Oncotarget

Vol 6, No 30

October 6, 2015

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About The Cover

MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis. See Runtsch et al.

Table of Contents

Editorial

Decoding poxvirus genome

Decoding poxvirus genome

https://doi.org/10.18632/oncotarget.5892

Zhilong Yang,  and Bernard Moss
28513-28514
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A 4D view on mRNA

A 4D view on mRNA

https://doi.org/10.18632/oncotarget.5121

Carlas Smith, Li-Chun Tu,  and David Grunwald
28515-28516
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S-nitrosylation and MSC-mediated body composition

S-nitrosylation and MSC-mediated body composition

https://doi.org/10.18632/oncotarget.5672

Yenong Cao, Wayne Balkan,  and Joshua M. Hare
28517-28518
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Type I collagen fibrils: an inducer of invadosomes

Type I collagen fibrils: an inducer of invadosomes

https://doi.org/10.18632/oncotarget.5804

Julie Di Martino, Violaine Moreau,  and Frederic Saltel
28519-28520
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Editorial: Immunology

Neuroimmune signaling by extracellular vesicles

Neuroimmune signaling by extracellular vesicles

https://doi.org/10.18632/oncotarget.5249

Stefan Momma
28521-28522
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Enhancing immunity by engineering DAMPs

Enhancing immunity by engineering DAMPs

https://doi.org/10.18632/oncotarget.5251

Felice Cervone, Frederick M. Ausubel,  and Giulia De Lorenzo
28523-28524
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STAT2-directed pathogen responses

STAT2-directed pathogen responses

https://doi.org/10.18632/oncotarget.5266

Hans Bluyssen
28525-28526
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Cross-presentation of antigens by dendritic cells: role of autophagy

Cross-presentation of antigens by dendritic cells: role of autophagy

https://doi.org/10.18632/oncotarget.5268

Mrinmoy Das, Srini V. Kaveri,  and Jagadeesh ayry
28527-28528
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Protective CD8+ T cell memory without help

Protective CD8+ T cell memory without help

https://doi.org/10.18632/oncotarget.5449

Min Fang,  and Luis J. Sigal
28529-28530
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MCPIP: a key player in macrophage polarization

MCPIP: a key player in macrophage polarization

https://doi.org/10.18632/oncotarget.5451

Pappachan Kolattukudy
28531-28532
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Defensins versus pathogens: an unfolding story

Defensins versus pathogens: an unfolding story

https://doi.org/10.18632/oncotarget.5109

Elena Kudryashova, Wuyuan Lu,  and Dmitri S. Kudryashov
28533-28534
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Quelling an innate response to dsRNA

Quelling an innate response to dsRNA

https://doi.org/10.18632/oncotarget.5110

Kristen M. Ogden,  and B. V. Venkataram Prasad
28535-28536
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DNAM-1: would the real natural killer cell please stand up!

DNAM-1: would the real natural killer cell please stand up!

https://doi.org/10.18632/oncotarget.5952

Nicholas D. Huntington, Ludovic Martinet,  and Mark J. Smyth
28537-28538
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Research Papers: Immunology

A novel human truncated IL12rβ1-Fc fusion protein ameliorates experimental autoimmune encephalomyelitis via specific binding of p40 to inhibit Th1 and Th17 cell differentiation

A novel human truncated IL12rβ1-Fc fusion protein ameliorates experimental autoimmune encephalomyelitis via specific binding of p40 to inhibit Th1 and Th17 cell differentiation

https://doi.org/10.18632/oncotarget.5164

Wei Guo, Chen Wang, Xin Wang, Cheng Luo, Dongmei Yu, Yuheng Wang, Yucong Chen, Wen Lei, Xiangdong Gao,  and Wenbing Yao
28539-28555
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis

MicroRNA-146a constrains multiple parameters of intestinal immunity and increases susceptibility to DSS colitis

https://doi.org/10.18632/oncotarget.5597

Marah C. Runtsch, Ruozhen Hu, Margaret Alexander, Jared Wallace, Dominique Kagele, Charisse Petersen, John F. Valentine, Noah C. Welker, Mary P. Bronner, Xinjian Chen, Daniel P. Smith, Nadim J. Ajami, Joseph F. Petrosino, June L. Round,  and Ryan M. O’Connell
28556-28572
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of human mast cells by retrocyclin and protegrin highlight their immunomodulatory and antimicrobial properties

Activation of human mast cells by retrocyclin and protegrin highlight their immunomodulatory and antimicrobial properties

https://doi.org/10.18632/oncotarget.5611

Kshitij Gupta, Akhil Kotian, Hariharan Subramanian, Henry Daniell,  and Hydar Ali
28573-28587
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CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b–/– mice favoring autoimmune cholangitis

CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b–/– mice favoring autoimmune cholangitis

https://doi.org/10.18632/oncotarget.5665

Axel R. Concepcion, January T. Salas, Elena Sáez, Sarai Sarvide, Alex Ferrer, Ainhoa Portu, Iker Uriarte, Sandra Hervás-Stubbs, Ronald P.J. Oude Elferink, Jesús Prieto,  and Juan F. Medina
28588-28606
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nickel chloride (NiCl2)-caused inflammatory responses via activation of NF-κB pathway and reduction of anti-inflammatory mediator expression in the kidney

Nickel chloride (NiCl2)-caused inflammatory responses via activation of NF-κB pathway and reduction of anti-inflammatory mediator expression in the kidney

https://doi.org/10.18632/oncotarget.5759

Hongrui Guo, Huidan Deng, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Junliang Deng, Xun Wang, Bangyuan Wu,  and Kejie Chen
28607-28620
Abstract  |  PDF  |  HTML  |  Order a Reprint

PDGF upregulates CLEC-2 to induce T regulatory cells

PDGF upregulates CLEC-2 to induce T regulatory cells

https://doi.org/10.18632/oncotarget.5765

Sudhanshu Agrawal, Sreerupa Ganguly, Pega Hajian, Jia-Ning Cao,  and Anshu Agrawal
28621-28632
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Antigen-specific human NKT cells from tuberculosis patients produce IL-21 to help B cells for the production of immunoglobulins

Antigen-specific human NKT cells from tuberculosis patients produce IL-21 to help B cells for the production of immunoglobulins

https://doi.org/10.18632/oncotarget.5764

Changyou Wu, Zitao Li, Xiaoying Fu, Sifei Yu, Suihua Lao,  and Binyan Yang
28633-28645
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A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation

A genome wide transcriptional model of the complex response to pre-TCR signalling during thymocyte differentiation

https://doi.org/10.18632/oncotarget.5796

Hemant Sahni, Susan Ross, Alessandro Barbarulo, Anisha Solanki, Ching-In Lau, Anna Furmanski, José Ignacio Saldaña, Masahiro Ono, Mike Hubank, Martino Barenco,  and Tessa Cromp­ton
28646-28660
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Vanadium toxicity in the thymic development

Vanadium toxicity in the thymic development

https://doi.org/10.18632/oncotarget.5798

Wei Cui, Hongrui Guo,  and Hengmin Cui
28661-28677
Abstract  |  PDF  |  HTML  |  Order a Reprint

Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity

Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity

https://doi.org/10.18632/oncotarget.5212

Bernhard F. Gibbs, Isabel Gonçalves Silva, Alexandr Prokhorov, Maryam Abooali, Inna Yasinska, Maxwell A. Casely-Hayford, Steffen M. Berger, Elizaveta Fasler-Kan,  and Vadim Sumbayev
28678-28692
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reviews

Molecular and clinical profiles of syndecan-1 in solid and hematological cancer for prognosis and precision medicine

Molecular and clinical profiles of syndecan-1 in solid and hematological cancer for prognosis and precision medicine

https://doi.org/10.18632/oncotarget.4981

Mohamed R. Akl, Poonam Nagpal, Nehad M. Ayoub, Sathyen A. Prabhu, Matthew Gliksman, Betty Tai, Ahmet Hatipoglu, Andre Goy,  and K. Stephen Suh
28693-28715
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Timing and extent of response in colorectal cancer: critical review of current data and implication for future trials

Timing and extent of response in colorectal cancer: critical review of current data and implication for future trials

https://doi.org/10.18632/oncotarget.4747

Giuseppe Aprile, Caterina Fontanella, Marta Bonotto, Karim Rihawi, Stefania Eufemia Lutrino, Laura Ferrari, Mariaelena Casagrande, Elena Ongaro, Massimiliano Berretta, Antonio Avallone, Gerardo Rosati, Francesco Giuliani,  and Gianpiero Fasola
28716-28730
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Vav1: A Dr. Jekyll and Mr. Hyde protein – good for the hematopoietic system, bad for cancer

