Oncotarget

Vol 6, No 37

November 24, 2015

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About The Cover

Heregulin, a new interactor of the telosome/shelterin complex in human telomeres. See Menendez et al

Table of Contents

Editorial

APOBEC3 in papillomavirus restriction, evolution and cancer progression

APOBEC3 in papillomavirus restriction, evolution and cancer progression

https://doi.org/10.18632/oncotarget.6324

Cody J. Warren,  and Dohun Pyeon
39385-39386
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Cell autonomous Vegf-C/Vegfr3 signaling in adult neural stem cells

Cell autonomous Vegf-C/Vegfr3 signaling in adult neural stem cells

https://doi.org/10.18632/oncotarget.6325

Tae Hyuk Kang, Jinah Han,  and Jean-Leon Thomas
39387-39388
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ASM in Alzheimer’s disease

ASM in Alzheimer’s disease

https://doi.org/10.18632/oncotarget.6333

Jong Kil Lee, Hee Kyung Jin,  and Jae-sung Bae
39389-39390
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Risk-reducing surgery in BRCA 1/2 mutation carries: a point of view

Risk-reducing surgery in BRCA 1/2 mutation carries: a point of view

https://doi.org/10.18632/oncotarget.6348

Francesca De Felice,  and Claudia Marchetti
39391-39392
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Sequencing rare T-cell populations

Sequencing rare T-cell populations

https://doi.org/10.18632/oncotarget.6349

Mikhail Shugay, Sergey Lukyanov,  and Dmitriy M. Chudakov
39393-39394
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Editorial: Gerotarget (Focus on Aging)

Measuring refractive index distribution in the human eye lens

Measuring refractive index distribution in the human eye lens

https://doi.org/10.18632/oncotarget.6322

James M. Pope,  and David A. Atchison
39395-39395
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Editorial: Autophagy and Cell Death

Defective autophagy gets to the brain

Defective autophagy gets to the brain

https://doi.org/10.18632/oncotarget.6318

Lorenzo Galluzzi,  and Guido Kroemer
39396-39397
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Research Perspectives

Metformin for cancer and aging prevention: is it a time to make the long story short?

Metformin for cancer and aging prevention: is it a time to make the long story short?

https://doi.org/10.18632/oncotarget.6347

Vladimir N. Anisimov
39398-39407
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Priority Research Papers

Heregulin, a new interactor of the telosome/shelterin complex in human telomeres

Heregulin, a new interactor of the telosome/shelterin complex in human telomeres

https://doi.org/10.18632/oncotarget.4962

Javier A. Menendez, Louisa Benboudjema, Luciano Vellon, Miguel A. Rubio, Ingrid Espinoza, Judith Campisi,  and Ruth Lupu
39408-39421
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Heregulin, a new regulator of telomere length in human cells

Heregulin, a new regulator of telomere length in human cells

https://doi.org/10.18632/oncotarget.4964

Javier A. Menendez, Miguel A. Rubio, Judith Campisi,  and Ruth Lupu
39422-39436
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Research Papers: Gerotarget (Focus on Aging)

Olfactory bulb proteome dynamics during the progression of sporadic Alzheimer’s disease: identification of common and distinct olfactory targets across Alzheimer-related co-pathologies

Olfactory bulb proteome dynamics during the progression of sporadic Alzheimer’s disease: identification of common and distinct olfactory targets across Alzheimer-related co-pathologies

https://doi.org/10.18632/oncotarget.6254

María Victoria Zelaya, Estela Pérez-Valderrama, Xabier Martínez de Morentin, Teresa Tuñon, Isidro Ferrer, María Rosario Luquin, Joaquín Fernandez-Irigoyen,  and Enrique Santamaría
39437-39456
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Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells

Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells

https://doi.org/10.18632/oncotarget.6277

Stefania Capasso, Nicola Alessio, Tiziana Squillaro, Giovanni Di Bernardo, Mariarosa A. Melone, Marilena Cipollaro, Gianfranco Peluso,  and Umberto Galderisi
39457-39468
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Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats

Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats

https://doi.org/10.18632/oncotarget.5783

Sabzali Javadov, Sehwan Jang, Natividad Rodriguez-Reyes, Ana E. Rodriguez-Zayas, Jessica Soto Hernandez, Tanja Krainz, Peter Wipf,  and Walter Frontera
39469-39481
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Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity

