Oncotarget

Vol 6, No 29

September 29, 2015

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About The Cover

The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization. See Zhou et al.

Table of Contents

Editorial

Viral infection at the endothelium

Viral infection at the endothelium

https://doi.org/10.18632/oncotarget.5246

Felicia Goodrum,  and Farah Bughio
26541-26542
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LG24 and sex chromosomes

LG24 and sex chromosomes

https://doi.org/10.18632/oncotarget.5250

Rong Huang, Zuoyan Zhu,  and Yaping Wang
26543-26543
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Targeting glutaminase and mTOR

Targeting glutaminase and mTOR

https://doi.org/10.18632/oncotarget.5263

Kazuhiro Tanaka, Takashi Sasayama,  and Eiji Kohmura
26544-26545
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Insight into miRNA biogenesis with RNA sequencing

Insight into miRNA biogenesis with RNA sequencing

https://doi.org/10.18632/oncotarget.5264

Thomas Conrad,  and Ulf Andersson Ørom
26546-26547
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LMOD3: the “missing link” in nemaline myopathy?

LMOD3: the “missing link” in nemaline myopathy?

https://doi.org/10.18632/oncotarget.5267

Sarah Sandaradura,  and Kathryn N. North
26548-26549
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Pharmacological manipulation of AID

Pharmacological manipulation of AID

https://doi.org/10.18632/oncotarget.5269

Stephen P. Methot,  and Javier M. Di Noia
26550-26551
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NKT10 cells: a novel iNKT cell subset

NKT10 cells: a novel iNKT cell subset

https://doi.org/10.18632/oncotarget.5270

Gerhard Wingender, Duygu Sag,  and Mitchell Kronenberg
26552-26553
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Regulation of extrathymic Treg cell conversion by CD5

Regulation of extrathymic Treg cell conversion by CD5

https://doi.org/10.18632/oncotarget.5809

Jacob G. Henderson,  and Daniel Hawiger
26554-26555
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Editorial: Chromosome

In vivo selection of novel biotherapeutics

In vivo selection of novel biotherapeutics

https://doi.org/10.18632/oncotarget.5247

Giulia Ruozi,  and Mauro Giacca
26556-26557
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RECQL: a DNA helicase in breast cancer

RECQL: a DNA helicase in breast cancer

https://doi.org/10.18632/oncotarget.5452

Mohammad R. Akbari,  and Cezary Cybulski
26558-26559
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Research Perspectives

Triple negative breast cancer: looking for the missing link between biology and treatments

Triple negative breast cancer: looking for the missing link between biology and treatments

https://doi.org/10.18632/oncotarget.5306

Giuseppe Palma, Giuseppe Frasci, Andrea Chirico, Emanuela Esposito, Claudio Siani, Carmela Saturnino, Claudio Arra, Gennaro Ciliberto, Antonio Giordano,  and Massimiliano D’Aiuto
26560-26574
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Targeting Batf2 for infectious diseases and cancer

Targeting Batf2 for infectious diseases and cancer

https://doi.org/10.18632/oncotarget.5576

Reto Guler, Sugata Roy, Harukazu Suzuki,  and Frank Brombacher
26575-26582
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Priority Research Papers

Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage

Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage

https://doi.org/10.18632/oncotarget.5612

Kamila A. Marzec, Mike Z. Lin, Janet L. Martin,  and Robert C. Baxter
26583-26598
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization

The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization

https://doi.org/10.18632/oncotarget.5613

Heng Zhou, Sabrina Forveille, Allan Sauvat, Valentina Sica, Valentina Izzo, Sylvère Durand, Kevin Müller, Peng Liu, Laurence Zitvogel, Øystein Rekdal, Oliver Kepp,  and Guido Kroemer
26599-26614
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling

Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling

https://doi.org/10.18632/oncotarget.5666

Lynn Feys, Benedicte Descamps, Christian Vanhove, Anne Vral, Liv Veldeman, Stefan Vermeulen, Carlos De Wagter, Marc Bracke,  and Olivier De Wever
26615-26632
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ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas

ALDH/CD44 identifies uniquely tumorigenic cancer stem cells in salivary gland mucoepidermoid carcinomas

https://doi.org/10.18632/oncotarget.5782

April Adams, Kristy Warner, Alexander T. Pearson, Zhaocheng Zhang, Hong Sun Kim, Daiki Mochizuki, Gregory Basura, Joseph Helman, Andrea Mantesso, Rogério M. Castilho, Max S. Wicha,  and Jacques E. Nör
26633-26650
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Liver X Receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization

Liver X Receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization

https://doi.org/10.18632/oncotarget.5791

Flavie Courtaut, Valentin Derangère, Angélique Chevriaux, Sylvain Ladoire, Alexia K. Cotte, Laurent Arnould, Romain Boidot, Mickaël Rialland, François Ghiringhelli,  and Cédric Rébé
26651-26662
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Research Papers: Gerotarget (Focus on Aging)

APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls

APOE-by-sex interactions on brain structure and metabolism in healthy elderly controls

https://doi.org/10.18632/oncotarget.5185

Frederic Sampedro, Eduard Vilaplana, Mony J. de Leon, Daniel Alcolea, Jordi Pegueroles, Victor Montal, María Carmona-Iragui, Isabel Sala, María-Belén Sánchez-Saudinos, Sofía Antón-Aguirre, Estrella Morenas-Rodríguez, Valle Camacho, Carles Falcón, Javier Pavía, Domènec Ros, Jordi Clarimón, Rafael Blesa, Alberto Lleó,  and Juan Fortea
26663-26674
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Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration

Reciprocal regulation between sirtuin-1 and angiotensin-II in the substantia nigra: implications for aging and neurodegeneration

https://doi.org/10.18632/oncotarget.5596

Carmen Diaz-Ruiz, Ana I. Rodriguez-Perez, Daniel Beiroa, Jannette Rodriguez-Pallares,  and Jose L. Labandeira-Garcia
26675-26689
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To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss

To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss

https://doi.org/10.18632/oncotarget.5614

Jaimie Hoh Kam,  and Glen Jeffery
26690-26701
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Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice

Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice

https://doi.org/10.18632/oncotarget.5760

Michael B. Stout, William R. Swindell, Xu Zhi, Kyle Rohde, Edward O. List, Darlene E. Berryman, John J. Kopchick, Adam Gesing, Yimin Fang,  and Michal M. Masternak
26702-26715
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Serotonin 6 receptor controls alzheimer’s disease and depression

Serotonin 6 receptor controls alzheimer’s disease and depression

https://doi.org/10.18632/oncotarget.5777

Hyung-Mun Yun, Kyung-Ran Park, Eun-Cheol Kim, Sanghyeon Kim,  and Jin Tae Hong
26716-26728
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Research Papers: Pathology

Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells

Genome-wide analysis of DNA methylation and gene expression patterns in purified, uncultured human liver cells and activated hepatic stellate cells

https://doi.org/10.18632/oncotarget.4925

Adil El Taghdouini, Anita L. Sørensen, Andrew H. Reiner, Mar Coll, Stefaan Verhulst, Inge Mannaerts, Cristina I. Øie, Bård Smedsrød, Mustapha Najimi, Etienne Sokal, Aernout Luttun, Pau Sancho-Bru, Philippe Collas,  and Leo A. van Grunsven
26729-26745
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Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer

Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer

https://doi.org/10.18632/oncotarget.4818

Hyun-Soo Kim, Gun Yoon, Ji-Yoon Ryu, Young-Jae Cho, Jung-Joo Choi, Yoo-Young Lee, Tae-Joong Kim, Chel-Hun Choi, Sang Yong Song, Byoung-Gie Kim, Duk-Soo Bae,  and Jeong-Won Lee
26746-26756
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A network meta-analysis of the efficacy and side effects of udca-based therapies for primary sclerosing cholangitis

A network meta-analysis of the efficacy and side effects of udca-based therapies for primary sclerosing cholangitis

https://doi.org/10.18632/oncotarget.5610

Gui-Qi Zhu, Ke-Qing Shi, Gui-Qian Huang, Li-Ren Wang, Yi-Qian Lin, Martin Braddock, Yong-Ping Chen, Meng-Tao Zhou,  and Ming-Hua Zheng
26757-26769
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TGF-ß isoforms in cancer: Immunohistochemical expression and Smad-pathway-activity-analysis in thirteen major tumor types with a critical appraisal of antibody specificity and immunohistochemistry assay validity