Vav1: A Dr. Jekyll and Mr. Hyde protein – good for the hematopoietic system, bad for cancer

https://doi.org/10.18632/oncotarget.5086

Shulamit Katzav
28731-28742
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers

Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients

Genetic interaction of P2X7 receptor and VEGFR-2 polymorphisms identifies a favorable prognostic profile in prostate cancer patients

https://doi.org/10.18632/oncotarget.4926

Anna Solini, Vittorio Simeon, Lisa Derosa, Paola Orlandi, Chiara Rossi, Andrea Fontana, Luca Galli, Teresa Di Desidero, Anna Fioravanti, Sara Lucchesi, Luigi Coltelli, Laura Ginocchi, Giacomo Allegrini, Romano Danesi, Alfredo Falcone,  and Guido Bocci
28743-28754
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Triple-layer dissection of the lung adenocarcinoma transcriptome – regulation at the gene, transcript, and exon levels

Triple-layer dissection of the lung adenocarcinoma transcriptome – regulation at the gene, transcript, and exon levels

https://doi.org/10.18632/oncotarget.4810

Min-Kung Hsu, I-Ching Wu, Ching-Chia Cheng, Jen-Liang Su, Chang-Huain Hsieh, Yeong-Shin Lin,  and Feng-Chi Chen
28755-28773
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

New therapeutic strategies in neuroblastoma: combined targeting of a novel tyrosine kinase inhibitor and liposomal siRNAs against ALK

New therapeutic strategies in neuroblastoma: combined targeting of a novel tyrosine kinase inhibitor and liposomal siRNAs against ALK

https://doi.org/10.18632/oncotarget.4342

Daniela Di Paolo, D. Yang, Fabio Pastorino, Laura Emionite, Michele Cilli, Antonio Daga, Elisa Destefanis, Annarita Di Fiore, Francesca Piaggio, Chiara Brignole, Xiaobao Xu, Chris Liang, James Gibbons, Mirco Ponzoni,  and Patrizia Perri
28774-28789
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The prognosis was poorer in colorectal cancers that expressed both VEGF and PROK1(No correlation coefficient between VEGF and PROK1)

The prognosis was poorer in colorectal cancers that expressed both VEGF and PROK1(No correlation coefficient between VEGF and PROK1)

https://doi.org/10.18632/oncotarget.4744

Takanori Goi, Toshiyuki Nakazawa, Yasuo Hirono,  and Akio Yamaguchi
28790-28799
Abstract  |  PDF  |  HTML  |  Order a Reprint

Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells

Primary tumor- and metastasis-derived colon cancer cells differently modulate connexin expression and function in human capillary endothelial cells

https://doi.org/10.18632/oncotarget.4894

Dominique Thuringer, Kevin Berthenet, Laurent Cronier, Eric Solary,  and Carmen Garrido
28800-28815
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation

FANCJ protein is important for the stability of FANCD2/FANCI proteins and protects them from proteasome and caspase-3 dependent degradation

https://doi.org/10.18632/oncotarget.5006

David W. Clark, Kaushlendra Tripathi, Josephine C. Dorsman,  and Komaraiah Palle
28816-28832
Abstract  |  PDF  |  HTML  |  Order a Reprint

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases

https://doi.org/10.18632/oncotarget.5008

Sebastian Drube, Franziska Weber, Christiane Göpfert, Romy Loschinski, Mandy Rothe, Franziska Boelke, Michaela A. Diamanti, Tobias Löhn, Julia Ruth, Dagmar Schütz, Norman Häfner, Florian R. Greten, Ralf Stumm, Karin Hartmann, Oliver H. Krämer, Anne Dudeck,  and Thomas Kamradt
28833-28850
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells

Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells

https://doi.org/10.18632/oncotarget.4767

Jen-Pi Tsai, Chien-Hsing Lee, Tsung-Ho Ying, Chu-Liang Lin, Chia-Liang Lin, Jung-Tsung Hsueh,  and Yi-Hsien Hsieh
28851-28866
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MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway

MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway

https://doi.org/10.18632/oncotarget.4814

Changjun He, Xuesong Dong, Bo Zhai, Xian Jiang, Deli Dong, Baoxin Li, Hongchi Jiang, Shidong Xu,  and Xueying Sun
28867-28881
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-1207 overexpression promotes cancer stem cell–like traits in ovarian cancer by activating the Wnt/β-catenin signaling pathway

MiR-1207 overexpression promotes cancer stem cell–like traits in ovarian cancer by activating the Wnt/β-catenin signaling pathway

https://doi.org/10.18632/oncotarget.4921

Geyan Wu, Aibin Liu, Jinrong Zhu, Fangyong Lei, Shu Wu, Xin Zhang, Liping Ye, Lixue Cao,  and Shanyang He
28882-28894
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1

PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1

https://doi.org/10.18632/oncotarget.5000

Chiara Giorgi, Aleksandar Boro, Florian Rechfeld, Laura A. Lopez-Garcia, Maria E. Gierisch, Beat W. Schäfer,  and Felix K. Niggli
28895-28910
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor

Rigorous optimization and validation of potent RNA CAR T cell therapy for the treatment of common epithelial cancers expressing folate receptor

https://doi.org/10.18632/oncotarget.5029

Keith Schutsky, De-Gang Song, Rachel Lynn, Jenessa B. Smith, Mathilde Poussin, Mariangela Figini, Yangbing Zhao,  and Daniel J. Powell Jr.
28911-28928
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification and characterization of RET fusions in advanced colorectal cancer

Identification and characterization of RET fusions in advanced colorectal cancer

https://doi.org/10.18632/oncotarget.4325

Anne-France Le Rolle, Samuel J. Klempner, Christopher R. Garrett, Tara Seery, Eric M. Sanford, Sohail Balasubramanian, Jeffrey S. Ross, Philip J. Stephens, Vincent A. Miller, Siraj M. Ali,  and Vi K. Chiu
28929-28937
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of 13-cis retinoic acid-induced gene expression of reactive-resistance genes by thalidomide in glioblastoma tumours in vivo

Inhibition of 13-cis retinoic acid-induced gene expression of reactive-resistance genes by thalidomide in glioblastoma tumours in vivo

https://doi.org/10.18632/oncotarget.4727

Dusan Milanovic, Carsten Sticht, Manuel Röhrich, Patrick Maier, Anca-L Grosu,  and Carsten Herskind
28938-28948
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of miR-200b promotes invasion via activating the Kindlin-2/integrin β1/AKT pathway in esophageal squamous cell carcinoma: An E-cadherin-independent mechanism

Loss of miR-200b promotes invasion via activating the Kindlin-2/integrin β1/AKT pathway in esophageal squamous cell carcinoma: An E-cadherin-independent mechanism

https://doi.org/10.18632/oncotarget.5027

Hai-Feng Zhang, Abdulraheem Alshareef, Chengsheng Wu, Shang Li, Ji-Wei Jiao, Hui-Hui Cao, Raymond Lai, Li-Yan Xu,  and En-Min Li
28949-28960
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis

Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis

https://doi.org/10.18632/oncotarget.5009

Zhengqi Wang, Magdalena Medrzycki, Silvia T. Bunting,  and Kevin D. Bunting
28961-28972
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metformin represses cancer cells via alternate pathways in N-cadherin expressing vs. N-cadherin deficient cells

Metformin represses cancer cells via alternate pathways in N-cadherin expressing vs. N-cadherin deficient cells

https://doi.org/10.18632/oncotarget.5023

Rongbin Ge, Zongwei Wang, Shulin Wu, Yangjia Zhuo, Aleksandar G. Otsetov, Chao Cai, Weide Zhong, Chin-Lee Wu,  and Aria F. Olumi
28973-28987
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Changes in the gene expression of co-cultured human fibroblast cells and osteosarcoma cells: the role of microenvironment

Changes in the gene expression of co-cultured human fibroblast cells and osteosarcoma cells: the role of microenvironment

https://doi.org/10.18632/oncotarget.4902

Viviana Salvatore, Stefano Focaroli, Gabrielli Teti, Antonio Mazzotti,  and Mirella Falconi
28988-28998
Abstract  |  PDF  |  HTML  |  Order a Reprint