Myeloma cells can corrupt senescent mesenchymal stromal cells and impair their anti-tumor activity

https://doi.org/10.18632/oncotarget.5430

Umberto Galderisi, Servet Özcan, Nicola Alessio, Mustafa Burak Acar, Guler Toprak, Zeynep Burcin Onal,  and Gianfranco Peluso
39482-39492
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Research Papers: Pathology

The redox sensitive glycogen synthase kinase 3β suppresses the self-protective antioxidant response in podocytes upon oxidative glomerular injury

The redox sensitive glycogen synthase kinase 3β suppresses the self-protective antioxidant response in podocytes upon oxidative glomerular injury

https://doi.org/10.18632/oncotarget.6303

Changbin Li, Yan Ge, Ai Peng,  and Rujun Gong
39493-39506
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Research Papers: Chromosome

A novel gammaretroviral shuttle vector insertional mutagenesis screen identifies SHARPIN as a breast cancer metastasis gene and prognostic biomarker

A novel gammaretroviral shuttle vector insertional mutagenesis screen identifies SHARPIN as a breast cancer metastasis gene and prognostic biomarker

https://doi.org/10.18632/oncotarget.6232

Victor M. Bii, Dustin T. Rae,  and Grant D. Trobridge
39507-39520
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Reviews

Novel agents for advanced pancreatic cancer

Novel agents for advanced pancreatic cancer

https://doi.org/10.18632/oncotarget.3999

Akintunde Akinleye, Chaitanya Iragavarapu, Muhammad Furqan, Shundong Cang,  and Delong Liu
39521-39537
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Influence of companion diagnostics on efficacy and safety of targeted anti-cancer drugs: systematic review and meta-analyses

Influence of companion diagnostics on efficacy and safety of targeted anti-cancer drugs: systematic review and meta-analyses

https://doi.org/10.18632/oncotarget.5946

Alberto Ocana, Josee-Lyne Ethier, Laura Díez-González, Verónica Corrales-Sánchez, Amirrtha Srikanthan, María J. Gascón-Escribano, Arnoud J. Templeton, Francisco Vera-Badillo, Bostjan Seruga, Saroj Niraula, Atanasio Pandiella,  and Eitan Amir
39538-39549
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Differentiation and transdifferentiation potentials of cancer stem cells

Differentiation and transdifferentiation potentials of cancer stem cells

https://doi.org/10.18632/oncotarget.6098

Zhengjie Huang, Tiantian Wu, Allan Yi Liu,  and Gaoliang Ouyang
39550-39563
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Research Papers

Multistep, effective drug distribution within solid tumors

Multistep, effective drug distribution within solid tumors

https://doi.org/10.18632/oncotarget.5051

Amotz Shemi, Elina Zorde Khvalevsky, Rachel Malka Gabai, Abraham Domb,  and Yechezkel Barenholz
39564-39577
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Epithelial neoplasia coincides with exacerbated injury and fibrotic response in the lungs of Gprc5a-knockout mice following silica exposure

Epithelial neoplasia coincides with exacerbated injury and fibrotic response in the lungs of Gprc5a-knockout mice following silica exposure

https://doi.org/10.18632/oncotarget.5532

Xiaofei Wang, Dongliang Xu, Yueling Liao, Shuangshuang Zhong, Hongyong Song, Beibei Sun, Binhua P. Zhou, Jiong Deng,  and Baohui Han
39578-39593
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Silibinin enhances the repair of ultraviolet B-induced DNA damage by activating p53-dependent nucleotide excision repair mechanism in human dermal fibroblasts

Silibinin enhances the repair of ultraviolet B-induced DNA damage by activating p53-dependent nucleotide excision repair mechanism in human dermal fibroblasts

https://doi.org/10.18632/oncotarget.5519

Ruth Guillermo-Lagae, Gagan Deep, Harold Ting, Chapla Agarwal,  and Rajesh Agarwal
39594-39606
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Molecular pathological epidemiology of colorectal cancer in Chinese patients with KRAS and BRAF mutations

Molecular pathological epidemiology of colorectal cancer in Chinese patients with KRAS and BRAF mutations

https://doi.org/10.18632/oncotarget.5551

Wenbin Li, Tian Qiu, Yun Ling, Lei Guo, Lin Li,  and Jianming Ying
39607-39613
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Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer

Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer

https://doi.org/10.18632/oncotarget.5554

Emmanuelle Nicolas, Sanjeevani Arora, Yan Zhou, Ilya G. Serebriiskii, Mark D. Andrake, Elizabeth D. Handorf, Dale L. Bodian, Joseph G. Vockley, Roland L. Dunbrack, Eric A. Ross, Brian L. Egleston, Michael J. Hall, Erica A. Golemis, Veda N. Giri,  and Mary B. Daly
39614-39633
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Mutant AKT1-E17K is oncogenic in lung epithelial cells

Mutant AKT1-E17K is oncogenic in lung epithelial cells

https://doi.org/10.18632/oncotarget.4022

Carmela De Marco, Donatella Malanga, Nicola Rinaldo, Fernanda De Vita, Marianna Scrima, Sara Lovisa, Linda Fabris, Maria Vincenza Carriero, Renato Franco, Antonia Rizzuto, Gustavo Baldassarre,  and Giuseppe Viglietto
39634-39650
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IDH1 mutation detection by droplet digital PCR in glioma

IDH1 mutation detection by droplet digital PCR in glioma

https://doi.org/10.18632/oncotarget.5630

Jing Wang, Yi-ying Zhao, Jian-feng Li, Cheng-cheng Guo, Fu-rong Chen, Hong-kai Su, Hua-fu Zhao, Ya-kang Long, Jian-yong Shao, Shing-shun Tony To,  and Zhong-ping Chen
39651-39660
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MiR-652 inhibits acidic microenvironment-induced epithelial-mesenchymal transition of pancreatic cancer cells by targeting ZEB1

MiR-652 inhibits acidic microenvironment-induced epithelial-mesenchymal transition of pancreatic cancer cells by targeting ZEB1

https://doi.org/10.18632/oncotarget.5350

Shichang Deng, Xiang Li, Yi Niu, Shuai Zhu, Yan Jin, Shijiang Deng, Jingyuan Chen, Yang Liu, Chi He, Tao Yin, Zhiyong Yang, Jing Tao, Jiongxin Xiong, Heshui Wu, Chunyou Wang,  and Gang Zhao
39661-39675
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responses

Tumor necrosis is an important hallmark of aggressive endometrial cancer and associates with hypoxia, angiogenesis and inflammation responses

https://doi.org/10.18632/oncotarget.5344

Geir Bredholt, Monica Mannelqvist, Ingunn M. Stefansson, Even Birkeland, Trond Hellem Bø, Anne M. Øyan, Jone Trovik, Karl-Henning Kalland, Inge Jonassen, Helga B. Salvesen, Elisabeth Wik,  and Lars A. Akslen
39676-39691
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CGK733-induced LC3 II formation is positively associated with the expression of cyclin-dependent kinase inhibitor p21Waf1/Cip1 through modulation of the AMPK and PERK/CHOP signaling pathways

CGK733-induced LC3 II formation is positively associated with the expression of cyclin-dependent kinase inhibitor p21Waf1/Cip1 through modulation of the AMPK and PERK/CHOP signaling pathways

https://doi.org/10.18632/oncotarget.5625

Yufeng Wang, Yasuhiro Kuramitsu, Byron Baron, Takao Kitagawa, Kazuhiro Tokuda, Junko Akada,  and Kazuyuki Nakamura
39692-39701
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mTOR inhibitors sensitize thyroid cancer cells to cytotoxic effect of vemurafenib

mTOR inhibitors sensitize thyroid cancer cells to cytotoxic effect of vemurafenib

https://doi.org/10.18632/oncotarget.4052

Elyse K. Hanly, Robert B. Bednarczyk, Neha Y. Tuli, Augustine L. Moscatello, H. Dorota Halicka, Jiangwei Li, Jan Geliebter, Zbigniew Darzynkiewicz,  and Raj K. Tiwari
39702-39713
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Suppressing NRIP1 inhibits growth of breast cancer cells in vitro and in vivo

Suppressing NRIP1 inhibits growth of breast cancer cells in vitro and in vivo

https://doi.org/10.18632/oncotarget.5356

Moammir H. Aziz, Xundi Chen, Qi Zhang, Chad DeFrain, Jared Osland, Yizhou Luo, Xin Shi,  and Rong Yuan
39714-39724
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Practice of traditional Chinese medicine for psycho-behavioral intervention improves quality of life in cancer patients: A systematic review and meta-analysis

