Oncotarget

Vol 6, No 35

November 10, 2015

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About The Cover

MDA-7/IL-24 functions as a tumor suppressor gene in vivo in transgenic mouse models of breast cancer. See Menezes et al.

Table of Contents

Editorial

Cancer stemness and progression: mitochondria on the stage

Cancer stemness and progression: mitochondria on the stage

https://doi.org/10.18632/oncotarget.6244

Paola Chiarugi,  and Persio Dello Sbarba
36924-36925
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Editorial: Autophagy and Cell Death

A single cut to pyroptosis

A single cut to pyroptosis

https://doi.org/10.18632/oncotarget.6142

Yoon Lim,  and Sharad Kumar
36926-36927
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Priority Research Papers

MDA-7/IL-24 functions as a tumor suppressor gene in vivo in transgenic mouse models of breast cancer

MDA-7/IL-24 functions as a tumor suppressor gene in vivo in transgenic mouse models of breast cancer

https://doi.org/10.18632/oncotarget.6047

Mitchell E. Menezes, Xue-Ning Shen, Swadesh K. Das, Luni Emdad, Chunqing Guo, Fang Yuan, You-Jun Li, Michael C. Archer, Eldad Zacksenhaus, Jolene J. Windle, Mark A. Subler, Yaacov Ben-David, Devanand Sarkar, Xiang-Yang Wang,  and Paul B. Fisher
36928-36942
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Suppression of Her2/Neu mammary tumor development in mda-7/IL-24 transgenic mice

Suppression of Her2/Neu mammary tumor development in mda-7/IL-24 transgenic mice

https://doi.org/10.18632/oncotarget.6046

You-Jun Li, Guodong Liu, Lei Xia, Xiao Xiao, Jeff C. Liu, Mitchell E. Menezes, Swadesh K. Das, Luni Emdad, Devanand Sarkar, Paul B. Fisher, Michael C. Archer, Eldad Zacksenhaus,  and Yaacov Ben-David
36943-36954
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Research Papers: Gerotarget (Focus on Aging)

Risk prediction for sporadic Alzheimer’s disease using genetic risk score in the Han Chinese population

Risk prediction for sporadic Alzheimer’s disease using genetic risk score in the Han Chinese population

https://doi.org/10.18632/oncotarget.6271

Qianyi Xiao, Zhi-Jun Liu, Sha Tao, Yi-Min Sun, Deke Jiang, Hong-Lei Li, Haitao Chen, Xu Liu, Brittany Lapin, Chi-Hsiung Wang, S. Lilly Zheng, Jianfeng Xu,  and Zhi-Ying Wu
36955-36964
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Prolonged ovarian hormone deprivation alters the effects of 17β-estradiol on microRNA expression in the aged female rat hypothalamus

Prolonged ovarian hormone deprivation alters the effects of 17β-estradiol on microRNA expression in the aged female rat hypothalamus

https://doi.org/10.18632/oncotarget.5433

Yathindar S. Rao, Cody L. Shults, Elena Pinceti,  and Toni R. Pak
36965-36983
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Research Papers: Pathology

Treatment of renal fibrosis by rebalancing TGF-β/Smad signaling with the combination of asiatic acid and naringenin

Treatment of renal fibrosis by rebalancing TGF-β/Smad signaling with the combination of asiatic acid and naringenin

https://doi.org/10.18632/oncotarget.6100

Xiao-ming Meng, Yun Zhang, Xiao-Ru Huang, Gui-ling Ren, Jun Li,  and Hui Yao Lan
36984-36997
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Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage

Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage

https://doi.org/10.18632/oncotarget.6076

Pengyun Li, Xianzhong Meng, Huining Bian, Nana Burns, Ke-seng Zhao,  and Rui Song
36998-37011
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Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine signaling

Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine signaling

https://doi.org/10.18632/oncotarget.6115

Su-Ren Chen, Ji-Xin Tang, Jin-Mei Cheng, Jian Li, Cheng Jin, Xiao-Yu Li, Shou-Long Deng, Yan Zhang, Xiu-Xia Wang,  and Yi-Xun Liu
37012-37027
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Downregulation of RPL15 may predict poor survival and associate with tumor progression in pancreatic ductal adenocarcinoma

Downregulation of RPL15 may predict poor survival and associate with tumor progression in pancreatic ductal adenocarcinoma

https://doi.org/10.18632/oncotarget.5939

Ting-Ting Yan, Xue-Liang Fu, Jiao Li, Ying-Nan Bian, De-Jun Liu, Rong Hua, Lin-Lin Ren, Cheng-Tao Li, Yong-Wei Sun, Hao-Yan Chen, Jing-Yuan Fang,  and Jie Hong
37028-37042
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

https://doi.org/10.18632/oncotarget.6158

YaXing Gui, Hai Liu, LiShan Zhang, Wen Lv,  and XingYue Hu
37043-37053
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Regenerating islet-derived protein 1 inhibits the activation of islet stellate cells isolated from diabetic mice

Regenerating islet-derived protein 1 inhibits the activation of islet stellate cells isolated from diabetic mice

https://doi.org/10.18632/oncotarget.6163

Wei Xu, Wei Li, Ying Wang, Min Zha, Honghong Yao, Peter M. Jones,  and Zilin Sun
37054-37065
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Research Papers: Autophagy and Cell Death

Sorafenib-induced defective autophagy promotes cell death by necroptosis

Sorafenib-induced defective autophagy promotes cell death by necroptosis

https://doi.org/10.18632/oncotarget.5797

Pedram Kharaziha, Dimitris Chioureas, George Baltatzis, Pedro Fonseca, Patricia Rodriguez, Vladimir Gogvadze, Lena Lennartsson, Ann-Charlotte Björklund, Boris Zhivotovsky, Dan Grandér, Lars Egevad, Sten Nilsson,  and Theocharis Panaretakis
37066-37082
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lithium increases proliferation of hippocampal neural stem/progenitor cells and rescues irradiation-induced cell cycle arrest in vitro

Lithium increases proliferation of hippocampal neural stem/progenitor cells and rescues irradiation-induced cell cycle arrest in vitro

https://doi.org/10.18632/oncotarget.5191

Giulia Zanni, Elena Di Martino, Anna Omelyanenko, Michael Andäng, Ulla Delle, Kecke Elmroth,  and Klas Blomgren
37083-37097
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Reviews

The different roles of selective autophagic protein degradation in mammalian cells

The different roles of selective autophagic protein degradation in mammalian cells

https://doi.org/10.18632/oncotarget.5776

Da-wei Wang, Zhen-ju Peng, Guang-fang Ren,  and Guang-xin Wang
37098-37116
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Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling

Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling

https://doi.org/10.18632/oncotarget.5076

Young Kwang Chae, Su Yun Chung, Andrew A Davis, Benedito A Carneiro, Sunandana Chandra, Jason Kaplan, Aparna Kaylan,  and Francis J Giles
37117-37134
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Caveolin-1, a stress-related oncotarget, in drug resistance

Caveolin-1, a stress-related oncotarget, in drug resistance

https://doi.org/10.18632/oncotarget.5789

Zhiyu Wang, Neng Wang, Pengxi Liu, Fu Peng, Hailin Tang, Qianjun Chen, Rui Xu, Yan Dai, Yi Lin, Xiaoming Xie, Cheng Peng,  and Honglin Situ
37135-37150
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Tumor-derived exosomes in cancer progression and treatment failure

Tumor-derived exosomes in cancer progression and treatment failure

https://doi.org/10.18632/oncotarget.6022

Shaorong Yu, Haixia Cao, Bo Shen,  and Jifeng Feng
37151-37168
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Research Papers

Remarkable similarities of chromosomal rearrangements between primary human breast cancers and matched distant metastases as revealed by whole-genome sequencing

Remarkable similarities of chromosomal rearrangements between primary human breast cancers and matched distant metastases as revealed by whole-genome sequencing

https://doi.org/10.18632/oncotarget.5951

Man-Hung Eric Tang, Malin Dahlgren, Christian Brueffer, Tamara Tjitrowirjo, Christof Winter, Yilun Chen, Eleonor Olsson, Kun Wang, Therese Törngren, Martin Sjöström, Dorthe Grabau, Pär-Ola Bendahl, Lisa Rydén, Emma Niméus, Lao H. Saal, Åke Borg,  and Sofia K. Gruvberger-Saal
37169-37184
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer

Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer

https://doi.org/10.18632/oncotarget.5953

Michael K.G. Stewart, John F. Bechberger, Ian Welch, Christian C. Naus,  and Dale W. Laird
37185-37199
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Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism

Plasma DCLK1 is a marker of hepatocellular carcinoma (HCC): Targeting DCLK1 prevents HCC tumor xenograft growth via a microRNA-dependent mechanism

https://doi.org/10.18632/oncotarget.5808

Sripathi M. Sureban, Mohammad F. Madhoun, Randal May, Dongfeng Qu, Naushad Ali, Javid Fazili, Nathaniel Weygant, Parthasarathy Chandrakesan, Kai Ding, Stanley A. Lightfoot,  and Courtney W. Houchen
37200-37215
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting mitochondrial RNA polymerase in acute myeloid leukemia

Targeting mitochondrial RNA polymerase in acute myeloid leukemia

https://doi.org/10.18632/oncotarget.6129

Fernando N. Bralha, Sanduni U. Liyanage, Rose Hurren, Xiaoming Wang, Meong Hi Son, Thomas A. Fung, Francine B. Chingcuanco, Aveline Y. W. Tung, Ana C. Andreazza, Pamela Psarianos, Aaron D. Schimmer, Leonardo Salmena,  and Rebecca R. Laposa
37216-37228
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Characterization of a mantle cell lymphoma cell line resistant to the Chk1 inhibitor PF-00477736

Characterization of a mantle cell lymphoma cell line resistant to the Chk1 inhibitor PF-00477736

https://doi.org/10.18632/oncotarget.5954

Valentina Restelli, Rosaria Chilà, Monica Lupi, Andrea Rinaldi, Ivo Kwee, Francesco Bertoni, Giovanna Damia,  and Laura Carrassa
37229-37240
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-135b suppresses tumorigenesis in glioblastoma stem-like cells impairing proliferation, migration and self-renewal

miR-135b suppresses tumorigenesis in glioblastoma stem-like cells impairing proliferation, migration and self-renewal

https://doi.org/10.18632/oncotarget.5925

Valentina Lulli, Mariachiara Buccarelli, Maurizio Martini, Michele Signore, Mauro Biffoni, Stefano Giannetti, Liliana Morgante, Giovanna Marziali, Ramona Ilari, Alfredo Pagliuca, Luigi Maria Larocca, Ruggero De Maria, Roberto Pallini,  and Lucia Ricci-Vitiani
37241-37256
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Wnt2 complements Wnt/β-catenin signaling in colorectal cancer

Wnt2 complements Wnt/β-catenin signaling in colorectal cancer

https://doi.org/10.18632/oncotarget.6133

Youn-Sang Jung, Sohee Jun, Sun Hye Lee, Amrish Sharma,  and Jae-Il Park
37257-37268
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients

MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients

https://doi.org/10.18632/oncotarget.5495

Leticia De Mattos-Arruda, Giulia Bottai, Paolo G. Nuciforo, Luca Di Tommaso, Elisa Giovannetti, Vicente Peg, Agnese Losurdo, José Pérez-Garcia, Giovanna Masci, Fabio Corsi, Javier Cortés, Joan Seoane, George A. Calin,  and Libero Santarpia
37269-37280
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression

Targeting metabolic flexibility by simultaneously inhibiting respiratory complex I and lactate generation retards melanoma progression

https://doi.org/10.18632/oncotarget.6134

Balkrishna Chaube, Parmanand Malvi, Shivendra Vikram Singh, Naoshad Mohammad, Avtar Singh Meena,  and Manoj Kumar Bhat
37281-37299
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth

Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth

https://doi.org/10.18632/oncotarget.5836

Wenchao Zhou, Lin Cheng, Yu Shi, Susan Q. Ke, Zhi Huang, Xiaoguang Fang, Cheng-wei Chu, Qi Xie, Xiu-wu Bian, Jeremy N. Rich,  and Shideng Bao
37300-37315
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Silencing of E2F3 suppresses tumor growth of Her2+ breast cancer cells by restricting mitosis

Silencing of E2F3 suppresses tumor growth of Her2+ breast cancer cells by restricting mitosis

https://doi.org/10.18632/oncotarget.5686

Miyoung Lee, Gabriela Oprea-Ilies,  and Harold I. Saavedra
37316-37334
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Honokiol inhibits bladder tumor growth by suppressing EZH2/miR-143 axis

Honokiol inhibits bladder tumor growth by suppressing EZH2/miR-143 axis

https://doi.org/10.18632/oncotarget.6135

Qing Zhang, Wei Zhao, Changxiao Ye, Junlong Zhuang, Cunjie Chang, Yuying Li, Xiaojing Huang, Lan Shen, Yan Li, Yangyan Cui, Jiannan Song, Bing Shen, Isaac Eliaz, Ruimin Huang, Hao Ying, Hongqian Guo,  and Jun Yan
37335-37348
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC

Mitochondrial translocation of EGFR regulates mitochondria dynamics and promotes metastasis in NSCLC

https://doi.org/10.18632/oncotarget.5736

Ting-Fang Che, Ching-Wen Lin, Yi-Ying Wu, Yu-Ju Chen, Chia-Li Han, Yih-leong Chang, Chen-Tu Wu, Tzu-Hung Hsiao, Tse-Ming Hong,  and Pan-Chyr Yang
37349-37366
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Role of cystathionine beta synthase in lipid metabolism in ovarian cancer

Role of cystathionine beta synthase in lipid metabolism in ovarian cancer

https://doi.org/10.18632/oncotarget.5424

Prabir K Chakraborty, Xunhao Xiong, Soumyajit Banerjee Mustafi, Sounik Saha, Danny Dhanasekaran, Nawajes A. Mandal, Scott McMeekin, Resham Bhattacharya,  and Priyabrata Mukherjee
37367-37384
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Rescuing lymphocytes from HLA-G immunosuppressive effects mediated by the tumor microenvironment

Rescuing lymphocytes from HLA-G immunosuppressive effects mediated by the tumor microenvironment

https://doi.org/10.18632/oncotarget.6044

Danli Wu, Isere Kuiaste, Philippe Moreau, Edgardo Carosella,  and Patricia Yotnda
37385-37397
Abstract  |  PDF  |  HTML  |  Order a Reprint

Expression of IL-1α correlates with distant metastasis in patients with head and neck squamous cell carcinoma

Expression of IL-1α correlates with distant metastasis in patients with head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.6054

Xavier León, Carolina Bothe, Jacinto García, Matilde Parreño, Sonia Alcolea, Miquel Quer, Luis Vila,  and Mercedes Camacho
37398-37409
Abstract  |  PDF  |  HTML  |  Order a Reprint

SMAC mimetic Debio 1143 synergizes with taxanes, topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells

SMAC mimetic Debio 1143 synergizes with taxanes, topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells

https://doi.org/10.18632/oncotarget.6138

Casey G. Langdon, Norbert Wiedemann, Matthew A. Held, Ramanaiah Mamillapalli, Pinar Iyidogan, Nicholas Theodosakis, James T. Platt, Frederic Levy, Gregoire Vuagniaux, Shaomeng Wang, Marcus W. Bosenberg,  and David F. Stern
37410-37425
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19-IL2 immunocytokine in human melanoma xenografts

Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19-IL2 immunocytokine in human melanoma xenografts

https://doi.org/10.18632/oncotarget.6055

Paola Orecchia, Romana Conte, Enrica Balza, Gabriella Pietra, Maria Cristina Mingari,  and Barbara Carnemolla
37426-37442
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The regulatory mechanisms of myogenin expression in doxorubicin-treated rat cardiomyocytes

The regulatory mechanisms of myogenin expression in doxorubicin-treated rat cardiomyocytes

https://doi.org/10.18632/oncotarget.5338

Shu-Ting Liu, Shih-Ming Huang, Ching-Liang Ho, Li-Chen Yen, Chi-Jung Huang, Wei-Shiang Lin,  and James Yi-Hsin Chan
37443-37457
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-27b, microRNA-101 and microRNA-128 inhibit angiogenesis by down-regulating vascular endothelial growth factor C expression in gastric cancers

MicroRNA-27b, microRNA-101 and microRNA-128 inhibit angiogenesis by down-regulating vascular endothelial growth factor C expression in gastric cancers

https://doi.org/10.18632/oncotarget.6059

Hai-Ting Liu, Ai-Yan Xing, Xu Chen, Ran-Ran Ma, Ya-Wen Wang, Duan-Bo Shi, Hui Zhang, Peng Li, Hong-Fang Chen, Yu-Hong Li,  and Peng Gao
37458-37470
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression and activity of eIF6 trigger Malignant Pleural Mesothelioma growth in vivo

Expression and activity of eIF6 trigger Malignant Pleural Mesothelioma growth in vivo

https://doi.org/10.18632/oncotarget.5462

Annarita Miluzio, Stefania Oliveto, Elisa Pesce, Luciano Mutti, Bruno Murer, Stefano Grosso, Sara Ricciardi, Daniela Brina,  and Stefano Biffo
37471-37485
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

In vivo imaging of therapy response to a novel Pan-HER antibody mixture using FDG and FLT positron emission tomography

In vivo imaging of therapy response to a novel Pan-HER antibody mixture using FDG and FLT positron emission tomography

https://doi.org/10.18632/oncotarget.6060

Carsten H. Nielsen, Mette M. Jensen, Lotte K. Kristensen, Anna Dahlman, Camilla Fröhlich, Helle J. Jacobsen, Thomas T. Poulsen, Johan Lantto, Ivan D. Horak, Michael Kragh,  and Andreas Kjaer
37486-37499
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Urine BLCA-4 exerts potential role in detecting patients with bladder cancers: a pooled analysis of individual studies

Urine BLCA-4 exerts potential role in detecting patients with bladder cancers: a pooled analysis of individual studies

https://doi.org/10.18632/oncotarget.6061

Qiliang Cai, Yudong Wu, Zhanjun Guo, Rui Gong, Yang Tang, Kuo Yang, Xiaodong Li, Xuemei Guo, Yuanjie Niu,  and Yan Zhao
37500-37510
Abstract  |  PDF  |  HTML  |  Order a Reprint

Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy

Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy

https://doi.org/10.18632/oncotarget.5527

Cristina Talarico, Lucia D'Antona, Domenica Scumaci, Agnese Barone, Francesco Gigliotti, Claudia Vincenza Fiumara, Vincenzo Dattilo, Enzo Gallo, Paolo Visca, Francesco Ortuso, Claudia Abbruzzese, Lorenzo Botta, Silvia Schenone, Giovanni Cuda, Stefano Alcaro, Cataldo Bianco, Patrizia Lavia, Marco G. Paggi, Nicola Perrotti,  and Rosario Amato
37511-37525
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combinatorial TGF-β attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells

Combinatorial TGF-β attenuation with paclitaxel inhibits the epithelial-to-mesenchymal transition and breast cancer stem-like cells

https://doi.org/10.18632/oncotarget.6063

So-Yeon Park, Min-Jin Kim, Sang-A Park, Jung-Shin Kim, Kyung-Nan Min, Dae-Kee Kim, Woosung Lim, Jeong-Seok Nam,  and Yhun Yhong Sheen
37526-37543
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation

Clinical value of integrated-signature miRNAs in colorectal cancer: miRNA expression profiling analysis and experimental validation

https://doi.org/10.18632/oncotarget.6065

XiangJian Chen, KeQing Shi, YuQun Wang, Mei Song, Wu Zhou, HongXiang Tu,  and Zhuo Lin
37544-37556
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-744 increases tumorigenicity of pancreatic cancer by activating Wnt/β-catenin pathway

MiR-744 increases tumorigenicity of pancreatic cancer by activating Wnt/β-catenin pathway

https://doi.org/10.18632/oncotarget.5317

Wei Zhou, Yongfeng Li, Shanmiao Gou, Jiongxin Xiong, Heshui Wu, Chunyou Wang, Haijiao Yan,  and Tao Liu
37557-37569
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells

Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells

https://doi.org/10.18632/oncotarget.6066

Simona Camorani, Elvira Crescenzi, David Colecchia, Andrea Carpentieri, Angela Amoresano, Monica Fedele, Mario Chiariello,  and Laura Cerchia
37570-37587
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

OX40 expression enhances the prognostic significance of CD8 positive lymphocyte infiltration in colorectal cancer

OX40 expression enhances the prognostic significance of CD8 positive lymphocyte infiltration in colorectal cancer

https://doi.org/10.18632/oncotarget.5940

Benjamin Weixler, Eleonora Cremonesi, Roberto Sorge, Manuele Giuseppe Muraro, Tarik Delko, Christian A. Nebiker, Silvio Däster, Valeria Governa, Francesca Amicarella, Savas D. Soysal, Christoph Kettelhack, Urs W. von Holzen, Serenella Eppenberger-Castori, Giulio C. Spagnoli, Daniel Oertli, Giandomenica Iezzi, Luigi Terracciano, Luigi Tornillo, Giuseppe Sconocchia,  and Raoul A. Droeser
37588-37599
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Revealing potential molecular targets bridging colitis and colorectal cancer based on multidimensional integration strategy

Revealing potential molecular targets bridging colitis and colorectal cancer based on multidimensional integration strategy

https://doi.org/10.18632/oncotarget.6067

Xu Guan, Ying Yi, Yan Huang, Yongfei Hu, Xiaobo Li, Xishan Wang, Huihui Fan, Guiyu Wang,  and Dong Wang
37600-37612
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer

Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer

https://doi.org/10.18632/oncotarget.6068

Baofang Yang, Minxia Zhang, Jian Gao, Jiahuang Li, Lu Fan, Gang Xiang, Xingqi Wang, Xiaoning Wang, Xuefeng Wu, Yang Sun, Xudong Wu, Guang Liang, Yan Shen,  and Qiang Xu
37613-37625
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High intensity focused ultrasound enhances anti-tumor immunity by inhibiting the negative regulatory effect of miR-134 on CD86 in a murine melanoma model

High intensity focused ultrasound enhances anti-tumor immunity by inhibiting the negative regulatory effect of miR-134 on CD86 in a murine melanoma model

https://doi.org/10.18632/oncotarget.5285

Shi-Mei Yuan, Huan Li, Min Yang, He Zha, Hui Sun, Xue-Ru Li, Ai-Fang Li, Yue Gu, Liang Duan, Jin-Yong Luo, Chong-Yan Li, Yan Wang, Zhi-Biao Wang, Tong-Chuan He,  and Lan Zhou
37626-37637
Abstract  |  PDF  |  HTML  |  Order a Reprint

Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response

Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response

https://doi.org/10.18632/oncotarget.5497

Meichun Xing, Xiaohui Wang, Timea Palmai-Pallag, Huahao Shen, Thomas Helleday, Ian D. Hickson,  and Songmin Ying
37638-37646
Abstract  |  PDF  |  HTML  |  Order a Reprint

Decrease of 5hmC in gastric cancers is associated with TET1 silencing due to with DNA methylation and bivalent histone marks at TET1 CpG island 3′-shore

Decrease of 5hmC in gastric cancers is associated with TET1 silencing due to with DNA methylation and bivalent histone marks at TET1 CpG island 3′-shore

https://doi.org/10.18632/oncotarget.6069

Jong-Lyul Park, Hee-Jin Kim, Eun-Hye Seo, Oh-Hyung Kwon, Byungho Lim, Mirang Kim, Seon-Young Kim, Kyu-Sang Song, Gyeong Hoon Kang, Hyun Ja Kim, Bo Youl Choi,  and Yong Sung Kim
37647-37662
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes

Molecular profiling of low grade serous ovarian tumours identifies novel candidate driver genes

https://doi.org/10.18632/oncotarget.5438

Sally M. Hunter, Michael S. Anglesio, Georgina L. Ryland, Raghwa Sharma, Yoke-Eng Chiew, Simone M. Rowley, Maria A. Doyle, Jason Li, C. Blake Gilks, Phillip Moss, Prue E. Allan, Andrew N. Stephens, David G. Huntsman, Anna deFazio, David D. Bowtell, Australian Ovarian Cancer Study Group, Kylie L. Gorringe,  and Ian G. Campbell
37663-37677
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model

YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model

https://doi.org/10.18632/oncotarget.5520

Tsion Zewdu Minas, Jenny Han, Tahereh Javaheri, Sung-Hyeok Hong, Michaela Schlederer, Yasemin Saygideğer-Kont, Haydar Çelik, Kristina M. Mueller, Idil Temel, Metin Özdemirli, Heinrich Kovar, Hayriye Verda Erkizan, Jeffrey Toretsky, Lukas Kenner, Richard Moriggl,  and Aykut Üren
37678-37694
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A bladder cancer microenvironment simulation system based on a microfluidic co-culture model

A bladder cancer microenvironment simulation system based on a microfluidic co-culture model

https://doi.org/10.18632/oncotarget.6070

Peng-fei Liu, Yan-wei Cao, Shu-dong Zhang, Yang Zhao, Xiao-guang Liu, Hao-qing Shi, Ke-yao Hu, Guan-qun Zhu, Bo Ma,  and Hai-tao Niu
37695-37705
Abstract  |  PDF  |  HTML  |  Order a Reprint

Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells

Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells

https://doi.org/10.18632/oncotarget.5342

Maria Lauda Tomasi, Minjung Ryoo, Komal Ramani, Ivan Tomasi, Pasquale Giordano, José M. Mato,  and Shelly C. Lu
37706-37723
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer

Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer

https://doi.org/10.18632/oncotarget.6075

Urszula L. McClurg, Victoria J. Harle, Arash Nabbi, Amanda Batalha-Pereira, Scott Walker, Kelly Coffey, Luke Gaughan, Stuart RC McCracken,  and Craig N. Robson
37724-37736
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Host JDP2 expression in the bone marrow contributes to metastatic spread

Host JDP2 expression in the bone marrow contributes to metastatic spread

https://doi.org/10.18632/oncotarget.5648

Yelena Barbarov, Michael Timaner, Dror Alishekevitz, Tsonwin Hai, Kazunari K. Yokoyama, Yuval Shaked,  and Ami Aronheim
37737-37749
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer

SF3A1 and pancreatic cancer: new evidence for the association of the spliceosome and cancer

https://doi.org/10.18632/oncotarget.5647

Jing Tian, Yaping Liu, Beibei Zhu, Yao Tian, Rong Zhong, Wei Chen, Xinghua Lu, Li Zou, Na Shen, Jiaming Qian, Hui Li, Xiaoping Miao,  and Li Wang
37750-37757
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro

Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro

https://doi.org/10.18632/oncotarget.5386

Yali Zhong, Xiaoran Li, Dandan Yu, Xiaoli Li, Yaqing Li, Yuan Long, Yuan Yuan, Zhenyu Ji, Mingzhi Zhang, Jian-Guo Wen, Jahn M. Nesland,  and Zhenhe Suo
37758-37769
Abstract  |  PDF  |  HTML  |  Order a Reprint

Migration-prone glioma cells show curcumin resistance associated with enhanced expression of miR-21 and invasion/anti-apoptosis-related proteins

Migration-prone glioma cells show curcumin resistance associated with enhanced expression of miR-21 and invasion/anti-apoptosis-related proteins

https://doi.org/10.18632/oncotarget.6092

Wei-Lan Yeh, Hsiao-Yun Lin, Chiung-Yin Huang, Bor-Ren Huang, Chingju Lin, Dah-Yuu Lu,  and Kuo-Chen Wei
37770-37781
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibiting bladder tumor growth with a cell penetrating R11 peptide derived from the p53 C-terminus

Inhibiting bladder tumor growth with a cell penetrating R11 peptide derived from the p53 C-terminus

https://doi.org/10.18632/oncotarget.5622

Tingting Zhang, Kaijie Wu, Chen Ding, Kangwei Sun, Zhenfeng Guan, Xinyang Wang, Jer-Tsong Hsieh, Dalin He,  and Jinhai Fan
37782-37791
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma

Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma

https://doi.org/10.18632/oncotarget.6096

Sushil Kumar, Bin Lu, Updesh Dixit, Sajjad Hossain, Yongzhang Liu, Jing Li, Peter Hornbeck, Weiming Zheng, Adam G. Sowalsky, Leszek Kotula,  and Raymond B. Birge
37792-37807
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-149 represses metastasis of hepatocellular carcinoma by targeting actin-regulatory proteins PPM1F

miR-149 represses metastasis of hepatocellular carcinoma by targeting actin-regulatory proteins PPM1F

https://doi.org/10.18632/oncotarget.5676

Gang Luo, Ya-Ling Chao, Bo Tang, Bo-Sheng Li, Yu-Feng Xiao, Rui Xie, Shu-Ming Wang, Yu-Yun Wu, Hui Dong, Xiang-De Liu,  and Shi-Ming Yang
37808-37823
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma

Heterogeneity revealed by integrated genomic analysis uncovers a molecular switch in malignant uveal melanoma

https://doi.org/10.18632/oncotarget.5637

Mark J. de Lange, Sake I. van Pelt, Mieke Versluis, Ekaterina S. Jordanova, Wilma G.M. Kroes, Claudia Ruivenkamp, Sjoerd H. van der Burg, Grégorius P.M. Luyten, Thorbald van Hall, Martine J. Jager,  and Pieter A. van der Velden
37824-37835
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

JNJ-26481585 primes rhabdomyosarcoma cells for chemotherapeutics by engaging the mitochondrial pathway of apoptosis

JNJ-26481585 primes rhabdomyosarcoma cells for chemotherapeutics by engaging the mitochondrial pathway of apoptosis

https://doi.org/10.18632/oncotarget.6097

Ulrike Heinicke, Johanna Kupka,  and Simone Fulda
37836-37851
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miRNA-regulated delivery of lincRNA-p21 suppresses β-catenin signaling and tumorigenicity of colorectal cancer stem cells

miRNA-regulated delivery of lincRNA-p21 suppresses β-catenin signaling and tumorigenicity of colorectal cancer stem cells

https://doi.org/10.18632/oncotarget.5635

Jun Wang, Zeng-jie Lei, Yan Guo, Tao Wang, Zhong-yi Qin, Hua-liang Xiao, Li-lin Fan, Dong-feng Chen, Xiu-wu Bian, Jia Liu,  and Bin Wang
37852-37870
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The dual topoisomerase inhibitor A35 preferentially and specially targets topoisomerase 2α by enhancing pre-strand and post-strand cleavage and inhibiting DNA religation

The dual topoisomerase inhibitor A35 preferentially and specially targets topoisomerase 2α by enhancing pre-strand and post-strand cleavage and inhibiting DNA religation

https://doi.org/10.18632/oncotarget.5680

Wuli Zhao, Guohua Jiang, Chongwen Bi, Yangbiao Li, Jingbo Liu, Hongwei He, Liang Li, Danqing Song,  and Rongguang Shao
37871-37894
Abstract  |  PDF  |  HTML  |  Order a Reprint

Allele frequencies of BRAFV600 mutations in primary melanomas and matched metastases and their relevance for BRAF inhibitor therapy in metastatic melanoma

Allele frequencies of BRAFV600 mutations in primary melanomas and matched metastases and their relevance for BRAF inhibitor therapy in metastatic melanoma

https://doi.org/10.18632/oncotarget.5634

Imke Satzger, Lena Marks, Martin Kerick, Sven Klages, Carola Berking, Rudolf Herbst, Bernward Völker, Vivien Schacht, Bernd Timmermann,  and Ralf Gutzmer
37895-37905
Abstract  |  PDF  |  HTML  |  Order a Reprint

Usp22 deficiency impairs intestinal epithelial lineage specification in vivo

Usp22 deficiency impairs intestinal epithelial lineage specification in vivo

https://doi.org/10.18632/oncotarget.5412

Robyn L. Kosinsky, Florian Wegwitz, Nicole Hellbach, Matthias Dobbelstein, Ahmed Mansouri, Tanja Vogel, Yvonne Begus-Nahrmann,  and Steven A. Johnsen
37906-37918
Abstract  |  PDF  |  HTML  |  Order a Reprint

Endosomal gene expression: a new indicator for prostate cancer patient prognosis?