A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme

A novel immune resistance mechanism of melanoma cells controlled by the ADAR1 enzyme

https://doi.org/10.18632/oncotarget.4905

Gilli Galore-Haskel, Yael Nemlich, Eyal Greenberg, Shira Ashkenazi, Motti Hakim, Orit Itzhaki, Noa Shoshani, Ronnie Shapira-Fromer, Eytan Ben-Ami, Efrat Ofek, Liat Anafi, Michal J. Besser, Jacob Schachter,  and Gal Markel
28999-29015
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients

Enhanced cell migration and apoptosis resistance may underlie the association between high SERPINE1 expression and poor outcome in head and neck carcinoma patients

https://doi.org/10.18632/oncotarget.5032

Miguel Angel Pavón, Irene Arroyo-Solera, Marta Téllez-Gabriel, Xavier León, David Virós, Montserrat López, Alberto Gallardo, Maria Virtudes Céspedes, Isolda Casanova, Antonio López-Pousa, Maria Antonia Mangues, Miquel Quer, Agustí Barnadas,  and Ramón Mangues
29016-29033
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IL-1β produced by aggressive breast cancer cells is one of the factors that dictate their interactions with mesenchymal stem cells through chemokine production

IL-1β produced by aggressive breast cancer cells is one of the factors that dictate their interactions with mesenchymal stem cells through chemokine production

https://doi.org/10.18632/oncotarget.4732

Pauline Escobar, Céline Bouclier, Julien Serret, Ivan Bièche, Madly Brigitte, Andres Caicedo, Elodie Sanchez, Sophie Vacher, Marie-Luce Vignais, Philippe Bourin, David Geneviève, Franck Molina, Christian Jorgensen,  and Gwendal Lazennec
29034-29047
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HBV preS2 promotes the expression of TAZ via miRNA-338-3p to enhance the tumorigenesis of hepatocellular carcinoma

HBV preS2 promotes the expression of TAZ via miRNA-338-3p to enhance the tumorigenesis of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4804

Peng Liu, Hualin Zhang, Xiaohong Liang, Hongxin Ma, Fang Luan, Bo Wang, Fuxiang Bai, Lifen Gao,  and Chunhong Ma
29048-29059
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition

TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition

https://doi.org/10.18632/oncotarget.5072

Samil Jung, Chengping Li, Jingjing Duan, Soonduck Lee, Kyeri Kim, Yeonji Park, Young Yang, Keun-Il Kim, Jong-Seok Lim, Chung-Il Cheon, Young-Sook Kang,  and Myeong-Sok Lee
29060-29075
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer

PDK1 induces JunB, EMT, cell migration and invasion in human gallbladder cancer

https://doi.org/10.18632/oncotarget.4931

Shixian Lian, Yebo Shao, Houbao Liu, Junyi He, Weiqi Lu, Yong Zhang, Ying Jiang,  and Jun Zhu
29076-29086
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer

Chromosomal catastrophe is a frequent event in clinically insignificant prostate cancer

https://doi.org/10.18632/oncotarget.4900

Irina V. Kovtun, Stephen J. Murphy, Sarah H. Johnson, John C. Cheville,  and George Vasmatzis
29087-29096
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Suppressor of cytokine signaling 1 gene mutation status as a prognostic biomarker in classical Hodgkin lymphoma

Suppressor of cytokine signaling 1 gene mutation status as a prognostic biomarker in classical Hodgkin lymphoma

https://doi.org/10.18632/oncotarget.4829

Jochen K. Lennerz, Karl Hoffmann, Anna-Maria Bubolz, Davor Lessel, Claudia Welke, Nele Rüther, Andreas Viardot,  and Peter Möller
29097-29110
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The importance of microenvironment: the role of CCL8 in metastasis formation of melanoma

The importance of microenvironment: the role of CCL8 in metastasis formation of melanoma

https://doi.org/10.18632/oncotarget.5059

Tamás Barbai, Zsuzsanna Fejős, Laszlo G. Puskas, József Tímár,  and Erzsébet Rásó
29111-29128
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miR-146b-5p functions as a tumor suppressor by targeting TRAF6 and predicts the prognosis of human gliomas

miR-146b-5p functions as a tumor suppressor by targeting TRAF6 and predicts the prognosis of human gliomas

https://doi.org/10.18632/oncotarget.4895

Jing Liu, Jinling Xu, Huining Li, Cuiyun Sun, Lin Yu, Yanyan Li, Cuijuan Shi, Xuexia Zhou, Xiuwu Bian, Yifang Ping, Yanjun Wen, Shujun Zhao, Hui Xu, Linlin Ren, Tongling An, Qian Wang,  and Shizhu Yu
29129-29142
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways

Global phosphotyrosine survey in triple-negative breast cancer reveals activation of multiple tyrosine kinase signaling pathways

https://doi.org/10.18632/oncotarget.5020

Xinyan Wu, Muhammad Saddiq Zahari, Binyun Ma, Ren Liu, Santosh Renuse, Nandini A. Sahasrabuddhe, Lily Chen, Raghothama Chaerkady, Min-Sik Kim, Jun Zhong, Christine Jelinek, Mustafa A. Bharbuiya, Pamela Leal-Rojas, Yi Yang, Manoj Kumar Kashyap, Arivusudar Marimuthu, Min Ling, Mary Jo Fackler, Vanessa Merino, Zhen Zhang, Cynthia A. Zahnow, Edward Gabrielson, Vered Stearns, Juan Carlos Roa, Saraswati Sukumar, Parkash S. Gill,  and Akhilesh Pandey
29143-29160
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chitosan nanoparticle-mediated delivery of miRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy

Chitosan nanoparticle-mediated delivery of miRNA-34a decreases prostate tumor growth in the bone and its expression induces non-canonical autophagy

https://doi.org/10.18632/oncotarget.4971

Sanchaika Gaur, Yunfei Wen, Jian H. Song, Nila U. Parikh, Lingegowda S. Mangala, Alicia M. Blessing, Cristina Ivan, Sherry Y. Wu, Andreas Varkaris, Yan Shi, Gabriel Lopez-Berestein, Daniel E. Frigo, Anil K. Sood,  and Gary E. Gallick
29161-29177
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Colorectal cancer-promoting activity of the senescent peritoneal mesothelium

Colorectal cancer-promoting activity of the senescent peritoneal mesothelium

https://doi.org/10.18632/oncotarget.4932

Justyna Mikuła-Pietrasik, Patrycja Sosińska, Konstantin Maksin, Małgorzata Kucińska, Hanna Piotrowska, Marek Murias, Aldona Woźniak, Dariusz Szpurek,  and Krzysztof Książek
29178-29195
Abstract  |  PDF  |  HTML  |  Order a Reprint

Up-regulation of human cervical cancer proto-oncogene contributes to hepatitis B virus-induced malignant transformation of hepatocyte by down-regulating E-cadherin

Up-regulation of human cervical cancer proto-oncogene contributes to hepatitis B virus-induced malignant transformation of hepatocyte by down-regulating E-cadherin

https://doi.org/10.18632/oncotarget.5039

Junfeng Li, Xiaopeng Dai, Hongfei Zhang, Wei Zhang, Shihui Sun, Tongtong Gao, Zhihua Kou, Hong Yu, Yan Guo, Lanying Du, Shibo Jiang, Jianying Zhang,  and Yusen Zhou
29196-29208
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b

H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b

https://doi.org/10.18632/oncotarget.4976

Constance Vennin, Nathalie Spruyt, Fatima Dahmani, Sylvain Julien, François Bertucci, Pascal Finetti, Thierry Chassat, Roland P. Bourette, Xuefen Le Bourhis,  and Eric Adriaenssens
29209-29223
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-155, identified as anti-metastatic by global miRNA profiling of a metastasis model, inhibits cancer cell extravasation and colonization in vivo and causes significant signaling alterations

miR-155, identified as anti-metastatic by global miRNA profiling of a metastasis model, inhibits cancer cell extravasation and colonization in vivo and causes significant signaling alterations

https://doi.org/10.18632/oncotarget.4942

Karina G. Thomsen, Mikkel G. Terp, Rikke R. Lund, Rolf Søkilde, Daniel Elias, Martin Bak, Thomas Litman, Hans C. Beck, Maria B. Lyng,  and Henrik J. Ditzel
29224-29239
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TEL2 suppresses metastasis by down-regulating SERPINE1 in nasopharyngeal carcinoma

TEL2 suppresses metastasis by down-regulating SERPINE1 in nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.5074