Practice of traditional Chinese medicine for psycho-behavioral intervention improves quality of life in cancer patients: A systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.5388

Weiwei Tao, Xi Luo, Bai Cui, Dapeng Liang, Chunli Wang, Yangyang Duan, Xiaofen Li, Shiyu Zhou, Mingjie Zhao, Yi Li, Yumin He, Shaowu Wang, Keith W. Kelley, Ping Jiang,  and Quentin Liu
39725-39739
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of CHI3L1 is associated with chemoresistance and poor outcome of epithelial ovarian carcinoma

Overexpression of CHI3L1 is associated with chemoresistance and poor outcome of epithelial ovarian carcinoma

https://doi.org/10.18632/oncotarget.5469

Ying-Cheng Chiang, Han-Wei Lin, Chi-Fang Chang, Ming-Cheng Chang, Chi-Feng Fu, Tsung-Ching Chen, Shu-Feng Hsieh, Chi-An Chen,  and Wen-Fang Cheng
39740-39755
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Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met

Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met

https://doi.org/10.18632/oncotarget.5476

Chengcao Sun, Ming Sang, Shujun Li, Xiaodong Sun, Cuili Yang, Yongyong Xi, Liang Wang, Feng Zhang, Yongyi Bi, Yunfeng Fu,  and Dejia Li
39756-39792
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns

LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns

https://doi.org/10.18632/oncotarget.5794

Yongsheng Li, Hong Chen, Tao Pan, Chunjie Jiang, Zheng Zhao, Zishan Wang, Jinwen Zhang, Juan Xu,  and Xia Li
39793-39805
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer – a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation

Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer – a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation

https://doi.org/10.18632/oncotarget.5655

Wei-Ling Chang, Lih-Ching Hsu, Wohn-Jenn Leu, Ching-Shih Chen,  and Jih-Hwa Guh
39806-39820
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer

Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer

https://doi.org/10.18632/oncotarget.5496

Alice Cavanaugh, Brendon Juengst, Kathleen Sheridan, John F. Danella,  and Heinric Williams
39821-39838
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Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells

Inhibition of autophagy promotes metastasis and glycolysis by inducing ROS in gastric cancer cells

https://doi.org/10.18632/oncotarget.5674

Wenjie Qin, Chao Li, Wen Zheng, Qingqu Guo, Yuefeng Zhang, Muxing Kang, Bo Zhang, Bin Yang, Baozhong Li, Haijun Yang,  and Yulian Wu
39839-39854
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Rs488087 single nucleotide polymorphism as predictive risk factor for pancreatic cancers

Rs488087 single nucleotide polymorphism as predictive risk factor for pancreatic cancers

https://doi.org/10.18632/oncotarget.5627

Emmanuelle Martinez, Françoise Silvy, Fréderic Fina, Marc Bartoli, Martin Krahn, Fabrice Barlesi, Dominique Figarella-Branger, Juan Iovanna, René Laugier, Mehdi Ouaissi, Dominique Lombardo,  and Eric Mas
39855-39864
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Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations

Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations

https://doi.org/10.18632/oncotarget.5399

Yunyun Jiang, Gabriel G. Malouf, Jianping Zhang, Xiaofeng Zheng, Yunxin Chen, Erika J Thompson, John N. Weinstein, Ying Yuan, Jean-Philippe Spano, Russell Broaddus, Nizar M. Tannir, David Khayat, Karen H. Lu,  and Xiaoping Su
39865-39876
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide

IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide

https://doi.org/10.18632/oncotarget.5631

Roger Ramcharan, Tamara Aleksic, Wilfride Petnga Kamdoum, Shan Gao, Sophia X. Pfister, Jordan Tanner, Esther Bridges, Ruth Asher, Amanda J. Watson, Geoffrey P. Margison, Mick Woodcock, Emmanouela Repapi, Ji-Liang Li, Mark R. Middleton,  and Valentine M. Macaulay
39877-39890
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas

INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas

https://doi.org/10.18632/oncotarget.5359

Meng Na Chi, Su Tang Guo, James S. Wilmott, Xiang Yun Guo, Xu Guang Yan, Chun Yan Wang, Xiao Ying Liu, Lei Jin, Hsin-Yi Tseng, Tao Liu, Amanda Croft, Hubert Hondermarck, Richard A. Scolyer, Chen Chen Jiang,  and Xu Dong Zhang
39891-39907
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Frizzled-7 promoter is highly active in tumors and promoter-driven Shiga-like toxin I inhibits hepatocellular carcinoma growth

Frizzled-7 promoter is highly active in tumors and promoter-driven Shiga-like toxin I inhibits hepatocellular carcinoma growth

https://doi.org/10.18632/oncotarget.5516

Hongpan Xu, Lailing Gong, Yanyan Xia, Lili Qu, Qiwen Li, Lu Pang, Jin Si,  and Zhiyang Li
39908-39923
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Key contribution of eIF4H-mediated translational control in tumor promotion

Key contribution of eIF4H-mediated translational control in tumor promotion

https://doi.org/10.18632/oncotarget.5442

Charlotte Vaysse, Céline Philippe, Yvan Martineau, Cathy Quelen, Corinne Hieblot, Claire Renaud, Yvan Nicaise, Aurore Desquesnes, Maria Pannese, Thomas Filleron, Ghislaine Escourrou, Malcolm Lawson, Robert C Rintoul, Marie Bernadette Delisle, Stéphane Pyronnet, Pierre Brousset, Hervé Prats,  and Christian Touriol
39924-39940
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression

Prostaglandins induce early growth response 1 transcription factor mediated microsomal prostaglandin E2 synthase up-regulation for colorectal cancer progression

https://doi.org/10.18632/oncotarget.5402

Konstantinos Stamatakis, Marta Jimenez-Martinez, Alba Jimenez-Segovia, Isabel Chico-Calero, Elisa Conde, Javier Galán-Martínez, Julia Ruiz, Alejandro Pascual, Beatriz Barrocal, Ricardo López-Pérez, María Laura García-Bermejo,  and Manuel Fresno
39941-39959
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Impact of wall shear stress and ligand avidity on binding of anti-CD146-coated nanoparticles to murine tumor endothelium under flow

Impact of wall shear stress and ligand avidity on binding of anti-CD146-coated nanoparticles to murine tumor endothelium under flow

https://doi.org/10.18632/oncotarget.5662

Stefan Thomann, Sunhwa Baek,  and Eduard Ryschich
39960-39968
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Degradation of the cancer genomic DNA deaminase APOBEC3B by SIV Vif

Degradation of the cancer genomic DNA deaminase APOBEC3B by SIV Vif

https://doi.org/10.18632/oncotarget.5483

Allison M. Land, Jiayi Wang, Emily K. Law, Ryan Aberle, Andrea Kirmaier, Annabel Krupp, Welkin E. Johnson,  and Reuben S. Harris
39969-39979
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The 5′-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding

The 5′-untranslated region of p16INK4a melanoma tumor suppressor acts as a cellular IRES, controlling mRNA translation under hypoxia through YBX1 binding

https://doi.org/10.18632/oncotarget.5387

Alessandra Bisio, Elisa Latorre, Virginia Andreotti, Brigitte Bressac-de Paillerets, Mark Harland, Giovanna Bianchi Scarra, Paola Ghiorzo, Robert C. Spitale, Alessandro Provenzani,  and Alberto Inga
39980-39994
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Polymorphisms involving gain or loss of CpG sites are significantly enriched in trait-associated SNPs

Polymorphisms involving gain or loss of CpG sites are significantly enriched in trait-associated SNPs

https://doi.org/10.18632/oncotarget.5650

Dan Zhou, Zhenli Li, Dan Yu, Ledong Wan, Yimin Zhu, Maode Lai,  and Dandan Zhang
39995-40004
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype

A multi-stage process including transient polyploidization and EMT precedes the emergence of chemoresistent ovarian carcinoma cells with a dedifferentiated and pro-inflammatory secretory phenotype

https://doi.org/10.18632/oncotarget.5552

Verena Rohnalter, Katrin Roth, Florian Finkernagel, Till Adhikary, Julia Obert, Kristina Dorzweiler, Maike Bensberg, Sabine Müller-Brüsselbach,  and Rolf Müller
40005-40025
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PIK3CA mutation detection in metastatic biliary cancer using cell-free DNA

