Oncotarget

Vol 6, No 32

October 20, 2015

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Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors. See Li et al.

Table of Contents

Editorial

The cerebral cavernous malformations proteins

The cerebral cavernous malformations proteins

https://doi.org/10.18632/oncotarget.5443

Xiaofeng Li, Oriana S. Fisher,  and Titus J. Boggon
32279-32280
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ENT1 and treatment of viral diseases

ENT1 and treatment of viral diseases

https://doi.org/10.18632/oncotarget.5859

Rajesh Panigrahi,  and Srikanta Dash
32281-32282
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Undoing SUMO aids polyQ AR

Undoing SUMO aids polyQ AR

https://doi.org/10.18632/oncotarget.5862

Andrew P. Lieberman,  and Jorge A. Iniguez-Lluhi
32283-32284
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Cancer metabolism of cone photoreceptors

Cancer metabolism of cone photoreceptors

https://doi.org/10.18632/oncotarget.5963

Thierry Léveillard
32285-32286
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Inheritance in MGUS and MM

Inheritance in MGUS and MM

https://doi.org/10.18632/oncotarget.5960

Michael Pfreundschuh
32287-32288
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Stathmin drives virus-induced metastasis

Stathmin drives virus-induced metastasis

https://doi.org/10.18632/oncotarget.5961

Adrian Whitehouse,  and Andrew Macdonald
32289-32290
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Armt1: a phoenix rises from the ashes

Armt1: a phoenix rises from the ashes

https://doi.org/10.18632/oncotarget.5964

Derek Hoelz
32291-32292
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Hsp70 proteins in mitosis and disease

Hsp70 proteins in mitosis and disease

https://doi.org/10.18632/oncotarget.5965

Laura O’Regan, Josephina Sampson,  and Andrew M. Fry
32293-32294
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MicroRNAs, T follicular helper cells and inflammaging

MicroRNAs, T follicular helper cells and inflammaging

https://doi.org/10.18632/oncotarget.6025

Jason E. Hawkes,  and Ryan M. O’Connell
32295-32296
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IL-11 in multiple sclerosis

IL-11 in multiple sclerosis

https://doi.org/10.18632/oncotarget.6027

Xin Zhang, Tracy Putoczki,  and Silva Markovic-Plese
32297-32298
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Editorial: Immunology

HSP60 – a double edge sword in autoimmunity

HSP60 – a double edge sword in autoimmunity

https://doi.org/10.18632/oncotarget.5869

Dorit Landstein, Rina Ulmansky,  and Yaakov Naparstek
32299-32300
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The negative NK cell maturation checkpoint Foxo1

The negative NK cell maturation checkpoint Foxo1

https://doi.org/10.18632/oncotarget.6109

Youcai Deng,  and Jianhua Yu
32301-32302
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Pathogenic Th2 (Tpath2) cells in airway inflammation

Pathogenic Th2 (Tpath2) cells in airway inflammation

https://doi.org/10.18632/oncotarget.6033

Yusuke Endo,  and Toshinori Nakayama
32303-32304
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The flavors of plasma cells

The flavors of plasma cells

https://doi.org/10.18632/oncotarget.4631

Lynn M. Corcoran,  and Stephen L. Nutt
32305-32306
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Adenosine: a selfish-immunity signal?

Adenosine: a selfish-immunity signal?

https://doi.org/10.18632/oncotarget.4685

Tomas Dolezal
32307-32308
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PTX3 acts as an extrinsic oncosuppressor

PTX3 acts as an extrinsic oncosuppressor

https://doi.org/10.18632/oncotarget.4845

Eduardo Bonavita, Alberto Mantovani,  and Cecilia Garlanda
32309-32310
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Tuning B cell responsiveness by antigen receptor isotype

Tuning B cell responsiveness by antigen receptor isotype

https://doi.org/10.18632/oncotarget.4880

Hassan Jumaa
32311-32312
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EFTUD2 on innate immunity

EFTUD2 on innate immunity

https://doi.org/10.18632/oncotarget.5863

Chuanlong Zhu, Fei Xiao,  and Wenyu Lin
32313-32314
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Immunosuppressive arenaviral exoribonuclease

Immunosuppressive arenaviral exoribonuclease

https://doi.org/10.18632/oncotarget.6110

Bjoern Meyer,  and Hinh Ly
32315-32316
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Research Perspectives

Cancer stem cell-driven efficacy of trastuzumab (Herceptin): towards a reclassification of clinically HER2-positive breast carcinomas

Cancer stem cell-driven efficacy of trastuzumab (Herceptin): towards a reclassification of clinically HER2-positive breast carcinomas

https://doi.org/10.18632/oncotarget.6094

Begoña Martin-Castillo, Eugeni Lopez-Bonet, Elisabet Cuyàs, Gemma Viñas, Sonia Pernas, Joan Dorca,  and Javier A. Menendez
32317-32338
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Priority Research Papers

Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors

Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors

https://doi.org/10.18632/oncotarget.5891

Yizhu Li, Priyanka Saini, Anusha Sriraman,  and Matthias Dobbelstein
32339-32352
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Caspase 3 in dying tumor cells mediates post-irradiation angiogenesis

Caspase 3 in dying tumor cells mediates post-irradiation angiogenesis

https://doi.org/10.18632/oncotarget.5898

Xiao Feng, Ling Tian, Zhengxiang Zhang, Yang Yu, Jin Cheng, Yanping Gong, Chuan-Yuan Li,  and Qian Huang
32353-32367
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Functional signaling pathway analysis of lung adenocarcinomas identifies novel therapeutic targets for KRAS mutant tumors

Functional signaling pathway analysis of lung adenocarcinomas identifies novel therapeutic targets for KRAS mutant tumors

https://doi.org/10.18632/oncotarget.5941

Elisa Baldelli, Guido Bellezza, Eric B. Haura, Lucio Crinó, W. Douglas Cress, Jianghong Deng, Vienna Ludovini, Angelo Sidoni, Matthew B. Schabath, Francesco Puma, Jacopo Vannucci, Annamaria Siggillino, Lance A. Liotta, Emanuel F. Petricoin III,  and Mariaelena Pierobon
32368-32379
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids

https://doi.org/10.18632/oncotarget.6116

Huabo Wang, Peter Teriete, Angela Hu, Dhanya Raveendra-Panickar, Kelsey Pendelton, John S. Lazo, Julie Eiseman, Toril Holien, Kristine Misund, Ganna Oliynyk, Marie Arsenian-Henriksson, Nicholas D. P. Cosford, Anders Sundan,  and Edward V. Prochownik
32380-32395
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition

Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition

https://doi.org/10.18632/oncotarget.6136

Fiona K. Middleton, Miranda J. Patterson, Claire J. Elstob, Sarah Fordham, Ashleigh Herriott, Mark A. Wade, Aiste McCormick, Richard Edmondson, Felicity E.B. May, James M. Allan, John R. Pollard,  and Nicola J. Curtin
32396-32409
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Immunology

NBAT1 suppresses breast cancer metastasis by regulating DKK1 via PRC2

NBAT1 suppresses breast cancer metastasis by regulating DKK1 via PRC2

https://doi.org/10.18632/oncotarget.5609

Pengnan Hu, Junjun Chu, Yanqing Wu, Lijuan Sun, Xiaobin Lv, Yinghua Zhu, Jingjing Li, Qiannan Guo, Chang Gong, Bodu Liu,  and Shicheng Su
32410-32425
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Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells

Antigen spreading-induced CD8+T cells confer protection against the lethal challenge of wild-type malignant mesothelioma by eliminating myeloid-derived suppressor cells

https://doi.org/10.18632/oncotarget.5856

Zhe Yu, Zhiwu Tan, Boon Kiat Lee, Jiansong Tang, Xilin Wu, Ka-Wai Cheung, Nathan Tin Lok Lo, Kwan Man, Li Liu,  and Zhiwei Chen
32426-32438
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Bortezomib enhances expression of effector molecules in anti-tumor CD8+ T lymphocytes by promoting Notch-nuclear factor-κB crosstalk

Bortezomib enhances expression of effector molecules in anti-tumor CD8+ T lymphocytes by promoting Notch-nuclear factor-κB crosstalk

https://doi.org/10.18632/oncotarget.5857

Menaka C. Thounaojam, Duafalia F. Dudimah, Samuel T. Pellom Jr., Roman V. Uzhachenko, David P. Carbone, Mikhail M. Dikov,  and Anil Shanker
32439-32455
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Lack of intracellular replication of M. tuberculosis and M. bovis BCG caused by delivering bacilli to lysosomes in murine brain microvascular endothelial cells