Yi Sang, Ming-yuan Chen, Donghua Luo, Ru-Hua Zhang, Li Wang, Mei Li, Rongzhen Luo, Chao-Nan Qian, Jian-Yong Shao, Yi-Xin Zeng,  and Tiebang Kang
29240-29253
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The metastatic infiltration at the metastasis/brain parenchyma-interface is very heterogeneous and has a significant impact on survival in a prospective study

The metastatic infiltration at the metastasis/brain parenchyma-interface is very heterogeneous and has a significant impact on survival in a prospective study

https://doi.org/10.18632/oncotarget.4201

Laila Siam, Annalen Bleckmann, Han-Ning Chaung, Alexander Mohr, Florian Klemm, Alonso Barrantes-Freer, Raquel Blazquez, Hendrik A. Wolff, Florian Lüke, Veit Rohde, Christine Stadelmann,  and Tobias Pukrop
29254-29267
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dynamic cellular and molecular modulations of diabetes mediated head and neck carcinogenesis

Dynamic cellular and molecular modulations of diabetes mediated head and neck carcinogenesis

https://doi.org/10.18632/oncotarget.4922

Chung-Ji Liu, Wan-Jung Chang, Chang-Yi Chen, Fang-Ju Sun, Hui-Wen Cheng, Tsai-Ying Chen, Shu-Chun Lin,  and Wan-Chun Li
29268-29284
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A five-miRNA signature with prognostic and predictive value for MGMT promoter-methylated glioblastoma patients

A five-miRNA signature with prognostic and predictive value for MGMT promoter-methylated glioblastoma patients

https://doi.org/10.18632/oncotarget.4978

Wen Cheng, Xiufang Ren, Jinquan Cai, Chuanbao Zhang, Mingyang Li, Kuanyu Wang, Yang Liu, Sheng Han,  and Anhua Wu
29285-29295
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High throughput screening of cytokines, chemokines and matrix metalloproteinases in wound fluid induced by mammary surgery

High throughput screening of cytokines, chemokines and matrix metalloproteinases in wound fluid induced by mammary surgery

https://doi.org/10.18632/oncotarget.4828

Dan Wang, Kebang Hu, Ningning Gao, Hao Zhang, Yanlin Jiang, Caigang Liu, Shouyu Wang,  and Zuowei Zhao
29296-29310
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Effect of latent membrane protein 1 expression on overall survival in Epstein-Barr virus-associated cancers: a literature-based meta-analysis

Effect of latent membrane protein 1 expression on overall survival in Epstein-Barr virus-associated cancers: a literature-based meta-analysis

https://doi.org/10.18632/oncotarget.4906

Yu-Pei Chen, Wen-Na Zhang, Lei Chen, Ling-Long Tang, Yan-Ping Mao, Wen-Fei Li, Xu Liu, Guan-Qun Zhou, Ying Sun, Tie-Bang Kang, Mu-Sheng Zeng, Na Liu,  and Jun Ma
29311-29323
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification and characterization of ANO9 in stage II and III colorectal carcinoma

Identification and characterization of ANO9 in stage II and III colorectal carcinoma

https://doi.org/10.18632/oncotarget.4979

Chunxiang Li, Sanjun Cai, Xishan Wang,  and Zheng Jiang
29324-29334
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inactivation of M2 AChR/NF-κB signaling axis reverses epithelial-mesenchymal transition (EMT) and suppresses migration and invasion in non-small cell lung cancer (NSCLC)

Inactivation of M2 AChR/NF-κB signaling axis reverses epithelial-mesenchymal transition (EMT) and suppresses migration and invasion in non-small cell lung cancer (NSCLC)

https://doi.org/10.18632/oncotarget.5004

Qingnan Zhao, Jinnan Yue, Chun Zhang, Xiajing Gu, Hongzhuan Chen,  and Lu Xu
29335-29346
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A method for predicting target drug efficiency in cancer based on the analysis of signaling pathway activation

A method for predicting target drug efficiency in cancer based on the analysis of signaling pathway activation

https://doi.org/10.18632/oncotarget.5119

Artem Artemov, Alexander Aliper, Michael Korzinkin, Ksenia Lezhnina, Leslie Jellen, Nikolay Zhukov, Sergey Roumiantsev, Nurshat Gaifullin, Alex Zhavoronkov, Nicolas Borisov,  and Anton Buzdin
29347-29356
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Positive feedback loop of hepatoma-derived growth factor and β-catenin promotes carcinogenesis of colorectal cancer

Positive feedback loop of hepatoma-derived growth factor and β-catenin promotes carcinogenesis of colorectal cancer

https://doi.org/10.18632/oncotarget.4982

Jiayan Lian, Jianming Tang, Huijuan Shi, Hui Li, Tiantian Zhen, Wenlin Xie, Fenfen Zhang, Yang Yang,  and Anjia Han
29357-29374
Abstract  |  PDF  |  HTML  |  Order a Reprint

Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma

Hexokinase and phosphofructokinase activity and intracellular distribution correlate with aggressiveness and invasiveness of human breast carcinoma

https://doi.org/10.18632/oncotarget.4910

Raquel G. Coelho, Isadora C. Calaça, Deborah M. Celestrini, Ana Helena P. Correia-Carneiro, Mauricio M. Costa, Patricia Zancan,  and Mauro Sola-Penna
29375-29387
Abstract  |  PDF  |  HTML  |  Order a Reprint

18F-fluorodeoxyglucose (FDG) PET/CT after two cycles of neoadjuvant therapy may predict response in HER2-negative, but not in HER2-positive breast cancer

18F-fluorodeoxyglucose (FDG) PET/CT after two cycles of neoadjuvant therapy may predict response in HER2-negative, but not in HER2-positive breast cancer

https://doi.org/10.18632/oncotarget.5001

Jingyi Cheng, Yujie Wang, Miao Mo, Xiao Bao, Yingjian Zhang, Guangyu Liu, Jun Zhang,  and Daoying Geng
29388-29395
Abstract  |  PDF  |  HTML  |  Order a Reprint

Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer

Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer

https://doi.org/10.18632/oncotarget.5120

Lakshmi Prabhu, Rasika Mundade, Benlian Wang, Han Wei, Antja-Voy Hartley, Matthew Martin, Kyle McElyea, Constance J. Temm, George Sandusky, Yunlong Liu,  and Tao Lu
29396-29412
Abstract  |  PDF  |  HTML  |  Order a Reprint

The PTTG1-targeting miRNAs miR-329, miR-300, miR-381, and miR-655 inhibit pituitary tumor cell tumorigenesis and are involved in a p53/PTTG1 regulation feedback loop

The PTTG1-targeting miRNAs miR-329, miR-300, miR-381, and miR-655 inhibit pituitary tumor cell tumorigenesis and are involved in a p53/PTTG1 regulation feedback loop

https://doi.org/10.18632/oncotarget.5003

Hai-qian Liang, Ren-jie Wang, Cai-feng Diao, Jian-wei Li, Jing-liang Su,  and Sai Zhang
29413-29427
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Exposure to airborne PM2.5 suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells

Exposure to airborne PM2.5 suppresses microRNA expression and deregulates target oncogenes that cause neoplastic transformation in NIH3T3 cells

https://doi.org/10.18632/oncotarget.5005

Chunling Liu, Huan Guo, Xinxin Cheng, Mingming Shao, Chen Wu, Suhan Wang, Hongmin Li, Lixuan Wei, Yanning Gao, Wen Tan, Shujun Cheng, Tangchun Wu, Dianke Yu,  and Dongxin Lin
29428-29439
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TRAIL-mediated killing of acute lymphoblastic leukemia by plasmacytoid dendritic cell-activated natural killer cells

TRAIL-mediated killing of acute lymphoblastic leukemia by plasmacytoid dendritic cell-activated natural killer cells

https://doi.org/10.18632/oncotarget.4984

Martin Lelaidier, Yildian Dìaz-Rodriguez, Martine Cordeau, Paulo Cordeiro, Elie Haddad, Sabine Herblot,  and Michel Duval
29440-29455
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of DNA-repair genes Ercc1 and Mgmt enhances temozolomide efficacy in gliomas treatment: a pre-clinical study

Inhibition of DNA-repair genes Ercc1 and Mgmt enhances temozolomide efficacy in gliomas treatment: a pre-clinical study

https://doi.org/10.18632/oncotarget.4909

Sandra G. Boccard, Sandie V. Marand, Sandra Geraci, Laurie Pycroft, François R. Berger,  and Laurent A. Pelletier
29456-29468
Abstract  |  PDF  |  HTML  |  Order a Reprint