TGF-ß isoforms in cancer: Immunohistochemical expression and Smad-pathway-activity-analysis in thirteen major tumor types with a critical appraisal of antibody specificity and immunohistochemistry assay validity

https://doi.org/10.18632/oncotarget.5780

Markus J. Riemenschneider, Maria Hirblinger, Arabel Vollmann-Zwerenz, Peter Hau, Martin A. Proescholdt, Frank Jaschinski, Tanja Rothhammer-Hampl, Katja Wosikowski, Michel Janicot,  and Eugen Leo
26770-26781
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Liver enzymes and metabolic syndrome: a large-scale case-control study

Liver enzymes and metabolic syndrome: a large-scale case-control study

https://doi.org/10.18632/oncotarget.5792

Lu Zhang, Xiangyu Ma, Zhi Jiang, Kejun Zhang, Mengxuan Zhang, Yafei Li, Xiaolan Zhao,  and Hongyan Xiong
26782-26788
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Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression

Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression

https://doi.org/10.18632/oncotarget.4628

Natalia Bednarz-Knoll, Paulina Nastały, Anna Żaczek, Małgorzata Stoupiec, Sabine Riethdorf, Harriet Wikman, Volkmar Müller, Jarosław Skokowski, Jolanta Szade, Aleksandra Sejda, Marzena Wełnicka-Jaśkiewicz,  and Klaus Pantel
26789-26803
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Research Papers: Neuroscience

Characterizing PCDH19 in human induced pluripotent stem cells (iPSCs) and iPSC-derived developing neurons: emerging role of a protein involved in controlling polarity during neurogenesis

Characterizing PCDH19 in human induced pluripotent stem cells (iPSCs) and iPSC-derived developing neurons: emerging role of a protein involved in controlling polarity during neurogenesis

https://doi.org/10.18632/oncotarget.5757

Claudia Compagnucci, Stefania Petrini, Norimichi Higuraschi, Marina Trivisano, Nicola Specchio, Shinichi Hirose, Enrico Bertini,  and Alessandra Terracciano
26804-26813
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Reviews

A decade of EGFR inhibition in EGFR-mutated non small cell lung cancer (NSCLC): Old successes and future perspectives

A decade of EGFR inhibition in EGFR-mutated non small cell lung cancer (NSCLC): Old successes and future perspectives

https://doi.org/10.18632/oncotarget.4254

Alessandro Russo, Tindara Franchina, Giuseppina Rosaria Rita Ricciardi, Antonio Picone, Giuseppa Ferraro, Mariangela Zanghì, Giuseppe Toscano, Antonio Giordano,  and Vincenzo Adamo
26814-26825
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Notch signaling deregulation in multiple myeloma: A rational molecular target

Notch signaling deregulation in multiple myeloma: A rational molecular target

https://doi.org/10.18632/oncotarget.5025

Michela Colombo, Serena Galletti, Silvia Garavelli, Natalia Platonova, Alessandro Paoli, Andrea Basile, Elisa Taiana, Antonino Neri,  and Raffaella Chiaramonte
26826-26840
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Research Papers

Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

https://doi.org/10.18632/oncotarget.4754

Abhishek D. Garg, Sanne Elsen, Dmitri V. Krysko, Peter Vandenabeele, Peter de Witte,  and Patrizia Agostinis
26841-26860
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Nanoparticle-induced intraperitoneal hyperthermia and targeted photoablation in treating ovarian cancer

Nanoparticle-induced intraperitoneal hyperthermia and targeted photoablation in treating ovarian cancer

https://doi.org/10.18632/oncotarget.4766

Chao-Chih Wu, Yuh-Cheng Yang, Yun-Ting Hsu, T.-C. Wu, Chien-Fu Hung, Jung-Tang Huang,  and Chih-Long Chang
26861-26875
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Activation of homologous recombination DNA repair in human skin fibroblasts continuously exposed to X-ray radiation

Activation of homologous recombination DNA repair in human skin fibroblasts continuously exposed to X-ray radiation

https://doi.org/10.18632/oncotarget.4946

Andreyan N. Osipov, Anna Grekhova, Margarita Pustovalova, Ivan V. Ozerov, Petr Eremin, Natalia Vorobyeva, Natalia Lazareva, Andrey Pulin, Alex Zhavoronkov, Sergey Roumiantsev, Dmitry Klokov,  and Ilya Eremin
26876-26885
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BRAF mutation testing with a rapid, fully integrated molecular diagnostics system

BRAF mutation testing with a rapid, fully integrated molecular diagnostics system

https://doi.org/10.18632/oncotarget.4723

Filip Janku, Bart Claes, Helen J. Huang, Gerald S. Falchook, Benoit Devogelaere, Mark Kockx, Isabelle Vanden Bempt, Martin Reijans, Aung Naing, Siqing Fu, Sarina A. Piha-Paul, David S. Hong, Veronica R. Holley, Apostolia M. Tsimberidou, Vanda M. Stepanek, Sapna P. Patel, E. Scott Kopetz, Vivek Subbiah, Jennifer J. Wheler, Ralph G. Zinner, Daniel D. Karp, Rajyalakshmi Luthra, Sinchita Roy-Chowdhuri, Erwin Sablon, Funda Meric-Bernstam, Geert Maertens,  and Razelle Kurzrock
26886-26894
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel small-molecule IAP antagonist, AZD5582, draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer

A novel small-molecule IAP antagonist, AZD5582, draws Mcl-1 down-regulation for induction of apoptosis through targeting of cIAP1 and XIAP in human pancreatic cancer

https://doi.org/10.18632/oncotarget.4822

Jai-Hee Moon, Jae-Sik Shin, Seung-Woo Hong, Soo-A Jung, Ih-Yeon Hwang, Jeong Hee Kim, Eun Kyoung Choi, Seung-Hee Ha, Jin-Sun Kim, Kyoung-Mok Kim, Dae-Won Hong, Daejin Kim, Yeong Seok Kim, Jeong Eun Kim, Kyu-Pyo Kim, Yong Sang Hong, Eun Kyung Choi, Jung Shin Lee, Maureen Hattersley, Dong-Hoon Jin,  and Tae Won Kim
26895-26908
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

https://doi.org/10.18632/oncotarget.4817

Aleksandra A. Pandyra, Peter J. Mullen, Carolyn A. Goard, Elke Ericson, Piyush Sharma, Manpreet Kalkat, Rosemary Yu, Janice T. Pong, Kevin R. Brown, Traver Hart, Marinella Gebbia, Karl S. Lang, Guri Giaever, Corey Nislow, Jason Moffat,  and Linda Z. Penn
26909-26921
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dexamethasone-induced cell death is restricted to specific molecular subgroups of multiple myeloma

Dexamethasone-induced cell death is restricted to specific molecular subgroups of multiple myeloma

https://doi.org/10.18632/oncotarget.4616

Charlotte Kervoëlen, Emmanuelle Ménoret, Patricia Gomez-Bougie, Régis Bataille, Catherine Godon, Séverine Marionneau-Lambot, Philippe Moreau, Catherine Pellat-Deceunynck,  and Martine Amiot
26922-26934
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer

Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer

https://doi.org/10.18632/oncotarget.4775

Maider Ibarrola-Villava, Marta J. Llorca-Cardeñosa, Noelia Tarazona, Cristina Mongort, Tania Fleitas, José Alejandro Perez-Fidalgo, Susana Roselló, Samuel Navarro, Gloria Ribas,  and Andrés Cervantes
26935-26945
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting annexin A2 reduces tumorigenesis and therapeutic resistance of nasopharyngeal carcinoma

Targeting annexin A2 reduces tumorigenesis and therapeutic resistance of nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.4521

Chang-Yu Chen, Yung-Song Lin, Chi-Long Chen, Pin-Zhir Chao, Jeng-Fong Chiou, Chia-Chun Kuo, Fei-Peng Lee, Yung-Feng Lin, Yu-Hsuan Sung, Yun-Tien Lin, Chang-Fan Li, Yin-Ju Chen,  and Chien-Ho Chen
26946-26959
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells

Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells

https://doi.org/10.18632/oncotarget.4745

Ji Tae Kim, Jing Li, Jun Song, Eun Y. Lee, Heidi L. Weiss, Courtney M. Townsend, Jr.,  and B. Mark Evers
26960-26970
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Exosomal levels of miRNA-21 from cerebrospinal fluids associated with poor prognosis and tumor recurrence of glioma patients