Lack of intracellular replication of M. tuberculosis and M. bovis BCG caused by delivering bacilli to lysosomes in murine brain microvascular endothelial cells

https://doi.org/10.18632/oncotarget.5932

Xi Chen, Kaori Sakamoto, Frederick D. Quinn, Huanchun Chen,  and Zhenfang Fu
32456-32467
Abstract  |  PDF  |  HTML  |  Order a Reprint

Piperine metabolically regulates peritoneal resident macrophages to potentiate their functions against bacterial infection

Piperine metabolically regulates peritoneal resident macrophages to potentiate their functions against bacterial infection

https://doi.org/10.18632/oncotarget.5957

Hao Pan, Li-Hui Xu, Mei-Yun Huang, Qing-Bing Zha, Gao-Xiang Zhao, Xiao-Feng Hou, Zi-Jian Shi, Qiu-Ru Lin, Dong-Yun Ouyang,  and Xian-Hui He
32468-32483
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nodal metastasis in cervical cancer occurs in clearly delineated fields of immune suppression in the pelvic lymph catchment area

Nodal metastasis in cervical cancer occurs in clearly delineated fields of immune suppression in the pelvic lymph catchment area

https://doi.org/10.18632/oncotarget.5398

A. Marijne Heeren, Eline de Boer, Maaike C.G. Bleeker, René J.P. Musters, Marrije R. Buist, Gemma G. Kenter, Tanja D. de Gruijl,  and Ekaterina S. Jordanova
32484-32493
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DNA-mediated adjuvant immunotherapy extends survival in two different mouse models of myeloid malignancies

DNA-mediated adjuvant immunotherapy extends survival in two different mouse models of myeloid malignancies

https://doi.org/10.18632/oncotarget.5572

Carole Le Pogam, Satyananda Patel, Petra Gorombei, Laura Guerenne, Patricia Krief, Nader Omidvar, Nilgun Tekin, Elena Bernasconi, Flore Sicre, Marie-Helene Schlageter, Martine Chopin, Maria-Elena Noguera, Robert West, Ansu Abu, Vikram Mathews, Marika Pla, Pierre Fenaux, Christine Chomienne,  and Rose Ann Padua
32494-32508
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reviews

The search for cis-regulatory driver mutations in cancer genomes

The search for cis-regulatory driver mutations in cancer genomes

https://doi.org/10.18632/oncotarget.5085

Rebecca C Poulos, Mathew A Sloane, Luke B Hesson,  and Jason W. H. Wong
32509-32525
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers

Hydrogen peroxide inducible clone-5 mediates reactive oxygen species signaling for hepatocellular carcinoma progression

Hydrogen peroxide inducible clone-5 mediates reactive oxygen species signaling for hepatocellular carcinoma progression

https://doi.org/10.18632/oncotarget.5322

Jia-Ru Wu, Chi-Tan Hu, Ren-In You, Siou-Mei Pan, Chuan-Chu Cheng, Ming-Che Lee, Chao-Chuan Wu, Yao-Jen Chang, Shu-Chuan Lin, Chang–Shan Chen, Teng-Yi Lin,  and Wen-Sheng Wu
32526-32544
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNAs as prognostic molecular signatures in renal cell carcinoma: a systematic review and meta-analysis

MicroRNAs as prognostic molecular signatures in renal cell carcinoma: a systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.5324

Liangyou Gu, Hongzhao Li, Luyao Chen, Xin Ma, Yu Gao, Xintao Li, Yu Zhang, Yang Fan,  and Xu Zhang
32545-32560
Abstract  |  PDF  |  HTML  |  Order a Reprint

An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer

An integrative approach for the identification of prognostic and predictive biomarkers in rectal cancer

https://doi.org/10.18632/oncotarget.4935

Marco Agostini, Klaus-Peter Janssen, Il-Jin Kim, Edoardo D’Angelo, Silvia Pizzini, Andrea Zangrando, Carlo Zanon, Chiara Pastrello, Isacco Maretto, Maura Digito, Chiara Bedin, Igor Jurisica, Flavio Rizzolio, Antonio Giordano, Stefania Bortoluzzi, Donato Nitti,  and Salvatore Pucciarelli
32561-32574
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF

EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF

https://doi.org/10.18632/oncotarget.5331

Yanke Chen, Xingchun Gou, Derek Kai Kong, Xiaofei Wang, Jianhui Wang, Zeming Chen, Chen Huang,  and Jiangbing Zhou
32575-32585
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2

MicroRNA-506 suppresses tumor proliferation and metastasis in colon cancer by directly targeting the oncogene EZH2

https://doi.org/10.18632/oncotarget.5309

Yi Zhang, Changwei Lin, Guoqing Liao, Sheng Liu, Jie Ding, Fang Tang, Zhenran Wang, Xingsi Liang, Bo Li, Yangchao Wei, Qi Huang, Xuan Li,  and Bo Tang
32586-32601
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular inimitability amongst tumors: implications for precision cancer medicine in the age of personalized oncology

Molecular inimitability amongst tumors: implications for precision cancer medicine in the age of personalized oncology

https://doi.org/10.18632/oncotarget.5289

Sandip Pravin Patel, Maria Schwaederle, Gregory A. Daniels, Paul T. Fanta, Richard B. Schwab, Kelly A. Shimabukuro, Santosh Kesari, David E. Piccioni, Lyudmila A. Bazhenova, Teresa L. Helsten, Scott M. Lippman, Barbara A. Parker,  and Razelle Kurzrock
32602-32609
Abstract  |  PDF  |  HTML  |  Order a Reprint

TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling

TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling

https://doi.org/10.18632/oncotarget.5362

Xiquan Ke, Yan Zhao, Xinlan Lu, Zhe Wang, Yuanyuan Liu, Mudan Ren, Guifang Lu, Dan Zhang, Zhenguo Sun, Zhipeng Xu, Jee Hoon Song, Yulan Cheng, Stephen J. Meltzer,  and Shuixiang He
32610-32621
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer

Acquired resistance to 5-fluorouracil via HSP90/Src-mediated increase in thymidylate synthase expression in colon cancer

https://doi.org/10.18632/oncotarget.5327

Ji-Young Ahn, Ji-Sun Lee, Hye-Young Min,  and Ho-Young Lee
32622-32633
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Normal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusions

Normal mammary epithelial cells promote carcinoma basement membrane invasion by inducing microtubule-rich protrusions

https://doi.org/10.18632/oncotarget.4728

Meng-Horng Lee, Pei-Hsun Wu, Daniele Gilkes, Ivie Aifuwa,  and Denis Wirtz
32634-32645
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors

Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors

https://doi.org/10.18632/oncotarget.5066

Theresa Baker, Sujata Nerle, Justin Pritchard, Boyang Zhao, Victor M. Rivera, Andrew Garner,  and Francois Gonzalvez
32646-32655
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

p62/IMP2 stimulates cell migration and reduces cell adhesion in breast cancer

p62/IMP2 stimulates cell migration and reduces cell adhesion in breast cancer

https://doi.org/10.18632/oncotarget.5328

Yang Li, Giulio Francia,  and Jian-Ying Zhang
32656-32668
Abstract  |  PDF  |  HTML  |  Order a Reprint

A CD21 low phenotype, with no evidence of autoantibodies to complement proteins, is consistent with a poor prognosis in CLL

A CD21 low phenotype, with no evidence of autoantibodies to complement proteins, is consistent with a poor prognosis in CLL

https://doi.org/10.18632/oncotarget.5404

Eva-Maria Nichols, Rachel Jones, Rachael Watson, Chris J. Pepper, Chris Fegan,  and Kevin J. Marchbank
32669-32680
Abstract  |  PDF  |  HTML  |  Order a Reprint

A nanostructure of functional targeting epirubicin liposomes dually modified with aminophenyl glucose and cyclic pentapeptide used for brain glioblastoma treatment

A nanostructure of functional targeting epirubicin liposomes dually modified with aminophenyl glucose and cyclic pentapeptide used for brain glioblastoma treatment

https://doi.org/10.18632/oncotarget.5354

Cheng-Xiang Zhang, Wei-Yu Zhao, Lei Liu, Rui-Jun Ju, Li-Min Mu, Yao Zhao, Fan Zeng, Hong-Jun Xie, Yan Yan,  and Wan-Liang Lu
32681-32700
Abstract  |  PDF  |  HTML  |  Order a Reprint

MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1α-TWIST signaling axis in breast cancer

MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1α-TWIST signaling axis in breast cancer

https://doi.org/10.18632/oncotarget.4702

De Chen, Bian-Li Dang, Jin-zhou Huang, Min Chen, Di Wu, Man-Li Xu, Rong Li,  and Guang-Rong Yan
32701-32712
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PDGF activation in PGDS-positive arachnoid cells induces meningioma formation in mice promoting tumor progression in combination with Nf2 and Cdkn2ab loss

PDGF activation in PGDS-positive arachnoid cells induces meningioma formation in mice promoting tumor progression in combination with Nf2 and Cdkn2ab loss

https://doi.org/10.18632/oncotarget.5296

Matthieu Peyre, Céline Salaud, Estelle Clermont-Taranchon, Michiko Niwa-Kawakita, Stephane Goutagny, Christian Mawrin, Marco Giovannini,  and Michel Kalamarides
32713-32722
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RhoGDI deficiency induces constitutive activation of Rho GTPases and COX-2 pathways in association with breast cancer progression

RhoGDI deficiency induces constitutive activation of Rho GTPases and COX-2 pathways in association with breast cancer progression

https://doi.org/10.18632/oncotarget.5416

William P. Bozza, Yaqin Zhang, Kory Hallett, Leslie A. Rivera Rosado,  and Baolin Zhang
32723-32736
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-99a inhibits tumor aggressive phenotypes through regulating HOXA1 in breast cancer cells

MicroRNA-99a inhibits tumor aggressive phenotypes through regulating HOXA1 in breast cancer cells

https://doi.org/10.18632/oncotarget.5355

Xiaolong Wang, Yaming Li, Wenwen Qi, Ning Zhang, Mingjuan Sun, Qiang Huo, Chang Cai, Shangge Lv,  and Qifeng Yang
32737-32747
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells

Glucose transporter isoform 1 expression enhances metastasis of malignant melanoma cells

https://doi.org/10.18632/oncotarget.4977

Andreas Koch, Sven Arke Lang, Peter Johannes Wild, Susanne Gantner, Abdo Mahli, Gerrit Spanier, Mark Berneburg, Martina Müller, Anja Katrin Bosserhoff,  and Claus Hellerbrand
32748-32760
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression

Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression

https://doi.org/10.18632/oncotarget.5018

Mingsong Wu, Shuhui Si, Yan Li, Susan Schoen, Guang-Qian Xiao, Xueying Li, Bin Tean Teh, Guan Wu,  and Jindong Chen
32761-32773
Abstract  |  PDF  |  HTML  |  Order a Reprint

miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity

miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity

https://doi.org/10.18632/oncotarget.5192

Keith O’Brien, Michelle C. Lowry, Claire Corcoran, Vanesa G. Martinez, Melissa Daly, Sweta Rani, William M. Gallagher, Marek W. Radomski, Roderick A.F. MacLeod,  and Lorraine O’Driscoll
32774-32789
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine

Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine

https://doi.org/10.18632/oncotarget.5411

Qi-Wei Jiang, Ke-Jun Cheng, Xiao-Long Mei, Jian-Ge Qiu, Wen-Ji Zhang, You-Qiu Xue, Wu-Ming Qin, Yang Yang, Di-Wei Zheng, Yao Chen, Meng-Ning Wei, Xu Zhang, Min Lv, Mei-Wan Chen, Xing Wei,  and Zhi Shi
32790-32804
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-200b regulates autophagy associated with chemoresistance in human lung adenocarcinoma

MiR-200b regulates autophagy associated with chemoresistance in human lung adenocarcinoma

https://doi.org/10.18632/oncotarget.5352

Banzhou Pan, Bing Feng, Yitian Chen, Guichun Huang, Rui Wang, Longbang Chen,  and Haizhu Song
32805-32820
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells

Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells

https://doi.org/10.18632/oncotarget.5104

Marta Nardella, Loredana Guglielmi, Carla Musa, Ilaria Iannetti, Giovanna Maresca, Donatella Amendola, Manuela Porru, Elisabetta Carico, Giuseppe Sessa, Rosalba Camerlingo, Carlo Dominici, Francesca Megiorni, Marika Milan, Claudia Bearzi, Roberto Rizzi, Giuseppe Pirozzi, Carlo Leonetti, Barbara Bucci, Delio Mercanti, Armando Felsani,  and Igea D’Agnano
32821-32840
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells

Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells

https://doi.org/10.18632/oncotarget.5301

Rui Chen, Jing Zhu, Yong Dong, Chao He,  and Xiaotong Hu
32841-32855
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2

Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2

https://doi.org/10.18632/oncotarget.5942

Atanasio Pandiella, Francisco Morís, Alberto Ocaña, Luz-Elena Núñez,  and Juan C. Montero
32856-32867
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Circulating microRNA signature as liquid-biopsy to monitor lung cancer in low-dose computed tomography screening

Circulating microRNA signature as liquid-biopsy to monitor lung cancer in low-dose computed tomography screening

https://doi.org/10.18632/oncotarget.5210

Stefano Sestini, Mattia Boeri, Alfonso Marchiano, Giuseppe Pelosi, Carlotta Galeone, Carla Verri, Paola Suatoni, Nicola Sverzellati, Carlo La Vecchia, Gabriella Sozzi,  and Ugo Pastorino
32868-32877
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Integrated miRNA profiling and bioinformatics analyses reveal potential causative miRNAs in gastric adenocarcinoma

Integrated miRNA profiling and bioinformatics analyses reveal potential causative miRNAs in gastric adenocarcinoma

https://doi.org/10.18632/oncotarget.5419

Xiaojing Zhang, Yin Peng, Zhe Jin, Weiling Huang, Yulan Cheng, Yudan Liu, Xianling Feng, Mengting Yang, Yong Huang, Zhenfu Zhao, Liang Wang, Yanjie Wei, Xinmin Fan, Duo Zheng,  and Stephen J. Meltzer
32878-32889
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression

LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression

https://doi.org/10.18632/oncotarget.5335

Yupeng Wu, Ming Liu, Zhuchen Li, Xiao-Bin Wu, Ying Wang, Yadong Wang, Min Nie, Feifei Huang, Junyi Ju, Chi Ma, Renxiang Tan, Ke Zen, Chen-Yu Zhang, Keqin Fu, Yu-Gen Chen, Ming-Rong Wang,  and Quan Zhao
32890-32901
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IL-13 receptor α2 is a negative prognostic factor in human lung cancer and stimulates lung cancer growth in mice

IL-13 receptor α2 is a negative prognostic factor in human lung cancer and stimulates lung cancer growth in mice

https://doi.org/10.18632/oncotarget.5361

Mian Xie, Xiao-jun Wu, Jin-jun Zhang,  and Chao-sheng He
32902-32913
Abstract  |  PDF  |  HTML  |  Order a Reprint

Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo

Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo

https://doi.org/10.18632/oncotarget.5441

Michaela Nelson, Ming Yang, Rebecca Millican-Slater,  and William J. Brackenbury
32914-32929
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo

Metformin and temozolomide act synergistically to inhibit growth of glioma cells and glioma stem cells in vitro and in vivo

https://doi.org/10.18632/oncotarget.5405

Zhiyun Yu, Gang Zhao, Guifang Xie, Liyan Zhao, Yong Chen, Hongquan Yu, Zhonghua Zhang, Cai Li,  and Yunqian Li
32930-32943
Abstract  |  PDF  |  HTML  |  Order a Reprint

MiR-208a stimulates the cocktail of SOX2 and β-catenin to inhibit the let-7 induction of self-renewal repression of breast cancer stem cells and formed miR208a/let-7 feedback loop via LIN28 and DICER1

MiR-208a stimulates the cocktail of SOX2 and β-catenin to inhibit the let-7 induction of self-renewal repression of breast cancer stem cells and formed miR208a/let-7 feedback loop via LIN28 and DICER1

https://doi.org/10.18632/oncotarget.5079

Xin Sun, Shiwen Jiang, Jian Liu, Huangzhen Wang, Yiwen Zhang, Shou-Ching Tang, Jichang Wang, Ning Du, Chongwen Xu, Chenguang Wang, Sida Qin, Jia Zhang, Dapeng Liu, Yunfeng Zhang, Xiaojun Li, Jiansheng Wang, Jun Dong, Xin Wang, Shaohua Xu, Zhen Tao, Fei Xu, Jie Zhou, Tao Wang,  and Hong Ren
32944-32954
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Deciphering the molecular basis of invasiveness in Sdhb-deficient cells