Characterization of the metastatic phenotype of a panel of established osteosarcoma cells

Characterization of the metastatic phenotype of a panel of established osteosarcoma cells

https://doi.org/10.18632/oncotarget.5177

Ling Ren, Arnulfo Mendoza, Jack Zhu, Joseph W. Briggs, Charles Halsey, Ellen S. Hong, Sandra S. Burkett, James J. Morrow, Michael M. Lizardo, Tanasa Osborne, Samuel Q. Li, Hue H. Luu, Paul Meltzer,  and Chand Khanna
29469-29481
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of autophagy potentiates pemetrexed and simvastatin-induced apoptotic cell death in malignant mesothelioma and non-small cell lung cancer cells

Inhibition of autophagy potentiates pemetrexed and simvastatin-induced apoptotic cell death in malignant mesothelioma and non-small cell lung cancer cells

https://doi.org/10.18632/oncotarget.5022

Ki-Eun Hwang, Young-Suk Kim, Jae-Wan Jung, Su-Jin Kwon, Do-Sim Park, Byong-Ki Cha, Seon-Hee Oh, Kwon-Ha Yoon, Eun-Taik Jeong,  and Hak-Ryul Kim
29482-29496
Abstract  |  PDF  |  HTML  |  Order a Reprint

Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activatio

Deoxypodophyllotoxin suppresses tumor vasculature in HUVECs by promoting cytoskeleton remodeling through LKB1-AMPK dependent Rho A activatio

https://doi.org/10.18632/oncotarget.4985

Yurong Wang, Bin Wang, Mounia Guerram, Li Sun, Wei Shi, Chongchong Tian, Xiong Zhu, Zhenzhou Jiang,  and Luyong Zhang
29497-29512
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dietary prevention of Helicobacter pylori-associated gastric cancer with kimchi

Dietary prevention of Helicobacter pylori-associated gastric cancer with kimchi

https://doi.org/10.18632/oncotarget.4897

Migyeong Jeong, Jong-Min Park, Young-Min Han, Kun Young Park, Don Haeng Lee, Joon-Hwan Yoo, Joo Young Cho,  and Ki-Baik Hahm
29513-29526
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1

MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1

https://doi.org/10.18632/oncotarget.5012

Jing-Jun Yan, Yu-Nan Zhang, Jia-Zhi Liao, Kun-peng Ke, Ying Chang, Pei-Yuan Li, Min Wang, Ju-Sheng Lin,  and Xing-Xing He
29527-29542
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression

Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression

https://doi.org/10.18632/oncotarget.4911

Marisa Granato, Maria Saveria Gilardini Montani, Maria Rosaria Filardi, Alberto Faggioni,  and Mara Cirone
29543-29554
Abstract  |  PDF  |  HTML  |  Order a Reprint

Methylomics analysis identifies ZNF671 as an epigenetically repressed novel tumor suppressor and a potential non-invasive biomarker for the detection of urothelial carcinoma

Methylomics analysis identifies ZNF671 as an epigenetically repressed novel tumor suppressor and a potential non-invasive biomarker for the detection of urothelial carcinoma

https://doi.org/10.18632/oncotarget.4986

Chia-Ming Yeh, Pi-Che Chen, Hsiao-Yen Hsieh, Yeong-Chin Jou, Chang-Te Lin, Ming-Hsuan Tsai, Wen-Yu Huang, Yi-Ting Wang, Ru-Inn Lin, Szu-Shan Ch, Chun-Liang Tung, Shu-Fen Wu, De-Ching Chang, Cheng-Huang Shen, Cheng-Da Hsu,  and Michael W.Y. Chan
29555-29572
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Stathmin 1 inhibition amplifies ruxolitinib-induced apoptosis in JAK2V617F cells

Stathmin 1 inhibition amplifies ruxolitinib-induced apoptosis in JAK2V617F cells

https://doi.org/10.18632/oncotarget.4998

João Agostinho Machado-Neto, Paula de Melo Campos, Patricia Favaro, Mariana Lazarini, Adriana da Silva Santos Duarte, Irene Lorand-Metze, Fernando Ferreira Costa, Sara Teresinha Olalla Saad,  and Fabiola Traina
29573-29584
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

S100P interacts with integrin α7 and increases cancer cell migration and invasion in lung cancer

S100P interacts with integrin α7 and increases cancer cell migration and invasion in lung cancer

https://doi.org/10.18632/oncotarget.4987

Ya-Ling Hsu, Jen-Yu Hung, Yung-Yu Liang, Yi-Shiuan Lin, Ming-Ju Tsai, Shah-Hwa Chou, Chi-Yu Lu,  and Po-Lin Kuo
29585-29598
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis

A conserved RAD6-MDM2 ubiquitin ligase machinery targets histone chaperone ASF1A in tumorigenesis

https://doi.org/10.18632/oncotarget.5011

Chen Wang, Jian-Feng Chang, Hongli Yan, Da-Liang Wang, Yan Liu, Yuanya Jing, Meng Zhang, Yu-Long Men, Dongdong Lu, Xiao-Mei Yang, Su Chen,  and Fang-Lin Sun
29599-29613
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto C/Ca2+/MICU1 dependent mitochondrial signaling

RPS3 regulates melanoma cell growth and apoptosis by targeting Cyto C/Ca2+/MICU1 dependent mitochondrial signaling

https://doi.org/10.18632/oncotarget.4868

Yun Tian, Lijun Qin, Huijuan Qiu, Dingbo Shi, Rui Sun, Wenbing Li, Tianze Liu, Jingshu Wang, Tingting Xu, Wei Guo, Tiebang Kang, Wenlin Huang, Guowen Wang,  and Wuguo Deng
29614-29625
Abstract  |  PDF  |  HTML  |  Order a Reprint

CAVEOLIN-1 expression in brain metastasis from lung cancer predicts worse outcome and radioresistance, irrespective of tumor histotype

CAVEOLIN-1 expression in brain metastasis from lung cancer predicts worse outcome and radioresistance, irrespective of tumor histotype

https://doi.org/10.18632/oncotarget.4988

Eleonora Duregon, Rebecca Senetta, Alessandra Pittaro, Ludovica Verdun di Cantogno, Giulia Stella, Pierpaolo De Blasi, Michele Zorzetto, Cristina Mantovani, Mauro Papotti,  and Paola Cassoni
29626-29636
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cyclooxygenase-2 in tumor-associated macrophages promotes breast cancer cell survival by triggering a positive-feedback loop between macrophages and cancer cells

Cyclooxygenase-2 in tumor-associated macrophages promotes breast cancer cell survival by triggering a positive-feedback loop between macrophages and cancer cells

https://doi.org/10.18632/oncotarget.4936

Hongzhong Li, Bing Yang, Jing Huang, Yong Lin, Tingxiu Xiang, Jingyuan Wan, Hongyuan Li, Salem Chouaib,  and Guosheng Ren
29637-29650
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulation and functional significance of CDC42 alternative splicing in ovarian cancer

Regulation and functional significance of CDC42 alternative splicing in ovarian cancer

https://doi.org/10.18632/oncotarget.4865

Xiaolong He, Chengfu Yuan,  and Jilai Yang
29651-29663
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anti-angiogenic efficacy of 5′-triphosphate siRNA combining VEGF silencing and RIG-I activation in NSCLCs

Anti-angiogenic efficacy of 5′-triphosphate siRNA combining VEGF silencing and RIG-I activation in NSCLCs

https://doi.org/10.18632/oncotarget.4869

Dongmei Yuan, Mao Xia, Gang Meng, Chun Xu, Yong Song,  and Jiwu Wei
29664-29674
Abstract  |  PDF  |  HTML  |  Order a Reprint

CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion

CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion

https://doi.org/10.18632/oncotarget.4896

Pengcheng Zhou, Sonia Erfani, Zeyi Liu, Changhe Jia, Yecang Chen, Bingwei Xu, Xinyu Deng, Jose E. Alfáro, Li Chen, Dana Napier, Michael Lu, Jian-An Huang, Chunming Liu, Olivier Thibault, Rosalind Segal, Binhua P. Zhou, Natasha Kyprianou, Craig Horbinski,  and Xiuwei H. Yang
29675-29693
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types