Exosomal levels of miRNA-21 from cerebrospinal fluids associated with poor prognosis and tumor recurrence of glioma patients

https://doi.org/10.18632/oncotarget.4699

Rui Shi, Pei-Yin Wang, Xin-Yi Li, Jian-Xin Chen, Yan Li, Xin-Zhong Zhang, Chen-Guang Zhang, Tao Jiang, Wen-Bin Li, Wei Ding,  and Shu-Jun Cheng
26971-26981
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Carfilzomib enhances natural killer cell-mediated lysis of myeloma linked with decreasing expression of HLA class I

Carfilzomib enhances natural killer cell-mediated lysis of myeloma linked with decreasing expression of HLA class I

https://doi.org/10.18632/oncotarget.4831

Guang Yang, Minjie Gao, Yiwen Zhang, Yuanyuan Kong, Lu Gao, Yi Tao, Ying Han, Huiqun Wu, Xiuqin Meng, Hongwei Xu, Fenghuang Zhan, Xiaosong Wu,  and Jumei Shi
26982-26994
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma

DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.4863

Alice N. Weaver, Tiffiny S. Cooper, Marcela Rodriguez, Hoa Q. Trummell, James A. Bonner, Eben L. Rosenthal,  and Eddy S. Yang
26995-27007
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Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer

Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer

https://doi.org/10.18632/oncotarget.4714

Laura E. Edgington-Mitchell, Jai Rautela, Hendrika M. Duivenvoorden, Krishnath M. Jayatilleke, Wouter A. van der Linden, Martijn Verdoes, Matthew Bogyo,  and Belinda S. Parker
27008-27022
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes

Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes

https://doi.org/10.18632/oncotarget.4809

Jessamy C. Tiffen, Dilini Gunatilake, Stuart J. Gallagher, Kavitha Gowrishankar, Anja Heinemann, Carleen Cullinane, Ken Dutton-Regester, Gulietta M. Pupo, Dario Strbenac, Jean Y. Yang, Jason Madore, Graham J. Mann, Nicholas K. Hayward, Grant A. McArthur, Fabian V. Filipp,  and Peter Hersey
27023-27036
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

C-kit signaling promotes proliferation and invasion of colorectal mucinous adenocarcinoma in a murine model

C-kit signaling promotes proliferation and invasion of colorectal mucinous adenocarcinoma in a murine model

https://doi.org/10.18632/oncotarget.4815

Jun Tan, Shu Yang, Ping Shen, Haimei Sun, Jie Xiao, Yaxi Wang, Bo Wu, Fengqing Ji, Jihong Yan, Hong Xue,  and Deshan Zhou
27037-27048
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells

Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells

https://doi.org/10.18632/oncotarget.4819

Feng Ge, Haishi Zhang, Daisy Dandan Wang, Linda Li,  and Peter Ping Lin
27049-27064
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Integrative transcriptomics-based identification of cryptic drivers of taxol-resistance genes in ovarian carcinoma cells: Analysis of the androgen receptor

Integrative transcriptomics-based identification of cryptic drivers of taxol-resistance genes in ovarian carcinoma cells: Analysis of the androgen receptor

https://doi.org/10.18632/oncotarget.4824

Nian-Kang Sun, Shang-Lang Huang, Hsing-Pang Lu, Ting-Chang Chang,  and Chuck C.-K. Chao
27065-27082
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5

The ZEB1/miR-200c feedback loop regulates invasion via actin interacting proteins MYLK and TKS5

https://doi.org/10.18632/oncotarget.4807

Vignesh Sundararajan, Nicolas Gengenbacher, Marc P. Stemmler, Julia A. Kleemann, Thomas Brabletz,  and Simone Brabletz
27083-27096
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AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf & TSC1/TSC2

AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf & TSC1/TSC2

https://doi.org/10.18632/oncotarget.4553

Hui-Ping Lin, Ching-Yu Lin, Chieh Huo, Yee-Jee Jan, Jen-Chih Tseng, Shih Sheng Jiang, Ying-Yu Kuo, Shyh-Chang Chen, Chih-Ting Wang, Tzu-Min Chan, Jun-Yang Liou, John Wang, Wun-Shaing Wayne Chang, Chung-Ho Chang, Hsing-Jien Kung,  and Chih-Pin Chuu
27097-27112
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SIRT1 in B[a]P-induced lung tumorigenesis

SIRT1 in B[a]P-induced lung tumorigenesis

https://doi.org/10.18632/oncotarget.4729

Jianyi Lu, Min Zhang, Zhiyong Huang, Sufang Sun, Yongliang Zhang, Lei Zhang, Lirong Peng, Ailing Ma, Pan Ji, Jia Dai, Tong Cui, Heping Liu,  and Jimin Gao
27113-27129
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RFPL3 and CBP synergistically upregulate hTERT activity and promote lung cancer growth

RFPL3 and CBP synergistically upregulate hTERT activity and promote lung cancer growth

https://doi.org/10.18632/oncotarget.4825

Yu Qin, Wangbing Chen, Yao Xiao, Wendan Yu, Xin Cai, Meng Dai, Tingting Xu, Wenlin Huang, Wei Guo, Wuguo Deng,  and Taihua Wu
27130-27145
Abstract  |  PDF  |  HTML  |  Order a Reprint

IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression

IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression

https://doi.org/10.18632/oncotarget.4354

Sang Chul Lee, Ok-Hee Kim, Sang Kuon Lee,  and Say-June Kim
27146-27159
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A core of kinase-regulated interactomes defines the neoplastic MDSC lineage

A core of kinase-regulated interactomes defines the neoplastic MDSC lineage

https://doi.org/10.18632/oncotarget.4746

Maria Gato-Cañas, Xabier Martinez de Morentin, Idoia Blanco-Luquin, Joaquin Fernandez-Irigoyen, Isabel Zudaire, Therese Liechtenstein, Hugo Arasanz, Teresa Lozano, Noelia Casares, Apirat Chaikuad, Stefan Knapp, David Guerrero-Setas, David Escors, Grazyna Kochan,  and Enrique Santamaría
27160-27175
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association of CELF2 polymorphism and the prognosis of nasopharyngeal carcinoma in southern Chinese population

Association of CELF2 polymorphism and the prognosis of nasopharyngeal carcinoma in southern Chinese population

https://doi.org/10.18632/oncotarget.4870

Yun-Miao Guo, Ming-Xia Sun, Jing Li, Tong-Tong Liu, Hang-Zhen Huang, Jie-Rong Chen, Wen-Sheng Liu, Qi-Sheng Feng, Li-Zhen Chen, Jin-Xin Bei,  and Yi-Xin Zeng
27176-27186
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis

By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis

https://doi.org/10.18632/oncotarget.4551

Jiujiao Gao, Xue Liu, Fan Yang, Tingjiao Liu, Qiu Yan,  and Xuesong Yang
27187-27198
Abstract  |  PDF  |  HTML  |  Order a Reprint

The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer

The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer

https://doi.org/10.18632/oncotarget.4508

Fabao Liu, Weiying Zhang, Xiaona You, Yunxia Liu, Yinghui Li, Zhen Wang, Yue Wang, Xiaodong Zhang,  and Lihong Ye
27199-27213
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer

Resveratrol and pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer

https://doi.org/10.18632/oncotarget.4877

Swati Dhar, Avinash Kumar, Agnes M Rimando, Xu Zhang,  and Anait S. Levenson
27214-27226
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combinatorial high-throughput experimental and bioinformatic approach identifies molecular pathways linked with the sensitivity to anticancer target drugs

Combinatorial high-throughput experimental and bioinformatic approach identifies molecular pathways linked with the sensitivity to anticancer target drugs

https://doi.org/10.18632/oncotarget.4507

Larisa Venkova, Alexander Aliper, Maria Suntsova, Roman Kholodenko, Denis Shepelin, Nicolas Borisov, Galina Malakhova, Raif Vasilov, Sergey Roumiantsev, Alex Zhavoronkov,  and Anton Buzdin
27227-27238
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Talin1 targeting potentiates anti-angiogenic therapy by attenuating invasion and stem-like features of glioblastoma multiforme