Deciphering the molecular basis of invasiveness in Sdhb-deficient cells

https://doi.org/10.18632/oncotarget.5106

Céline Loriot, Mélanie Domingues, Adeline Berger, Mélanie Menara, Maëva Ruel, Aurélie Morin, Luis-Jaime Castro-Vega, Éric Letouzé, Cosimo Martinelli, Alexis-Pierre Bemelmans, Lionel Larue, Anne-Paule Gimenez-Roqueplo,  and Judith Favier
32955-32965
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IL-17 producing mast cells promote the expansion of myeloid-derived suppressor cells in a mouse allergy model of colorectal cancer

IL-17 producing mast cells promote the expansion of myeloid-derived suppressor cells in a mouse allergy model of colorectal cancer

https://doi.org/10.18632/oncotarget.5435

Xiaowei Chen, Michael J. Churchill, Karan K. Nagar, Yagnesh H. Tailor, Timothy Chu, Brittany S. Rush, Zhengyu Jiang, Edwin B.C. Wang, Bernhard W. Renz, Hongshan Wang, Ming Chiu Fung, Daniel L. Worthley, Siddhartha Mukherjee,  and Timothy C. Wang
32966-32979
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Immature myeloid progenitors promote disease progression in a mouse model of Barrett’s-like metaplasia

Immature myeloid progenitors promote disease progression in a mouse model of Barrett’s-like metaplasia

https://doi.org/10.18632/oncotarget.5431

Jianping Kong, Hong Sai, Mary Ann S. Crissey, Nirag Jhala, Gary W. Falk, Gregory G. Ginsberg, Julian A. Abrams, Hiroshi Nakagawa, Kenneth Wang, Anil K. Rustgi, Timothy C. Wang,  and John P Lynch
32980-33005
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Twist1-mediated 4E-BP1 regulation through mTOR in non-small cell lung cancer

Twist1-mediated 4E-BP1 regulation through mTOR in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.5026

Tangfeng Lv, Qian Wang, Meghan Cromie, Hongbing Liu, Song Tang, Yong Song,  and Weimin Gao
33006-33018
Abstract  |  PDF  |  HTML  |  Order a Reprint

PD-L1 is remarkably over-expressed in EBV-associated pulmonary lymphoepithelioma-like carcinoma and related to poor disease-free survival

PD-L1 is remarkably over-expressed in EBV-associated pulmonary lymphoepithelioma-like carcinoma and related to poor disease-free survival

https://doi.org/10.18632/oncotarget.5028

Wenfeng Fang, Shaodong Hong, Nan Chen, Xiaobo He, Jianhua Zhan, Tao Qin, Ting Zhou, Zhihuang Hu, Yuxiang Ma, Yuanyuan Zhao, Ying Tian, Yunpeng Yang, Cong Xue, Yanna Tang, Yan Huang, Hongyun Zhao,  and Li Zhang
33019-33032
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Breast cancer associated a2 isoform vacuolar ATPase immunomodulates neutrophils: potential role in tumor progression

Breast cancer associated a2 isoform vacuolar ATPase immunomodulates neutrophils: potential role in tumor progression

https://doi.org/10.18632/oncotarget.5439

Safaa A. Ibrahim, Gajendra K. Katara, Arpita Kulshrestha, Mukesh K. Jaiswal, Magdy A. Amin,  and Kenneth D. Beaman
33033-33045
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis

Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis

https://doi.org/10.18632/oncotarget.5422

Da Eun Jeong, Hye Jin Song, Sharon Lim, Se Jeong Lee, Joung Eun Lim, Do-Hyun Nam, Kyeung Min Joo, Byong Chang Jeong, Seong Soo Jeon, Han Yong Choi,  and Hye Won Lee
33046-33064
Abstract  |  PDF  |  HTML  |  Order a Reprint

Lysine-specific demethylase 1 promotes tumorigenesis and predicts prognosis in gallbladder cancer

Lysine-specific demethylase 1 promotes tumorigenesis and predicts prognosis in gallbladder cancer

https://doi.org/10.18632/oncotarget.5279

Shixian Lian, Yebo Shao, Houbao Liu, Junyi He, Weiqi Lu, Yong Zhang, Ying Jiang,  and Jun Zhu
33065-33076
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Down-regulation of IKKβ expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma

Down-regulation of IKKβ expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma

https://doi.org/10.18632/oncotarget.5310

Jakub Mieczkowski, Marta Kocyk, Pawel Nauman, Konrad Gabrusiewicz, Małgorzata Sielska, Piotr Przanowski, Marta Maleszewska, Wenson D. Rajan, Dominika Pszczolkowska, Tomasz Tykocki, Wieslawa Grajkowska, Katarzyna Kotulska, Marcin Roszkowski, Boguslaw Kostkiewicz,  and Bozena Kaminska
33077-33090
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling

Sur8/Shoc2 promotes cell motility and metastasis through activation of Ras-PI3K signaling

https://doi.org/10.18632/oncotarget.5173

Saluja Kaduwal, Woo-Jeong Jeong, Jong-Chan Park, Kug Hwa Lee, Young-Mi Lee, Soung Hoo Jeon, Yong-Beom Lim, Do Sik Min,  and Kang-Yell Choi
33091-33105
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibiting NFAT1 for breast cancer therapy: New insights into the mechanism of action of MDM2 inhibitor JapA

Inhibiting NFAT1 for breast cancer therapy: New insights into the mechanism of action of MDM2 inhibitor JapA

https://doi.org/10.18632/oncotarget.5851

Jiang-Jiang Qin, Wei Wang, Sukesh Voruganti, Hui Wang, Wei-Dong Zhang,  and Ruiwen Zhang
33106-33119
Abstract  |  PDF  |  HTML  |  Order a Reprint

Isolation and characterization of novel RECK tumor suppressor gene splice variants

Isolation and characterization of novel RECK tumor suppressor gene splice variants

https://doi.org/10.18632/oncotarget.5305

Marina Trombetta-Lima, Sheila Maria Brochado Winnischofer, Marcos Angelo Almeida Demasi, Renato Astorino Filho, Ana Claudia Oliveira Carreira, Beiyang Wei, Thais de Assis Ribas, Michelle Silberspitz Konig, Christian Bowman-Colin, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie, William Stetler-Stevenson,  and Mari Cleide Sogayar
33120-33133
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

t-Darpp overexpression in HER2-positive breast cancer confers a survival advantage in lapatinib

t-Darpp overexpression in HER2-positive breast cancer confers a survival advantage in lapatinib

https://doi.org/10.18632/oncotarget.5311

Jessica L. Christenson, Erin C. Denny,  and Susan E. Kane
33134-33145
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges

Role of the short isoform of the progesterone receptor in breast cancer cell invasiveness at estrogen and progesterone levels in the pre- and post-menopausal ranges

https://doi.org/10.18632/oncotarget.5082

Thomas McFall, Mugdha Patki, Rayna Rosati,  and Manohar Ratnam
33146-33164
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer

Vesicular stomatitis virus expressing interferon-β is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer

https://doi.org/10.18632/oncotarget.5320

Manish R. Patel, Blake A. Jacobson, Yan Ji, Jeremy Drees, Shaogeng Tang, Kerry Xiong, Hengbing Wang, Jennifer E. Prigge, Alexander S. Dash, Andrea K. Kratzke, Emily Mesev, Ryan Etchison, Mark J. Federspiel, Stephen J. Russell,  and Robert A. Kratzke
33165-33177
Abstract  |  PDF  |  HTML  |  Order a Reprint

p73 regulates basal and starvation-induced liver metabolism in vivo

p73 regulates basal and starvation-induced liver metabolism in vivo

https://doi.org/10.18632/oncotarget.5090

Zhaoyue He, Massimiliano Agostini, He Liu, Gerry Melino,  and Hans-Uwe Simon
33178-33190
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Extracting tumor tissue immune status from expression profiles: correlating renal cancer prognosis with tumor-associated immunome

Extracting tumor tissue immune status from expression profiles: correlating renal cancer prognosis with tumor-associated immunome

https://doi.org/10.18632/oncotarget.5052

Omri Teltsh, Angel Porgador,  and Eitan Rubin
33191-33205
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pre-clinical evidence of PIM kinase inhibitor activity in BCR-ABL1 unmutated and mutated Philadelphia chromosome-positive (Ph+) leukemias

