Oncotarget

Vol 6, No 28

September 22, 2015

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Editorial

Ciliopathy in PCS (MVA) syndrome

Ciliopathy in PCS (MVA) syndrome

https://doi.org/10.18632/oncotarget.5244

Tatsuo Miyamoto,  and Shinya Matsuura
24582-24583
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ICOS regulates ILC2s in asthma

ICOS regulates ILC2s in asthma

https://doi.org/10.18632/oncotarget.5245

Hadi Maazi,  and Omid Akbari
24584-24585
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ULK1 in type I interferon response

ULK1 in type I interferon response

https://doi.org/10.18632/oncotarget.5241

Diana Saleiro,  and Leonidas C. Platanias
24586-24587
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RSK-c-Fos in KSHV lytic progression

RSK-c-Fos in KSHV lytic progression

https://doi.org/10.18632/oncotarget.5262

Xiaojuan Li,  and Ersheng Kuang
24588-24589
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Clearance of dying cells accelerates malignancy

Clearance of dying cells accelerates malignancy

https://doi.org/10.18632/oncotarget.5670

David B. Vaught,  and Rebecca S. Cook
24590-24591
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Gli2, hedgehog and TCR signalling

Gli2, hedgehog and TCR signalling

https://doi.org/10.18632/oncotarget.5017

Anna L. Furmanski,  and Tessa Crompton
24592-24593
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Editorial: Chromosome

Nek5: a new regulator of centrosome integrity

Nek5: a new regulator of centrosome integrity

https://doi.org/10.18632/oncotarget.5139

Suzanna L. Prosser,  and Andrew M. Fry
24594-24595
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Progenitor cell fate, SOXC and WNT

Progenitor cell fate, SOXC and WNT

https://doi.org/10.18632/oncotarget.5237

Pallavi Bhattaram, Kenji Kato,  and Véronique Lefebvre
24596-24597
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Putting the brakes on chondrosarcoma

Putting the brakes on chondrosarcoma

https://doi.org/10.18632/oncotarget.5242

Pavel Krejci
24598-24598
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Priority Research Papers

Quaking and miR-155 interactions in inflammation and leukemogenesis

Quaking and miR-155 interactions in inflammation and leukemogenesis

https://doi.org/10.18632/oncotarget.5248

Esmerina Tili, Marcela Chiabai, Dario Palmieri, Melissa Brown, Ri Cui, Cecilia Fernandes, Tim Richmond, Taewan Kim, Tyler Sheetz, Hui-Lung Sun, Alessandro Lagana, Dario Veneziano, Stefano Volinia, Laura Rassenti, Thomas Kipps, Hamdy Awad, Jean-Jacques Michaille,  and Carlo M. Croce
24599-24610
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Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo

Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo

https://doi.org/10.18632/oncotarget.5232

Claudia Tonelli, Marco J. Morelli, Salvatore Bianchi, Luca Rotta, Thelma Capra, Arianna Sabò, Stefano Campaner,  and Bruno Amati
24611-24626
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Age-related somatic mutations in the cancer genome

Age-related somatic mutations in the cancer genome

https://doi.org/10.18632/oncotarget.5685

Brandon Milholland, Adam Auton, Yousin Suh,  and Jan Vijg
24627-24635
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Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction

Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour action via extracellular matrix metalloproteases (MMPs) induction

https://doi.org/10.18632/oncotarget.4323

Ibtissam Marchiq, Jean Albrengues, Sara Granja, Cédric Gaggioli, Jacques Pouysségur,  and Marie-Pierre Simon
24636-24648
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Priority Research Papers: Immunology

Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors

Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors

https://doi.org/10.18632/oncotarget.5584

Emily J. Colbeck, James P. Hindley, Kathryn Smart, Emma Jones, Anja Bloom, Hayley Bridgeman, Rhoanne C. McPherson, Darryl G. Turner, Kristin Ladell, David A. Price, Richard A. O’Connor, Stephen M. Anderton, Andrew J. Godkin,  and Awen M. Gallimore
24649-24659
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Research Papers: Gerotarget (Focus on Aging)

Neuroprotective effect of cellular prion protein (PrPC) is related with activation of alpha7 nicotinic acetylcholine receptor (α7nAchR)-mediated autophagy flux

Neuroprotective effect of cellular prion protein (PrPC) is related with activation of alpha7 nicotinic acetylcholine receptor (α7nAchR)-mediated autophagy flux

https://doi.org/10.18632/oncotarget.4953

Jae-Kyo Jeong,  and Sang-Youel Park
24660-24674
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Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways

Bradykinin inhibits oxidative stress-induced senescence of endothelial progenitor cells through the B2R/AKT/RB and B2R/EGFR/RB signal pathways

https://doi.org/10.18632/oncotarget.5071

Cong Fu, Bing Li, Yuning Sun, Genshan Ma,  and Yuyu Yao
24675-24689
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Research Papers: Pathology

Identification of deregulation of apoptosis and cell cycle in neuroendocrine tumors of the lung via NanoString nCounter expression analysis

Identification of deregulation of apoptosis and cell cycle in neuroendocrine tumors of the lung via NanoString nCounter expression analysis

https://doi.org/10.18632/oncotarget.3992

Robert Fred Henry Walter, Robert Werner, Saskia Ting, Claudia Vollbrecht, Dirk Theegarten, Daniel Christian Christoph, Kurt Werner Schmid, Jeremias Wohlschlaeger,  and Fabian Dominik Mairinger
24690-24698
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Apocynin improving cardiac remodeling in chronic renal failure disease is associated with up-regulation of epoxyeicosatrienoic acids

Apocynin improving cardiac remodeling in chronic renal failure disease is associated with up-regulation of epoxyeicosatrienoic acids

https://doi.org/10.18632/oncotarget.5084

Kun Zhang, Yu Liu, Xiaoqiang Liu, Jie Chen, Qingqing Cai, Jingfeng Wang,  and Hui Huang
24699-24708
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N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy

N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy

https://doi.org/10.18632/oncotarget.5077

Bin Wang, Shuping Zhong, Fuchun Zheng, Yanmei Zhang, Fenfei Gao, Yicun Chen, Binger Lu, Han Xu,  and Ganggang Shi
24709-24721
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ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma

ALDH1A1-overexpressing cells are differentiated cells but not cancer stem or progenitor cells in human hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4406

Kaori Tanaka, Hiroyuki Tomita, Kenji Hisamatsu, Noriyuki Nakashima, Yuichiro Hatano, Yoshiyuki Sasaki, Shinji Osada, Takuji Tanaka, Tatsuhiko Miyazaki, Kazuhiro Yoshida,  and Akira Hara
24722-24732
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Reviews

The 26S proteasome is a multifaceted target for anti-cancer therapies

The 26S proteasome is a multifaceted target for anti-cancer therapies

https://doi.org/10.18632/oncotarget.4619

Tatyana A. Grigoreva, Vyacheslav G. Tribulovich, Alexander V. Garabadzhiu, Gerry Melino,  and Nickolai A. Barlev
24733-24749
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Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy

Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy

https://doi.org/10.18632/oncotarget.4990

Ismael Riquelme, Kathleen Saavedra, Jaime A. Espinoza, Helga Weber, Patricia García, Bruno Nervi, Marcelo Garrido, Alejandro H. Corvalán, Juan Carlos Roa,  and Carolina Bizama
24750-24779
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New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS?