Talin1 targeting potentiates anti-angiogenic therapy by attenuating invasion and stem-like features of glioblastoma multiforme

https://doi.org/10.18632/oncotarget.4835

Wonyoung Kang, Sung Heon Kim, Hee Jin Cho, Juyoun Jin, Jeongwu Lee, Kyeung Min Joo,  and Do-Hyun Nam
27239-27251
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

TLR3 agonist and Sorafenib combinatorial therapy promotes immune activation and controls hepatocellular carcinoma progression

https://doi.org/10.18632/oncotarget.4583

Victor Ho, Tong Seng Lim, Justin Lee, Jeffrey Steinberg, Radoslaw Szmyd, Muly Tham, Jadegoud Yaligar, Philipp Kaldis, Jean-Pierre Abastado,  and Valerie Chew
27252-27266
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel pathogenic germline mutation in the adenomatous polyposis coli gene in a Chinese family with familial adenomatous coli

A novel pathogenic germline mutation in the adenomatous polyposis coli gene in a Chinese family with familial adenomatous coli

https://doi.org/10.18632/oncotarget.4776

Shan-Shan Jiang, Jian-Jun Li, Yin Li, Long-Jun He, Qi-Jing Wang, De-Sheng Weng, Ke Pan, Qing Liu, Jing-Jing Zhao, Qiu-Zhong Pan, Xiao-Fei Zhang, Yan Tang, Chang-Long Chen, Hong-xia Zhang, Guo-Liang Xu, Yi-Xin Zeng,  and Jian-Chuan Xia
27267-27274
Abstract  |  PDF  |  HTML  |  Order a Reprint

Low doses of X-rays induce prolonged and ATM-independent persistence of γH2AX foci in human gingival mesenchymal stem cells

Low doses of X-rays induce prolonged and ATM-independent persistence of γH2AX foci in human gingival mesenchymal stem cells

https://doi.org/10.18632/oncotarget.4739

Andreyan N. Osipov, Margarita Pustovalova, Anna Grekhova, Petr Eremin, Natalia Vorobyova, Andrey Pulin, Alex Zhavoronkov, Sergey Roumiantsev, Dmitry Y. Klokov,  and Ilya Eremin
27275-27287
Abstract  |  PDF  |  HTML  |  Order a Reprint

Sphere-derived tumor cells exhibit impaired metastasis by a host-mediated quiescent phenotype

Sphere-derived tumor cells exhibit impaired metastasis by a host-mediated quiescent phenotype

https://doi.org/10.18632/oncotarget.4803

Anne-Marie Bleau, Carolina Zandueta, Miriam Redrado, Susana Martínez-Canarias, Leyre Larzábal, Luis M Montuenga, Alfonso Calvo,  and Fernando Lecanda
27288-27303
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Detection and enumeration of circulating tumor cells based on their invasive property

Detection and enumeration of circulating tumor cells based on their invasive property

https://doi.org/10.18632/oncotarget.4454

Haizhen Wang, Yannis Hara, Xingtong Liu, James M. Reuben, Yongzhuang Xie, Huaxi Xu, Guojun Bu, Yihua Pei, Vineet Gupta,  and Xiangwei Wu
27304-27311
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells

Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells

https://doi.org/10.18632/oncotarget.4743

Masaya Jimbo, Fernando F. Blanco, Yu-Hung Huang, Aristeidis G. Telonis, Brad A. Screnci, Gabriela L. Cosma, Vitali Alexeev, Gregory E. Gonye, Charles J. Yeo, Janet A. Sawicki, Jordan M. Winter,  and Jonathan R. Brody
27312-27331
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Harnessing Noxa demethylation to overcome Bortezomib resistance in mantle cell lymphoma

Harnessing Noxa demethylation to overcome Bortezomib resistance in mantle cell lymphoma

https://doi.org/10.18632/oncotarget.2903

Violetta V. Leshchenko, Pei-Yu Kuo, Zewei Jiang, Marc A. Weniger, Jessica Overbey, Kieron Dunleavy, Wyndham H. Wilson, Adrian Wiestner,  and Samir Parekh
27332-27342
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts

Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts

https://doi.org/10.18632/oncotarget.4398

Maria Rita Pitari, Marco Rossi, Nicola Amodio, Cirino Botta, Eugenio Morelli, Cinzia Federico, Annamaria Gullà, Daniele Caracciolo, Maria Teresa Di Martino, Mariamena Arbitrio, Antonio Giordano, Pierosandro Tagliaferri,  and Pierfrancesco Tassone
27343-27358
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model

LAG3 and PD1 co-inhibitory molecules collaborate to limit CD8+ T cell signaling and dampen antitumor immunity in a murine ovarian cancer model

https://doi.org/10.18632/oncotarget.4751

Ruea-Yea Huang, Cheryl Eppolito, Shashikant Lele, Protul Shrikant, Junko Matsuzaki,  and Kunle Odunsi
27359-27377
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Upregulation of COL6A1 is predictive of poor prognosis in clear cell renal cell carcinoma patients

Upregulation of COL6A1 is predictive of poor prognosis in clear cell renal cell carcinoma patients

https://doi.org/10.18632/oncotarget.4860

Fangning Wan, Hongkai Wang, Yijun Shen, Hailiang Zhang, Guohai Shi, Yao Zhu, Bo Dai,  and Dingwei Ye
27378-27387
Abstract  |  PDF  |  HTML  |  Order a Reprint

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2

https://doi.org/10.18632/oncotarget.4489

Andrew R. Lavik, Fei Zhong, Ming-Jin Chang, Edward Greenberg, Yuvraj Choudhary, Mitchell R. Smith, Karen S. McColl, John Pink, Frederic J. Reu, Shigemi Matsuyama,  and Clark W. Distelhorst
27388-27402
Abstract  |  PDF  |  HTML  |  Order a Reprint

Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10

Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10

https://doi.org/10.18632/oncotarget.4741

Nan Li, Xi Chen, Bing Zhu, Verónica Ramírez-Alcántara, Joshua C. Canzoneri, Kevin Lee, Sara Sigler, Bernard Gary, Yonghe Li, Wei Zhang, Mary P. Moyer, E. Alan Salter, Andrzej Wierzbicki, Adam B. Keeton,  and Gary A. Piazza
27403-27415
Abstract  |  PDF  |  HTML  |  Order a Reprint

SALL4 is a novel therapeutic target in intrahepatic cholangiocarcinoma

SALL4 is a novel therapeutic target in intrahepatic cholangiocarcinoma

https://doi.org/10.18632/oncotarget.4862

Gang Deng, Lei Zhu, Feizhou Huang, Wanpin Nie, Wei Huang, Hongbo Xu, Shaopeng Zheng, Zhongjie Yi,  and Tao Wan
27416-27426
Abstract  |  PDF  |  HTML  |  Order a Reprint

The positive feedback between Snail and DAB2IP regulates EMT, invasion and metastasis in colorectal cancer

The positive feedback between Snail and DAB2IP regulates EMT, invasion and metastasis in colorectal cancer

https://doi.org/10.18632/oncotarget.4861

Jianmei Wang, Xiaohui Zhu, Jinlong Hu, Guoyang He, Xiaomei Li, Pingxiang Wu, Xiaoli Ren, Feifei Wang, Wenting Liao, Li Liang,  and Yanqing Ding
27427-27439
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo

Galeterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo

https://doi.org/10.18632/oncotarget.4578

Andrew K. Kwegyir-Afful, Senthilmurugan Ramalingam, Puranik Purushottamachar, Vidya P. Ramamurthy,  and Vincent C. O. Njar
27440-27460
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation

STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation

https://doi.org/10.18632/oncotarget.4742

Mohini Singh, Neha Garg, Chitra Venugopal, Robin Hallett, Tomas Tokar, Nicole McFarlane, Sujeivan Mahendram, David Bakhshinyan, Branavan Manoranjan, Parvez Vora, Maleeha Qazi, Carolynn C. Arpin, Brent Page, Sina Haftchenary, David A. Rosa, Ping-Shan Lai, Rodolfo F. Gómez-Biagi, Ahmed M. Ali, Andrew Lewis, Mulu Geletu, Naresh K. Murty, John A. Hassell, Igor Jurisica, Patrick T. Gunning,  and Sheila K. Singh
27461-27477
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model

Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model

https://doi.org/10.18632/oncotarget.4393

Claudia Sorrentino, Lucio Miele, Amalia Porta, Aldo Pinto,  and Silvana Morello
27478-27489
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene

Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene

https://doi.org/10.18632/oncotarget.4748

Lingbo Wang, Weili Cai, Wei Zhang, Xueying Chen, Wenqian Dong, Dongqi Tang, Yun Zhang, Chunyan Ji,  and Mingxiang Zhang
27490-27504
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nuclear estrogen receptor-α expression is an independent predictor of recurrence in male patients with pT1aN0 lung adenocarcinomas, and correlates with regulatory T-cell infiltration

Nuclear estrogen receptor-α expression is an independent predictor of recurrence in male patients with pT1aN0 lung adenocarcinomas, and correlates with regulatory T-cell infiltration

https://doi.org/10.18632/oncotarget.4752

Kyuichi Kadota, Takashi Eguchi, Jonathan Villena-Vargas, Kaitlin M. Woo, Camelia S. Sima, David R. Jones, William D. Travis,  and Prasad S. Adusumilli
27505-27518
Abstract  |  PDF  |  HTML  |  Order a Reprint

Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells

Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells

https://doi.org/10.18632/oncotarget.4823

Nourdine Hamdane, Chelsea Herdman, Jean-Clement Mars, Victor Stefanovsky, Michel G. Tremblay,  and Tom Moss
27519-27536
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dequalinium blocks macrophage-induced metastasis following local radiation

Dequalinium blocks macrophage-induced metastasis following local radiation

https://doi.org/10.18632/oncotarget.4826

Michael Timaner, Rotem Bril, Orit Kaidar-Person, Chen Rachman-Tzemah, Dror Alishekevitz, Ruslana Kotsofruk, Valeria Miller, Alexander Nevelsky, Shahar Daniel, Ziv Raviv, Susan A. Rotenberg,  and Yuval Shaked
27537-27554
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2α/androgen receptor signals

Infiltrating bone marrow mesenchymal stem cells (BM-MSCs) increase prostate cancer cell invasion via altering the CCL5/HIF2α/androgen receptor signals

https://doi.org/10.18632/oncotarget.4515

Jie Luo, Soo Ok Lee, Yun Cui, Rachel Yang, Lei Li,  and Chawnshang Chang
27555-27565
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inverse expression of somatostatin and CXCR4 chemokine receptors in gastroenteropancreatic neuroendocrine neoplasms of different malignancy

Inverse expression of somatostatin and CXCR4 chemokine receptors in gastroenteropancreatic neuroendocrine neoplasms of different malignancy

https://doi.org/10.18632/oncotarget.4491

Daniel Kaemmerer, Tina Träger, Maike Hoffmeister, Bence Sipos, Merten Hommann, Jörg Sänger, Stefan Schulz,  and Amelie Lupp
27566-27579
Abstract  |  PDF  |  HTML  |  Order a Reprint

Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1

Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1

https://doi.org/10.18632/oncotarget.4768

Wen-Ying Lee, Wai-Theng Lee, Chia-Hsiung Cheng, Ku-Chung Chen, Chih-Ming Chou, Chu-Hung Chung, Min-Siou Sun, Hung-Wei Cheng, Meng-Ni Ho,  and Cheng-Wei Lin
27580-27595
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, Stichoposide D inhibits growth of leukemia xenografts

By activating Fas/ceramide synthase 6/p38 kinase in lipid rafts, Stichoposide D inhibits growth of leukemia xenografts

https://doi.org/10.18632/oncotarget.4820

Seong-Hoon Yun, Eun-Seon Park, Sung-Won Shin, Mi-Ha Ju, Jin-Yeong Han, Jin-Sook Jeong, Sung-Hyun Kim, Valentin A. Stonik, Jong-Young Kwak,  and Joo-In Park
27596-27612
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression

Genetic determinants of FOXM1 overexpression in epithelial ovarian cancer and functional contribution to cell cycle progression

https://doi.org/10.18632/oncotarget.4546

Carter J Barger, Wa Zhang, Joanna Hillman, Aimee B. Stablewski, Michael J. Higgins, Barbara C. Vanderhyden, Kunle Odunsi,  and Adam R. Karpf
27613-27627
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Zinc finger transcription factor CASZ1 interacts with histones, DNA repair proteins and recruits NuRD complex to regulate gene transcription

Zinc finger transcription factor CASZ1 interacts with histones, DNA repair proteins and recruits NuRD complex to regulate gene transcription

https://doi.org/10.18632/oncotarget.4733

Zhihui Liu, Norris Lam,  and Carol J. Thiele
27628-27640
Abstract  |  PDF  |  HTML  |  Order a Reprint

NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer

NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer

https://doi.org/10.18632/oncotarget.4737

Yunlong Li, Yaohui Li, Wenping Chen, Fenfei He, Zhaobang Tan, Jianyong Zheng, Weizhong Wang, Qingchuan Zhao,  and Jipeng Li
27641-27650
Abstract  |  PDF  |  HTML  |  Order a Reprint

IL-6 signaling contributes to cisplatin resistance in non-small cell lung cancer via the up-regulation of anti-apoptotic and DNA repair associated molecules

IL-6 signaling contributes to cisplatin resistance in non-small cell lung cancer via the up-regulation of anti-apoptotic and DNA repair associated molecules

https://doi.org/10.18632/oncotarget.4753

Shanzhou Duan, Ying Tsai, Peter Keng, Yongbing Chen, Soo Ok Lee,  and Yuhchyau Chen
27651-27660
Abstract  |  PDF  |  HTML  |  Order a Reprint

Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells

Crocetinic acid inhibits hedgehog signaling to inhibit pancreatic cancer stem cells

https://doi.org/10.18632/oncotarget.4871

Parthasarathy Rangarajan, Dharmalingam Subramaniam, Santanu Paul, Deep Kwatra, Kanagaraj Palaniyandi, Shamima Islam, Sitaram Harihar, Satish Ramalinagam, William Gutheil, Sandeep Putty, Rohan Pradhan, Subhash Padhye, Danny R. Welch, Shrikant Anant,  and Animesh Dhar
27661-27673
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining

Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining

https://doi.org/10.18632/oncotarget.4876

Jason M. Beckta, Seth M. Dever, Nisha Gnawali, Ashraf Khalil, Amrita Sule, Sarah E. Golding, Elizabeth Rosenberg, Aarthi Narayanan, Kylene Kehn-Hall, Bo Xu, Lawrence F. Povirk,  and Kristoffer Valerie
27674-27687
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer

FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer

https://doi.org/10.18632/oncotarget.4280

Qipeng Fan, Qingchun Cai,  and Yan Xu
27688-27699
Abstract  |  PDF  |  HTML  |  Order a Reprint

Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis

Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis

https://doi.org/10.18632/oncotarget.4392

Jianxun Wang, Chang Feng, Yuqi He, Wei Ding, Jianqiu Sheng, Muhammad Arshad, Xiaojie Zhang,  and Peifeng Li
27700-27713
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model

Target therapy of multiple myeloma by PTX-NPs and ABCG2 antibody in a mouse xenograft model

https://doi.org/10.18632/oncotarget.4663

Cuiping Yang, Fei Xiong, Jun Dou, Jun Xue, Xi Zhan, Fangfang Shi, Miao Li, Songyan Wu, Shouhua Luo, Tianzhu Zhang, Yu Zhang, Ji Ming,  and Ning Gu
27714-27724
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clonal origins and parallel evolution of regionally synchronous colorectal adenoma and carcinoma

Clonal origins and parallel evolution of regionally synchronous colorectal adenoma and carcinoma

https://doi.org/10.18632/oncotarget.4834

Tae-Min Kim, Chang Hyeok An, Je-Keun Rhee, Seung-Hyun Jung, Sung Hak Lee, In-Pyo Baek, Min Sung Kim, Sug Hyung Lee,  and Yeun-Jun Chung
27725-27735
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-424 inhibits Akt3/E2F3 axis and tumor growth in hepatocellular carcinoma

MicroRNA-424 inhibits Akt3/E2F3 axis and tumor growth in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4811

Hao Yang, Wei Zheng, Xiao Shuai, Rui-Min Chang, Lei Yu, Feng Fang,  and Lian-Yue Yang
27736-27750
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pancreatic adenocarcinoma upregulated factor serves as adjuvant by activating dendritic cells through stimulation of TLR4