Pre-clinical evidence of PIM kinase inhibitor activity in BCR-ABL1 unmutated and mutated Philadelphia chromosome-positive (Ph+) leukemias

https://doi.org/10.18632/oncotarget.5091

Dany A Curi, Elspeth M Beauchamp, Gavin T Blyth, Ahmet Dirim Arslan, Nicholas J Donato, Francis J Giles, Jessica K Altman,  and Leonidas C Platanias
33206-33216
Abstract  |  PDF  |  HTML  |  Order a Reprint

High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis

High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis

https://doi.org/10.18632/oncotarget.5202

Hsiao-Wen Kao, Der-Cherng Liang, Ming-Chung Kuo, Jin-Hou Wu, Po Dunn, Po-Nan Wang, Tung-Liang Lin, Yu-Shu Shih, Sung-Tzu Liang, Tung-Huei Lin, Chen-Yu Lai, Chun-Hui Lin,  and Lee-Yung Shih
33217-33225
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation

Cigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation

https://doi.org/10.18632/oncotarget.5429

Hyun-Wook Lee, Hsiang-Tsui Wang, Mao-wen Weng, Chiu Chin, William Huang, Herbert Lepor, Xue-Ru Wu, William N. Rom, Lung-Chi Chen,  and Moon-shong Tang
33226-33236
Abstract  |  PDF  |  HTML  |  Order a Reprint

An epigenetic auto-feedback loop regulates TGF-β type II receptor expression and function in NSCLC

An epigenetic auto-feedback loop regulates TGF-β type II receptor expression and function in NSCLC

https://doi.org/10.18632/oncotarget.4893

Shanzhong Yang, Yong-Jig Cho, Lin Jin, Guandou Yuan, Arunima Datta, Phillip Buckhaults,  and Pran K. Datta
33237-33252
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A common promoter hypomethylation signature in invasive breast, liver and prostate cancer cell lines reveals novel targets involved in cancer invasiveness

A common promoter hypomethylation signature in invasive breast, liver and prostate cancer cell lines reveals novel targets involved in cancer invasiveness

https://doi.org/10.18632/oncotarget.5291

David Cheishvili, Barbara Stefanska, Cao Yi, Chen Chen Li, Patricia Yu, Ani Arakelian, Imrana Tanvir, Haseeb Ahmed Khan, Shafaat Rabbani,  and Moshe Szyf
33253-33268
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting of RUNX3 by miR-130a and miR-495 cooperatively increases cell proliferation and tumor angiogenesis in gastric cancer cells

Targeting of RUNX3 by miR-130a and miR-495 cooperatively increases cell proliferation and tumor angiogenesis in gastric cancer cells

https://doi.org/10.18632/oncotarget.5037

Sun Hee Lee, Yuk Dong Jung, Young Sun Choi,  and You Mie Lee
33269-33278
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of BMK1 pathway suppresses cancer stem cells through BNIP3 and BNIP3L

Inhibition of BMK1 pathway suppresses cancer stem cells through BNIP3 and BNIP3L

https://doi.org/10.18632/oncotarget.5337

Chengli Song, Qiang Xu, Kui Jiang, Guangyu Zhou, Xuebin Yu, Lina Wang, Yuting Zhu, Liping Fang, Zhe Yu, Jiing-Dwan Lee, Shi-Cang Yu,  and Qingkai Yang
33279-33289
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Simultaneous targeting of 5-LOX-COX and EGFR blocks progression of pancreatic ductal adenocarcinoma

Simultaneous targeting of 5-LOX-COX and EGFR blocks progression of pancreatic ductal adenocarcinoma

https://doi.org/10.18632/oncotarget.5396

Chinthalapally V. Rao, Naveena B. Janakiram, Venkateshwar Madka, Vishal Devarkonda, Misty Brewer, Laura Biddick, Stan Lightfoot, Vernon E. Steele,  and Altaf Mohammed
33290-33305
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Contrasting breast cancer molecular subtypes across serial tumor progression stages: biological and prognostic implications

Contrasting breast cancer molecular subtypes across serial tumor progression stages: biological and prognostic implications

https://doi.org/10.18632/oncotarget.5089

Siker Kimbung, Anikó Kovács, Anna Danielsson, Pär-Ola Bendahl, Kristina Lövgren, Marianne Frostvik Stolt, Nicholas P Tobin, Linda Lindström, Jonas Bergh, Zakaria Einbeigi, Mårten Fernö, Thomas Hatschek,  and Ingrid Hedenfalk
33306-33318
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genomic landscape of endometrial stromal sarcoma of uterus

Genomic landscape of endometrial stromal sarcoma of uterus

https://doi.org/10.18632/oncotarget.5384

Youn Jin Choi, Seung-Hyun Jung, Min Sung Kim, In-Pyo Baek, Jae-Keun Rhee, Sung Hak Lee, Soo Young Hur, Tae-Min Kim, Yeun-Jun Chung,  and Sug Hyung Lee
33319-33328
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results from in vitro and in vivo studies with bromelain and N-acetylcysteine

Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results from in vitro and in vivo studies with bromelain and N-acetylcysteine

https://doi.org/10.18632/oncotarget.5259

Afshin Amini, Samar Masoumi-Moghaddam, Anahid Ehteda, Winston Liauw,  and David L Morris
33329-33344
Abstract  |  PDF  |  HTML  |  Order a Reprint

Liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via up-regulation of ABCA1 expression

Liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via up-regulation of ABCA1 expression

https://doi.org/10.18632/oncotarget.5428

Tetsuharu Kaneko, Chihiro Kanno, Naoki Ichikawa-Tomikawa, Korehito Kashiwagi, Nanae Yaginuma, Chihiro Ohkoshi, Mizuko Tanaka, Takashi Sugino, Tetsuya Imura, Hiroshi Hasegawa,  and Hideki Chiba
33345-33357
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The NEXT-1 (Next generation pErsonalized tX with mulTi-omics and preclinical model) trial: prospective molecular screening trial of metastatic solid cancer patients, a feasibility analysis

The NEXT-1 (Next generation pErsonalized tX with mulTi-omics and preclinical model) trial: prospective molecular screening trial of metastatic solid cancer patients, a feasibility analysis

https://doi.org/10.18632/oncotarget.5188

Seung Tae Kim, Jeeyun Lee, Mineui Hong, Kyunghee Park, Joon Oh Park, Tae Jin Ahn, Se Hoon Park, Young Suk Park, Ho Yeong Lim, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Hee Cheol Kim, Tae Sung Sohn, Dong Il Choi, Jong Ho Cho, Jin Seok Heo, Wooil Kwon, Sang Won Uhm, Hyuk Lee, Byung-Hoon Min, Sung No Hong, Duk Hwan Kim, Sin Ho Jung, Woongyang Park, Kyoung-Mee Kim, Won Ki Kang,  and Keunchil Park
33358-33368
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lowered circulating aspartate is a metabolic feature of human breast cancer

Lowered circulating aspartate is a metabolic feature of human breast cancer

https://doi.org/10.18632/oncotarget.5409

Guoxiang Xie, Bingsen Zhou, Aihua Zhao, Yunping Qiu, Xueqing Zhao, Lana Garmire, Yurii B. Shvetsov, Herbert Yu, Yun Yen,  and Wei Jia
33369-33381
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer

Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer

https://doi.org/10.18632/oncotarget.5407

Sun-Yong Kim, Haeng-Jun Kim, Sung Un Kang, Yang Eun Kim, Ju Kyeong Park, Yoo Seob Shin, Yeon Soo Kim, Keunho Lee,  and Chul-Ho Kim
33382-33396
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells

BRD4-targeted therapy induces Myc-independent cytotoxicity in Gnaq/11-mutatant uveal melanoma cells

https://doi.org/10.18632/oncotarget.5179

Grazia Ambrosini, Ashley D. Sawle, Elgilda Musi,  and Gary K. Schwartz
33397-33409
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia

T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia

https://doi.org/10.18632/oncotarget.5418

Houda Alachkar, Martin Mutonga, Gregory Malnassy, Jae-Hyun Park, Noreen Fulton, Alex Woods, Liping Meng, Justin Kline, Gordana Raca, Olatoyosi Odenike, Naofumi Takamatsu, Takashi Miyamoto, Yo Matsuo, Wendy Stock,  and Yusuke Nakamura
33410-33425
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Role of N-cadherin in proliferation, migration, and invasion of germ cell tumours