PIK3CA mutation detection in metastatic biliary cancer using cell-free DNA

https://doi.org/10.18632/oncotarget.5432

Seung Tae Kim, Maruja Lira, Shibing Deng, Sujin Lee, Young Suk Park, Ho Yeong Lim, Won Ki Kang, Mao Mao, Jin Seok Heo, Wooil Kwon, Jeeyun Lee, Kee-Taek Jang,  and Joon Oh Park
40026-40035
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Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells

Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells

https://doi.org/10.18632/oncotarget.5486

Victoria I. Bunik, Artem Artiukhov, Alexey Kazantsev, Renata Goncalves, Danilo Daloso, Henry Oppermann, Elena Kulakovskaya, Nikolay Lukashev, Alisdair Fernie, Martin Brand,  and Frank Gaunitz
40036-40052
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LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma

LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma

https://doi.org/10.18632/oncotarget.5548

Gabriella Cunha Vieira, S. Chockalingam, Zsombor Melegh, Alexander Greenhough, Sally Malik, Marianna Szemes, Ji Hyun Park, Abderrahmane Kaidi, Li Zhou, Daniel Catchpoole, Rhys Morgan, David O. Bates, Peter J. Gabb,  and Karim Malik
40053-40067
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The herbal compound Songyou Yin (SYY) inhibits hepatocellular carcinoma growth and improves survival in models of chronic fibrosis via paracrine inhibition of activated hepatic stellate cells

The herbal compound Songyou Yin (SYY) inhibits hepatocellular carcinoma growth and improves survival in models of chronic fibrosis via paracrine inhibition of activated hepatic stellate cells

https://doi.org/10.18632/oncotarget.5313

Yang Bu, Qing-An Jia, Zheng-Gang Ren, Tong-Chun Xue, Quan-Bao Zhang, Ke-Zhi Zhang, Qiang-Bo Zhang, Yang You, Hui Tian, Lun-Xiu Qin,  and Zhao-You Tang
40068-40080
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aberrant high expression of immunoglobulin G in epithelial stem/progenitor-like cells contributes to tumor initiation and metastasis

Aberrant high expression of immunoglobulin G in epithelial stem/progenitor-like cells contributes to tumor initiation and metastasis

https://doi.org/10.18632/oncotarget.5542

Qinyuan Liao, Wei Liu, Yang Liu, Fulin Wang, Chong Wang, Jingxuan Zhang, Ming Chu, Dongyang Jiang, Lin Xiao, Wenwei Shao, Zhengzuo Sheng, Xia Tao, Lei Huo, C. Cameron Yin, Youhui Zhang, Gregory Lee, Jing Huang, Zihai Li,  and Xiaoyan. Qiu
40081-40094
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of young HERV-H loci in the course of colorectal carcinoma and correlation with molecular subtypes

Expression of young HERV-H loci in the course of colorectal carcinoma and correlation with molecular subtypes

https://doi.org/10.18632/oncotarget.5539

Philippe Pérot, Christina Susanne Mullins, Magali Naville, Cédric Bressan, Maja Hühns, Michael Gock, Florian Kühn, Jean-Nicolas Volff, Véronique Trillet-Lenoir, Michael Linnebacher,  and François Mallet
40095-40111
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma

Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma

https://doi.org/10.18632/oncotarget.5556

Stefan Nagel, Corinna Meyer, Maren Kaufmann, Hans G. Drexler,  and Roderick A.F. MacLeod
40112-40126
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comparative effectiveness study of breast-conserving surgery and mastectomy in the general population: A NCDB analysis

Comparative effectiveness study of breast-conserving surgery and mastectomy in the general population: A NCDB analysis

https://doi.org/10.18632/oncotarget.5394

Kai Chen, Jieqiong Liu, Liling Zhu, Fengxi Su, Erwei Song,  and Lisa K. Jacobs
40127-40140
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells

The PIM inhibitor AZD1208 synergizes with ruxolitinib to induce apoptosis of ruxolitinib sensitive and resistant JAK2-V617F-driven cells and inhibit colony formation of primary MPN cells

https://doi.org/10.18632/oncotarget.5653

Lucia Mazzacurati, Que T. Lambert, Anuradha Pradhan, Lori N. Griner, Dennis Huszar,  and Gary W. Reuther
40141-40157
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Induction of metastatic potential by TrkB via activation of IL6/JAK2/STAT3 and PI3K/AKT signaling in breast cancer