Differential targeting of the cyclin-dependent kinase inhibitor, p21CIP1/WAF1, by chelators with anti-proliferative activity in a range of tumor cell-types

https://doi.org/10.18632/oncotarget.5088

Rayan S. Moussa, Zaklina Kovacevic,  and Des R. Richardson
29694-29711
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heat shock factor 1, an inhibitor of non-homologous end joining repair

Heat shock factor 1, an inhibitor of non-homologous end joining repair

https://doi.org/10.18632/oncotarget.5073

Ga-Young Kang, Eun-Ho Kim, Hae-June Lee, Na-Yeon Gil, Hyuk-Jin Cha,  and Yun-Sil Lee
29712-29724
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

https://doi.org/10.18632/oncotarget.5065

Richard D.A. Wilkinson, Sinead M. Magorrian, Rich Williams, Andrew Young, Donna M. Small, Christopher J. Scott,  and Roberta E. Burden
29725-29739
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma

The phosphorylation status of VASP at serine 322 can be predictive for aggressiveness of invasive ductal carcinoma

https://doi.org/10.18632/oncotarget.4965

Heike Döppler, Ligia Bastea, Sahra Borges, Xochiquetzal Geiger,  and Peter Storz
29740-29752
Abstract  |  PDF  |  HTML  |  Order a Reprint

The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells

The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells

https://doi.org/10.18632/oncotarget.4995

Artur Cieślar-Pobuda, Mayur Vilas Jain, Gunnar Kratz, Joanna Rzeszowska-Wolny, Saeid Ghavami,  and Emilia Wiechec
29753-29770
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H2O2 generation: antagonism by tetrathiomolybdate

Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H2O2 generation: antagonism by tetrathiomolybdate

https://doi.org/10.18632/oncotarget.4833

Ali Calderon-Aparicio, Mary Strasberg-Rieber,  and Manuel Rieber
29771-29781
Abstract  |  PDF  |  HTML  |  Order a Reprint

FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer

FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer

https://doi.org/10.18632/oncotarget.4927

Dominic Jones, Mark Wade, Sirintra Nakjang, Lewis Chaytor, James Grey, Craig N. Robson,  and Luke Gaughan
29782-29794
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Aberrant reduction of telomere repetitive sequences in plasma cell-free DNA for early breast cancer detection

Aberrant reduction of telomere repetitive sequences in plasma cell-free DNA for early breast cancer detection

https://doi.org/10.18632/oncotarget.5083

Xi Wu,  and Hiromi Tanaka
29795-29807
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Double autophagy modulators reduce 2-deoxyglucose uptake in sarcoma patients

Double autophagy modulators reduce 2-deoxyglucose uptake in sarcoma patients

https://doi.org/10.18632/oncotarget.5060

Mau-Shin Chi, Cheng-Yen Lee, Su-Chen Huang, Kai-Lin Yang, Hui-Ling Ko, Yen-Kung Chen, Chen-Han Chung, Kuang-Wen Liao,  and Kwan-Hwa Chi
29808-29817
Abstract  |  PDF  |  HTML  |  Order a Reprint

Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans

Age-related obesity and type 2 diabetes dysregulate neuronal associated genes and proteins in humans

https://doi.org/10.18632/oncotarget.4904

Mehran Rahimi, Manlio Vinciguerra, Mojtaba Daghigh, Behiye Özcan, Vishtaseb Akbarkhanzadeh, Fareeba Sheedfar, Marzyeh Amini, Tommaso Mazza, Valerio Pazienza, Mahdi. M. Motazacker, Morteza Mahmoudi, Felix W.M. De Rooij, Eric Sijbrands, Maikel P. Peppelenbosch,  and Farhad Rezaee
29818-29832
Abstract  |  PDF  |  HTML  |  Order a Reprint

Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells

Simvastatin and downstream inhibitors circumvent constitutive and stromal cell-induced resistance to doxorubicin in IGHV unmutated CLL cells

https://doi.org/10.18632/oncotarget.4006

Micol Rigoni, Chiara Riganti, Candida Vitale, Valentina Griggio, Ivana Campia, Marta Robino, Myriam Foglietta, Barbara Castella, Patrizia Sciancalepore, Ilaria Buondonno, Daniela Drandi, Marco Ladetto, Mario Boccadoro, Massimo Massaia,  and Marta Coscia
29833-29846
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NDRG1 promotes growth of hepatocellular carcinoma cells by directly interacting with GSK-3β and Nur77 to prevent β-catenin degradation

NDRG1 promotes growth of hepatocellular carcinoma cells by directly interacting with GSK-3β and Nur77 to prevent β-catenin degradation

https://doi.org/10.18632/oncotarget.4913

Wen-Jing Lu, Mei-Sze Chua, Wei Wei,  and Samuel K. So
29847-29859
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ELK1 is up-regulated by androgen in bladder cancer cells and promotes tumor progression

ELK1 is up-regulated by androgen in bladder cancer cells and promotes tumor progression

https://doi.org/10.18632/oncotarget.5007

Takashi Kawahara, Hasanain Khaleel Shareef, Ali Kadhim Aljarah, Hiroki Ide, Yi Li, Eiji Kashiwagi, George J. Netto, Yichun Zheng,  and Hiroshi Miyamoto
29860-29876
Abstract  |  PDF  |  HTML  |  Order a Reprint

Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p

Pancreatic cancer-derived exosomes transfer miRNAs to dendritic cells and inhibit RFXAP expression via miR-212-3p

https://doi.org/10.18632/oncotarget.4924

Guoping Ding, Liangjing Zhou, Yingming Qian, Mingnian Fu, Jian Chen, Jionghuang Chen, Jianyang Xiang, Zhengrong Wu, Guixing Jiang,  and Liping Cao
29877-29888
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pretreatment with VEGF(R)-inhibitors reduces interstitial fluid pressure, increases intraperitoneal chemotherapy drug penetration, and impedes tumor growth in a mouse colorectal carcinomatosis model

Pretreatment with VEGF(R)-inhibitors reduces interstitial fluid pressure, increases intraperitoneal chemotherapy drug penetration, and impedes tumor growth in a mouse colorectal carcinomatosis model

https://doi.org/10.18632/oncotarget.5092

Félix Gremonprez, Benedicte Descamps, Andrei Izmer, Christian Vanhove, Frank Vanhaecke, Olivier De Wever,  and Wim Ceelen
29889-29900
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3

NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3

https://doi.org/10.18632/oncotarget.4898

Min Xie, Farhad Vesuna, Mahendran Botlagunta, Guus Martinus Bol, Ashley Irving, Yehudit Bergman, Ramachandra S Hosmane, Yoshinori Kato, Paul T Winnard Jr.,  and Venu Raman
29901-29913
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype

https://doi.org/10.18632/oncotarget.4939

Camilla Pellegrini, Marta Columbaro, Cristina Capanni, Maria Rosaria D’Apice, Carola Cavallo, Michela Murdocca, Giovanna Lattanzi,  and Stefano Squarzoni
29914-29928
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Stroma derived COL6A3 is a potential prognosis marker of colorectal carcinoma revealed by quantitative proteomics

Stroma derived COL6A3 is a potential prognosis marker of colorectal carcinoma revealed by quantitative proteomics

https://doi.org/10.18632/oncotarget.4966

Jie Qiao, Cai-Yun Fang, Sun-Xia Chen, Xiao-Qing Wang, Shu-Jian Cui, Xiao-Hui Liu, Ying-Hua Jiang, Jie Wang, Yang Zhang, Peng-Yuan Yang,  and Feng Liu
29929-29946
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Honokiol activates LKB1-miR-34a axis and antagonizes the oncogenic actions of leptin in breast cancer

Honokiol activates LKB1-miR-34a axis and antagonizes the oncogenic actions of leptin in breast cancer

https://doi.org/10.18632/oncotarget.4937

Dimiter B. Avtanski, Arumugam Nagalingam, Michael Y. Bonner, Jack L. Arbiser, Neeraj K. Saxena,  and Dipali Sharma
29947-29962
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent

Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent

https://doi.org/10.18632/oncotarget.4676

Carole Sourbier, Bradley T. Scroggins, Philip Z. Mannes, Pei-Jyun Liao, Karsten Siems, Dietmar Wolf, John A. Beutler, W. Marston Linehan,  and Leonard Neckers
29963-29974
Abstract  |  PDF  |  HTML  |  Order a Reprint

Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors

Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors

https://doi.org/10.18632/oncotarget.5034

Seiko Kamimae, Eiichiro Yamamoto, Masahiro Kai, Takeshi Niinuma, Hiro-o Yamano, Masanori Nojima, Kennjiro Yoshikawa, Tomoaki Kimura, Ryo Takagi, Eiji Harada, Taku Harada, Reo Maruyama, Yasushi Sasaki, Takashi Tokino, Yasuhisa Shinomura, Tamotsu Sugai, Kohzoh Imai,  and Hiromu Suzuki
29975-29990
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma

Combinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma

https://doi.org/10.18632/oncotarget.5031

Kian Ngiap Chua, Li Ren Kong, Wen Jing Sim, Hsien Chun Ng, Weijie Richard Ong, Jean Paul Thiery, Hung Huynh,  and Boon Cher Goh
29991-30005
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-146b-5p mediates p16-dependent repression of IL-6 and suppresses paracrine procarcinogenic effects of breast stromal fibroblasts

miR-146b-5p mediates p16-dependent repression of IL-6 and suppresses paracrine procarcinogenic effects of breast stromal fibroblasts

https://doi.org/10.18632/oncotarget.4933

Mysoon M. Al-Ansari,  and Abdelilah Aboussekhra
30006-30016
Abstract  |  PDF  |  HTML  |  Order a Reprint

Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution

Bax-PGAM5L-Drp1 complex is required for intrinsic apoptosis execution

https://doi.org/10.18632/oncotarget.5013

Wenjuan Xu, Linlin Jing, Quanshi Wang, Chung-Chih Lin, Xiaoting Chen, Jianxin Diao, Yuanliang Liu,  and Xuegang Sun
30017-30034
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention

Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention

https://doi.org/10.18632/oncotarget.5046

Malin Åkerfelt, Neslihan Bayramoglu, Sean Robinson, Mervi Toriseva, Hannu-Pekka Schukov, Ville Härmä, Johannes Virtanen, Raija Sormunen, Mika Kaakinen, Juho Kannala, Lauri Eklund, Janne Heikkilä,  and Matthias Nees
30035-30056
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of therapeutic targets in ovarian cancer through active tyrosine kinase profiling

Identification of therapeutic targets in ovarian cancer through active tyrosine kinase profiling

https://doi.org/10.18632/oncotarget.4996

Juan Carlos Montero, Sara García-Alonso, Alberto Ocaña,  and Atanasio Pandiella
30057-30071
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Base excision repair-mediated resistance to cisplatin in KRAS(G12C) mutant NSCLC cells

Base excision repair-mediated resistance to cisplatin in KRAS(G12C) mutant NSCLC cells

https://doi.org/10.18632/oncotarget.5019

Elisa Caiola, Daniela Salles, Roberta Frapolli, Monica Lupi, Giuseppe Rotella, Anna Ronchi, Marina Chiara Garassino, Nikola Mattschas, Stefano Colavecchio, Massimo Broggini, Lisa Wiesmüller,  and Mirko Marabese
30072-30087
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The HGF inhibitory peptide HGP-1 displays promising in vitro and in vivo efficacy for targeted cancer therapy

The HGF inhibitory peptide HGP-1 displays promising in vitro and in vivo efficacy for targeted cancer therapy

https://doi.org/10.18632/oncotarget.3937

Lisha Chen, Chunlin Li,  and Yimin Zhu
30088-30101
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death

Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death

https://doi.org/10.18632/oncotarget.4945

Daniela Catanzaro, Edoardo Gaude, Genny Orso, Carla Giordano, Giulia Guzzo, Andrea Rasola, Eugenio Ragazzi, Laura Caparrotta, Christian Frezza,  and Monica Montopoli
30102-30114
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dissecting the contribution of EBNA3C domains important for EBV-induced B-cell growth and proliferation

Dissecting the contribution of EBNA3C domains important for EBV-induced B-cell growth and proliferation

https://doi.org/10.18632/oncotarget.5002

Hem Chandra Jha, Sanket Kumar Shukla, Jie Lu, Mahadesh Prasad Aj, Shuvomoy Banerjee,  and Erle S. Robertson
30115-30129
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition

Vaccinia-related kinase 1 promotes hepatocellular carcinoma by controlling the levels of cell cycle regulators associated with G1/S transition

https://doi.org/10.18632/oncotarget.4967

Namgyu Lee, Jung-Hee Kwon, Young Bae Kim, Seong-Hoon Kim, Sung Jin Park, Weiguang Xu, Hoe-Yune Jung, Kyong-Tai Kim, Hee Jung Wang,  and Kwan Yong Choi
30130-30148
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting autophagy enhances the anti-tumoral action of crizotinib in ALK-positive anaplastic large cell lymphoma

Targeting autophagy enhances the anti-tumoral action of crizotinib in ALK-positive anaplastic large cell lymphoma

https://doi.org/10.18632/oncotarget.4999

Géraldine Mitou, Julie Frentzel, Aurore Desquesnes, Sophie Le Gonidec, Talal AlSaati, Isabelle Beau, Laurence Lamant, Fabienne Meggetto, Estelle Espinos, Patrice Codogno, Pierre Brousset,  and Sylvie Giuriato
30149-30164
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RASSF8 regulates progression of cutaneous melanoma through nuclear factor-κb

RASSF8 regulates progression of cutaneous melanoma through nuclear factor-κb

https://doi.org/10.18632/oncotarget.5030

Jinhua Wang, Wei Hua, Sharon K. Huang, Kun Fan, Ling Takeshima, Ying Mao,  and Dave S.B. Hoon
30165-30177
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma

https://doi.org/10.18632/oncotarget.4903

Alyssa L. Kennedy, Mounica Vallurupalli, Liying Chen, Brian Crompton, Glenn Cowley, Francisca Vazquez, Barbara A. Weir, Aviad Tsherniak, Sudha Parasuraman, Sunkyu Kim, Gabriela Alexe,  and Kimberly Stegmaier
30178-30193
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors

Membrane associated cancer-oocyte neoantigen SAS1B/ovastacin is a candidate immunotherapeutic target for uterine tumors

https://doi.org/10.18632/oncotarget.4734

Eusebio S Pires, Ryan S D’Souza, Marisa A Needham, Austin K Herr, Amir A Jazaeri, Hui Li, Mark H Stoler, Kiley L Anderson-Knapp, Theodore Thomas, Arabinda Mandal, Alain Gougeon, Charles J Flickinger, David E Bruns, Brian A Pollok,  and John C Herr
30194-30211
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical impact of CD200 expression in patients with acute myeloid leukemia and correlation with other molecular prognostic factors

Clinical impact of CD200 expression in patients with acute myeloid leukemia and correlation with other molecular prognostic factors

https://doi.org/10.18632/oncotarget.4901

Daniela Damiani, Mario Tiribelli, Donatella Raspadori, Santina Sirianni, Alessia Meneghel, Margherita Cavalllin, Angela Michelutti, Eleonora Toffoletti, Antonella Geromin, Erica Simeone, Monica Bocchia,  and Renato Fanin
30212-30221
Abstract  |  PDF  |  HTML  |  Order a Reprint

Histidine-rich glycoprotein function in hepatocellular carcinoma depends on its N-glycosylation status, and it regulates cell proliferation by inhibiting Erk1/2 phosphorylation

Histidine-rich glycoprotein function in hepatocellular carcinoma depends on its N-glycosylation status, and it regulates cell proliferation by inhibiting Erk1/2 phosphorylation

https://doi.org/10.18632/oncotarget.4997

Qinle Zhang, Kai Jiang, Yan Li, Dongmei Gao, Lu Sun, Shu Zhang, Tianhua Liu, Kun Guo,  and Yinkun Liu
30222-30231
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IDH1/2 mutation status combined with Ki-67 labeling index defines distinct prognostic groups in glioma

IDH1/2 mutation status combined with Ki-67 labeling index defines distinct prognostic groups in glioma

https://doi.org/10.18632/oncotarget.4920

Ailiang Zeng, Qi Hu, Yanwei Liu, Zheng Wang, Xiaoming Cui, Rui Li, Wei Yan,  and Yongping You
30232-30238
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN

MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN

https://doi.org/10.18632/oncotarget.4972

Tao Yu, Lei Liu, Jing Li, Mingxia Yan, Hechun Lin, Ying Liu, Dandan Chu, Hong Tu, Aiqin Gu,  and Ming Yao
30239-30250
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LDL suppresses angiogenesis through disruption of the HIF pathway via NF-κB inhibition which is reversed by the proteasome inhibitor BSc2118