New findings on primary and acquired resistance to anti-EGFR therapy in metastatic colorectal cancer: do all roads lead to RAS?

https://doi.org/10.18632/oncotarget.4959

Giuseppe Bronte, Nicola Silvestris, Marta Castiglia, Antonio Galvano, Francesco Passiglia, Giovanni Sortino, Giuseppe Cicero, Christian Rolfo, Marc Peeters, Viviana Bazan, Daniele Fanale, Antonio Giordano,  and Antonio Russo
24780-24796
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Research Papers

Dissecting tRNA-derived fragment complexities using personalized transcriptomes reveals novel fragment classes and unexpected dependencies

Dissecting tRNA-derived fragment complexities using personalized transcriptomes reveals novel fragment classes and unexpected dependencies

https://doi.org/10.18632/oncotarget.4695

Aristeidis G. Telonis, Phillipe Loher, Shozo Honda, Yi Jing, Juan Palazzo, Yohei Kirino,  and Isidore Rigoutsos
24797-24822
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Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma

Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma

https://doi.org/10.18632/oncotarget.4485

Luigi Fattore, Debora Malpicci, Emanuele Marra, Francesca Belleudi, Alessia Noto, Claudia De Vitis, Maria Elena Pisanu, Pierpaolo Coluccia, Rosa Camerlingo, Giuseppe Roscilli, Antoni Ribas, Arianna Di Napoli, Maria Rosaria Torrisi, Luigi Aurisicchio, Paolo Antonio Ascierto, Rita Mancini,  and Gennaro Ciliberto
24823-24841
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Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow

Distinct kinetic and mechanical properties govern mucin 16- and podocalyxin-mediated tumor cell adhesion to E- and L-selectin in shear flow

https://doi.org/10.18632/oncotarget.4704

Daniel J. Shea, Denis Wirtz, Kathleen J. Stebe,  and Konstantinos Konstantopoulos
24842-24855
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models

Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models

https://doi.org/10.18632/oncotarget.4498

Carol Ward, James Meehan, Peter Mullen, Claudiu Supuran, J. Michael Dixon, Jeremy S. Thomas, Jean-Yves Winum, Philippe Lambin, Ludwig Dubois, Nanda-Kumar Pavathaneni, Edward J. Jarman, Lorna Renshaw, InHwa Um, Charlene Kay, David J. Harrison, Ian H. Kunkler,  and Simon P. Langdon
24856-24870
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TERT promoter mutations contribute to IDH mutations in predicting differential responses to adjuvant therapies in WHO grade II and III diffuse gliomas

TERT promoter mutations contribute to IDH mutations in predicting differential responses to adjuvant therapies in WHO grade II and III diffuse gliomas

https://doi.org/10.18632/oncotarget.4549

Zhen-Yu Zhang, Aden Ka-Yin Chan, Xiao-Jie Ding, Zhi-Yong Qin, Christopher S. Hong, Ling-Chao Chen, Xin Zhang, Fang-Ping Zhao, Yin Wang, Yang Wang, Liang-Fu Zhou, Zhengping Zhuang, Ho-Keung Ng, Hai Yan, Yu Yao,  and Ying Mao
24871-24883
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing

A novel anti-GD2/4-1BB chimeric antigen receptor triggers neuroblastoma cell killing

https://doi.org/10.18632/oncotarget.4670

Malvina Prapa, Sara Caldrer, Carlotta Spano, Marco Bestagno, Giulia Golinelli, Giulia Grisendi, Tiziana Petrachi, Pierfranco Conte, Edwin M Horwitz, Dario Campana, Paolo Paolucci,  and Massimo Dominici
24884-24894
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A measles virus selectively blind to signaling lymphocytic activation molecule shows anti-tumor activity against lung cancer cells

A measles virus selectively blind to signaling lymphocytic activation molecule shows anti-tumor activity against lung cancer cells

https://doi.org/10.18632/oncotarget.4366

Tomoko Fujiyuki, Misako Yoneda, Yosuke Amagai, Kunie Obayashi, Fusako Ikeda, Koichiro Shoji, Yoshinori Murakami, Hiroki Sato,  and Chieko Kai
24895-24903
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Continuation of epidermal growth factor receptor tyrosine kinase inhibitor treatment prolongs disease control in non-small-cell lung cancers with acquired resistance to EGFR tyrosine kinase inhibitors

Continuation of epidermal growth factor receptor tyrosine kinase inhibitor treatment prolongs disease control in non-small-cell lung cancers with acquired resistance to EGFR tyrosine kinase inhibitors

https://doi.org/10.18632/oncotarget.4570

Qi Chen, Qi Quan, Lingyu Ding, Xiangchan Hong, Ningning Zhou, Ying Liang,  and Haiying Wu
24904-24911
Abstract  |  PDF  |  HTML  |  Order a Reprint

Over-expression of ROR2 and Wnt5a cooperatively correlates with unfavorable prognosis in patients with non-small cell lung cancer

Over-expression of ROR2 and Wnt5a cooperatively correlates with unfavorable prognosis in patients with non-small cell lung cancer

https://doi.org/10.18632/oncotarget.4701

Chenlin Lu, Xudong Wang, Huijun Zhu, Jian Feng, Songshi Ni,  and Jianfei Huang
24912-24921
Abstract  |  PDF  |  HTML  |  Order a Reprint

Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity

Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity

https://doi.org/10.18632/oncotarget.4679

Arnaud Jabouille, Maylis Delugin, Raphaël Pineau, Alexandre Dubrac, Fabienne Soulet, Stéphanie Lhomond, Nestor Pallares-Lupon, Hervé Prats, Andreas Bikfalvi, Eric Chevet, Christian Touriol,  and Michel Moenner
24922-24934
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MDA5 complements TLR3 in suppression of neuroblastoma

MDA5 complements TLR3 in suppression of neuroblastoma

https://doi.org/10.18632/oncotarget.4511

Wen-Ming Hsu, Chao-Cheng Huang, Hsin-Yu Lee, Pei-Yi Wu, Min-Tsui Wu, Hui-Ching Chuang, Li-Ling Lin,  and Jiin-Haur Chuang
24935-24946
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer

An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer

https://doi.org/10.18632/oncotarget.4453

Mei-Ying Liao, Jun-Kai Lai, Mark Yen-Ping Kuo, Ruei-Min Lu, Cheng-Wei Lin, Ping-Chang Cheng, Kang-Hao Liang,  and Han-Chung Wu
24947-24968
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Azathioprine induction of tumors with microsatellite instability: risk evaluation using a mouse model

Azathioprine induction of tumors with microsatellite instability: risk evaluation using a mouse model

https://doi.org/10.18632/oncotarget.4638

Sahra Bodo, Magali Svrcek, Isabelle Sourrouille, Peggy Cuillières-Dartigues, Tatiana Ledent, Sylvie Dumont, Laetitia Dinard, Philippe Lafitte, Camille Capel, Ada Collura, Olivier Buhard, Kristell Wanherdrick, Alexandra Chalastanis, Virginie Penard-Lacronique, Bettina Fabiani, Jean-François Fléjou, Nicole Brousse, Laurent Beaugerie, Alex Duval,  and Martine Muleris
24969-24977
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Local production of the chemokines CCL5 and CXCL10 attracts CD8+ T lymphocytes into esophageal squamous cell carcinoma

Local production of the chemokines CCL5 and CXCL10 attracts CD8+ T lymphocytes into esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.4617

Jinyan Liu, Feng Li, Yu Ping, Liping Wang, Xinfeng Chen, Dan Wang, Ling Cao, Song Zhao, Bing Li, Pawel Kalinski, Stephen H. Thorne, Bin Zhang,  and Yi Zhang
24978-24989
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens

Characterization of tumor infiltrating lymphocytes in paired primary and metastatic renal cell carcinoma specimens

https://doi.org/10.18632/oncotarget.4572

Marina K Baine, Gabriela Turcu, Christopher R Zito, Adebowale J Adeniran, Robert L Camp, Lieping Chen, Harriet M. Kluger,  and Lucia B Jilaveanu
24990-25002
Abstract  |  PDF  |  HTML  |  Order a Reprint

Construction and analysis of lncRNA-lncRNA synergistic networks to reveal clinically relevant lncRNAs in cancer

Construction and analysis of lncRNA-lncRNA synergistic networks to reveal clinically relevant lncRNAs in cancer

https://doi.org/10.18632/oncotarget.4660

Yongsheng Li, Juan Chen, Jinwen Zhang, Zishan Wang, Tingting Shao, Chunjie Jiang, Juan Xu,  and Xia Li
25003-25016
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Detection of soluble EpCAM (sEpCAM) in malignant ascites predicts poor overall survival in patients treated with catumaxomab

Detection of soluble EpCAM (sEpCAM) in malignant ascites predicts poor overall survival in patients treated with catumaxomab

https://doi.org/10.18632/oncotarget.4496

Andreas Seeber, Ioana Braicu, Gerold Untergasser, Mani Nassir, Dominic Fong, Laura Botta, Guenther Gastl, Heidi Fiegl, Alain Zeimet, Jalid Sehouli,  and Gilbert Spizzo
25017-25023
Abstract  |  PDF  |  HTML  |  Order a Reprint

MiR-215, an activator of the CTNNBIP1/β-catenin pathway, is a marker of poor prognosis in human glioma

