Oncotarget

Vol 6, No 36

November 17, 2015

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LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation. See Mardilovich et al.

Table of Contents

Editorial

Q-ing tumor glutaminase for therapy

Q-ing tumor glutaminase for therapy

https://doi.org/10.18632/oncotarget.6301

Zachary E. Stine,  and Chi V. Dang
38440-38441
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Mitochondrial mass and DNA repair in breast cancer stem cells

Mitochondrial mass and DNA repair in breast cancer stem cells

https://doi.org/10.18632/oncotarget.6305

Richard G. Pestell, Alesandro Fatatis,  and Xuanmao Jiao
38442-38443
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Inflammasome effects in GvHD

Inflammasome effects in GvHD

https://doi.org/10.18632/oncotarget.6307

Brent H. Koehn, Robert Zeiser,  and Bruce R. Blazar
38444-38445
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Research Perspectives

Glucocorticoid-induced leucine zipper (GILZ) in immuno suppression: master regulator or bystander?

Glucocorticoid-induced leucine zipper (GILZ) in immuno suppression: master regulator or bystander?

https://doi.org/10.18632/oncotarget.6197

Jessica Hoppstädter,  and Alexandra K. Kiemer
38446-38457
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Priority Research Papers

Intermittent high-dose treatment with erlotinib enhances therapeutic efficacy in EGFR-mutant lung cancer

Intermittent high-dose treatment with erlotinib enhances therapeutic efficacy in EGFR-mutant lung cancer

https://doi.org/10.18632/oncotarget.6276

Jakob Schöttle, Sampurna Chatterjee, Caroline Volz, Maike Siobal, Alexandra Florin, Dennis Rokitta, Yvonne Hinze, Felix Dietlein, Dennis Plenker, Katharina König, Kerstin Albus, Johannes M. Heuckmann, Daniel Rauh, Thomas Franz, Bernd Neumaier, Uwe Fuhr, Lukas C. Heukamp,  and Roland T. Ullrich
38458-38468
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

https://doi.org/10.18632/oncotarget.6288

Katerina Mardilovich, Mark Baugh, Diane Crighton, Dominika Kowalczyk, Mads Gabrielsen, June Munro, Daniel R. Croft, Filipe Lourenco, Daniel James, Gabriella Kalna, Lynn McGarry, Oliver Rath, Emma Shanks, Mathew J. Garnett, Ultan McDermott, Joanna Brookfield, Mark Charles, Tim Hammonds,  and Michael F. Olson
38469-38486
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An inducible transgenic mouse breast cancer model for the analysis of tumor antigen specific CD8+ T-cell responses

An inducible transgenic mouse breast cancer model for the analysis of tumor antigen specific CD8+ T-cell responses

https://doi.org/10.18632/oncotarget.5750

Michael Bruns, Jara Wanger, Olaf Utermöhlen,  and Wolfgang Deppert
38487-38503
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Research Papers: Immunology

Recombinant rabies virus expressing dog GM-CSF is an efficacious oral rabies vaccine for dogs

Recombinant rabies virus expressing dog GM-CSF is an efficacious oral rabies vaccine for dogs

https://doi.org/10.18632/oncotarget.5904

Ming Zhou, Lei Wang, Songqin Zhou, Zhao Wang, Juncheng Ruan, Lijun Tang, Ziming Jia, Min Cui, Ling Zhao,  and Zhen F. Fu
38504-38516
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PPE26 induces TLR2-dependent activation of macrophages and drives Th1-type T-cell immunity by triggering the cross-talk of multiple pathways involved in the host response

PPE26 induces TLR2-dependent activation of macrophages and drives Th1-type T-cell immunity by triggering the cross-talk of multiple pathways involved in the host response

https://doi.org/10.18632/oncotarget.5956

Haibo Su, Cong Kong, Lin Zhu, Qi Huang, Liulin Luo, Honghai Wang,  and Ying Xu
38517-38537
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The cAMP response element modulator (CREM) regulates TH2 mediated inflammation

The cAMP response element modulator (CREM) regulates TH2 mediated inflammation

https://doi.org/10.18632/oncotarget.6041

Eva Verjans, Kim Ohl, Lucy K. Reiss, Femke van Wijk, Antonaneta A. Toncheva, Anastasia Wiener, Yin Yu, Annette D. Rieg, Vincent D. Gaertner, Johannes Roth, Edward Knol, Michael Kabesch, Norbert Wagner, Stefan Uhlig, Christian Martin,  and Klaus Tenbrock
38538-38551
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Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll

Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll

https://doi.org/10.18632/oncotarget.6035

Dawei Liu, Zeeshan Shaukat, Robert B. Saint,  and Stephen L. Gregory
38552-38565
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Decreased severity of collagen antibody and lipopolysaccharide-induced arthritis in human IL-32β overexpressed transgenic mice

Decreased severity of collagen antibody and lipopolysaccharide-induced arthritis in human IL-32β overexpressed transgenic mice

https://doi.org/10.18632/oncotarget.6160

Mi Hee Park, Do-Young Yoon, Jung Ok Ban, Dae Hwan Kim, Dong Hun Lee, Sukgil Song, Youngsoo Kim, Sang-Bae Han, Hee Pom Lee,  and Jin Tae Hong
38566-38577
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Hepatic TLR4 signaling is activated by LPS from digestive tract during SARA, and epigenetic mechanisms contribute to enforced TLR4 expression

Hepatic TLR4 signaling is activated by LPS from digestive tract during SARA, and epigenetic mechanisms contribute to enforced TLR4 expression

https://doi.org/10.18632/oncotarget.6161

Guangjun Chang, Su Zhuang, Hans-Martin Seyfert, Kai Zhang, Tianle Xu, Di Jin, Junfei Guo,  and Xiangzhen Shen
38578-38590
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Reviews

MYC-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical management

MYC-driven aggressive B-cell lymphomas: biology, entity, differential diagnosis and clinical management

https://doi.org/10.18632/oncotarget.5774

Qingqing Cai, L. Jeffrey Medeiros, Xiaolu Xu,  and Ken H. Young
38591-38616
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Targeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?

Targeted cancer therapy with ribosome biogenesis inhibitors: a real possibility?

https://doi.org/10.18632/oncotarget.5775

Elisa Brighenti, Davide Treré,  and Massimo Derenzini
38617-38627
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miRNA interventions serve as ‘magic bullets’ in the reversal of glioblastoma hallmarks

miRNA interventions serve as ‘magic bullets’ in the reversal of glioblastoma hallmarks

https://doi.org/10.18632/oncotarget.5926

Luyue Chen,  and Chunsheng Kang
38628-38642
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Detection of cancer through exhaled breath: a systematic review

Detection of cancer through exhaled breath: a systematic review

https://doi.org/10.18632/oncotarget.5938

Agne Krilaviciute, Jonathan Alexander Heiss, Marcis Leja, Juozas Kupcinskas, Hossam Haick,  and Hermann Brenner
38643-38657
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Research Papers

Pattern of distant metastases in colorectal cancer: a SEER based study

Pattern of distant metastases in colorectal cancer: a SEER based study

https://doi.org/10.18632/oncotarget.6130

Miaozhen Qiu, Jianming Hu, Dajun Yang, David Peter Cosgrove,  and Ruihua Xu
38658-38666
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Hes1 promotes cell proliferation and migration by activating Bmi-1 and PTEN/Akt/GSK3β pathway in human colon cancer

Hes1 promotes cell proliferation and migration by activating Bmi-1 and PTEN/Akt/GSK3β pathway in human colon cancer

https://doi.org/10.18632/oncotarget.5484

Fei Gao, Wei Huang, YuQin Zhang, ShaoHui Tang, Lin Zheng, Feng Ma, YiMing Wang, Hui Tang,  and Xin Li
38667-38680
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Whole-transcriptome analysis of flow-sorted cervical cancer samples reveals that B cell expressed TCL1A is correlated with improved survival

Whole-transcriptome analysis of flow-sorted cervical cancer samples reveals that B cell expressed TCL1A is correlated with improved survival

https://doi.org/10.18632/oncotarget.4526

Simone Punt, Willem E. Corver, Sander A.J. van der Zeeuw, Szymon M. Kielbasa, Elisabeth M. Osse, Henk P.J. Buermans, Cornelis D. de Kroon, Ekaterina S. Jordanova,  and Arko Gorter
38681-38694
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MicroRNA expression profiling identifies miR-31-5p/3p as associated with time to progression in wild-type RAS metastatic colorectal cancer treated with cetuximab