Pancreatic adenocarcinoma upregulated factor serves as adjuvant by activating dendritic cells through stimulation of TLR4

https://doi.org/10.18632/oncotarget.4859

Tae Heung Kang, Young Seob Kim, Seokho Kim, Benjamin Yang, Je-Jung Lee, Hyun-Ju Lee, Jaemin Lee, In Duk Jung, Hee Dong Han, Seung-Hyun Lee, Sang Seok Koh, T.-C. Wu,  and Yeong-Min Park
27751-27762
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nef-M1, a peptide antagonist of CXCR4, inhibits tumor angiogenesis and epithelial‑to‑mesenchymal transition in colon and breast cancers

Nef-M1, a peptide antagonist of CXCR4, inhibits tumor angiogenesis and epithelial‑to‑mesenchymal transition in colon and breast cancers

https://doi.org/10.18632/oncotarget.4615

Venkat R. Katkoori, Marc D. Basson, Vincent C. Bond, Upender Manne,  and Harvey L. Bumpers
27763-27777
Abstract  |  PDF  |  HTML  |  Order a Reprint

HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-β pathways

HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-β pathways

https://doi.org/10.18632/oncotarget.4813

Ran Duan, Lei Han, Qixue Wang, Jianwei Wei, Luyue Chen, Jianning Zhang, Chunsheng Kang,  and Lei Wang
27778-27793
Abstract  |  PDF  |  HTML  |  Order a Reprint

PIWIL1 destabilizes microtubule by suppressing phosphorylation at Ser16 and RLIM-mediated degradation of stathmin1

PIWIL1 destabilizes microtubule by suppressing phosphorylation at Ser16 and RLIM-mediated degradation of stathmin1

https://doi.org/10.18632/oncotarget.4533

Chao Li, Xiaoyan Zhou, Jianhui Chen, Yilu Lu, Qianqian Sun, Dachang Tao, Wei Hu, Xulei Zheng, Shasha Bian, Yunqiang Liu,  and Yongxin Ma
27794-27804
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-625-3p promotes cell migration and invasion via inhibition of SCAI in colorectal carcinoma cells

MiR-625-3p promotes cell migration and invasion via inhibition of SCAI in colorectal carcinoma cells

https://doi.org/10.18632/oncotarget.4738

Hailun Zheng, Renqiang Ma, Qizhi Wang, Pei Zhang, Dapeng Li, Qiangwu Wang, Jianchao Wang, Huabin Li, Hao Liu,  and Zhiwei Wang
27805-27815
Abstract  |  PDF  |  HTML  |  Order a Reprint

Rituximab-induced HMGB1 release is associated with inhibition of STAT3 activity in human diffuse large B-cell lymphoma

Rituximab-induced HMGB1 release is associated with inhibition of STAT3 activity in human diffuse large B-cell lymphoma

https://doi.org/10.18632/oncotarget.4816

Tiansuo Zhao, He Ren, Xiuchao Wang, Pengfei Liu, Fan Yan, Wenna Jiang, Yang Li, Jing Li, John G Gribben, Li Jia,  and Jihui Hao
27816-27831
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site

Vaccine-induced tumor regression requires a dynamic cooperation between T cells and myeloid cells at the tumor site

https://doi.org/10.18632/oncotarget.4940

Maxime Thoreau, HweiXian Leong Penny, KarWai Tan, Fabienne Regnier, Julia Miriam Weiss, Bernett Lee, Ludger Johannes, Estelle Dransart, Agnès Le Bon, Jean-Pierre Abastado, Eric Tartour, Alain Trautmann,  and Nadège Bercovici
27832-27846
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2

LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2

https://doi.org/10.18632/oncotarget.4443

Haiyan Li, Jiahui An, Mengying Wu, Qidi Zheng, Xin Gui, Tianming Li, Hu Pu,  and Dongdong Lu
27847-27864
Abstract  |  PDF  |  HTML  |  Order a Reprint

Immunoprofile from tissue microarrays to stratify familial breast cancer patients

Immunoprofile from tissue microarrays to stratify familial breast cancer patients

https://doi.org/10.18632/oncotarget.4720

Laura Schirosi, Simona De Summa, Stefania Tommasi, Angelo Paradiso, Domenico Sambiasi, Ondina Popescu, Giovanni Simone,  and Anita Mangia
27865-27879
Abstract  |  PDF  |  HTML  |  Order a Reprint

A novel mitosis-associated lncRNA, MA-linc1, is required for cell cycle progression and sensitizes cancer cells to Paclitaxel

A novel mitosis-associated lncRNA, MA-linc1, is required for cell cycle progression and sensitizes cancer cells to Paclitaxel

https://doi.org/10.18632/oncotarget.4944

Or Bida, Moriah Gidoni, Diana Ideses, Sol Efroni,  and Doron Ginsberg
27880-27890
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2

USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2

https://doi.org/10.18632/oncotarget.4451

Chunyan Liu, Lina Wang, Weiwen Chen, Shihu Zhao, Chunli Yin, Yani Lin, Anli Jiang,  and Pengju Zhang
27891-27906
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells

Targeting SOD1 induces synthetic lethal killing in BLM- and CHEK2-deficient colorectal cancer cells

https://doi.org/10.18632/oncotarget.4875

Babu V. Sajesh,  and Kirk J. McManus
27907-27922
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer

Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer

https://doi.org/10.18632/oncotarget.4736

María Dolores Cuenca-López, Gemma Serrano-Heras, Juan Carlos Montero, Verónica Corrales-Sánchez, Mónica Gomez-Juarez, Maria José Gascón-Escribano, Jorge Carlos Morales, Veronique Voisin, Luz Elena Núñez, Francisco Moris, Gary D. Bader, Atanasio Pandiella,  and Alberto Ocaña
27923-27937
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Automated tumor analysis for molecular profiling in lung cancer

Automated tumor analysis for molecular profiling in lung cancer

https://doi.org/10.18632/oncotarget.4391

Peter W. Hamilton, Yinhai Wang, Clinton Boyd, Jacqueline A. James, Maurice B. Loughrey, Joseph P. Hougton, David P. Boyle, Paul Kelly, Perry Maxwell, David McCleary, James Diamond, Darragh G. McArt, Jonathon Tunstall, Peter Bankhead,  and Manuel Salto-Tellez
27938-27952
Abstract  |  PDF  |  HTML  |  Order a Reprint

Growth arrest DNA damage-inducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma

Growth arrest DNA damage-inducible gene 45 gamma expression as a prognostic and predictive biomarker in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4446

Da-Liang Ou, Song-Kun Shyue, Liang-In Lin, Zi-Rui Feng, Jun-Yang Liou, Hsiang-Hsuan Fan, Bin-Shyun Lee, Chiun Hsu,  and Ann-Lii Cheng
27953-27965
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genomic deletion of chromosome 12p is an independent prognostic marker in prostate cancer

Genomic deletion of chromosome 12p is an independent prognostic marker in prostate cancer

https://doi.org/10.18632/oncotarget.4626

Martina Kluth, Ramin Ahrary, Claudia Hube-Magg, Malik Ahmed, Heinke Volta, Catina Schwemin, Stefan Steurer, Corinna Wittmer, Waldemar Wilczak, Eike Burandt, Till Krech, Meike Adam, Uwe Michl, Hans Heinzer, Georg Salomon, Markus Graefen, Christina Koop, Sarah Minner, Ronald Simon, Guido Sauter,  and Thorsten Schlomm
27966-27979
Abstract  |  PDF  |  HTML  |  Order a Reprint

A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines

A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines

https://doi.org/10.18632/oncotarget.4735

Julien Bouley, Lina Saad, Romain Grall, Amelie Schellenbauer, Denis Biard, Vincent Paget, Sandrine Morel-Altmeyer, Olivier Guipaud, Christophe Chambon, Bernard Salles, Karim Maloum, Hélène Merle-Béral, Sylvie Chevillard,  and Jozo Delic
27980-28000
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AZD1775 sensitizes T cell acute lymphoblastic leukemia cells to cytarabine by promoting apoptosis over DNA repair