MiR-215, an activator of the CTNNBIP1/β-catenin pathway, is a marker of poor prognosis in human glioma

https://doi.org/10.18632/oncotarget.4622

Yong-Qing Tong, Bei Liu, Hong-Yun Zheng, Jian Gu, Hang Liu, Feng Li, Bi-Hua Tan, Melanie Hartman, Chunhua Song,  and Yan Li
25024-25033
Abstract  |  PDF  |  HTML  |  Order a Reprint

Cytosolic TMEM88 promotes triple-negative breast cancer by interacting with Dvl

Cytosolic TMEM88 promotes triple-negative breast cancer by interacting with Dvl

https://doi.org/10.18632/oncotarget.4379

Xinmiao Yu, Xiupeng Zhang, Yong Zhang, Guiyang Jiang, Xiaoyun Mao,  and Feng Jin
25034-25045
Abstract  |  PDF  |  HTML  |  Order a Reprint

A meta-analysis including dose-response relationship between night shift work and the risk of colorectal cancer

A meta-analysis including dose-response relationship between night shift work and the risk of colorectal cancer

https://doi.org/10.18632/oncotarget.4502

Xiao Wang, Alin Ji, Yi Zhu, Zhen Liang, Jian Wu, Shiqi Li, Shuai Meng, Xiangyi Zheng,  and Liping Xie
25046-25060
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Hepatitis B virus-associated diffuse large B-cell lymphoma: unique clinical features, poor outcome, and hepatitis B surface antigen-driven origin

Hepatitis B virus-associated diffuse large B-cell lymphoma: unique clinical features, poor outcome, and hepatitis B surface antigen-driven origin

https://doi.org/10.18632/oncotarget.4677

Lijuan Deng, Yuqin Song, Ken H. Young, Shimin Hu, Ning Ding, Weiwei Song, Xianghong Li, Yunfei Shi, Huiying Huang, Weiping Liu, Wen Zheng, Xiaopei Wang, Yan Xie, Ningjing Lin, Meifeng Tu, Lingyan Ping, Zhitao Ying, Chen Zhang, Yingli Sun,  and Jun Zhu
25061-25073
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Annexin A1 is involved in the acquisition and maintenance of a stem cell-like/aggressive phenotype in prostate cancer cells with acquired resistance to zoledronic acid

Annexin A1 is involved in the acquisition and maintenance of a stem cell-like/aggressive phenotype in prostate cancer cells with acquired resistance to zoledronic acid

https://doi.org/10.18632/oncotarget.4725

Valentina Bizzarro, Raffaella Belvedere, Maria Rita Milone, Biagio Pucci, Rita Lombardi, Francesca Bruzzese, Ada Popolo, Luca Parente, Alfredo Budillon,  and Antonello Petrella
25074-25092
Abstract  |  PDF  |  HTML  |  Order a Reprint

Hepatocellular carcinoma associated microRNA expression signature: integrated bioinformatics analysis, experimental validation and clinical significance

Hepatocellular carcinoma associated microRNA expression signature: integrated bioinformatics analysis, experimental validation and clinical significance

https://doi.org/10.18632/oncotarget.4437

Ke-Qing Shi, Zhuo Lin, Xiang-Jian Chen, Mei Song, Yu-Qun Wang, Yi-Jing Cai, Nai-Bing Yang, Ming-Hua Zheng, Jin-Zhong Dong, Lei Zhang,  and Yong-Ping Chen
25093-25108
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association between TERT promoter polymorphisms and acute myeloid leukemia risk and prognosis

Association between TERT promoter polymorphisms and acute myeloid leukemia risk and prognosis

https://doi.org/10.18632/oncotarget.4668

Mohamed Ali Mosrati, Kerstin Willander, Ingrid Jakobsen Falk, Monica Hermanson, Martin Höglund, Dick Stockelberg, Yuan Wei, Kourosh Lotfi,  and Peter Söderkvist
25109-25120
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Intracellular lactate-mediated induction of estrogen receptor beta (ERβ) in biphasic malignant pleural mesothelioma cells

Intracellular lactate-mediated induction of estrogen receptor beta (ERβ) in biphasic malignant pleural mesothelioma cells

https://doi.org/10.18632/oncotarget.4486

Arcangela G. Manente, Giulia Pinton, Sara Zonca, Michele Cilli, Maurizio Rinaldi, Antonio Daga, Stefan Nilsson,  and Laura Moro
25121-25134
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC)

Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC)

https://doi.org/10.18632/oncotarget.4722

Ivan Casaburi, Paola Avena, Arianna De Luca, Adele Chimento, Rosa Sirianni, Rocco Malivindi, Vittoria Rago, Marco Fiorillo, Francesco Domanico, Carmela Campana, Anna Rita Cappello, Federica Sotgia, Michael P. Lisanti,  and Vincenzo Pezzi
25135-25148
Abstract  |  PDF  |  HTML  |  Order a Reprint

An isocorydine derivative (d-ICD) inhibits drug resistance by downregulating IGF2BP3 expression in hepatocellular carcinoma

An isocorydine derivative (d-ICD) inhibits drug resistance by downregulating IGF2BP3 expression in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4438

Meng Li, Lixing Zhang, Chao Ge, Lijuan Chen, Tao Fang, Hong Li, Hua Tian, Junxi Liu, Taoyang Chen, Guoping Jiang, Haiyang Xie, Ying Cui, Ming Yao,  and Jinjun Li
25149-25160
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model

Coupling the modules of EMT and stemness: A tunable ‘stemness window’ model

https://doi.org/10.18632/oncotarget.4629

Mohit Kumar Jolly, Dongya Jia, Marcelo Boareto, Sendurai A. Mani, Kenneth J. Pienta, Eshel Ben-Jacob,  and Herbert Levine
25161-25174
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Tumorigenesis by Meis1 overexpression is accompanied by a change of DNA target-sequence specificity which allows binding to the AP-1 element

Tumorigenesis by Meis1 overexpression is accompanied by a change of DNA target-sequence specificity which allows binding to the AP-1 element

https://doi.org/10.18632/oncotarget.4488

Leila Dardaei, Dmitry Penkov, Lisa Mathiasen, Pranami Bora, Marco J. Morelli,  and Francesco Blasi
25175-25187
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation

LDOC1 silenced by cigarette exposure and involved in oral neoplastic transformation

https://doi.org/10.18632/oncotarget.4512

Chia-Huei Lee, Kao-Lu Pan, Ya-Chu Tang, Ming-Hsien Tsai, Ann-Joy Cheng, Mei-Ya Shen, Ying-Min Cheng, Tze-Ta Huang,  and Pinpin Lin
25188-25201
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Adenomatous polyposis coli mutants dominantly activate Hsf1-dependent cell stress pathways through inhibition of microtubule dynamics

Adenomatous polyposis coli mutants dominantly activate Hsf1-dependent cell stress pathways through inhibition of microtubule dynamics

https://doi.org/10.18632/oncotarget.4513

Alexander E. Davies, Kaitlyn Kortright,  and Kenneth B. Kaplan
25202-25216
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Non genomic loss of function of tumor suppressors in CML: BCR-ABL promotes IκBα mediated p53 nuclear exclusion

Non genomic loss of function of tumor suppressors in CML: BCR-ABL promotes IκBα mediated p53 nuclear exclusion

https://doi.org/10.18632/oncotarget.4611

Sabrina Crivellaro, Cristina Panuzzo, Giovanna Carrà, Alessandro Volpengo, Francesca Crasto, Enrico Gottardi, Ubaldo Familiari, Mauro Papotti, Davide Torti, Rocco Piazza, Sara Redaelli, Riccardo Taulli, Angelo Guerrasio, Giuseppe Saglio,  and Alessandro Morotti
25217-25225
Abstract  |  PDF  |  HTML  |  Order a Reprint

Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer

Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer

https://doi.org/10.18632/oncotarget.4712

Mingxin Wen, Yongwon Kwon, Yongsheng Wang, Jian-Hua Mao,  and Guangwei Wei
25226-25239
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes

Functional isogenic modeling of BRCA1 alleles reveals distinct carrier phenotypes

https://doi.org/10.18632/oncotarget.4595

Rory L. Cochran, Justin Cidado, Minsoo Kim, Daniel J. Zabransky, Sarah Croessmann, David Chu, Hong Yuen Wong, Julia A. Beaver, Karen Cravero, Bracha Erlanger, Heather Parsons, Christopher M. Heaphy, Alan K. Meeker, Josh Lauring,  and Ben Ho Park
25240-25251
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death