MicroRNA expression profiling identifies miR-31-5p/3p as associated with time to progression in wild-type RAS metastatic colorectal cancer treated with cetuximab

https://doi.org/10.18632/oncotarget.5735

Jitka Mlcochova, Petra Faltejskova-Vychytilova, Manuela Ferracin, Barbara Zagatti, Lenka Radova, Marek Svoboda, Radim Nemecek, Stanislav John, Igor Kiss, Rostislav Vyzula, Massimo Negrini,  and Ondrej Slaby
38695-38704
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

microRNA-214 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting the suppressor-of-fused protein (Sufu)

microRNA-214 promotes epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting the suppressor-of-fused protein (Sufu)

https://doi.org/10.18632/oncotarget.5478

Haixia Long, Zhongyu Wang, Junying Chen, Tong Xiang, Qijing Li, Xinwei Diao,  and Bo Zhu
38705-38718
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy

A link between lipid metabolism and epithelial-mesenchymal transition provides a target for colon cancer therapy

https://doi.org/10.18632/oncotarget.5340

Ruth Sánchez-Martínez, Silvia Cruz-Gil, Marta Gómez de Cedrón, Mónica Álvarez-Fernández, Teodoro Vargas, Susana Molina, Belén García, Jesús Herranz, Juan Moreno-Rubio, Guillermo Reglero, Mirna Pérez-Moreno, Jaime Feliu, Marcos Malumbres,  and Ana Ramírez de Molina
38719-38736
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic impact of mismatch repair genes germline defects in colorectal cancer patients: are all mutations equal?

Prognostic impact of mismatch repair genes germline defects in colorectal cancer patients: are all mutations equal?

https://doi.org/10.18632/oncotarget.5395

Elena Maccaroni, Raffaella Bracci, Riccardo Giampieri, Francesca Bianchi, Laura Belvederesi, Cristiana Brugiati, Silvia Pagliaretta, Michela Del Prete, Mario Scartozzi,  and Stefano Cascinu
38737-38748
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Cytokeratin-19 positivity is acquired along cancer progression and does not predict cell origin in rat hepatocarcinogenesis

Cytokeratin-19 positivity is acquired along cancer progression and does not predict cell origin in rat hepatocarcinogenesis

https://doi.org/10.18632/oncotarget.5501

Marta Anna Kowalik, Pia Sulas, Giovanna Maria Ledda-Columbano, Silvia Giordano, Amedeo Columbano,  and Andrea Perra
38749-38763
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A microfluidic approach towards hybridoma generation for cancer immunotherapy

A microfluidic approach towards hybridoma generation for cancer immunotherapy

https://doi.org/10.18632/oncotarget.5550

Yen-Ta Lu, Gaurav Prashant Pendharkar, Chung-Huan Lu, Chia-Ming Chang,  and Cheng-Hsien Liu
38764-38776
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Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors

Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors

https://doi.org/10.18632/oncotarget.6091

Attje S. Hoekstra, Marieke A. de Graaff, Inge H. Briaire-de Bruijn, Cor Ras, Reza Maleki Seifar, Ivonne van Minderhout, Cees J. Cornelisse, Pancras C.W. Hogendoorn, Martijn H. Breuning, Johnny Suijker, Esther Korpershoek, Henricus P.M. Kunst, Norma Frizzell, Peter Devilee, Jean-Pierre Bayley,  and Judith V.M.G. Bovée
38777-38788
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer

In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer

https://doi.org/10.18632/oncotarget.5887

Toshiyuki Hirano, Hiroyuki Yasuda, Tetsuo Tani, Junko Hamamoto, Ayano Oashi, Kota Ishioka, Daisuke Arai, Shigenari Nukaga, Masayoshi Miyawaki, Ichiro Kawada, Katsuhiko Naoki, Daniel B. Costa, Susumu S. Kobayashi, Tomoko Betsuyaku,  and Kenzo Soejima
38789-38803
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Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia

Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia

https://doi.org/10.18632/oncotarget.5661

Manja Wobus, Martin Bornhäuser, Angela Jacobi, Martin Kräter, Oliver Otto, Claudia Ortlepp, Jochen Guck, Gerhard Ehninger, Christian Thiede,  and Uta Oelschlägel
38804-38815
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Deletion of cyclooxygenase-2 inhibits K-ras–induced lung carcinogenesis

Deletion of cyclooxygenase-2 inhibits K-ras–induced lung carcinogenesis

https://doi.org/10.18632/oncotarget.5558

Yong Pan, Yan Jiang, Lin Tan, Murali K. Ravoori, Mihai Gagea, Vikus Kundra, Susan M. Fischer,  and Peiying Yang
38816-38826
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial

Biomarker-driven stratification of disease-risk in non-metastatic medulloblastoma: Results from the multi-center HIT-SIOP-PNET4 clinical trial

https://doi.org/10.18632/oncotarget.5149

Steven C. Clifford, Birgitta Lannering, Ed C. Schwalbe, Debbie Hicks, Kieran O’ Toole, Sarah Leigh Nicholson, Tobias Goschzik, Anja zur Mühlen, Dominique Figarella-Branger, Franҫois Doz, Stefan Rutkowski, Göran Gustafsson,  and Torsten Pietsch
38827-38839
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Synergistic antitumor efficacy against the EGFRvIII+HER2+ breast cancers by combining trastuzumab with anti-EGFRvIII antibody CH12

Synergistic antitumor efficacy against the EGFRvIII+HER2+ breast cancers by combining trastuzumab with anti-EGFRvIII antibody CH12

https://doi.org/10.18632/oncotarget.6111

Wen Xu, Yanyu Bi, Jiqin Zhang, Juan Kong, Hua Jiang, Mi Tian, Kesang Li, Biao Wang, Cheng Chen, Fei Song, Xiaorong Pan, Bizhi Shi, Xianming Kong, Jianren Gu, Xiumei Cai,  and Zonghai Li
38840-38853
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MDP, a database linking drug response data to genomic information, identifies dasatinib and statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells

MDP, a database linking drug response data to genomic information, identifies dasatinib and statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells

https://doi.org/10.18632/oncotarget.5749

Cristian Taccioli, Giovanni Sorrentino, Alessandro Zannini, Jimmy Caroli, Domenico Beneventano, Laura Anderlucci, Marco Lolli, Silvio Bicciato,  and Giannino Del Sal
38854-38865
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Interleukin-1 beta transactivates epidermal growth factor receptor via the CXCL1-CXCR2 axis in oral cancer

Interleukin-1 beta transactivates epidermal growth factor receptor via the CXCL1-CXCR2 axis in oral cancer

https://doi.org/10.18632/oncotarget.5640

Chia-Huei Lee, Shih-Han Syu, Ko-Jiunn Liu, Pei-Yi Chu, Wen-Chan Yang, Pinpin Lin,  and Wan-Yu Shieh
38866-38880
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Characterization of novel biomarkers in selecting for subtype specific medulloblastoma phenotypes

Characterization of novel biomarkers in selecting for subtype specific medulloblastoma phenotypes

https://doi.org/10.18632/oncotarget.6195

Lisa Liang, Christopher Aiken, Robyn McClelland, Ludivine Coudière Morrison, Nazanin Tatari, Marc Remke, Vijay  Ramaswamy, Magimairajan Issaivanan, Timothy Ryken, Marc R. Del Bigio, Michael D. Taylor,  and Tamra E. Werbowetski-Ogilvie
38881-38900
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD40 controls CXCR5-induced recruitment of myeloid-derived suppressor cells to gastric cancer

CD40 controls CXCR5-induced recruitment of myeloid-derived suppressor cells to gastric cancer

https://doi.org/10.18632/oncotarget.5644

Yixin Ding, Jin Shen, Guangbo Zhang, Xiaojuan Chen, JiaMing Wu,  and Weichang Chen
38901-38911
Abstract  |  PDF  |  HTML  |  Order a Reprint

Tunicamycin enhances the antitumor activity of trastuzumab on breast cancer in vitro and in vivo

Tunicamycin enhances the antitumor activity of trastuzumab on breast cancer in vitro and in vivo

https://doi.org/10.18632/oncotarget.5334

Xiqian Han, Xiaobing Zhang, Hui Li, Shengshi Huang, Shu Zhang, Fengshan Wang,  and Yikang Shi
38912-38925
Abstract  |  PDF  |  HTML  |  Order a Reprint

Potential role of aquaporin 3 in gastric intestinal metaplasia

Potential role of aquaporin 3 in gastric intestinal metaplasia

https://doi.org/10.18632/oncotarget.5370

Haijian Zhao, Xiaojun Yang, Yangchun Zhou, Weiming Zhang, Yao Wang, Jianfei Wen, Zhihong Zhang,  and Lizong Shen
38926-38933
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells

Inhibition of c-MYC with involvement of ERK/JNK/MAPK and AKT pathways as a novel mechanism for shikonin and its derivatives in killing leukemia cells

https://doi.org/10.18632/oncotarget.5380

Qiaoli Zhao, Andreana N. Assimopoulou, Sabine M. Klauck, Harilaos Damianakos, Ioanna Chinou, Nadine Kretschmer, José-Luis Rios, Vassilios P. Papageorgiou, Rudolf Bauer,  and Thomas Efferth
38934-38951
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling

The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling

https://doi.org/10.18632/oncotarget.5731

Gao-Xiang Zhao, Li-Hui Xu, Hao Pan, Qiu-Ru Lin, Mei-Yun Huang, Ji-Ye Cai, Dong-Yun Ouyang,  and Xian-Hui He
38952-38966
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulation of Aldo-keto-reductase family 1 B10 by 14-3-3ε and their prognostic impact of hepatocellular carcinoma

Regulation of Aldo-keto-reductase family 1 B10 by 14-3-3ε and their prognostic impact of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.5734

Tzu-An Liu, Yee-Jee Jan, Bor-Sheng Ko, Yi-Ju Wu, Yi-Jhu Lu, Shu-Man Liang, Chia-Chia Liu, Shyh-Chang Chen, John Wang, Song-Kun Shyue,  and Jun-Yang Liou
38967-38982
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Role of miR-182 in response to oxidative stress in the cell fate of human fallopian tube epithelial cells

Role of miR-182 in response to oxidative stress in the cell fate of human fallopian tube epithelial cells

https://doi.org/10.18632/oncotarget.5493

Yugang Liu, Wenan Qiang, Xiaofei Xu, Ruifen Dong, Alison M. Karst, Zhaojian Liu, Beihua Kong, Ronny I. Drapkin,  and Jian-Jun Wei
38983-38998
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of the β-catenin/JNK/prothymosin-alpha axis as a novel target of sorafenib in hepatocellular carcinoma cells

Identification of the β-catenin/JNK/prothymosin-alpha axis as a novel target of sorafenib in hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.5738

Yi-Te Lin,  and Chuck C.-K. Chao
38999-39017
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Neutropenia predicts better prognosis in patients with metastatic gastric cancer on a combined epirubicin, oxaliplatin and 5-fluorouracil regimen

Neutropenia predicts better prognosis in patients with metastatic gastric cancer on a combined epirubicin, oxaliplatin and 5-fluorouracil regimen

https://doi.org/10.18632/oncotarget.5730

Rujiao Liu, Mingzhu Huang, Xiaoying Zhao, Wei Peng, Si Sun, Jun Cao, Dongmei Ji, Chenchen Wang, Weijian Guo, Jin Li, Jiliang Yin,  and Xiaodong Zhu
39018-39027
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NTRK1 rearrangement in colorectal cancer patients: evidence for actionable target using patient-derived tumor cell line

NTRK1 rearrangement in colorectal cancer patients: evidence for actionable target using patient-derived tumor cell line

https://doi.org/10.18632/oncotarget.5494

Su Jin Lee, Gang Gary Li, Seung Tae Kim, Min Eui Hong, Jiryeon Jang, Nara Yoon, Soo Min Ahn, Danielle Murphy, Jason Christiansen, Ge Wei, Zachary Hornby, Dong Woo Lee, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Sung No Hong, Seok-Hyeong Kim, Won Ki Kang, Keunchil Park, Woong Yang Park, Kyoung-Mee Kim,  and Jeeyun Lee
39028-39035
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Necrosis avid near infrared fluorescent cyanines for imaging cell death and their use to monitor therapeutic efficacy in mouse tumor models

Necrosis avid near infrared fluorescent cyanines for imaging cell death and their use to monitor therapeutic efficacy in mouse tumor models

https://doi.org/10.18632/oncotarget.5498

Bangwen Xie, Marieke A. Stammes, Pieter B.A.A. van Driel, Luis J. Cruz, Vicky T. Knol-Blankevoort, Martijn A.M. Löwik, Laura Mezzanotte, Ivo Que, Alan Chan, Jeroen P.H.M. van den Wijngaard, Maria Siebes, Sven Gottschalk, Daniel Razansky, Vasilis Ntziachristos, Stijn Keereweer, Richard W. Horobin, Mathias Hoehn, Eric L. Kaijzel, Ermond R. van Beek, Thomas J.A. Snoeks,  and Clemens W.G.M. Löwik
39036-39049
Abstract  |  PDF  |  HTML  |  Order a Reprint

RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration

RKIP regulates CCL5 expression to inhibit breast cancer invasion and metastasis by controlling macrophage infiltration

https://doi.org/10.18632/oncotarget.5176

Ila Datar, Xiaoliang Qiu, Hong Zhi Ma, Miranda Yeung, Shweta Aras, Ivana de la Serna, Fahd Al-Mulla, Jean Paul Thiery, Robert Trumbly, Xuan Fan, Hongjuan Cui,  and Kam C. Yeung
39050-39061
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IGK with conserved IGΚV/IGΚJ repertoire is expressed in acute myeloid leukemia and promotes leukemic cell migration

IGK with conserved IGΚV/IGΚJ repertoire is expressed in acute myeloid leukemia and promotes leukemic cell migration

https://doi.org/10.18632/oncotarget.5393

Chong Wang, Miaoran Xia, Xiaoping Sun, Zhiqiao He, Fanlei Hu, Lei Chen, Carlos E. Bueso-Ramos, Xiaoyan Qiu,  and Cameron C. Yin
39062-39072
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Simple and rapid determination of homozygous transgenic mice via in vivo fluorescence imaging

Simple and rapid determination of homozygous transgenic mice via in vivo fluorescence imaging

https://doi.org/10.18632/oncotarget.5535

Xiaolin Lin, Junshuang Jia, Yujuan Qin, Xia Lin, Wei Li, Gaofang Xiao, Yanqing Li, Raoying Xie, Hailu Huang, Lin Zhong, Qinghong Wu, Wanshan Wang, Wenhua Huang, Kaitai Yao, Dong Xiao,  and Yan Sun
39073-39087
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Prognostic role and implications of mutation status of tumor suppressor gene ARID1A in cancer: a systematic review and meta-analysis

Prognostic role and implications of mutation status of tumor suppressor gene ARID1A in cancer: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.5142

Claudio Luchini, Nicola Veronese, Marco Solmi, Hanbyoul Cho, Jae-Hoon Kim, Angela Chou, Anthony J. Gill, Sheila F. Faraj, Alcides Chaux, George J. Netto, Kentaro Nakayama, Satoru Kyo, Sun Young Lee, Duck-Woo Kim, George M. Yousef, Andreas Scorilas, Gregg S. Nelson, Martin Köbel, Steve E. Kalloger, David F. Schaeffer, Hai-Bo Yan, Feng Liu, Yoshihito Yokoyama, Xianyu Zhang, Da Pang, Zsuzsanna Lichner, Giuseppe Sergi, Enzo Manzato, Paola Capelli, Laura D. Wood, Aldo Scarpa,  and Christoph U. Correll
39088-39097
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype

An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype

https://doi.org/10.18632/oncotarget.5390

Ming-Kai Chuang, Yu-Chiao Chiu, Wen-Chien Chou, Hsin-An Hou, Mei-Hsuan Tseng, Yi-Yi Kuo, Yidong Chen, Eric Y. Chuang,  and Hwei-Fang Tien
39098-39110
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogenic features of the bone morphogenic protein 7 (BMP7) in pheochromocytoma

Oncogenic features of the bone morphogenic protein 7 (BMP7) in pheochromocytoma

https://doi.org/10.18632/oncotarget.4912

Ines Leinhäuser, Andrea Richter, Misu Lee, Ines Höfig, Nataša Anastasov, Falko Fend, Tonino Ercolino, Massimo Mannelli, Anne-Paule Gimenez-Roqueplo, Mercedes Robledo, Ronald de Krijger, Felix Beuschlein, Michael J. Atkinson,  and Natalia S. Pellegata
39111-39126
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic microRNAs modulate the RHO adhesion pathway: A potential therapeutic target in undifferentiated pleomorphic sarcomas

Prognostic microRNAs modulate the RHO adhesion pathway: A potential therapeutic target in undifferentiated pleomorphic sarcomas

https://doi.org/10.18632/oncotarget.3926

Philip Wong, Angela Hui, Jie Su, Shijun Yue, Benjamin Haibe-Kains, Nalan Gokgoz, Wei Xu, Jeff Bruce, Justin Williams, Charles Catton, Jay S. Wunder, Irene L. Andrulis, Rebecca Gladdy, Brendan Dickson, Brian O’Sullivan,  and Fei-Fei Liu
39127-39139
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Gemcitabine triggers angiogenesis-promoting molecular signals in pancreatic cancer cells: Therapeutic implications