Endosomal gene expression: a new indicator for prostate cancer patient prognosis?

https://doi.org/10.18632/oncotarget.6114

Ian R.D. Johnson, Emma J. Parkinson-Lawrence, Helen Keegan, Cathy D. Spillane, Jacqui Barry-O’Crowley, William R. Watson, Stavros Selemidis, Lisa M. Butler, John J. O’Leary,  and Doug A. Brooks
37919-37929
Abstract  |  PDF  |  HTML  |  Order a Reprint

The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression

The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression

https://doi.org/10.18632/oncotarget.6122

Masako Harada, Juliana Benito, Shinichi Yamamoto, Surinder Kaur, Dirim Arslan, Santiago Ramirez, Rodrigo Jacamo, Leonidas Platanias, Hiromichi Matsushita, Tsutomu Fujimura, Saiko Kazuno, Kensuke Kojima, Yoko Tabe,  and Marina Konopleva
37930-37947
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A combination of tyrosine kinase inhibitors, crizotinib and dasatinib for the treatment of glioblastoma multiforme

A combination of tyrosine kinase inhibitors, crizotinib and dasatinib for the treatment of glioblastoma multiforme

https://doi.org/10.18632/oncotarget.5698

Hayley Nehoff, Neha N. Parayath, Melanie J. McConnell, Sebastien Taurin,  and Khaled Greish
37948-37964
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lapatinib increases motility of triple-negative breast cancer cells by decreasing miRNA-7 and inducing Raf-1/MAPK-dependent interleukin-6

Lapatinib increases motility of triple-negative breast cancer cells by decreasing miRNA-7 and inducing Raf-1/MAPK-dependent interleukin-6

https://doi.org/10.18632/oncotarget.5700

Yu-Chun Hsiao, Ming-Hsin Yeh, Yun-Ju Chen, Ju-Fang Liu, Chih-Hsin Tang,  and Wei-Chien Huang
37965-37978
Abstract  |  PDF  |  HTML  |  Order a Reprint

SNP-SNP interaction analysis of NF-κB signaling pathway on breast cancer survival

SNP-SNP interaction analysis of NF-κB signaling pathway on breast cancer survival

https://doi.org/10.18632/oncotarget.4991

Maral Jamshidi, Rainer Fagerholm, Sofia Khan, Kristiina Aittomäki, Kamila Czene, Hatef Darabi, Jingmei Li, Irene L. Andrulis, Jenny Chang-Claude, Peter Devilee, Peter A. Fasching, Kyriaki Michailidou, Manjeet K. Bolla, Joe Dennis, Qin Wang, Qi Guo, Valerie Rhenius, Sten Cornelissen, Anja Rudolph, Julia A. Knight, Christian R. Loehberg, Barbara Burwinkel, Frederik Marme, John L. Hopper, Melissa C. Southey, Stig E. Bojesen, Henrik Flyger, Hermann Brenner, Bernd Holleczek, Sara Margolin, Arto Mannerma, Veli-Matti Kosma, kConFab Investigators, Laurien Van Dyck, Ines Nevelsteen, Fergus J. Couch, Janet E. Olson, Graham G. Giles, Catriona McLean, Christopher A. Haiman, Brian E. Henderson, Robert Winqvist, Katri Pylkäs, Rob A.E.M. Tollenaar, Montserrat García-Closas, Jonine Figueroa, Maartje J. Hooning, John W.M. Martens, Angela Cox, Simon S. Cross, Jacques Simard, Alison M. Dunning, Douglas F. Easton, Paul D.P. Pharoah, Per Hall, Carl Blomqvist, Marjanka K. Schmidt,  and Heli Nevanlinna
37979-37994
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of the epigenetic mark, 5-Hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma

Loss of the epigenetic mark, 5-Hydroxymethylcytosine, correlates with small cell/nevoid subpopulations and assists in microstaging of human melanoma

https://doi.org/10.18632/oncotarget.6062

Jonathan J. Lee, Martin Cook, Martin C. Mihm, Shuyun Xu, Qian Zhan, Thomas J. Wang, George F. Murphy,  and Christine G. Lian
37995-38004
Abstract  |  PDF  |  HTML  |  Order a Reprint

LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma

LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma

https://doi.org/10.18632/oncotarget.5357

Haibing Xiao, Kun Tang, Peijun Liu, Ke Chen, Junhui Hu, Jin Zhen, Wei Xiao, Gan Yu, Weiming Yao, Hui Zhou, Heng Li, Yingtian Pan, Anping Li, Zhangqun Ye, Ji Wang, Hua Xu,  and Qihong Huang
38005-38015
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of hallmarks of lung adenocarcinoma prognosis using whole genome sequencing

Identification of hallmarks of lung adenocarcinoma prognosis using whole genome sequencing

https://doi.org/10.18632/oncotarget.5697

Li Liu, Jiao Huang, Ke Wang, Li Li, Yangkai Li, Jingsong Yuan,  and Sheng Wei
38016-38028
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Polarized cell migration induces cancer type-specific CD133/integrin/Src/Akt/GSK3β/β-catenin signaling required for maintenance of cancer stem cell properties

Polarized cell migration induces cancer type-specific CD133/integrin/Src/Akt/GSK3β/β-catenin signaling required for maintenance of cancer stem cell properties

https://doi.org/10.18632/oncotarget.5703

Ying-Jhen Su, Wei-Hsin Lin, Yi-Wen Chang, Kuo-Chen Wei, Chi-Lung Liang, Shin-Cheh Chen,  and Jia-Lin Lee
38029-38045
Abstract  |  PDF  |  HTML  |  Order a Reprint

The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells

The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells

https://doi.org/10.18632/oncotarget.5710

Yu-Chih Liang, Wei-Cheng Lin, Ying-Ju Lin,  and Jung-Chun Lin
38046-38060
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia

CDC25A governs proliferation and differentiation of FLT3-ITD acute myeloid leukemia

https://doi.org/10.18632/oncotarget.5706

Sarah Bertoli, Helena Boutzen, Laure David, Clément Larrue, François Vergez, Anne Fernandez-Vidal, Lingli Yuan, Marie-Anne Hospital, Jérôme Tamburini, Cécile Demur, Eric Delabesse, Estelle Saland, Jean-Emmanuel Sarry, Marie-Odile Galcera, Véronique Mansat-De Mas, Christine Didier, Christine Dozier, Christian Récher,  and Stéphane Manenti
38061-38078
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells

Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells

https://doi.org/10.18632/oncotarget.5752

Xinyu Ci, Bingnan Li, Xueping Ma, Feng Kong, Chengyun Zheng, Magnus Björkholm, Jihui Jia,  and Dawei Xu
38079-38092
Abstract  |  PDF  |  HTML  |  Order a Reprint

Upregulated in Hepatitis B virus-associated hepatocellular carcinoma cells, miR-331-3p promotes proliferation of hepatocellular carcinoma cells by targeting ING5

Upregulated in Hepatitis B virus-associated hepatocellular carcinoma cells, miR-331-3p promotes proliferation of hepatocellular carcinoma cells by targeting ING5

https://doi.org/10.18632/oncotarget.5642

Yiyi Cao, Juan Chen, Dan Wang, Hong Peng, Xixi Tan, Dongmei Xiong, Ailong Huang,  and Hua Tang
38093-38106
Abstract  |  PDF  |  HTML  |  Order a Reprint

ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription

ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription

https://doi.org/10.18632/oncotarget.5646

Kai Li, Bo Gao, Jun Li, Haining Chen, Yanyan Li, Yuyan Wei, Di Gong, Junping Gao, Jie Zhang, Weiwei Tan, Tianfu Wen, Le Zhang, Lugang Huang, Rong Xiang, Ping Lin,  and Yuquan Wei
38107-38126
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF-1α degradation

Suppression of mitochondrial respiration with auraptene inhibits the progression of renal cell carcinoma: involvement of HIF-1α degradation

https://doi.org/10.18632/oncotarget.5511

Yunseon Jang, Jeongsu Han, Soo Jeong Kim, Jungim Kim, Min Joung Lee, Soyeon Jeong, Min Jeong Ryu, Kang-Sik Seo, Song-Yi Choi, Minho Shong, Kyu Lim, Jun Young Heo,  and Gi Ryang Kweon
38127-38138
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1

miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1

https://doi.org/10.18632/oncotarget.5709

Zhiheng Chen, Shaojun Liu, Li Tian, Minghao Wu, Feiyan Ai, Wuliang Tang, Lian Zhao, Juan Ding, Liyang Zhang,  and Anliu Tang
38139-38150
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenetic silencing of HIC1 promotes epithelial-mesenchymal transition and drives progression in esophageal squamous cell carcinoma

Epigenetic silencing of HIC1 promotes epithelial-mesenchymal transition and drives progression in esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.5832

Pei Li, Xiang Liu, Zi-Ming Dong,  and Zhi-Qiang Ling
38151-38165
Abstract  |  PDF  |  HTML  |  Order a Reprint

Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways

Molecular profiling of cetuximab and bevacizumab treatment of colorectal tumours reveals perturbations in metabolic and hypoxic response pathways

https://doi.org/10.18632/oncotarget.6241

David W. Greening, Sze Ting Lee, Hong Ji, Richard J. Simpson, Angela Rigopoulos, Carmel Murone, Catherine Fang, Sylvia Gong, Graeme O’Keefe,  and Andrew M. Scott
38166-38180
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt’s lymphoma B cells

Subcellular localization of PUMA regulates its pro-apoptotic activity in Burkitt’s lymphoma B cells

https://doi.org/10.18632/oncotarget.5901

Gorbatchev Ambroise, Alain Portier, Nathalie Roders, Damien Arnoult,  and Aimé Vazquez
38181-38194
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mechanisms linking obesity to altered metabolism in mice colon carcinogenesis

Mechanisms linking obesity to altered metabolism in mice colon carcinogenesis

https://doi.org/10.18632/oncotarget.5561

Lili Nimri, Janan Saadi, Irena Peri, Einav Yehuda-Shnaidman,  and Betty Schwartz
38195-38209
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Increased metastasis with loss of E2F2 in Myc-driven tumors

Increased metastasis with loss of E2F2 in Myc-driven tumors

https://doi.org/10.18632/oncotarget.5690

Inez Yuwanita, Danielle Barnes, Michael D. Monterey, Sandra O’Reilly,  and Eran R. Andrechek
38210-38224
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of Lyn is a promising treatment for mantle cell lymphoma with bortezomib resistance

Inhibition of Lyn is a promising treatment for mantle cell lymphoma with bortezomib resistance

https://doi.org/10.18632/oncotarget.5425

Areumnuri Kim, Ki Moon Seong, Hye Jin Kang, Sunhoo Park,  and Seung-Sook Lee
38225-38238
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells

Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells

https://doi.org/10.18632/oncotarget.5664

Bàrbara Castellana, Trond Aasen, Gema Moreno-Bueno, Sandra E. Dunn,  and Santiago Ramón y Cajal
38239-38256
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Co-expression of mitosis-regulating genes contributes to malignant progression and prognosis in oligodendrogliomas

Co-expression of mitosis-regulating genes contributes to malignant progression and prognosis in oligodendrogliomas

https://doi.org/10.18632/oncotarget.5499

Yanwei Liu, Huimin Hu, Chuanbao Zhang, Haoyuan Wang, Wenlong Zhang, Zheng Wang, Mingyang Li, Wei Zhang, Dabiao Zhou,  and Tao Jiang
38257-38269
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-15a/16-1 cluster located at chromosome 13q14 is down-regulated but displays different expression pattern and prognostic significance in multiple myeloma

MicroRNA-15a/16-1 cluster located at chromosome 13q14 is down-regulated but displays different expression pattern and prognostic significance in multiple myeloma

https://doi.org/10.18632/oncotarget.5681

Fei Li, Yan Xu, Shuhui Deng, Zengjun Li, Dehui Zou, Shuhua Yi, Weiwei Sui, Mu Hao,  and Lugui Qiu
38270-38282
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Traditional Chinese patent medicines for cancer treatment in China: a nationwide medical insurance data analysis

Traditional Chinese patent medicines for cancer treatment in China: a nationwide medical insurance data analysis

https://doi.org/10.18632/oncotarget.5711

Min Wu, Peng Lu, Luwen Shi,  and Shao Li
38283-38295
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combining plasma Epstein-Barr virus DNA and nodal maximal standard uptake values of 18F-fluoro-2-deoxy-D-glucose positron emission tomography improved prognostic stratification to predict distant metastasis for locoregionally advanced nasopharyngeal carcinoma