AZD1775 sensitizes T cell acute lymphoblastic leukemia cells to cytarabine by promoting apoptosis over DNA repair

https://doi.org/10.18632/oncotarget.4830

James B. Ford, Dmitry Baturin, Tamara M. Burleson, Annemie A. Van Linden, Yong-Mi Kim,  and Christopher C. Porter
28001-28010
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure

https://doi.org/10.18632/oncotarget.4377

Yves-Paul Vandewynckel, Debby Laukens, Lindsey Devisscher, Annelies Paridaens, Eliene Bogaerts, Xavier Verhelst, Anja Van den Bussche, Sarah Raevens, Christophe Van Steenkiste, Marleen Van Troys, Christophe Ampe, Benedicte Descamps, Chris Vanhove, Olivier Govaere, Anja Geerts,  and Hans Van Vlierberghe
28011-28025
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer

COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer

https://doi.org/10.18632/oncotarget.4731

Shujun Gao, Lekun Fang, Liem Minh Phan, Aiham Qdaisat, Sai-Ching J Yeung,  and Mong-Hong Lee
28026-28041
Abstract  |  PDF  |  HTML  |  Order a Reprint

Interferon-gamma inducible protein 10 (IP10) induced cisplatin resistance of HCC after liver transplantation through ER stress signaling pathway

Interferon-gamma inducible protein 10 (IP10) induced cisplatin resistance of HCC after liver transplantation through ER stress signaling pathway

https://doi.org/10.18632/oncotarget.4832

Wei Geng, Chung-Mau Lo, Kevin T.P. Ng, Chang-Chun Ling, Xiang Qi, Chang-Xian Li, Yuan Zhai, Xiao-Bing Liu, Yuen-Yuen Ma,  and Kwan Man
28042-28056
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy

V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy

https://doi.org/10.18632/oncotarget.4812

Nathalie Meo-Evoli, Eugènia Almacellas, Francesco Alessandro Massucci, Antonio Gentilella, Santiago Ambrosio, Sara C. Kozma, George Thomas,  and Albert Tauler
28057-28070
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FCGR2A, FCGR3A polymorphisms and therapeutic efficacy of anti-EGFR monoclonal antibody in metastatic colorectal cancer

FCGR2A, FCGR3A polymorphisms and therapeutic efficacy of anti-EGFR monoclonal antibody in metastatic colorectal cancer

https://doi.org/10.18632/oncotarget.4872

Hou-Qun Ying, Feng Wang, Xiao-Lin Chen, Bang-Shun He, Yu-Qin Pan, Chen Jie, Xian Liu, Wei-Jun Cao, Hong-Xin Peng, Kang Lin,  and Shu-Kui Wang
28071-28083
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells

Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells

https://doi.org/10.18632/oncotarget.4394

Anne-Sophie Bach, Danielle Derocq, Valérie Laurent-Matha, Philippe Montcourrier, Salwa Sebti, Béatrice Orsetti, Charles Theillet, Céline Gongora, Sophie Pattingre, Eva Ibing, Pascal Roger, Laetitia K Linares, Thomas Reinheckel, Guillaume Meurice, Frank J. Kaiser, Christian Gespach,  and Emmanuelle Liaudet-Coopman
28084-28103
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HIF isoforms have divergent effects on invasion, metastasis, metabolism and formation of lipid droplets

HIF isoforms have divergent effects on invasion, metastasis, metabolism and formation of lipid droplets

https://doi.org/10.18632/oncotarget.4612

Tariq Shah, Balaji Krishnamachary, Flonne Wildes, Yelena Mironchik, Samata M. Kakkad, Desmond Jacob, Dmitri Artemov,  and Zaver M. Bhujwalla
28104-28119
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RICTOR involvement in the PI3K/AKT pathway regulation in melanocytes and melanoma

RICTOR involvement in the PI3K/AKT pathway regulation in melanocytes and melanoma

https://doi.org/10.18632/oncotarget.4866

Florence Laugier, Adeline Finet-Benyair, Jocelyne André, P. Sivaramakrishna Rachakonda, Rajiv Kumar, Armand Bensussan,  and Nicolas Dumaz
28120-28131
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells

RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells

https://doi.org/10.18632/oncotarget.4654

Jessica L. Brusgard, Moran Choe, Saranya Chumsri, Keli Renoud, Alexander D. MacKerell Jr., Marius Sudol,  and Antonino Passaniti
28132-28150
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LincRNA-p21 activates endoplasmic reticulum stress and inhibits hepatocellular carcinoma

LincRNA-p21 activates endoplasmic reticulum stress and inhibits hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4661

Ning Yang, Yong Fu, Haibin Zhang, Hui Sima, Nan Zhu,  and Guangshun Yang
28151-28163
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Functional genomic mRNA profiling of a large cancer data base demonstrates mesothelin overexpression in a broad range of tumor types

Functional genomic mRNA profiling of a large cancer data base demonstrates mesothelin overexpression in a broad range of tumor types

https://doi.org/10.18632/oncotarget.4461

Laetitia E. Lamberts, Derk Jan A. de Groot, Rico D. Bense, Elisabeth G.E. de Vries,  and Rudolf S.N. Fehrmann
28164-28172
Abstract  |  PDF  |  HTML  |  Order a Reprint

Whole-transcriptome analysis links trastuzumab sensitivity of breast tumors to both HER2 dependence and immune cell infiltration

Whole-transcriptome analysis links trastuzumab sensitivity of breast tumors to both HER2 dependence and immune cell infiltration

https://doi.org/10.18632/oncotarget.4405

Tiziana Triulzi, Loris De Cecco, Marco Sandri, Aleix Prat, Marta Giussani, Biagio Paolini, Marialuisa L. Carcangiu, Silvana Canevari, Alberto Bottini, Andrea Balsari, Sylvie Menard, Daniele Generali, Manuela Campiglio, Serena Di Cosimo,  and Elda Tagliabue
28173-28182
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Na+/K+-ATPase α1 subunit, a novel therapeutic target for hepatocellular carcinoma

Na+/K+-ATPase α1 subunit, a novel therapeutic target for hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4726

Liping Zhuang, Litao Xu, Peng Wang, Yan Jiang, Pan Yong, Chenyue Zhang, Haibin Zhang, Zhiqiang Meng,  and Peiying Yang
28183-28193
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A poxviral-based cancer vaccine the transcription factor twist inhibits primary tumor growth and metastases in a model of metastatic breast cancer and improves survival in a spontaneous prostate cancer model

A poxviral-based cancer vaccine the transcription factor twist inhibits primary tumor growth and metastases in a model of metastatic breast cancer and improves survival in a spontaneous prostate cancer model

https://doi.org/10.18632/oncotarget.4442

Anna R. Kwilas, Andressa Ardiani, Ulrike Dirmeier, Cornelia Wottawah, Jeffery Schlom,  and James W. Hodge
28194-28210
Abstract  |  PDF  |  HTML  |  Order a Reprint

Gastrointestinal malignancies harbor actionable MET exon 14 deletions

Gastrointestinal malignancies harbor actionable MET exon 14 deletions

https://doi.org/10.18632/oncotarget.4721

Jeeyun Lee, Sai-Hong Ignatius Ou, Ji Min Lee, Hee Cheol Kim, Mineui Hong, Sun Young Kim, Jiryeon Jang, Soomin Ahn, So Young Kang, Sujin Lee, Seung Tae Kim, Bogyou Kim, Jaehyun Choi, Kyung-Ah Kim, Jiyun Lee, Charny Park, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Keunchil Park, Young Suk Park,  and Kyoung-Mee Kim
28211-28222
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

WT1-mediated repression of the proapoptotic transcription factor ZNF224 is triggered by the BCR-ABL oncogene

WT1-mediated repression of the proapoptotic transcription factor ZNF224 is triggered by the BCR-ABL oncogene

https://doi.org/10.18632/oncotarget.4950

Giorgia Montano, Karina Vidovic, Chiara Palladino, Elena Cesaro, Gaetano Sodaro, Concetta Quintarelli, Biagio De Angelis, Santa Errichiello, Fabrizio Pane, Paola Izzo, Michela Grosso, Urban Gullberg,  and Paola Costanzo
28223-28237
Abstract  |  PDF  |  HTML  |  Order a Reprint

Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress

Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress

https://doi.org/10.18632/oncotarget.4958

Daniel Domínguez, Purificación Feijoo, Aina Bernal, Amaia Ercilla, Neus Agell, Anna Genescà,  and Laura Tusell
28238-28256
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2

Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2

https://doi.org/10.18632/oncotarget.4960

Shingo Inaguma, Hideaki Ito, Miho Riku, Hiroshi Ikeda,  and Kenji Kasai
28257-28268
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair

The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair

https://doi.org/10.18632/oncotarget.4961

Wei Wang, Yongju Lu, Paul M. Stemmer, Xiangmin Zhang, Yongyi Bi, Zhengping Yi,  and Fei Chen
28269-28281
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells

Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells

https://doi.org/10.18632/oncotarget.5061

Rachid Zagani, Wissal El-Assaad, Isabelle Gamache,  and Jose G. Teodoro
28282-28295
Abstract  |  PDF  |  HTML  |  Order a Reprint

Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells

Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells

https://doi.org/10.18632/oncotarget.5064

Harish Chandra Pal, Ronald D. Baxter, Katherine M. Hunt, Jyoti Agarwal, Craig A. Elmets, Mohammad Athar,  and Farrukh Afaq
28296-28311
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer

Identification of the DEAD box RNA helicase DDX3 as a therapeutic target in colorectal cancer

https://doi.org/10.18632/oncotarget.4873

Marise R. Heerma van Voss, Farhad Vesuna, Kari Trumpi, Justin Brilliant, Cynthia Berlinicke, Wendy de Leng, Onno Kranenburg, G. Johan Offerhaus, Horst Bürger, Elsken van der Wall, Paul J. van Diest,  and Venu Raman
28312-28326
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ovarian carcinoma patient derived xenografts reproduce their tumor of origin and preserve an oligoclonal structure

Ovarian carcinoma patient derived xenografts reproduce their tumor of origin and preserve an oligoclonal structure

https://doi.org/10.18632/oncotarget.5069

Pierre-Emmanuel Colombo, Stanislas du Manoir, Béatrice Orsetti, Rui Bras-Gonçalves, Mario B. Lambros, Alan MacKay, Tien-Tuan Nguyen, Florence Boissière, Didier Pourquier, Frédéric Bibeau, Jorge S. Reis-Filho,  and Charles Theillet
28327-28340
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-23a sensitizes nasopharyngeal carcinoma to irradiation by targeting IL-8/Stat3 pathway

MiR-23a sensitizes nasopharyngeal carcinoma to irradiation by targeting IL-8/Stat3 pathway

https://doi.org/10.18632/oncotarget.5117

Jia-Quan Qu, Hong-Mei Yi, Xu Ye, Li-Na Li, Jin-Feng Zhu, Ta Xiao, Li Yuan, Jiao-Yang Li, Yuan-Yuan Wang, Juan Feng, Qiu-Yan He, Shan-Shan Lu, Hong Yi,  and Zhi-Qiang Xiao
28341-28356
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

microRNA-106b-mediated down-regulation of C1orf24 expression induces apoptosis and suppresses invasion of thyroid cancer

microRNA-106b-mediated down-regulation of C1orf24 expression induces apoptosis and suppresses invasion of thyroid cancer

https://doi.org/10.18632/oncotarget.4947

Gianna Carvalheira, Bruno Heidi Nozima,  and Janete Maria Cerutti
28357-28370
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulation of p53 expression and apoptosis by vault RNA2-1-5p in cervical cancer cells

Regulation of p53 expression and apoptosis by vault RNA2-1-5p in cervical cancer cells

https://doi.org/10.18632/oncotarget.4948

Lu Kong, Qi Hao, Ying Wang, Ping Zhou, Binbin Zou,  and Yu-xiang Zhang
28371-28388
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2

Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2

https://doi.org/10.18632/oncotarget.4949

Carmen Ghilardi, Antonietta Silini, Sara Figini, Alessia Anastasia, Monica Lupi, Robert Fruscio, Raffaella Giavazzi,  and MariaRosa Bani
28389-28400
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Elevated S100A9 expression in tumor stroma functions as an early recurrence marker for early-stage oral cancer patients through increased tumor cell invasion, angiogenesis, macrophage recruitment and interleukin-6 production

Elevated S100A9 expression in tumor stroma functions as an early recurrence marker for early-stage oral cancer patients through increased tumor cell invasion, angiogenesis, macrophage recruitment and interleukin-6 production

https://doi.org/10.18632/oncotarget.4951

Wei-Yu Fang, Yi-Wen Chen, Jenn-Ren Hsiao, Chiang-Shin Liu, Yi-Zih Kuo, Yi-Ching Wang, Kung-Chao Chang, Sen-Tien Tsai, Mei-Zhu Chang, Siao-Han Lin,  and Li-Wha Wu
28401-28424
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NKX6.3 controls gastric differentiation and tumorigenesis

NKX6.3 controls gastric differentiation and tumorigenesis

https://doi.org/10.18632/oncotarget.4952

Jung Hwan Yoon, Won Suk Choi, Olga Kim, Sung Sook Choi, Eun Kyung Lee, Suk Woo Nam, Jung Young Lee,  and Won Sang Park
28425-28439
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma

ATAD2 overexpression links to enrichment of B-MYB-translational signatures and development of aggressive endometrial carcinoma

https://doi.org/10.18632/oncotarget.4955

Camilla Krakstad, Ingvild L. Tangen, Erling A. Hoivik, Mari K. Halle, Anna Berg, Henrica M. Werner, Maria B. Ræder, Kanthida Kusonmano, June X. Zou, Anne M. Øyan, Ingunn Stefansson, Jone Trovik, Karl-Henning Kalland, Hong-Wu Chen,  and Helga B. Salvesen
28440-28452
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Exploring response signals and targets in aggressive unresectable hepatocellular carcinoma: an analysis of targeted therapy phase 1 trials

Exploring response signals and targets in aggressive unresectable hepatocellular carcinoma: an analysis of targeted therapy phase 1 trials

https://doi.org/10.18632/oncotarget.4601

Ishwaria M. Subbiah, Gerald S. Falchook, Ahmed O. Kaseb, Kenneth R. Hess, Apostolia M. Tsimberidou, Siqing Fu, Vivek Subbiah, David S. Hong, Aung Naing, Sarina A. Piha-Paul, Owais Akmal, Filip Janku,  and Razelle Kurzrock
28453-28462
Abstract  |  PDF  |  HTML  |  Order a Reprint

A new computational model for human thyroid cancer enhances the preoperative diagnostic efficacy

A new computational model for human thyroid cancer enhances the preoperative diagnostic efficacy

https://doi.org/10.18632/oncotarget.4691

Tuo Li, Jianguo Sheng, Weiqin Li, Xin Zhang, Hongyu Yu, Xueyun Chen, Jianquan Zhang, Quancai Cai, Yongquan Shi,  and Zhimin Liu
28463-28477
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High expression of XPA confers poor prognosis for nasopharyngeal carcinoma patients treated with platinum-based chemoradiotherapy

High expression of XPA confers poor prognosis for nasopharyngeal carcinoma patients treated with platinum-based chemoradiotherapy

https://doi.org/10.18632/oncotarget.4424

Xiang Fu, Jiali Hu, Hong-yu Han, Yi-jun Hua, Ling Zhou, Wen-di Shuai, Wu-ying Du, Chun-mei Kuang, Shuai Chen, Wenlin Huang,  and Ran-yi Liu
28478-28490
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Vascular endothelial growth factor expression correlates with serum CA125 and represents a useful tool in prediction of refractoriness to platinum-based chemotherapy and ascites formation in epithelial ovarian cancer

Vascular endothelial growth factor expression correlates with serum CA125 and represents a useful tool in prediction of refractoriness to platinum-based chemotherapy and ascites formation in epithelial ovarian cancer

https://doi.org/10.18632/oncotarget.4427

Samar Masoumi-Moghaddam, Afshin Amini, Ai-Qun Wei, Gregory Robertson,  and David L. Morris
28491-28501
Abstract  |  PDF  |  HTML  |  Order a Reprint

Therapeutic efficacy of combined BRAF and MEK inhibition in metastatic melanoma: a comprehensive network meta-analysis of randomized controlled trials

Therapeutic efficacy of combined BRAF and MEK inhibition in metastatic melanoma: a comprehensive network meta-analysis of randomized controlled trials

https://doi.org/10.18632/oncotarget.4375

Ruiqin Mai, Songxia Zhou, Weixiang Zhong, Siming Rong, Zhichao Cong, Yunxian Li, Qizhi Xie, Huanming Chen, Xiaoyun Li, Shuhui Liu, Yabin Cheng, Yuanshen Huang, Youwen Zhou,  and Guohong Zhang
28502-28512
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