Induction of metastatic potential by TrkB via activation of IL6/JAK2/STAT3 and PI3K/AKT signaling in breast cancer

https://doi.org/10.18632/oncotarget.5522

Min Soo Kim, Won Sung Lee, Joon Jeong, Seong-Jin Kim,  and Wook Jin
40158-40171
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5

Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5

https://doi.org/10.18632/oncotarget.5502

Wen Shi, Jing Yang, Siyuan Li, Xiaofeng Shan, Xiaosong Liu, Hong Hua, Chuanke Zhao, Zhendong Feng, Zhigang Cai, Lihe Zhang,  and Demin Zhou
40172-40185
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Elucidating drivers of oral epithelial dysplasia formation and malignant transformation to cancer using RNAseq

Elucidating drivers of oral epithelial dysplasia formation and malignant transformation to cancer using RNAseq

https://doi.org/10.18632/oncotarget.5529

Caroline Conway, Jennifer L. Graham, Preetha Chengot, Catherine Daly, Rebecca Chalkley, Lisa Ross, Alastair Droop, Pamela Rabbitts,  and Lucy F. Stead
40186-40201
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells

Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells

https://doi.org/10.18632/oncotarget.5473

Alessandra Capasso, Carmen Cerchia, Carmen Di Giovanni, Giuseppina Granato, Francesco Albano, Simona Romano, Emmanuele De Vendittis, Maria Rosaria Ruocco,  and Antonio Lavecchia
40202-40222
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Peritumoral Cbl is a strong independent prognostic marker after curative resection of hepatocellular carcinoma

Peritumoral Cbl is a strong independent prognostic marker after curative resection of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.5540

Ju-Bo Zhang, Bo Zhang, Lei Guo, Zhen-Hai Lin, Xiao-Qiang Li, Kun Guo, Hui-Chuan Sun,  and Qing-Hai Ye
40223-40234
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genes with stable DNA methylation levels show higher evolutionary conservation than genes with fluctuant DNA methylation levels

Genes with stable DNA methylation levels show higher evolutionary conservation than genes with fluctuant DNA methylation levels

https://doi.org/10.18632/oncotarget.5504

Ruijie Zhang, Wenhua Lv, Meiwei Luan, Jiajia Zheng, Miao Shi, Hongjie Zhu, Jin Li, Hongchao Lv, Mingming Zhang, Zhenwei Shang, Lian Duan,  and Yongshuai Jiang
40235-40246
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ERβ regulation of NF-kB activation in prostate cancer is mediated by HIF-1

ERβ regulation of NF-kB activation in prostate cancer is mediated by HIF-1

https://doi.org/10.18632/oncotarget.5377

Paul Mak, Jiarong Li, Sanjoy Samanta,  and Arthur M. Mercurio
40247-40254
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeting stemness is an effective strategy to control EML4-ALK+ non-small cell lung cancer cells

Targeting stemness is an effective strategy to control EML4-ALK+ non-small cell lung cancer cells

https://doi.org/10.18632/oncotarget.5434

Se Jin Oh, Kyung Hee Noh, Young-Ho Lee, Soon-Oh Hong, Kwon-Ho Song, Hyo-Jung Lee, Soyeon Kim, Tae Min Kim, Ju-Hong Jeon, Dong-Wan Kim, Jae Hong Seo,  and Tae Woo Kim
40255-40267
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines

Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines

https://doi.org/10.18632/oncotarget.5592

Liangkun You, Jiawei Shou, Danchen Deng, Liming Jiang, Zhao Jing, Junlin Yao, Hongsen Li, Jiansheng Xie, Zhanggui Wang, Qin Pan, Hongming Pan, Wendong Huang,  and Weidong Han
40268-40282
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma

Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma

https://doi.org/10.18632/oncotarget.5375

Qingxia Wei, Yuning J Tang, Veronique Voisin, Shingo Sato, Makoto Hirata, Heather Whetstone, Ilkyu Han, Laurie Ailles, Gary D. Bader, Jay Wunder,  and Benjamin A. Alman
40283-40294
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Changes in microRNA (miRNA) expression during pancreatic cancer development and progression in a genetically engineered KrasG12D;Pdx1-Cre mouse (KC) model