Combining plasma Epstein-Barr virus DNA and nodal maximal standard uptake values of 18F-fluoro-2-deoxy-D-glucose positron emission tomography improved prognostic stratification to predict distant metastasis for locoregionally advanced nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.5699

Wen-Hui Chen, Lin-Quan Tang, Lu Zhang, Qiu-Yan Chen, Shan-Shan Guo, Li-Ting Liu, Wei Fan, Xu Zhang, Ling Guo, Chong Zhao, Ka-Jia Cao, Chao-Nan Qian, Xiang Guo, Dan Xie, Mu-Sheng Zeng,  and Hai-Qiang Mai
38296-38307
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of the MDR1 promoter activity

Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of the MDR1 promoter activity

https://doi.org/10.18632/oncotarget.5702

Bing-Hua Su, Gia-Shing Shieh, Yau-Lin Tseng, Ai-Li Shiau,  and Chao-Liang Wu
38308-38326
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Validation of a rectal cancer outcome prediction model with a cohort of Chinese patients

Validation of a rectal cancer outcome prediction model with a cohort of Chinese patients

https://doi.org/10.18632/oncotarget.5195

Lijun Shen, Johan van Soest, Jiazhou Wang, Jialu Yu, Weigang Hu, Yutao U. T. Gong, Vincenzo Valentini, Ying Xiao, Andre Dekker,  and Zhen Zhang
38327-38335
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Better survival of renal cell carcinoma in patients with inflammatory bowel disease

Better survival of renal cell carcinoma in patients with inflammatory bowel disease

https://doi.org/10.18632/oncotarget.5186

Lauranne A.A.P. Derikx, Loes H.C. Nissen, Joost P.H. Drenth, Carla M. van Herpen, Wietske Kievit, Rob H.A. Verhoeven, Peter F.A. Mulders, Christina A. Hulsbergen-van de Kaa, Marye J. Boers-Sonderen, Tim R.A. van den Heuvel, Marieke Pierik, Iris D. Nagtegaal, Frank Hoentjen, on behalf of the Dutch Initiative on Crohn and Colitis (ICC),  and PALGA group and IBD/RCC group
38336-38347
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Development and validation of a pretreatment prognostic index to predict death and lung metastases in extremity osteosarcoma

Development and validation of a pretreatment prognostic index to predict death and lung metastases in extremity osteosarcoma

https://doi.org/10.18632/oncotarget.5276

Bo Wang, Jian Tu, Junqiang Yin, Changye Zou, Jin Wang, Gang Huang, Xianbiao Xie,  and Jingnan Shen
38348-38359
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The use of personalized biomarkers and liquid biopsies to monitor treatment response and disease recurrence in locally advanced rectal cancer after neoadjuvant chemoradiation

The use of personalized biomarkers and liquid biopsies to monitor treatment response and disease recurrence in locally advanced rectal cancer after neoadjuvant chemoradiation

https://doi.org/10.18632/oncotarget.5256

Paola Carpinetti, Elisa Donnard, Fabiana Bettoni, Paula Asprino, Fernanda Koyama, Andrei Rozanski, Jorge Sabbaga, Angelita Habr-Gama, Raphael B. Parmigiani, Pedro A.F. Galante, Rodrigo O. Perez,  and Anamaria A. Camargo
38360-38371
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Ideal number of biopsy tumor fragments for predicting HER2 status in gastric carcinoma resection specimens

Ideal number of biopsy tumor fragments for predicting HER2 status in gastric carcinoma resection specimens

https://doi.org/10.18632/oncotarget.5368

Sangjeong Ahn, Soomin Ahn, Michael Van Vrancken, Minju Lee, Sang Yun Ha, Hyuk Lee, Byung-Hoon Min, Jun Haeng Lee, Jae J. Kim, Sunkyu Choi, Sin-Ho Jung, Min Gew Choi, Jun-Ho Lee, Tae Sung Sohn, Jae Moon Bae, Sung Kim,  and Kyoung-Mee Kim
38372-38380
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Treatment outcomes and late toxicities of 869 patients with nasopharyngeal carcinoma treated with definitive intensity modulated radiation therapy: new insight into the value of total dose of cisplatin and radiation boost

Treatment outcomes and late toxicities of 869 patients with nasopharyngeal carcinoma treated with definitive intensity modulated radiation therapy: new insight into the value of total dose of cisplatin and radiation boost

https://doi.org/10.18632/oncotarget.5420

Xiaomin Ou, Xin Zhou, Qi Shi, Xing Xing, Youqi Yang, Tingting Xu, Chunying Shen, Xiaoshen Wang, Xiayun He, Lin Kong, Hongmei Ying,  and Chaosu Hu
38381-38397
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Breastfeeding and the incidence of endometrial cancer: A meta-analysis

Breastfeeding and the incidence of endometrial cancer: A meta-analysis

https://doi.org/10.18632/oncotarget.5049

Baojian Zhan, Xiaoqin Liu, Fang Li,  and Dongfeng Zhang
38398-38409
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Plasma fibrinogen levels are correlated with postoperative distant metastasis and prognosis in esophageal squamous cell carcinoma

Plasma fibrinogen levels are correlated with postoperative distant metastasis and prognosis in esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.4800

Danhong Zhang, Xia Zhou, Wuan Bao, Ying Chen, Lei Cheng, Guoqin Qiu, Liming Sheng, Yongling Ji,  and Xianghui Du
38410-38420
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Distinguishing grade I meningioma from higher grade meningiomas without biopsy

Distinguishing grade I meningioma from higher grade meningiomas without biopsy

https://doi.org/10.18632/oncotarget.5376

John Varlotto, John Flickinger, Martin T. Pavelic, Charles S. Specht, Jonas M. Sheehan, Dana T. Timek, Michael J. Glantz, Steven Sogge, Christopher Dimaio, Richard Moser, Shakeeb Yunus, Thomas J. Fitzgerald, Urvashi Upadhyay, Paul Rava, Matthew Tangel, Aaron Yao,  and Sangam Kanekar
38421-38428
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Concurrent radiotherapy with gefitinib in elderly patients with esophageal squamous cell carcinoma: Preliminary results of a phase II study

Concurrent radiotherapy with gefitinib in elderly patients with esophageal squamous cell carcinoma: Preliminary results of a phase II study

https://doi.org/10.18632/oncotarget.5193

Yaping Xu, Yuanda Zheng, Xiaojiang Sun, Xinmin Yu, Jialei Gu, Wei Wu, Gu Zhang, Jinlin Hu, Wenyong Sun,  and Weimin Mao
38429-38439
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