Role of N-cadherin in proliferation, migration, and invasion of germ cell tumours

https://doi.org/10.18632/oncotarget.5288

Felix Bremmer, Simon Schallenberg, Hubertus Jarry, Stefan Küffer, Silke Kaulfuss, Peter Burfeind, Arne Strauß, Paul Thelen, Heinz Joachim Radzun, Philipp Ströbel, Friedemann Honecker,  and Carl Ludwig Behnes
33426-33437
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation

Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation

https://doi.org/10.18632/oncotarget.5586

Laura A. Kresty, Katherine M. Weh, Bree Zeyzus-Johns, Laura N. Perez,  and Amy B. Howell
33438-33455
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components

Expression profile of innate immune receptors, NLRs and AIM2, in human colorectal cancer: correlation with cancer stages and inflammasome components

https://doi.org/10.18632/oncotarget.5587

Rongrong Liu, Agnieszka D. Truax, Liang Chen, Peizhen Hu, Zengshan Li, Jun Chen, Chaojun Song, Lihua Chen,  and Jenny Pan-Yun Ting
33456-33469
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Silencing NKD2 by promoter region hypermethylation promotes gastric cancer invasion and metastasis by up-regulating SOX18 in human gastric cancer

Silencing NKD2 by promoter region hypermethylation promotes gastric cancer invasion and metastasis by up-regulating SOX18 in human gastric cancer

https://doi.org/10.18632/oncotarget.5272

Yan Jia, Baoping Cao, Yunsheng Yang, Enqiang Linghu, Qimin Zhan, Youyong Lu, Yingyan Yu, James G. Herman,  and Mingzhou Guo
33470-33485
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD19+CD24hiCD38hiBregs involved in downregulate helper T cells and upregulate regulatory T cells in gastric cancer

CD19+CD24hiCD38hiBregs involved in downregulate helper T cells and upregulate regulatory T cells in gastric cancer

https://doi.org/10.18632/oncotarget.5588

Weiwei Wang, Xiangliang Yuan, Hui Chen, Guohua Xie, Yanhui Ma, Yingxia Zheng, Yunlan Zhou,  and Lisong Shen
33486-33499
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis

Prostaglandin E receptor 4 (EP4) promotes colonic tumorigenesis

https://doi.org/10.18632/oncotarget.5589

Jian Chang, Jean Vacher, Bing Yao, Xiaofeng Fan, Bixiang Zhang, Raymond C. Harris,  and Ming-Zhi Zhang
33500-33511
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility

MT1-MMP dependent repression of the tumor suppressor SPRY4 contributes to MT1-MMP driven melanoma cell motility

https://doi.org/10.18632/oncotarget.5258

Khvaramze Shaverdashvili, Keman Zhang, Iman Osman, Kord Honda, Rauli Jobava,  and Barbara Bedogni
33512-33522
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion

Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion

https://doi.org/10.18632/oncotarget.5590

Di Jin, Jun Tao, Dan Li, Yanan Wang, Li Li, Zhongdong Hu, Zhenzhen Zhou, Xiuli Chang, Chunfeng Qu,  and Hongbing Zhang
33523-33533
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden

Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden

https://doi.org/10.18632/oncotarget.5214

Erik W. Martin, Marguerite S. Buzza, Kathryn H. Driesbaugh, Shihui Liu, Yolanda M. Fortenberry, Stephen H. Leppla,  and Toni M. Antalis
33534-33553
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The NF-κB p65/miR-23a-27a-24 cluster is a target for leukemia treatment

The NF-κB p65/miR-23a-27a-24 cluster is a target for leukemia treatment

https://doi.org/10.18632/oncotarget.5591

Yong-Chang Zhang, Hui Ye, Zhi Zeng, Y. Eugene Chin, Yu-Ning Huang,  and Guo-Hui Fu
33554-33567
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation

Effective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation

https://doi.org/10.18632/oncotarget.5598

Derek James Hanson, Shingen Nakamura, Ryota Amachi, Masahiro Hiasa, Asuka Oda, Daisuke Tsuji, Kohji Itoh, Takeshi Harada, Kazuki Horikawa, Jumpei Teramachi, Hirokazu Miki, Toshio Matsumoto,  and Masahiro Abe
33568-33586
Abstract  |  PDF  |  HTML  |  Order a Reprint

Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression

Long noncoding RNA HOXA-AS2 promotes gastric cancer proliferation by epigenetically silencing P21/PLK3/DDIT3 expression

https://doi.org/10.18632/oncotarget.5599

Min Xie, Ming Sun, Ya-nan Zhu, Rui Xia, Yan-wen Liu, Jie Ding, Hong-wei Ma, Xue-zhi He, Zhi-hong Zhang, Zhi-jun Liu, Xiang-hua Liu,  and Wei De
33587-33601
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The pan-HER family tyrosine kinase inhibitor afatinib overcomes HER3 ligand heregulin-mediated resistance to EGFR inhibitors in non-small cell lung cancer

The pan-HER family tyrosine kinase inhibitor afatinib overcomes HER3 ligand heregulin-mediated resistance to EGFR inhibitors in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.5286

Kimio Yonesaka, Keita Kudo, Satomi Nishida, Takayuki Takahama, Tsutomu Iwasa, Takeshi Yoshida, Kaoru Tanaka, Masayuki Takeda, Hiroyasu Kaneda, Isamu Okamoto, Kazuto Nishio,  and Kazuhiko Nakagawa
33602-33611
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The hypomethylating agent decitabine prior to chemotherapy improves the therapy efficacy in refractory/relapsed acute myeloid leukemia patients

The hypomethylating agent decitabine prior to chemotherapy improves the therapy efficacy in refractory/relapsed acute myeloid leukemia patients

https://doi.org/10.18632/oncotarget.5600

Xuejie Jiang, Zhixiang Wang, Bingjie Ding, Changxin Yin, Qingxiu Zhong, Bing Z. Carter, Guopan Yu, Ling Jiang, Jieyu Ye, Min Dai, Yu Zhang, Shuang Liang, Qingxia Zhao, Qifa Liu,  and Fanyi Meng
33612-33622
Abstract  |  PDF  |  HTML  |  Order a Reprint

Induction of USP17 by combining BET and HDAC inhibitors in breast cancer cells

Induction of USP17 by combining BET and HDAC inhibitors in breast cancer cells

https://doi.org/10.18632/oncotarget.5601

Gabor Borbely, Lars-Arne Haldosen, Karin Dahlman-Wright,  and Chunyan Zhao
33623-33635
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells

SIP1 is a downstream effector of GADD45G in senescence induction and growth inhibition of liver tumor cells

https://doi.org/10.18632/oncotarget.5602

Guiqin Xu, Li Zhang, Aihui Ma, Yu Qian, Qi Ding, Yun Liu, Boshi Wang, Zhaojuan Yang,  and Yongzhong Liu
33636-33647
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells

GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells

https://doi.org/10.18632/oncotarget.5203

Shingo Inaguma, Miho Riku, Hideaki Ito, Takumi Tsunoda, Hiroshi Ikeda,  and Kenji Kasai
33648-33657
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GRP78 confers the resistance to 5-FU by activating the c-Src/LSF/TS Axis in hepatocellular carcinoma

GRP78 confers the resistance to 5-FU by activating the c-Src/LSF/TS Axis in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.5603

Yan-jiao Gu, Hong-dan Li, Liang Zhao, Song Zhao, Wu-bin He, Li Rui, Chang Su, Hua-chuan Zheng,  and Rong-jian Su
33658-33674
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heme oxygenase-1 in macrophages controls prostate cancer progression

Heme oxygenase-1 in macrophages controls prostate cancer progression

https://doi.org/10.18632/oncotarget.5284

Zsuzsanna Nemeth, Mailin Li, Eva Csizmadia, Balazs Döme, Martin Johansson, Jenny Liao Persson, Pankaj Seth, Leo Otterbein,  and Barbara Wegiel
33675-33688
Abstract  |  PDF  |  HTML  |  Order a Reprint

Differential susceptibility to colorectal cancer due to naturally occurring gut microbiota

Differential susceptibility to colorectal cancer due to naturally occurring gut microbiota

https://doi.org/10.18632/oncotarget.5604

Aaron C. Ericsson, Sadia Akter, Marina M. Hanson, Susheel B. Busi, Taybor W. Parker, Rebecca J. Schehr, Miriam A. Hankins, Carin E. Ahner, Justin W. Davis, Craig L. Franklin, James M. Amos-Landgraf,  and Elizabeth C. Bryda
33689-33704
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HSulf-1 deficiency dictates a metabolic reprograming of glycolysis and TCA cycle in ovarian cancer