PERK/CHOP contributes to the CGK733-induced vesicular calcium sequestration which is accompanied by non-apoptotic cell death

https://doi.org/10.18632/oncotarget.4487

Yufeng Wang, Yasuhiro Kuramitsu, Byron Baron, Takao Kitagawa, Junko Akada, Kazuhiro Tokuda, Dan Cui,  and Kazuyuki Nakamura
25252-25265
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3

MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3

https://doi.org/10.18632/oncotarget.4457

Zhongyi Fan, Hanzhi Cui, Xiaojie Xu, Zhi Lin, Xuelin Zhang, Lei Kang, Baiyu Han, Jing Meng, Zhifeng Yan, Xiang Yan,  and Shunchang Jiao
25266-25280
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RY-2f, an isoflavone analog, overcomes cisplatin resistance to inhibit ovarian tumorigenesis via targeting the PI3K/AKT/mTOR signaling pathway

RY-2f, an isoflavone analog, overcomes cisplatin resistance to inhibit ovarian tumorigenesis via targeting the PI3K/AKT/mTOR signaling pathway

https://doi.org/10.18632/oncotarget.4634

Mingming Liu, Zihao Qi, Bingzhi Liu, Yi Ren, Hanbin Li, Gong Yang,  and Qian Zhang
25281-25294
Abstract  |  PDF  |  HTML  |  Order a Reprint

Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions

Contact-dependent carcinoma aggregate dispersion by M2a macrophages via ICAM-1 and β2 integrin interactions

https://doi.org/10.18632/oncotarget.4716

Jing Bai, Giulia Adriani, Truong-Minh Dang, Ting-Yuan Tu, Hwei-Xian Leong Penny, Siew-Cheng Wong, Roger D. Kamm,  and Jean-Paul Thiery
25295-25307
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer

Calmodulin antagonists promote TRA-8 therapy of resistant pancreatic cancer

https://doi.org/10.18632/oncotarget.4490

Kaiyu Yuan, Sun Yong, Fei Xu, Tong Zhou, Jay M McDonald,  and Yabing Chen
25308-25319
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition

Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition

https://doi.org/10.18632/oncotarget.4659

Xiaoping Zhu, Jing Zhong, Zhen Zhao, Jianting Sheng, Jiang Wang, Jiyong Liu, Kemi Cui, Jenny Chang, Hong Zhao,  and Stephen Wong
25320-25338
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186

CRNDE affects the malignant biological characteristics of human glioma stem cells by negatively regulating miR-186

https://doi.org/10.18632/oncotarget.4509

Jian Zheng, Xiao-dong Li, Ping Wang, Xiao-bai Liu, Yi-xue Xue, Yi Hu, Zhen Li, Zhi-qing Li, Zhen-hua Wang,  and Yun-hui Liu
25339-25355
Abstract  |  PDF  |  HTML  |  Order a Reprint

CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer

CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer

https://doi.org/10.18632/oncotarget.4516

Claudia Paret, Petra Simon, Kirsten Vormbrock, Christian Bender, Anne Kölsch, Andrea Breitkreuz, Özlem Yildiz, Tana Omokoko, Stefanie Hubich-Rau, Christoph Hartmann, Sabine Häcker, Meike Wagner, Diana Barea Roldan, Abderaouf Selmi, Özlem Türeci,  and Ugur Sahin
25356-25367
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Characterization of SLC22A18 as a tumor suppressor and novel biomarker in colorectal cancer

Characterization of SLC22A18 as a tumor suppressor and novel biomarker in colorectal cancer

https://doi.org/10.18632/oncotarget.4681

Yeonjoo Jung, Yukyung Jun, Hee-Young Lee, Suyeon Kim, Yeonhwa Jung, Juhee Keum, Yeo Song Lee, Yong Beom Cho, Sanghyuk Lee,  and Jaesang Kim
25368-25380
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A long noncoding RNA AB073614 promotes tumorigenesis and predicts poor prognosis in ovarian cancer

A long noncoding RNA AB073614 promotes tumorigenesis and predicts poor prognosis in ovarian cancer

https://doi.org/10.18632/oncotarget.4541

Zhongping Cheng, Jing Guo, Li Chen, Ning Luo, Weihong Yang,  and Xiaoyan Qu
25381-25389
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells

Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.4455

Li Ma, Xiaolin Wang, Tao Jia, Wei Wei, Mei-Sze Chua,  and Samuel So
25390-25401
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2

KLF8 promotes tumorigenesis, invasion and metastasis of colorectal cancer cells by transcriptional activation of FHL2

https://doi.org/10.18632/oncotarget.4517

Qingqing Yan, Wenjing Zhang, Yao Wu, Meiyan Wu, Mengnan Zhang, Xinpeng Shi, Jinjun Zhao, Qingzhen Nan, Ye Chen, Long Wang, Tianming Cheng, Jiachu Li, Yang Bai, Side Liu,  and Jide Wang
25402-25417
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer

MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer

https://doi.org/10.18632/oncotarget.4456

Xinyang Liu, Xiaoxiao Ge, Zhe Zhang, Xiaowei Zhang, Jinjia Chang, Zheng Wu, Wenbo Tang, Lu Gan, Menghong Sun,  and Jin Li
25418-25428
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting endosialin/CD248 through antibody-mediated internalization results in impaired pericyte maturation and dysfunctional tumor microvasculature

Targeting endosialin/CD248 through antibody-mediated internalization results in impaired pericyte maturation and dysfunctional tumor microvasculature

https://doi.org/10.18632/oncotarget.4559

Katherine Rybinski, Hongxia Z. Imtiyaz, Barrie Mittica, Brian Drozdowski, James Fulmer, Keiji Furuuchi, Shawn Fernando, Marianne Henry, Qimin Chao, Brad Kline, Earl Albone, Jason Wustner, JianMin Lin, Nicholas C. Nicolaides, Luigi Grasso,  and Yuhong Zhou
25429-25440
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

eIF3a improve cisplatin sensitivity in ovarian cancer by regulating XPC and p27Kip1 translation

eIF3a improve cisplatin sensitivity in ovarian cancer by regulating XPC and p27Kip1 translation

https://doi.org/10.18632/oncotarget.4555

Yu Zhang, Jing-Jing Yu, Yan Tian, Zheng-Zheng Li, Cai-Yi Zhang, Shu-Fen Zhang, Lan-Qin Cao, Yi Zhang, Chen-Yue Qian, Wei Zhang, Hong-Hao Zhou, Ji-Ye Yin,  and Zhao-Qian Liu
25441-25451
Abstract  |  PDF  |  HTML  |  Order a Reprint

Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures

Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures

https://doi.org/10.18632/oncotarget.4545

Soraya Curiel-Olmo, Almudena García-Castaño, Rebeca Vidal, Helena Pisonero, Ignacio Varela, Alicia León-Castillo, Eugenio Trillo, Carmen González-Vela, Nuria García-Diaz, Carmen Almaraz, Thaidy Moreno, Laura Cereceda, Rebeca Madureira, Nerea Martinez, Pablo Ortiz-Romero, Elsa Valdizán, Miguel Angel Piris,  and José Pedro Vaqué
25452-25465
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells

Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells

https://doi.org/10.18632/oncotarget.4510

Lara Gibellini, Marcello Pinti, Regina Bartolomeo, Sara De Biasi, Antonella Cormio, Clara Musicco, Gianluca Carnevale, Simone Pecorini, Milena Nasi, Anto De Pol,  and Andrea Cossarizza
25466-25483
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High LIFr expression stimulates melanoma cell migration and is associated with unfavorable prognosis in melanoma

High LIFr expression stimulates melanoma cell migration and is associated with unfavorable prognosis in melanoma

https://doi.org/10.18632/oncotarget.4688

Hongwei Guo, Yabin Cheng, Magdalena Martinka,  and Kevin McElwee
25484-25498
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas

Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas

https://doi.org/10.18632/oncotarget.4548

Desheng Xiao, Jiantao Jia, Ying Shi, Chunyan Fu, Ling Chen, Yiqun Jiang, Li Zhou, Shuang Liu,  and Yongguang Tao
25499-25505
Abstract  |  PDF  |  HTML  |  Order a Reprint

Thioredoxin 1 mediates TGF-β-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma

Thioredoxin 1 mediates TGF-β-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma

https://doi.org/10.18632/oncotarget.4635

Yang Jiang, Xin Feng, Lei Zheng, Shenglin Li, Xiyuan Ge,  and Jian-Guo Zhang
25506-25519
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines

The PI3K/AKT/mTOR pathway is a potential predictor of distinct invasive and migratory capacities in human ovarian cancer cell lines

https://doi.org/10.18632/oncotarget.4550

Huimin Bai, Haixia Li, Weihua Li, Ting Gui, Jiaxin Yang, Dongyan Cao,  and Keng Shen
25520-25532
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Down-regulation of c-Met and Bcl2 by microRNA-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation

Down-regulation of c-Met and Bcl2 by microRNA-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation

https://doi.org/10.18632/oncotarget.4575

Chengcao Sun, Shujun Li, Cuili Yang, Ruilin Xue, Yongyong Xi, Liang Wang, Suqing Wang, Qiqiang He, Jie Huang, Songping Xie, Wenyang Jiang,  and Dejia Li
25533-25574
Abstract  |  PDF  |  HTML  |  Order a Reprint

Increased SYK activity is associated with unfavorable outcome among patients with acute myeloid leukemia

Increased SYK activity is associated with unfavorable outcome among patients with acute myeloid leukemia

https://doi.org/10.18632/oncotarget.4669

Katalin Boros, Alexandre Puissant, Morgan Back, Gabriela Alexe, Christopher F. Bassil, Papiya Sinha, Eleni Tholouli, Kimberly Stegmaier, Richard J Byers,  and Scott J Rodig
25575-25587
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of ERRα suppresses epithelial mesenchymal transition of triple negative breast cancer cells by directly targeting fibronectin

Inhibition of ERRα suppresses epithelial mesenchymal transition of triple negative breast cancer cells by directly targeting fibronectin

https://doi.org/10.18632/oncotarget.4436

Ying-Min Wu, Zhuo-Jia Chen, Hao Liu, Wei-Dong Wei, Lin-Lin Lu, Xiang-Ling Yang, Wei-Ting Liang, Tao Liu, Huan-Liang Liu, Jun Du,  and Hong-Sheng Wang
25588-25601
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation

A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation

https://doi.org/10.18632/oncotarget.4693

Fabio Morandi, Barbara Morandi, Alberto L. Horenstein, Antonella Chillemi, Valeria Quarona, Gianluca Zaccarello, Paolo Carrega, Guido Ferlazzo, Maria Cristina Mingari, Lorenzo Moretta, Vito Pistoia,  and Fabio Malavasi
25602-25618
Abstract  |  PDF  |  HTML  |  Order a Reprint

Patient-derived cell models as preclinical tools for genome-directed targeted therapy

Patient-derived cell models as preclinical tools for genome-directed targeted therapy

https://doi.org/10.18632/oncotarget.4627

Ji Yun Lee, Sun Young Kim, Charny Park, Nayoung K. D. Kim, Jiryeon Jang, Kyunghee Park, Jun Ho Yi, Mineui Hong, Taejin Ahn, Oliver Rath, Julia Schueler, Seung Tae Kim, In-Gu Do, Sujin Lee, Se Hoon Park, Yong Ick Ji, Dukwhan Kim, Joon Oh Park, Young Suk Park, Won Ki Kang, Kyoung-Mee Kim, Woong-Yang Park, Ho Yeong Lim,  and Jeeyun Lee
25619-25630
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genomic landscape of salivary gland tumors

Genomic landscape of salivary gland tumors

https://doi.org/10.18632/oncotarget.4554

Shumei Kato, Sheryl K. Elkin, Maria Schwaederle, Brett N. Tomson, Teresa Helsten, Jennifer L. Carter,  and Razelle Kurzrock
25631-25645
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation

Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation

https://doi.org/10.18632/oncotarget.4662

Qian Qian Wang, Xin Yi Zhou, Yan Fang Zhang, Na Bu, Jin Zhou, Feng Lin Cao,  and Hua Naranmandura
25646-25659
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Disruption and inactivation of the PP2A complex promotes the proliferation and angiogenesis of hemangioma endothelial cells through activating AKT and ERK

Disruption and inactivation of the PP2A complex promotes the proliferation and angiogenesis of hemangioma endothelial cells through activating AKT and ERK

https://doi.org/10.18632/oncotarget.4705

Furong Xie, Xin Bao, Jingshuang Yu, Wantao Chen, Lizhen Wang, Zhiyuan Zhang,  and Qin Xu
25660-25676
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models

A comparative analysis of inhibitors of the glycolysis pathway in breast and ovarian cancer cell line models

https://doi.org/10.18632/oncotarget.4499

Chrysi Xintaropoulou, Carol Ward, Alan Wise, Hugh Marston, Arran Turnbull,  and Simon P. Langdon
25677-25695
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The BIM deletion polymorphism is a prognostic biomarker of EGFR-TKIs response in NSCLC: A systematic review and meta-analysis

The BIM deletion polymorphism is a prognostic biomarker of EGFR-TKIs response in NSCLC: A systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.4678

Wei Nie, Xia Tao, Hua Wei, Wan-sheng Chen,  and Bing Li
25696-25700
Abstract  |  PDF  |  HTML  |  Order a Reprint

NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway

NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/β-catenin pathway

https://doi.org/10.18632/oncotarget.4573

Jin-Ju Lei, Rou-Jun Peng, Bo-Hua Kuang, Zhong-Yu Yuan, Tao Qin, Wen-Sheng Liu, Yun-Miao Guo, Hui-Qiong Han, Yi-Fan Lian, Cheng-Cheng Deng, Hao-Jiong Zhang, Li-Zhen Chen, Qi-Sheng Feng, Miao Xu, Lin Feng, Jin-Xin Bei,  and Yi-Xin Zeng
25701-25714
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Reduced rate of copy number aberrations in mucinous colorectal carcinoma

Reduced rate of copy number aberrations in mucinous colorectal carcinoma

https://doi.org/10.18632/oncotarget.4706

Niek Hugen, Femke Simmer, Leonie J.M. Mekenkamp, Miriam Koopman, Evert van den Broek, Johannes H.W. de Wilt, Cornelis J.A. Punt, Bauke Ylstra, Gerrit A. Meijer,  and Iris D. Nagtegaal
25715-25725
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TNF signaling mediates an enzalutamide-induced metastatic phenotype of prostate cancer and microenvironment cell co-cultures

TNF signaling mediates an enzalutamide-induced metastatic phenotype of prostate cancer and microenvironment cell co-cultures

https://doi.org/10.18632/oncotarget.4535

Kai Sha, Shuyuan Yeh, Chawnshang Chang, Kent L. Nastiuk,  and John J. Krolewski
25726-25740
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice

Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice

https://doi.org/10.18632/oncotarget.4348

Tse-Hung Huang, Yi-Han Chiu, Yi-Lin Chan, Hang Wang, Tsung-Lin Li, Chien-Yin Liu, Cheng-Ta Yang, Tzung-Yan Lee, Jyh-Sheng You, Kuang-Hung Hsu,  and Chang-Jer Wu
25741-25754
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways

Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways

https://doi.org/10.18632/oncotarget.4697

Li Yang, Yixuan Hou, Jie Yuan, Shifu Tang, Hailong Zhang, Qing Zhu, Yan-e Du, Mingli Zhou, Siyang Wen, Liyun Xu, Xi Tang, Xiaojiang Cui,  and Manran Liu
25755-25769
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Repairing of N-mustard derivative BO-1055 induced DNA damage requires NER, HR, and MGMT-dependent DNA repair mechanisms

Repairing of N-mustard derivative BO-1055 induced DNA damage requires NER, HR, and MGMT-dependent DNA repair mechanisms

https://doi.org/10.18632/oncotarget.4514

Ching-Ying Kuo, Wen-Cheng Chou, Chin-Chung Wu, Teng-Song Wong, Rajesh Kakadiya, Te-Chang Lee, Tsann-Long Su,  and Hui-Chun Wang
25770-25783
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3

AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3

https://doi.org/10.18632/oncotarget.4703

Khalil Ahmad, Bastian Scholz, Ricardo Capelo, Ilona Schweighöfer, Astrid Stefanie Kahnt, Rolf Marschalek,  and Dieter Steinhilber
25784-25800
Abstract  |  PDF  |  HTML  |  Order a Reprint