Gemcitabine triggers angiogenesis-promoting molecular signals in pancreatic cancer cells: Therapeutic implications

https://doi.org/10.18632/oncotarget.3784

Mohammad Aslam Khan, Sanjeev K. Srivastava, Arun Bhardwaj, Seema Singh, Sumit Arora, Haseeb Zubair, James E. Carter,  and Ajay P. Singh
39140-39150
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Subpathway-GMir: identifying miRNA-mediated metabolic subpathways by integrating condition-specific genes, microRNAs, and pathway topologies

Subpathway-GMir: identifying miRNA-mediated metabolic subpathways by integrating condition-specific genes, microRNAs, and pathway topologies

https://doi.org/10.18632/oncotarget.5341

Li Feng, Yanjun Xu, Yunpeng Zhang, Zeguo Sun, Junwei Han, Chunlong Zhang, Haixiu Yang, Desi Shang, Fei Su, Xinrui Shi, Shang Li, Chunquan Li,  and Xia Li
39151-39164
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miRNAs in multiple myeloma – a survival relevant complex regulator of gene expression

miRNAs in multiple myeloma – a survival relevant complex regulator of gene expression

https://doi.org/10.18632/oncotarget.5381

Anja Seckinger, Tobias Meißner, Jérôme Moreaux, Vladimir Benes, Jens Hillengass, Mirco Castoldi, Jürgen Zimmermann, Anthony D. Ho, Anna Jauch, Hartmut Goldschmidt, Bernard Klein,  and Dirk Hose
39165-39183
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Effects of interferons and double-stranded RNA on human prostate cancer cell apoptosis

Effects of interferons and double-stranded RNA on human prostate cancer cell apoptosis

https://doi.org/10.18632/oncotarget.5508

Haiyan Tan, Chun Zeng, Junbo Xie, Norah J. Alghamdi, Ya Song, Hongbing Zhang, Aimin Zhou,  and Di Jin
39184-39195
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Bladder cancer cells re-educate TAMs through lactate shuttling in the microfluidic cancer microenvironment

Bladder cancer cells re-educate TAMs through lactate shuttling in the microfluidic cancer microenvironment

https://doi.org/10.18632/oncotarget.5538

Yang Zhao, Degui Wang, Ting Xu, Pengfei Liu, Yanwei Cao, Yonghua Wang, Xuecheng Yang, Xiaodong Xu, Xinsheng Wang,  and Haitao Niu
39196-39210
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

REC8 is a novel tumor suppressor gene epigenetically robustly targeted by the PI3K pathway in thyroid cancer

REC8 is a novel tumor suppressor gene epigenetically robustly targeted by the PI3K pathway in thyroid cancer

https://doi.org/10.18632/oncotarget.5391

Dingxie Liu, Xiaopei Shen, Guangwu Zhu,  and Mingzhao Xing
39211-39224
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-454 functions as an oncogene by inhibiting CHD5 in hepatocellular carcinoma

miR-454 functions as an oncogene by inhibiting CHD5 in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4407

Lei Yu, Xuejun Gong, Lei Sun, Hong Yao, Baoling Lu,  and Liying Zhu
39225-39234
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NOX5-L can stimulate proliferation and apoptosis depending on its levels and cellular context, determining cancer cell susceptibility to cisplatin

NOX5-L can stimulate proliferation and apoptosis depending on its levels and cellular context, determining cancer cell susceptibility to cisplatin

https://doi.org/10.18632/oncotarget.5743

So Hee Dho, Ji Young Kim, Eun-Soo Kwon, Jae Cheong Lim, Sung Sup Park,  and Ki-Sun Kwon
39235-39246
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Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics

Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics

https://doi.org/10.18632/oncotarget.5746

Melanie Hussmann, Kirsten Janke, Philip Kranz, Fabian Neumann, Evgenija Mersch, Melanie Baumann, Kirsten Goepelt, Ulf Brockmeier,  and Eric Metzen
39247-39261
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NF-κB contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro

NF-κB contributes to MMP1 expression in breast cancer spheroids causing paracrine PAR1 activation and disintegrations in the lymph endothelial barrier in vitro

https://doi.org/10.18632/oncotarget.5741

Chi Huu Nguyen, Daniel Senfter, Jose Basilio, Silvio Holzner, Serena Stadler, Sigurd Krieger, Nicole Huttary, Daniela Milovanovic, Katharina Viola, Ingrid Simonitsch-Klupp, Walter Jäger, Rainer de Martin,  and Georg Krupitza
39262-39275
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A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo

A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo

https://doi.org/10.18632/oncotarget.5747

Nagaraju Anreddy, Atish Patel, Yun-Kai Zhang, Yi-Jun Wang, Suneet Shukla, Rishil J. Kathawala, Priyank Kumar, Pranav Gupta, Suresh V. Ambudkar, John N. D. Wurpel, Zhe-Sheng Chen,  and Huiqin Guo
39276-39291
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate

Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate

https://doi.org/10.18632/oncotarget.5751

Jiyoon Cho, Lisa Tremmel, Okkyung Rho, Andrew M. Camelio, Dionicio Siegel, Thomas J. Slaga,  and John DiGiovanni
39292-39306
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Stromal cells promote anti-estrogen resistance of breast cancer cells through an insulin-like growth factor binding protein 5 (IGFBP5)/B-cell leukemia/lymphoma 3 (Bcl-3) axis

Stromal cells promote anti-estrogen resistance of breast cancer cells through an insulin-like growth factor binding protein 5 (IGFBP5)/B-cell leukemia/lymphoma 3 (Bcl-3) axis

https://doi.org/10.18632/oncotarget.5624

Benjamin Leyh, Angela Dittmer, Theresia Lange, John W. M. Martens,  and Jürgen Dittmer
39307-39328
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline

Suppression of mTOR pathway and induction of autophagy-dependent cell death by cabergoline

https://doi.org/10.18632/oncotarget.5744

Shao Jian Lin, Zhi Gen Leng, Yu Hang Guo, Lin Cai, Yu Cai, Ning Li, Han Bing Shang, Wei-Dong Le, Wei Guo Zhao,  and Zhe Bao Wu
39329-39341
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Celecoxib increases lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1

Celecoxib increases lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1

https://doi.org/10.18632/oncotarget.5745

Melina Schellhorn, Maria Haustein, Marcus Frank, Michael Linnebacher,  and Burkhard Hinz
39342-39356
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinical Research Papers

The diagnostic and prognostic value of MRP8/MRP14 in intrahepatic cholangiocarcinoma

The diagnostic and prognostic value of MRP8/MRP14 in intrahepatic cholangiocarcinoma

https://doi.org/10.18632/oncotarget.5329

Guang-Zhi Jin, Wei Dong, Hui Dong, Hua Yu, Jia Chen, Wen-Long Yu, Ai-Jun Li, Wen-Ming Cong,  and Meng-Chao Wu
39357-39364
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Efficacy and safety of capecitabine-based first-line chemotherapy in advanced or metastatic breast cancer: a meta-analysis of randomised controlled trials

Efficacy and safety of capecitabine-based first-line chemotherapy in advanced or metastatic breast cancer: a meta-analysis of randomised controlled trials

https://doi.org/10.18632/oncotarget.5460

Weijiao Yin, Guangsheng Pei, Gang Liu, Li Huang, Shegan Gao,  and Xiaoshan Feng
39365-39372
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic score models for survival of nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy and chemotherapy

Prognostic score models for survival of nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy and chemotherapy

https://doi.org/10.18632/oncotarget.5781

Lei Zeng, Pi Guo, Jin-Gao Li, Fei Han, Qiang Li, Yong Lu, Xiao-Wu Deng, Qing-Ying Zhang,  and Tai-Xiang Lu
39373-39383
Abstract  |  PDF  |  HTML  |  Order a Reprint

Errata

Erratum: Changes in expression levels of ERCC1, DPYD, and VEGFA mRNA after first-line chemotherapy of metastatic colorectal cancer: results of a multicenter study

Erratum: Changes in expression levels of ERCC1, DPYD, and VEGFA mRNA after first-line chemotherapy of metastatic colorectal cancer: results of a multicenter study

https://doi.org/10.18632/oncotarget.6335

Hideo Baba, Yoshifumi Baba, Shinji Uemoto, Kazuhiro Yoshida, Akio Saiura, Masayuki Watanabe, Yoshihiko Maehara, Eiji Oki, Yasuharu Ikeda, Hiroyuki Matsuda, Masakazu Yamamoto, Mitsuo Shimada, Akinobu Taketomi, Michiaki Unno, Kenichi Sugihara, Yutaka Ogata, Susumu Eguchi, Seigo Kitano, Kazuo Shirouzu, Yasumitsu Saiki, Hiroshi Takamori, Masaki Mori, Toshihiko Hirata, Go Wakabayashi,  and Norihiro Kokudo
39384-39384
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