LDL suppresses angiogenesis through disruption of the HIF pathway via NF-κB inhibition which is reversed by the proteasome inhibitor BSc2118

https://doi.org/10.18632/oncotarget.4943

Gang Yao, Qi Zhang, Thorsten R. Doeppner, Feng Niu, Qiaochuan Li, Yanping Yang, Ulrike Kuckelkorn, Nina Hagemann, Wei Li, D.M. Hemann, Wen Zhou,  and Fengyan Jin
30251-30262
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer

Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer

https://doi.org/10.18632/oncotarget.4749

Chih-Jen Yang, Yu-Peng Liu, Hong-Ying Dai, Yow-Ling Shiue, Chia-Jung Tsai, Ming-Shyan Huang,  and Yao-Tsung Yeh
30263-30276
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Extramural depth of rectal cancer tumor invasion at thin-section MRI: predicting treatment response to neoadjuvant chemoradiation

Extramural depth of rectal cancer tumor invasion at thin-section MRI: predicting treatment response to neoadjuvant chemoradiation

https://doi.org/10.18632/oncotarget.4623

Tong Tong, Yiqun Sun, Sanjun Cai, Zhen Zhang,  and Yajia Gu
30277-30286
Abstract  |  PDF  |  HTML  |  Order a Reprint

Survival outcome according to KRAS mutation status in newly diagnosed patients with stage IV non-small cell lung cancer treated with platinum doublet chemotherapy

Survival outcome according to KRAS mutation status in newly diagnosed patients with stage IV non-small cell lung cancer treated with platinum doublet chemotherapy

https://doi.org/10.18632/oncotarget.4711

Anna K. Brady, Jonathan D. McNeill, Brendan Judy, Joshua Bauml, Tracey L. Evans, Roger B. Cohen, Corey Langer, Anil Vachani,  and Charu Aggarwal
30287-30294
Abstract  |  PDF  |  HTML  |  Order a Reprint

IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas

IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas

https://doi.org/10.18632/oncotarget.4497

Heather E. Leeper, Alissa A. Caron, Paul A. Decker, Robert B. Jenkins, Daniel H. Lachance,  and Caterina Giannini
30295-30305
Abstract  |  PDF  |  HTML  |  Order a Reprint

Integrative proteomic and gene expression analysis identify potential biomarkers for adjuvant trastuzumab resistance: analysis from the Fin-her phase III randomized trial

Integrative proteomic and gene expression analysis identify potential biomarkers for adjuvant trastuzumab resistance: analysis from the Fin-her phase III randomized trial

https://doi.org/10.18632/oncotarget.5080

Amir Sonnenblick, Sylvain Brohée, Debora Fumagalli, Françoise Rothé, Delphine Vincent, Michael Ignatiadis, Christine Desmedt, Roberto Salgado, Nicolas Sirtaine, Sherene Loi, Patrick Neven, Sibylle Loibl, Carsten Denkert, Heikki Joensuu, Martine Piccart,  and Christos Sotiriou
30306-30316
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Post-treatment plasma EBV-DNA positivity predicts early relapse and poor prognosis for patients with extranodal NK/T cell lymphoma in the era of asparaginase

Post-treatment plasma EBV-DNA positivity predicts early relapse and poor prognosis for patients with extranodal NK/T cell lymphoma in the era of asparaginase

https://doi.org/10.18632/oncotarget.4505

Liang Wang, Hua Wang, Jing-hua Wang, Zhong-jun Xia, Yue Lu, Hui-qiang Huang, Wen-qi Jiang,  and Yu-jing Zhang
30317-30326
Abstract  |  PDF  |  HTML  |  Order a Reprint

Expression of high affinity folate receptor in breast cancer brain metastasis

Expression of high affinity folate receptor in breast cancer brain metastasis

https://doi.org/10.18632/oncotarget.4639

José Pablo Leone, Rohit Bhargava, Brian K. Theisen, Ronald L. Hamilton, Adrian V. Lee,  and Adam M. Brufsky
30327-30333
Abstract  |  PDF  |  HTML  |  Order a Reprint

Plasma biomarkers of clinical response during chemotherapy plus combination antiretroviral therapy (cART) in HIV+ patients with advanced Kaposi sarcoma

Plasma biomarkers of clinical response during chemotherapy plus combination antiretroviral therapy (cART) in HIV+ patients with advanced Kaposi sarcoma

https://doi.org/10.18632/oncotarget.4571

Rosamaria Tedeschi, Ettore Bidoli, Maria Teresa Bortolin, Ornella Schioppa, Emanuela Vaccher,  and Paolo De Paoli
30334-30342
Abstract  |  PDF  |  HTML  |  Order a Reprint

High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer

High casein kinase 1 epsilon levels are correlated with better prognosis in subsets of patients with breast cancer

https://doi.org/10.18632/oncotarget.4850

Jose Luis Lopez-Guerra, Eva M. Verdugo-Sivianes, Daniel Otero-Albiol, Begoña Vieites, Maria J. Ortiz-Gordillo, Jose M. De León, Juan M. Praena-Fernandez, Juan J. Marin,  and Amancio Carnero
30343-30356
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of prostate cancer biomarkers in urinary exosomes

Identification of prostate cancer biomarkers in urinary exosomes

https://doi.org/10.18632/oncotarget.4851

Anders Øverbye, Tore Skotland, Christian J. Koehler, Bernd Thiede, Therese Seierstad, Viktor Berge, Kirsten Sandvig,  and Alicia Llorente
30357-30376
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Implications for determining the optimal treatment for locally advanced rectal cancer in elderly patients aged 75 years and older

Implications for determining the optimal treatment for locally advanced rectal cancer in elderly patients aged 75 years and older

https://doi.org/10.18632/oncotarget.4599

Jue-feng Wan, Ji Zhu, Gui-chao Li, Wen-jie Sun,  and Zhen Zhang
30377-30383
Abstract  |  PDF  |  HTML  |  Order a Reprint

89Zr-cetuximab PET imaging in patients with advanced colorectal cancer

89Zr-cetuximab PET imaging in patients with advanced colorectal cancer

https://doi.org/10.18632/oncotarget.4672

Catherina Willemien Menke-van der Houven, Elske C Gootjes, Marc C Huisman, Danielle J Vugts, Chantal Roth, Anne Marije Luik, Emma R Mulder, Robert C Schuit, Ronald Boellaard, Otto S Hoekstra, Guus AMS van Dongen,  and Henk MW Verheul
30384-30393
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Critical role of bevacizumab scheduling in combination with pre-surgical chemo-radiotherapy in MRI-defined high-risk locally advanced rectal cancer: Results of the BRANCH trial

Critical role of bevacizumab scheduling in combination with pre-surgical chemo-radiotherapy in MRI-defined high-risk locally advanced rectal cancer: Results of the BRANCH trial

https://doi.org/10.18632/oncotarget.4724

Antonio Avallone, Biagio Pecori, Franco Bianco, Luigi Aloj, Fabiana Tatangelo, Carmela Romano, Vincenza Granata, Pietro Marone, Alessandra Leone, Gerardo Botti, Antonella Petrillo, Corradina Caracò, Vincenzo R. Iaffaioli, Paolo Muto, Giovanni Romano, Pasquale Comella, Alfredo Budillon,  and Paolo Delrio
30394-30407
Abstract  |  PDF  |  HTML  |  Order a Reprint

A phase 2, open-label, multicenter study of the long-term safety of siltuximab (an anti-interleukin-6 monoclonal antibody) in patients with multicentric Castleman disease

A phase 2, open-label, multicenter study of the long-term safety of siltuximab (an anti-interleukin-6 monoclonal antibody) in patients with multicentric Castleman disease

https://doi.org/10.18632/oncotarget.4655

Frits van Rhee, Corey Casper, Peter M. Voorhees, Luis E. Fayad, Helgi van de Velde, Jessica Vermeulen, Xiang Qin, Ming Qi, Brenda Tromp,  and Razelle Kurzrock
30408-30419
Abstract  |  PDF  |  HTML  |  Order a Reprint

Retraction

Retraction: Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling

Retraction: Guggulsterone inhibits prostate cancer growth via inactivation of Akt regulated by ATP citrate lyase signaling

https://doi.org/10.18632/oncotarget.6005

Yajuan Gao, Yan Zeng, Jian Tian, Mohammad Shyful Islam, Guoqin Jiang,  and Dong Xiao
30420
Retraction  |  PDF  |  Order a Reprint


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