Survival of primary, but not of cancer cells after combined Plk1-HDAC inhibition

Survival of primary, but not of cancer cells after combined Plk1-HDAC inhibition

https://doi.org/10.18632/oncotarget.4445

Lisa Lange, Peter Hemmerich,  and Birgit Spänkuch
25801-25814
Abstract  |  PDF  |  HTML  |  Order a Reprint

SERPINA1 is a direct estrogen receptor target gene and a predictor of survival in breast cancer patients

SERPINA1 is a direct estrogen receptor target gene and a predictor of survival in breast cancer patients

https://doi.org/10.18632/oncotarget.4441

Hei Jason Chan, Haiqing Li, Zheng Liu, Yate-Ching Yuan, Joanne Mortimer,  and Shiuan Chen
25815-25827
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Understanding of tolerance in TRAIL-induced apoptosis and cancelation of its machinery by α-mangostin, a xanthone derivative

Understanding of tolerance in TRAIL-induced apoptosis and cancelation of its machinery by α-mangostin, a xanthone derivative

https://doi.org/10.18632/oncotarget.4558

Minami Kumazaki, Haruka Shinohara, Kohei Taniguchi, Hiroshi Ueda, Mayuko Nishi, Akihide Ryo,  and Yukihiro Akao
25828-25842
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

KMT Set7/9 affects genotoxic stress response via the Mdm2 axis

KMT Set7/9 affects genotoxic stress response via the Mdm2 axis

https://doi.org/10.18632/oncotarget.4584

Larissa Lezina, Vasilisa Aksenova, Olga Fedorova, Daria Malikova, Oleg Shuvalov, Alexey V. Antonov, Dmitri Tentler, Alexander V. Garabadgiu, Gerry Melino,  and Nikolai A. Barlev
25843-25855
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CCDC34 is up-regulated in bladder cancer and regulates bladder cancer cell proliferation, apoptosis and migration

CCDC34 is up-regulated in bladder cancer and regulates bladder cancer cell proliferation, apoptosis and migration

https://doi.org/10.18632/oncotarget.4624

Yanqing Gong, Wei Qiu, Xianghui Ning, Xinyu Yang, Libo Liu, Zicheng Wang, Jian Lin, Xuesong Li,  and Yinglu Guo
25856-25867
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Analysis of SDHD promoter mutations in various types of melanoma

Analysis of SDHD promoter mutations in various types of melanoma

https://doi.org/10.18632/oncotarget.4665

Simone L. Scholz, Susanne Horn, Rajmohan Murali, Inga Möller, Antje Sucker, Wiebke Sondermann, Mathias Stiller, Bastian Schilling, Elisabeth Livingstone, Lisa Zimmer, Henning Reis, Claudia H. Metz, Michael Zeschnigk, Annette Paschen, Klaus-Peter Steuhl, Dirk Schadendorf, Henrike Westekemper,  and Klaus G. Griewank
25868-25882
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer

ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer

https://doi.org/10.18632/oncotarget.4540

Qiongrong Chen, Shumei Song, Shaozhong Wei, Bin Liu, Soichiro Honjo, Ailing Scott, Jiankang Jin, Lang Ma, Haitao Zhu, Heath D. Skinner, Randy L. Johnson,  and Jaffer A. Ajani
25883-25896
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma

IGFBP2 modulates the chemoresistant phenotype in esophageal adenocarcinoma

https://doi.org/10.18632/oncotarget.4532

Amy L. Myers, Lin Lin, Derek J. Nancarrow, Zhuwen Wang, Daysha Ferrer-Torres, Dafydd G. Thomas, Mark B. Orringer, Jules Lin, Rishindra M. Reddy, David G. Beer,  and Andrew C. Chang
25897-25916
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway

Sulforaphane inhibits thyroid cancer cell growth and invasiveness through the reactive oxygen species-dependent pathway

https://doi.org/10.18632/oncotarget.4542

Liping Wang, Zhufang Tian, Qi Yang, Heng Li, Haixia Guan, Bingyin Shi, Peng Hou,  and Meiju Ji
25917-25931
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Curcumin combined with FAPαc vaccine elicits effective antitumor response by targeting indolamine-2,3-dioxygenase and inhibiting EMT induced by TNF-α in melanoma

Curcumin combined with FAPαc vaccine elicits effective antitumor response by targeting indolamine-2,3-dioxygenase and inhibiting EMT induced by TNF-α in melanoma

https://doi.org/10.18632/oncotarget.4577

Guan-Min Jiang, Wan-Ying Xie, Hong-Sheng Wang, Jun Du, Bai-Ping Wu, Wei Xu, Hui-Fang Liu, Ping Xiao, Zhi-Gang Liu, Hong-Yan Li, Shuang-Quan Liu, Wen-Jun Yin, Qiu-Gui Zhang, Jian-Ping Liang,  and Hong-Jun Huang
25932-25942
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeted or whole genome sequencing of formalin fixed tissue samples: potential applications in cancer genomics

Targeted or whole genome sequencing of formalin fixed tissue samples: potential applications in cancer genomics

https://doi.org/10.18632/oncotarget.4671

Sarah Munchel, Yen Hoang, Yue Zhao, Joseph Cottrell, Brandy Klotzle, Andrew K. Godwin, Devin Koestler, Peter Beyerlein, Jian-Bing Fan, Marina Bibikova,  and Jeremy Chien
25943-25961
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin

miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin

https://doi.org/10.18632/oncotarget.4504

Wen-Shu Chen, Chia-Jui Yen, Yun-Ju Chen, Jhen-Yu Chen, Li-Yun Wang, Shu-Jun Chiu, Wen-Ling Shih, Chien-Yi Ho, Tzu-Tang Wei, Hsiao-Lin Pan, Pei-Hsuan Chien, Mien-Chie Hung, Ching-Chow Chen,  and Wei-Chien Huang
25962-25974
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/β-catenin/MMP-7 signaling pathway

5-hydroxytryptamine receptor (5-HT1DR) promotes colorectal cancer metastasis by regulating Axin1/β-catenin/MMP-7 signaling pathway

https://doi.org/10.18632/oncotarget.4543

Hua Sui, Hanchen Xu, Qing Ji, Xuan Liu, Lihong Zhou, Haiyan Song, Xiqiu Zhou, Yangxian Xu, Zhe-Sheng Chen, Guang Ji,  and Qi Li
25975-25987
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Bortezomib inhibits Burkitt’s lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression

Bortezomib inhibits Burkitt’s lymphoma cell proliferation by downregulating sumoylated hnRNP K and c-Myc expression

https://doi.org/10.18632/oncotarget.4620

Fat-Moon Suk, Shyr-Yi Lin, Ren-Jye Lin, Yung-Hsin Hsine, Yen-Ju Liao, Sheng-Uei Fang,  and Yu-Chih Liang
25988-26001
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metabolic alterations caused by HNF1β expression in ovarian clear cell carcinoma contribute to cell survival

Metabolic alterations caused by HNF1β expression in ovarian clear cell carcinoma contribute to cell survival

https://doi.org/10.18632/oncotarget.4692

Yasuaki Amano, Masaki Mandai, Ken Yamaguchi, Noriomi Matsumura, Budiman Kharma, Tsukasa Baba, Kaoru Abiko, Junzo Hamanishi, Yumiko Yoshioka,  and Ikuo Konishi
26002-26017
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Zoledronic acid prevents the tumor-promoting effects of mesenchymal stem cells via MCP-1 dependent recruitment of macrophages

Zoledronic acid prevents the tumor-promoting effects of mesenchymal stem cells via MCP-1 dependent recruitment of macrophages

https://doi.org/10.18632/oncotarget.4658

Xiao-Hua Jia, Yang Du, Duo Mao, Zhong-Liang Wang, Zhen-Qiang He, Jing-Dan Qiu, Xi-Bo Ma, Wen-Ting Shang, Dan Ding,  and Jie Tian
26018-26028
Abstract  |  PDF  |  HTML  |  Order a Reprint

Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy

Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy

https://doi.org/10.18632/oncotarget.4347

Daniel O’Neill, Dominic Jones, Mark Wade, James Grey, Sirintra Nakjang, Wenrui Guo, David Cork, Barry R. Davies, Steve R. Wedge, Craig N. Robson,  and Luke Gaughan
26029-26040
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ZIP4 silencing improves bone loss in pancreatic cancer

