendra K. Shukla, Aneesha Dasgupta, Kamiya Mehla, Venugopal Gunda, Enza Vernucci, Joshua Souchek, Gennifer Goode, Ryan King, Anusha Mishra, Ibha Rai, Sangeetha Nagarajan, Nina V. Chaika, Fang Yu,  and Pankaj K. Singh
41146-41161
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P2X3 purinergic receptor overexpression is associated with poor recurrence-free survival in hepatocellular carcinoma patients

P2X3 purinergic receptor overexpression is associated with poor recurrence-free survival in hepatocellular carcinoma patients

https://doi.org/10.18632/oncotarget.6240

Janielle P. Maynard, Ju-Seog Lee, Bo Hwa Sohn, Xiaoying Yu, Dolores Lopez-Terrada, Milton J. Finegold, John A. Goss,  and Sundararajah Thevananther
41162-41179
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Isothiocyanatostilbenes as novel c-Met inhibitors

Isothiocyanatostilbenes as novel c-Met inhibitors

https://doi.org/10.18632/oncotarget.5748

Alana L. Gray, David T. Coleman, Reneau F. Castore, Mohamed M. Mohyeldin, Khalid A. El Sayed,  and James A. Cardelli
41180-41193
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Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells

Tetracycline-inducible shRNA targeting long non-coding RNA PVT1 inhibits cell growth and induces apoptosis in bladder cancer cells

https://doi.org/10.18632/oncotarget.5880

Chengle Zhuang, Jianfa Li, Yuchen Liu, Mingwei Chen, Jiancheng Yuan, Xing Fu, Yonghao Zhan, Li Liu, Junhao Lin, Qing Zhou, Wen Xu, Guoping Zhao, Zhiming Cai,  and Weiren Huang
41194-41203
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Morphometric analysis of immunoselection against hyperploid cancer cells

Morphometric analysis of immunoselection against hyperploid cancer cells

https://doi.org/10.18632/oncotarget.5400

Norma Bloy, Allan Sauvat, Kariman Chaba, Aitziber Buqué, Juliette Humeau, José Manuel Bravo-San Pedro, Jack Bui, Oliver Kepp, Guido Kroemer,  and Laura Senovilla
41204-41215
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Identifying clinically relevant drug resistance genes in drug-induced resistant cancer cell lines and post-chemotherapy tissues

Identifying clinically relevant drug resistance genes in drug-induced resistant cancer cell lines and post-chemotherapy tissues

https://doi.org/10.18632/oncotarget.5649

Mengsha Tong, Weicheng Zheng, Xingrong Lu, Lu Ao, Xiangyu Li, Qingzhou Guan, Hao Cai, Mengyao Li, Haidan Yan, You Guo, Pan Chi,  and Zheng Guo
41216-41227
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Serum levels of soluble programmed death ligand 1 predict treatment response and progression free survival in multiple myeloma

Serum levels of soluble programmed death ligand 1 predict treatment response and progression free survival in multiple myeloma

https://doi.org/10.18632/oncotarget.5682

Liang Wang, Hua Wang, Hao Chen, Wei-da Wang, Xiao-qin Chen, Qi-rong Geng, Zhong-jun Xia,  and Yue Lu
41228-41236
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Novel insights into Notum and glypicans regulation in colorectal cancer

Novel insights into Notum and glypicans regulation in colorectal cancer

https://doi.org/10.18632/oncotarget.5652

Mariangela De Robertis, Maddalena Arigoni, Luisa Loiacono, Federica Riccardo, Raffaele Adolfo Calogero, Yana Feodorova, Dessislava Tashkova, Vesselin Belovejdov, Victoria Sarafian, Federica Cavallo,  and Emanuela Signori
41237-41257
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Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment

Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment

https://doi.org/10.18632/oncotarget.5692

Guanlian Hu, Xingli Chun, Yang Wang, Qin He,  and Huile Gao
41258-41274
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Junctional adhesion molecule-A is overexpressed in advanced multiple myeloma and determines response to oncolytic reovirus

Junctional adhesion molecule-A is overexpressed in advanced multiple myeloma and determines response to oncolytic reovirus

https://doi.org/10.18632/oncotarget.5753

Kevin R. Kelly, Claudia M. Espitia, Weiguo Zhao, Erik Wendlandt, Guido Tricot, Fenghuang Zhan, Jennifer S. Carew,  and Steffan T. Nawrocki
41275-41289
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TIP60-miR-22 axis as a prognostic marker of breast cancer progression