Changes in microRNA (miRNA) expression during pancreatic cancer development and progression in a genetically engineered KrasG12D;Pdx1-Cre mouse (KC) model

https://doi.org/10.18632/oncotarget.5641

Satyanarayana Rachagani, Muzafar A. Macha, Melanie S Menning, Parama Dey, Priya Pai, Lynette M. Smith, Yin-Yuan Mo,  and Surinder K. Batra
40295-40309
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion

Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion

https://doi.org/10.18632/oncotarget.5643

Claire Henry, Estelle Llamosas, Alexandra Knipprath-Meszaros, Andreas Schoetzau, Ellen Obermann, Maya Fuenfschilling, Rosemarie Caduff, Daniel Fink, Neville Hacker, Robyn Ward, Viola Heinzelmann-Schwarz,  and Caroline Ford
40310-40326
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genome-wide association study identifies two new susceptibility loci for colorectal cancer at 5q23.3 and 17q12 in Han Chinese

Genome-wide association study identifies two new susceptibility loci for colorectal cancer at 5q23.3 and 17q12 in Han Chinese

https://doi.org/10.18632/oncotarget.5530

Kewei Jiang, Yimin Sun, Cheng Wang, Jiafu Ji, Yaoping Li, Yingjiang Ye, Liang Lv, Yong Guo, Sutang Guo, Hai Li, Lianhai Zhang, Yanbing Zhou, Bo Jiang, Yonghong Ren, Youchun Xu, Xiongfei Yang, Hongxia Liu, Yirui Wang, Zhanlong Shen, Wenyan Qin, Peng Guo, Yuyang Jiang, Zhibin Hu, Hongbing Shen, Jing Cheng, Yinxue Yang,  and Shan Wang
40327-40336
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Three-dimensional structure discrepancy between HLA alleles for effective prediction of aGVHD severity and optimal selection of recipient-donor pairs: a proof-of-concept study

Three-dimensional structure discrepancy between HLA alleles for effective prediction of aGVHD severity and optimal selection of recipient-donor pairs: a proof-of-concept study

https://doi.org/10.18632/oncotarget.5378

Hongxing Han, Fang Yuan, Yuying Sun, Jinfeng Liu, Shuguang Liu, Yuan Luo, Fei Liang, Nan Liu, Juan Long, Xiao Zhao, Fanhua Kong,  and Yongzhi Xi
40337-40359
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prospective blinded study of somatic mutation detection in cell-free DNA utilizing a targeted 54-gene next generation sequencing panel in metastatic solid tumor patients

Prospective blinded study of somatic mutation detection in cell-free DNA utilizing a targeted 54-gene next generation sequencing panel in metastatic solid tumor patients

https://doi.org/10.18632/oncotarget.5465

Seung Tae Kim, Won Suk Lee, Richard B. Lanman, Stefanie Mortimer, Oliver A. Zill, Kyoung-Mee Kim, Kee Taek Jang, Seok-Hyung Kim, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Helmy Eltoukhy, Won Ki Kang, Woo Yong Lee, Hee-Cheol Kim, Keunchil Park, Jeeyun Lee,  and AmirAli Talasaz
40360-40369
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of caldesmon is associated with tumor progression in patients with primary non-muscle-invasive bladder cancer

Overexpression of caldesmon is associated with tumor progression in patients with primary non-muscle-invasive bladder cancer

https://doi.org/10.18632/oncotarget.5458

Myung-Shin Lee, Jisu Lee, Joo Heon Kim, Won Tae Kim, Wun-Jae Kim, Hanjong Ahn,  and Jinsung Park
40370-40384
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Errata

Erratum: A novel cancer immunotherapy based on the combination of a synthetic carbohydrate-pulsed dendritic cell vaccine and glycoengineered cancer cells

Erratum: A novel cancer immunotherapy based on the combination of a synthetic carbohydrate-pulsed dendritic cell vaccine and glycoengineered cancer cells

https://doi.org/10.18632/oncotarget.6369

Lei Qiu, Jie Li, Shichong Yu, Qianli Wang, Yinghua Li, Zhenlin Hu, Qiuye Wu, Zhongwu Guo,  and Junping Zhang
40385-40385
Erratum  |  PDF  |  Order a Reprint


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