ZIP4 silencing improves bone loss in pancreatic cancer

https://doi.org/10.18632/oncotarget.4667

Qiang Zhang, Xiaotian Sun, Jingxuan Yang, Hao Ding, Drake LeBrun, Kai Ding, Courtney W. Houchen, Russell G. Postier, Catherine G. Ambrose, Zhaoshen Li, Xiaohong Bi,  and Min Li
26041-26051
Abstract  |  PDF  |  HTML  |  Order a Reprint

Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation

Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation

https://doi.org/10.18632/oncotarget.4482

Stuart Duncan Morton, Massimiliano Cadamuro, Simone Brivio, Marta Vismara, Tommaso Stecca, Marco Massani, Nicolò Bassi, Alberto Furlanetto, Ruth Elizabeth Joplin, Annarosa Floreani, Luca Fabris,  and Mario Strazzabosco
26052-26064
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals

Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals

https://doi.org/10.18632/oncotarget.4569

Zhenyu Ou, Yongjie Wang, Longfei Liu, Lei Li, Shuyuan Yeh, Lin Qi,  and Chawnshang Chang
26065-26078
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Stemness and chemotherapeutic drug resistance induced by EIF5A2 overexpression in esophageal squamous cell carcinoma

Stemness and chemotherapeutic drug resistance induced by EIF5A2 overexpression in esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.4581

Hong Yang, Xiao-dong Li, Ying Zhou, Xiaojiao Ban, Ting-ting Zeng, Lei Li, Bao-zhu Zhang, Jingping Yun, Dan Xie, Xin-Yuan Guan,  and Yan Li
26079-26089
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status

Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status

https://doi.org/10.18632/oncotarget.4636

Luigi Formisano, Valentina D’Amato, Alberto Servetto, Simona Brillante, Lucia Raimondo, Concetta Di Mauro, Roberta Marciano, Roberta Clara Orsini, Sandro Cosconati, Antonio Randazzo, Sarah J. Parsons, Nunzia Montuori, Bianca Maria Veneziani, Sabino De Placido, Roberta Rosa,  and Roberto Bianco
26090-26103
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma

Folate deficiency-triggered redox pathways confer drug resistance in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4422

Chun-Te Ho, Hung-Sheng Shang, Jin-Biou Chang, Jun-Jen Liu,  and Tsan-Zon Liu
26104-26118
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NF-κB/RelA-PKM2 mediates inhibition of glycolysis by fenofibrate in glioblastoma cells

NF-κB/RelA-PKM2 mediates inhibition of glycolysis by fenofibrate in glioblastoma cells

https://doi.org/10.18632/oncotarget.4444

Dongfeng Han, Wenjin Wei, Xincheng Chen, Yaxuan Zhang, Yingyi Wang, Junxia Zhang, Xiefeng Wang, Tianfu Yu, Qi Hu, Ning Liu,  and Yongping You
26119-26128
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias

A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias

https://doi.org/10.18632/oncotarget.4674

Marta Lionetti, Marzia Barbieri, Katia Todoerti, Luca Agnelli, Sonia Fabris, Giovanni Tonon, Simona Segalla, Ingrid Cifola, Eva Pinatel, Pierfrancesco Tassone, Pellegrino Musto, Luca Baldini,  and Antonino Neri
26129-26141
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Afatinib reverses multidrug resistance in ovarian cancer via dually inhibiting ATP binding cassette subfamily B member 1

Afatinib reverses multidrug resistance in ovarian cancer via dually inhibiting ATP binding cassette subfamily B member 1

https://doi.org/10.18632/oncotarget.4536

Sheng-qi Wang, Shi-ting Liu, Bo-xin Zhao, Fu-heng Yang, Ya-tian Wang, Qian-ying Liang, Ya-bin Sun, Yuan Liu, Zhi-hua Song, Yun Cai,  and Guo-feng Li
26142-26160
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression

Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression

https://doi.org/10.18632/oncotarget.4544

Xinyuan Xu, Jianying Li, Xiang Sun, Yan Guo, Dake Chu, Li Wei, Xia Li, Guodong Yang, Xinping Liu, Libo Yao, Jian Zhang,  and Lan Shen
26161-26176
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Enhanced transfection efficiency and targeted delivery of self-assembling h-R3-dendriplexes in EGFR-overexpressing tumor cells

Enhanced transfection efficiency and targeted delivery of self-assembling h-R3-dendriplexes in EGFR-overexpressing tumor cells

https://doi.org/10.18632/oncotarget.4614

Jun Lia, Shengnan Li, Songyun Xia, Jinfeng Feng, Xuedi Zhang, Yanli Hao, Lei Chen,  and Xiaoning Zhang
26177-26191
Abstract  |  PDF  |  HTML  |  Order a Reprint

Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells

Combined expressional analysis, bioinformatics and targeted proteomics identify new potential therapeutic targets in glioblastoma stem cells

https://doi.org/10.18632/oncotarget.4613

Biljana Stangeland, Awais A. Mughal, Zanina Grieg, Cecilie Jonsgar Sandberg, Mrinal Joel, Ståle Nygård, Torstein Meling, Wayne Murrell, Einar O. Vik Mo,  and Iver A. Langmoen
26192-26215
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-494 inhibits cell proliferation and invasion of chondrosarcoma cells in vivo and in vitro by directly targeting SOX9

MicroRNA-494 inhibits cell proliferation and invasion of chondrosarcoma cells in vivo and in vitro by directly targeting SOX9

https://doi.org/10.18632/oncotarget.4460

Jingyuan Li, Lijuan Wang, Zongzhi Liu, Chao Zu, Fanfan Xing, Pei Yang, Yongkang Yang, Xiaoqian Dang,  and Kunzheng Wang
26216-26229
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

OSI-027 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine both in vitro and in vivo

OSI-027 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine both in vitro and in vivo

https://doi.org/10.18632/oncotarget.4579

Xiao Zhi, Wei Chen, Fei Xue, Chao Liang, Bryan Wei Chen, Yue Zhou, Liang Wen, Liqiang Hu, Jian Shen, Xueli Bai,  and Tingbo Liang
26230-26241
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prokineticin 2 (PROK2) is an important factor for angiogenesis in colorectal cancer

Prokineticin 2 (PROK2) is an important factor for angiogenesis in colorectal cancer

https://doi.org/10.18632/oncotarget.4385

Hidetaka Kurebayashi , Takanori Goi, Michiaki Shimada, Noriyuki Tagai, Takayuki Naruse, Toshiyuki Nakazawa, Youhei Kimura, Yasuo Hirono,  and Akio Yamaguchi
26242-26251
Abstract  |  PDF  |  HTML  |  Order a Reprint

Rhodomycin A, a novel Src-targeted compound, can suppress lung cancer cell progression via modulating Src-related pathways

Rhodomycin A, a novel Src-targeted compound, can suppress lung cancer cell progression via modulating Src-related pathways

https://doi.org/10.18632/oncotarget.4761

Yi-Hua Lai, Min-Hsuan Chen, Sih-Yin Lin, Sheng-Yi Lin, Yung-Hao Wong, Sung-Liang Yu, Huei-Wen Chen, Chih-Hsin Yang, Gee-Chen Chang,  and Jeremy J.W. Chen
26252-26265
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model

Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model

https://doi.org/10.18632/oncotarget.4656

Devaraja Rajasekaran, Ayesha Siddiq, Jennifer L.S. Willoughby, Jessica M. Biagi, Lisa M. Christadore, Sarah A. Yunes, Rachel Gredler, Nidhi Jariwala, Chadia L. Robertson, Maaged A. Akiel, Xue-Ning Shen, Mark A. Subler, Jolene J. Windle, Scott E. Schaus, Paul B. Fisher, Ulla Hansen,  and Devanand Sarkar
26266-26277
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients

MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients

https://doi.org/10.18632/oncotarget.4495

Kristiaan Lenos, Jeroen A.C.M. Goos, Ilona M. Vuist, Sjoerd H. den Uil, Pien M. Delis-van Diemen, Eric J.Th. Belt, Hein B.A.C. Stockmann, Herman Bril, Meike de Wit, Beatriz Carvalho, Susan Giblett, Catrin A. Pritchard, Gerrit A. Meijer, Yvette van Kooyk, Remond J.A. Fijneman,  and Sandra J. van Vliet
26278-26290
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK/FOXO3a pathway