TIP60-miR-22 axis as a prognostic marker of breast cancer progression

https://doi.org/10.18632/oncotarget.5636

Amit Kumar Pandey, Yanzhou Zhang, Siting Zhang, Ying Li, Greg Tucker-Kellogg, Henry Yang,  and Sudhakar Jha
41290-41306
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E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling

E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling

https://doi.org/10.18632/oncotarget.5846

Sharon McGonigle, Zhihong Chen, Jiayi Wu, Paul Chang, Donna Kolber-Simonds, Karen Ackermann, Natalie C. Twine, Jue-lon Shie, Jingzang Tao Miu, Kuan-Chun Huang, George A. Moniz,  and Kenichi Nomoto
41307-41323
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling

Suppression of death receptor 5 enhances cancer cell invasion and metastasis through activation of caspase-8/TRAF2-mediated signaling

https://doi.org/10.18632/oncotarget.5847

You-Take Oh, Ping Yue, Dongsheng Wang, Jing-Shan Tong, Zhuo G. Chen, Fadlo R. Khuri,  and Shi-Yong Sun
41324-41338
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Clinical Research Papers

A phase I clinical trial utilizing autologous tumor-infiltrating lymphocytes in patients with primary hepatocellular carcinoma

A phase I clinical trial utilizing autologous tumor-infiltrating lymphocytes in patients with primary hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.5463

Shan-Shan Jiang, Yan Tang, Yao-Jun Zhang, De-Sheng Weng, Zhong-Guo Zhou, Ke Pan, Qiu-Zhong Pan, Qi-Jing Wang, Qing Liu, Jia He, Jing-Jing Zhao, Jiang Li, Min-Shan Chen, Alfred E. Chang, Qiao Li,  and Jian-Chuan Xia
41339-41349
Abstract  |  PDF  |  HTML  |  Order a Reprint

The prognostic value of peripheral CD4+CD25+ T lymphocytes among early stage and triple negative breast cancer patients receiving dendritic cells-cytokine induced killer cells infusion

The prognostic value of peripheral CD4+CD25+ T lymphocytes among early stage and triple negative breast cancer patients receiving dendritic cells-cytokine induced killer cells infusion

https://doi.org/10.18632/oncotarget.5534

Qing-Kun Song, Jun Ren, Xin-Na Zhou, Xiao-Li Wang, Guo-Hong Song, Li-Jun Di, Jing Yu, Amy Hobeika, Michael A. Morse, Yan-Hua Yuan, Hua-Bing Yang,  and Herbert Kim Lyerly
41350-41359
Abstract  |  PDF  |  HTML  |  Order a Reprint

ALDH1A1 mRNA expression in association with prognosis of triple-negative breast cancer

ALDH1A1 mRNA expression in association with prognosis of triple-negative breast cancer

https://doi.org/10.18632/oncotarget.6023

Yan Liu, Michelle Baglia, Ying Zheng, William Blot, Ping-Ping Bao, Hui Cai, Sarah Nechuta, Wei Zheng, Qiuyin Cai,  and Xiao Ou Shu
41360-41369
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Prognostic significance of the combination of preoperative hemoglobin, albumin, lymphocyte and platelet in patients with gastric carcinoma: a retrospective cohort study

Prognostic significance of the combination of preoperative hemoglobin, albumin, lymphocyte and platelet in patients with gastric carcinoma: a retrospective cohort study

https://doi.org/10.18632/oncotarget.5629

Xiao-Long Chen, Lian Xue, Wei Wang, Hai-Ning Chen, Wei-Han Zhang, Kai Liu, Xin-Zu Chen, Kun Yang, Bo Zhang, Zhi-Xin Chen, Jia-Ping Chen, Zong-Guang Zhou,  and Jian-Kun Hu
41370-41382
Abstract  |  PDF  |  HTML  |  Order a Reprint

A novel prognostic biomarker SPC24 up-regulated in hepatocellular carcinoma

A novel prognostic biomarker SPC24 up-regulated in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.5510

Pengpeng Zhu, Junfei Jin, Yan Liao, Jun Li, Xue-Zhong Yu, Weijia Liao,  and Songqing He
41383-41397
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Errata

Erratum: Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: Role in osteoclast-mediated NK cell activation

Erratum: Bisphosphonate-induced differential modulation of immune cell function in gingiva and bone marrow in vivo: Role in osteoclast-mediated NK cell activation

https://doi.org/10.18632/oncotarget.6431

Han-Ching Tseng, Keiichi Kanayama, Kawaljit Kaur, So-Hyun Park, Sil Park, Anna Kozlowska, Shuting Sun, Charles E. McKenna, Ichiro Nishimura,  and Anahid Jewett
41398
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