HSulf-1 deficiency dictates a metabolic reprograming of glycolysis and TCA cycle in ovarian cancer

https://doi.org/10.18632/oncotarget.5605

Susmita Mondal, Debarshi Roy, Juliana Camacho-Pereira, Ashwani Khurana, Eduardo Chini, Lifeng Yang, Joelle Baddour, Katherine Stilles, Seth Padmabandu, Sam Leung, Steve Kalloger, Blake Gilks, Val Lowe, Thomas Dierks, Edward Hammond, Keith Dredge, Deepak Nagrath,  and Viji Shridhar
33705-33719
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting EZH2 regulates tumor growth and apoptosis through modulating mitochondria dependent cell-death pathway in HNSCC

Targeting EZH2 regulates tumor growth and apoptosis through modulating mitochondria dependent cell-death pathway in HNSCC

https://doi.org/10.18632/oncotarget.5606

Xuan Zhou, Yu Ren, Lingping Kong, Guoshuai Cai, Shanshan Sun, Wangzhao Song, Yu Wang, Rui Jin, Lisha Qi, Mei Mei, Xudong Wang, Chunsheng Kang, Min Li,  and Lun Zhang
33720-33732
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Imaging of carbonic anhydrase IX with an 111In-labeled dual-motif inhibitor

Imaging of carbonic anhydrase IX with an 111In-labeled dual-motif inhibitor

https://doi.org/10.18632/oncotarget.5254

Xing Yang, Il Minn, Steven P. Rowe, Sangeeta Ray Banerjee, Michael A. Gorin, Mary Brummet, Hye Soo Lee, Soo Min Koo, Polina Sysa-Shah, Ronnie C. Mease, Sridhar Nimmagadda, Mohamad E. Allaf,  and Martin G. Pomper
33733-33742
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AR-v7 protein expression is regulated by protein kinase and phosphatase

AR-v7 protein expression is regulated by protein kinase and phosphatase

https://doi.org/10.18632/oncotarget.5608

Yinan Li, Ning Xie, Martin E. Gleave, Paul S. Rennie,  and Xuesen Dong
33743-33754
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM

Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM

https://doi.org/10.18632/oncotarget.5274

Maja T. Tomicic, Ruth Meise, Dorthe Aasland, Nancy Berte, Rebekka Kitzinger, Oliver H. Krämer, Bernd Kaina,  and Markus Christmann
33755-33768
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration

Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration

https://doi.org/10.18632/oncotarget.5615

Wei Xiang, Jit Kong Cheong, Shi Hui Ang, Bryan Teo, Peng Xu, Kartini Asari, Wen Tian Sun, Hein Than, Ralph M. Bunte, David M. Virshup,  and Charles Chuah
33769-33780
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dendritic cell vaccination with a toll-like receptor agonist derived from mycobacteria enhances anti-tumor immunity

Dendritic cell vaccination with a toll-like receptor agonist derived from mycobacteria enhances anti-tumor immunity

https://doi.org/10.18632/oncotarget.5281

Manh-Cuong Vo, Hyun-Ju Lee, Jong-Seok Kim, My-Dung Hoang, Nu-Ri Choi, Joon Haeng Rhee, Vinoth-Kumar Lakshmanan, Sung-Jae Shin,  and Je-Jung Lee
33781-33790
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma

HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.5667

Jin-lan Huang, Ting-yu Ren, Shun-wang Cao, Shi-hao Zheng, Xiu-mei Hu, Yan-wei Hu, Li Lin, Jing Chen, Lei Zheng,  and Qian Wang
33791-33804
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MUC4-promoted neural invasion is mediated by the axon guidance factor netrin-1 in PDAC

MUC4-promoted neural invasion is mediated by the axon guidance factor netrin-1 in PDAC

https://doi.org/10.18632/oncotarget.5668

Linjun Wang, Xiaofei Zhi, Yi Zhu, Qun Zhang, Weizhi Wang, Zheng Li, Jie Tang, Jiwei Wang, Song Wei, Bowen Li, Jianping Zhou, Jianguo Jiang, Li Yang, Hao Xu,  and Zekuan Xu
33805-33822
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells

Differential expression and biochemical activity of the immune receptor Tim-3 in healthy and malignant human myeloid cells

https://doi.org/10.18632/oncotarget.5257

Isabel Gonçalves Silva, Bernhard F. Gibbs, Marco Bardelli, Luca Varani,  and Vadim V. Sumbayev
33823-33833
Abstract  |  PDF  |  HTML  |  Order a Reprint

The association between let-7, RAS and HIF-1α in Ewing Sarcoma tumor growth

The association between let-7, RAS and HIF-1α in Ewing Sarcoma tumor growth

https://doi.org/10.18632/oncotarget.5616

Michal Hameiri-Grossman, Adi Porat-Klein, Isaac Yaniv, Shifra Ash, Ian J. Cohen, Yona Kodman, Ronit Haklai, Galit Elad-Sfadia, Yoel Kloog, Elena Chepurko, Meora Feinmesser, Josephine Issakov, Osnat Sher, Drorit Luria, Yehuda Kollender, Avraham Weizman,  and Smadar Avigad
33834-33848
Abstract  |  PDF  |  HTML  |  Order a Reprint

Primary CNS lymphoproliferative disease, mycophenolate and calcineurin inhibitor usage

Primary CNS lymphoproliferative disease, mycophenolate and calcineurin inhibitor usage

https://doi.org/10.18632/oncotarget.5292

Genevieve M. Crane, Helen Powell, Rumen Kostadinov, Patrick Tim Rocafort, Dena E. Rifkin, Peter C. Burger, Richard F. Ambinder, Lode J. Swinnen, Michael J. Borowitz,  and Amy S. Duffield
33849-33866
Abstract  |  PDF  |  HTML  |  Order a Reprint

EGFRvIII does not affect radiosensitivity with or without gefitinib treatment in glioblastoma cells

EGFRvIII does not affect radiosensitivity with or without gefitinib treatment in glioblastoma cells

https://doi.org/10.18632/oncotarget.5293

Nina Struve, Matthias Riedel, Alexander Schulte, Thorsten Rieckmann, Tobias J. Grob, Andreas Gal, Kai Rothkamm, Katrin Lamszus, Cordula Petersen, Ekkehard Dikomey,  and Malte Kriegs
33867-33877
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

BPTF promotes tumor growth and predicts poor prognosis in lung adenocarcinomas

BPTF promotes tumor growth and predicts poor prognosis in lung adenocarcinomas

https://doi.org/10.18632/oncotarget.5302

Meng Dai, Jian-Jun Lu, Wei Guo, Wendan Yu, Qimin Wang, Ranran Tang, Zhipeng Tang, Yao Xiao, Zhenglin Li, Wei Sun, Xiuna Sun, Yu Qin, Wenlin Huang, Wuguo Deng,  and Taihua Wu
33878-33892
Abstract  |  PDF  |  HTML  |  Order a Reprint

The metastasis suppressor, NDRG1, inhibits “stemness” of colorectal cancer via down-regulation of nuclear β-catenin and CD44

The metastasis suppressor, NDRG1, inhibits “stemness” of colorectal cancer via down-regulation of nuclear β-catenin and CD44

https://doi.org/10.18632/oncotarget.5294

Xiongzhi Wangpu, Xiao Yang, Jingkun Zhao, Jiaoyang Lu, Shaopei Guan, Jun Lu, Zaklina Kovacevic, Wensheng Liu, Lan Mi, Runsen Jin, Jing Sun, Fei Yue, Junjun Ma, Aiguo Lu, Des R. Richardson, Lishun Wang,  and Minhua Zheng
33893-33911
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Lymph node ratio is a prognostic factor for non-small cell lung cancer

Lymph node ratio is a prognostic factor for non-small cell lung cancer

https://doi.org/10.18632/oncotarget.5669

Guangyuan Sun, Lei Xue, Mingdong Wang,  and Xuewei Zhao
33912-33918
Abstract  |  PDF  |  HTML  |  Order a Reprint

The value of forceps biopsy and core needle biopsy in prediction of pathologic complete remission in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy

The value of forceps biopsy and core needle biopsy in prediction of pathologic complete remission in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy

https://doi.org/10.18632/oncotarget.5287

Jinghua Tang, Xin An, Xi Lin, Yuanhong Gao, Guochen Liu, Lingheng Kong, Zhizhong Pan,  and Peirong Ding
33919-33925
Abstract  |  PDF  |  HTML  |  Order a Reprint

The efficacy and safety of Endostar combined with chemoradiotherapy for patients with advanced, locally recurrent nasopharyngeal carcinoma

The efficacy and safety of Endostar combined with chemoradiotherapy for patients with advanced, locally recurrent nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.5271

Ying Guan, Anchuan Li, Weiwei Xiao, Shuai Liu, Binbin Chen, Taixiang Lu, Chong Zhao,  and Fei Han
33926-33934
Abstract  |  PDF  |  HTML  |  Order a Reprint

Comparison of survival and clinicopathologic features in colorectal cancer among African American, Caucasian, and Chinese patients treated in the United States: Results from the surveillance epidemiology and end results (SEER) database

Comparison of survival and clinicopathologic features in colorectal cancer among African American, Caucasian, and Chinese patients treated in the United States: Results from the surveillance epidemiology and end results (SEER) database

https://doi.org/10.18632/oncotarget.5223

Junzhong Lin, Miaozhen Qiu, Ruihua Xu,  and Adrian Sandra Dobs
33935-33943
Abstract  |  PDF  |  HTML  |  Order a Reprint

Effects of first- and second-generation tyrosine kinase inhibitor therapy on glucose and lipid metabolism in chronic myeloid leukemia patients: a real clinical problem?

Effects of first- and second-generation tyrosine kinase inhibitor therapy on glucose and lipid metabolism in chronic myeloid leukemia patients: a real clinical problem?

https://doi.org/10.18632/oncotarget.5580

Alessandra Iurlo, Emanuela Orsi, Daniele Cattaneo, Veronica Resi, Cristina Bucelli, Nicola Orofino, Mariarita Sciumè, Chiara Elena, Valeria Grancini, Dario Consonni, Ester Maria Orlandi,  and Agostino Cortelezzi
33944-33951
Abstract  |  PDF  |  HTML  |  Order a Reprint

Reducing the probability of radiation-induced hepatic toxicity by changing the treatment modality from helical tomotherapy to fixed-beam intensity-modulated radiotherapy

Reducing the probability of radiation-induced hepatic toxicity by changing the treatment modality from helical tomotherapy to fixed-beam intensity-modulated radiotherapy

https://doi.org/10.18632/oncotarget.5581

Jin Ho Song, Seok Hyun Son, Chul Seung Kay,  and Hong Seok Jang
33952-33960
Abstract  |  PDF  |  HTML  |  Order a Reprint

Efficiency of CD19 chimeric antigen receptor-modified T cells for treatment of B cell malignancies in phase I clinical trials: a meta-analysis

Efficiency of CD19 chimeric antigen receptor-modified T cells for treatment of B cell malignancies in phase I clinical trials: a meta-analysis

https://doi.org/10.18632/oncotarget.5582

Tengfei Zhang, Ling Cao, Jing Xie, Ni Shi, Zhen Zhang, Zhenzhen Luo, Dongli Yue, Zimeng Zhang, Liping Wang, Weidong Han, Zhongwei Xu, Hu Chen,  and Yi Zhang
33961-33971
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer

High PD-L1 expression was associated with poor prognosis in 870 Chinese patients with breast cancer

https://doi.org/10.18632/oncotarget.5583

Tao Qin, Yin-duo Zeng, Ge Qin, Fei Xu, Jia-bin Lu, Wen-feng Fang, Cong Xue, Jian-hua Zhan, Xin-ke Zhang, Qiu-fan Zheng, Rou-jun Peng, Zhong-yu Yuan, Li Zhang,  and Shu-sen Wang
33972-33981
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic clinical factors in pretreated colorectal cancer patients receiving regorafenib: implications for clinical management.

Prognostic clinical factors in pretreated colorectal cancer patients receiving regorafenib: implications for clinical management.

https://doi.org/10.18632/oncotarget.5053

Michela Del Prete, Riccardo Giampieri, Fotios Loupakis, Tiziana Prochilo, Lisa Salvatore, Luca Faloppi, Maristella Bianconi, Alessandro Bittoni, Giuseppe Aprile, Alberto Zaniboni, Alfredo Falcone, Mario Scartozzi,  and Stefano Cascinu
33982-33992
Abstract  |  PDF  |  HTML  |  Order a Reprint

RET mutation p.S891A in a Chinese family with familial medullary thyroid carcinoma and associated cutaneous amyloidosis binding OSMR variant p.G513D

RET mutation p.S891A in a Chinese family with familial medullary thyroid carcinoma and associated cutaneous amyloidosis binding OSMR variant p.G513D

https://doi.org/10.18632/oncotarget.4992

Xiao-Ping Qi, Jian-Qiang Zhao, Zhen-Guang Chen, Jin-Lin Cao, Juan Du, Nai-Fang Liu, Feng Li, Mao Sheng, Er Fu, Jian Guo, Hong Jia, Yi-Ming Zhang,  and Ju-Ming Ma
33993-34003
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Changes in expression levels of ERCC1, DPYD, and VEGFA mRNA after first-line chemotherapy of metastatic colorectal cancer: results of a multicenter study

Changes in expression levels of ERCC1, DPYD, and VEGFA mRNA after first-line chemotherapy of metastatic colorectal cancer: results of a multicenter study

https://doi.org/10.18632/oncotarget.5227

Hideo Baba, Yoshifumi Baba, Shinji Uemoto, Kazuhiro Yoshida, Akio Saiura, Masayuki Watanabe, Yoshihiko Maehara, Eiji Oki, Yasuharu Ikeda, Hiroyuki Matsuda, Masakazu Yamamoto, Mitsuo Shimada, Akinobu Taketomi, Michiaki Unno, Kenichi Sugihara, Yutaka Ogata, Susumu Eguchi, Seigo Kitano, Kazuo Shirouzu, Yasumitsu Saiki, Hiroshi Takamori, Masaki Mori, Toshihiko Hirata, Go Wakabayashi,  and Norihiro Kokudo
34004-34013
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

KRAS mutations affect prognosis of non-small-cell lung cancer patients treated with first-line platinum containing chemotherapy

KRAS mutations affect prognosis of non-small-cell lung cancer patients treated with first-line platinum containing chemotherapy

https://doi.org/10.18632/oncotarget.5607

Mirko Marabese, Monica Ganzinelli, Marina C. Garassino, Frances A. Shepherd, Sheila Piva, Elisa Caiola, Marianna Macerelli, Anna Bettini, Calogero Lauricella, Irene Floriani, Gabriella Farina, Flavia Longo, Lucia Bonomi, M. Agnese Fabbri, Silvio Veronese, Silvia Marsoni, Massimo Broggini,  and Eliana Rulli
34014-34022
Abstract  |  PDF  |  HTML  |  Order a Reprint

Association of FGFR3 and FGFR4 gene polymorphisms with breast cancer in Chinese women of Heilongjiang province

Association of FGFR3 and FGFR4 gene polymorphisms with breast cancer in Chinese women of Heilongjiang province

https://doi.org/10.18632/oncotarget.5850

Yongdong Jiang, Shanshan Sun, Wei Wei, Yanlv Ren, Jing Liu,  and Da Pang
34023-34029
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Case Reports

Afatinib, an irreversible ErbB family blocker, with protracted temozolomide in recurrent glioblastoma: A case report

Afatinib, an irreversible ErbB family blocker, with protracted temozolomide in recurrent glioblastoma: A case report

https://doi.org/10.18632/oncotarget.5297

Jad Alshami, Marie-Christine Guiot, Scott Owen, Petr Kavan, Neil Gibson, Flavio Solca, Agnieszka Cseh, David A. Reardon,  and Thierry Muanza
34030-34037
Abstract  |  PDF  |  HTML  |  Order a Reprint

Errata

Erratum: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts

Erratum: Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts

https://doi.org/10.18632/oncotarget.6187

Marco Trerotola, Kirat K. Ganguly, Ladan Fazli, Carmine Fedele, Huimin Lu, Anindita Dutta, Qin Liu, Tiziana De Angelis, Luke W. Riddell, Natalia A. Riobo, Martin E. Gleave, Amina Zoubeidi, Richard G. Pestell, Dario C. Altieri,  and Lucia R. Languino
34038
Erratum  |  PDF


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