GL-V9, a new synthetic flavonoid derivative, ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK/FOXO3a pathway

https://doi.org/10.18632/oncotarget.4657

Yue Zhao, Yang Sun, Youxiang Ding, Xiaoping Wang, Yuxin Zhou, Wenjun Li, Shaoliang Huang, Zhiyu Li, Lingyi Kong, Qinglong Guo,  and Na Lu
26291-26307
Abstract  |  PDF  |  HTML  |  Order a Reprint

CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination

CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination

https://doi.org/10.18632/oncotarget.4763

Abhilash K. Ravindranath, Swayamjot Kaur, Roman P. Wernyj, Muthu N. Kumaran, Karl E. Miletti-Gonzalez, Rigel Chan, Elaine Lim, Kiran Madura,  and Lorna Rodriguez-Rodriguez
26308-26321
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy

An engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy

https://doi.org/10.18632/oncotarget.4709

Jian Xu, Xiu-Jun Liu, Liang Li, Sheng-Hua Zhang, Yi Li, Rui-Juan Gao,  and Yong-Su Zhen
26322-26334
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of GALNT14 as a novel neuroblastoma predisposition gene

Identification of GALNT14 as a novel neuroblastoma predisposition gene

https://doi.org/10.18632/oncotarget.4501

Marilena De Mariano, Roberta Gallesio, Marco Chierici, Cesare Furlanello, Massimo Conte, Alberto Garaventa, Michela Croce, Silvano Ferrini, Gian Paolo Tonini,  and Luca Longo
26335-26346
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

IKK inhibition increases bortezomib effectiveness in ovarian cancer

IKK inhibition increases bortezomib effectiveness in ovarian cancer

https://doi.org/10.18632/oncotarget.4713

Bipradeb Singha, Himavanth Reddy Gatla, Sai Phyo, Atish Patel, Zhe-Sheng Chen,  and Ivana Vancurova
26347-26358
Abstract  |  PDF  |  HTML  |  Order a Reprint

Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC

Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC

https://doi.org/10.18632/oncotarget.4560

Shruti U. Gandhy, Parisa Imanirad, Un-Ho Jin, Vijayalekshmi Nair, Eric Hedrick, Yating Cheng, Christopher J. Corton, KyoungHyun Kim,  and Stephen Safe
26359-26372
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AMF/PGI-mediated tumorigenesis through MAPK-ERK signaling in endometrial carcinoma

AMF/PGI-mediated tumorigenesis through MAPK-ERK signaling in endometrial carcinoma

https://doi.org/10.18632/oncotarget.4708

Yiran Li, Yuanhui Jia, Qi Che, Qian Zhou, Kai Wang,  and Xiao-Ping Wan
26373-26387
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The sum of gains and losses of genes encoding the protein tyrosine kinase targets predicts response to multi-kinase inhibitor treatment: Characterization, validation, and prognostic value

The sum of gains and losses of genes encoding the protein tyrosine kinase targets predicts response to multi-kinase inhibitor treatment: Characterization, validation, and prognostic value

https://doi.org/10.18632/oncotarget.4557

Xiaojun Jiang, Daniel Pissaloux, Christelle De La Fouchardiere, Françoise Desseigne, Qing Wang, Valery Attignon, Marie-Eve Fondrevelle, Arnaud De La Fouchardiere, Maurice Perol, Philippe Cassier, Christelle Seigne, David Perol, Isabelle Ray-Coquard, Pierre Meeus, Jerome Fayette, Aude Flechon, Axel Le Cesne, Nicolas Penel, Olivier Tredan,  and Jean-Yves Blay
26388-26399
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor necrosis targeted radiotherapy of non-small cell lung cancer using radioiodinated protohypericin in a mouse model

Tumor necrosis targeted radiotherapy of non-small cell lung cancer using radioiodinated protohypericin in a mouse model

https://doi.org/10.18632/oncotarget.4568

Xuejiao Liu, Cuihua Jiang, Dongjian Zhang, Meng Gao, Fei Peng, Dejian Huang, Ziping Sun, Yicheng Ni, Jian Zhang,  and Zhiqi Yin
26400-26410
Abstract  |  PDF  |  HTML  |  Order a Reprint

A genome-wide assessment of rare copy number variants in colorectal cancer

A genome-wide assessment of rare copy number variants in colorectal cancer

https://doi.org/10.18632/oncotarget.4621

Zhenli Li, Dan Yu, Meifu Gan, Qiaonan Shan, Xiaoyang Yin, Shunli Tang, Shuai Zhang, Yongyong Shi, Yimin Zhu, Maode Lai,  and Dandan Zhang
26411-26423
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA biomarker identification for pediatric acute myeloid leukemia based on a novel bioinformatics model

MicroRNA biomarker identification for pediatric acute myeloid leukemia based on a novel bioinformatics model

https://doi.org/10.18632/oncotarget.4459

Wenying Yan, Lihua Xu, Zhandong Sun, Yuxin Lin, Wenyu Zhang, Jiajia Chen, Shaoyan Hu,  and Bairong Shen
26424-26436
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Protein kinase C-related kinase 1 and 2 play an essential role in thromboxane-mediated neoplastic responses in prostate cancer

Protein kinase C-related kinase 1 and 2 play an essential role in thromboxane-mediated neoplastic responses in prostate cancer

https://doi.org/10.18632/oncotarget.4664

Aine G. O’Sullivan, Eamon P. Mulvaney, Paula B. Hyland,  and B. Therese Kinsella
26437-26456
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1

MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1

https://doi.org/10.18632/oncotarget.4762

Shaohua Xu, Guang-Bo Fu, Zhen Tao, Jun OuYang, Fanfei Kong, Bing-Hua Jiang, Xiaoping Wan,  and Ke Chen
26457-26471
Abstract  |  PDF  |  HTML  |  Order a Reprint

Evaluating blood levels of neuron specific enolase, chromogranin A, and circulating tumor cells as Merkel cell carcinoma biomarkers

Evaluating blood levels of neuron specific enolase, chromogranin A, and circulating tumor cells as Merkel cell carcinoma biomarkers

https://doi.org/10.18632/oncotarget.4500

Maria Rita Gaiser, Kenneth Daily, Jochen Hoffmann, Maik Brune, Alexander Enk,  and Isaac Brownell
26472-26482
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genomic amplification of 9p24.1 targeting JAK2, PD-L1, and PD-L2 is enriched in high-risk triple negative breast cancer

Genomic amplification of 9p24.1 targeting JAK2, PD-L1, and PD-L2 is enriched in high-risk triple negative breast cancer

https://doi.org/10.18632/oncotarget.4494

Michael T. Barrett, Karen S. Anderson, Elizabeth Lenkiewicz, Mariacarla Andreozzi, Heather E. Cunliffe, Christine L. Klassen, Amylou C. Dueck, Ann E. McCullough, Srikanth K. Reddy, Ramesh K. Ramanathan, Donald W. Northfelt,  and Barbara A. Pockaj
26483-26493
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway

SIRT3 inhibits prostate cancer by destabilizing oncoprotein c-MYC through regulation of the PI3K/Akt pathway

https://doi.org/10.18632/oncotarget.4764

Yizhou Quan, Naitao Wang, Qianqian Chen, Jin Xu, Wei Cheng, Meijuan Di, Weiliang Xia,  and Wei-Qiang Gao
26494-26507
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genome-wide pharmacologic unmasking identifies tumor suppressive microRNAs in multiple myeloma

Genome-wide pharmacologic unmasking identifies tumor suppressive microRNAs in multiple myeloma

https://doi.org/10.18632/oncotarget.4769

Chonglei Bi, Tae-Hoon Chung, Gaofeng Huang, Jianbiao Zhou, Junli J. Yan, Rafael Fonseca,  and Wee Joo Chng
26508-26518
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Host genotype and tumor phenotype of chemokine decoy receptors integrally affect breast cancer relapse

Host genotype and tumor phenotype of chemokine decoy receptors integrally affect breast cancer relapse

https://doi.org/10.18632/oncotarget.4470

Ke-Da Yu, Xin Wang, Chen Yang, Xiao-Hua Zeng,  and Zhi-Ming Shao
26519-26527
Abstract  |  PDF  |  HTML  |  Order a Reprint

Selective inhibition of histone deacetylase 2 induces p53-dependent survivin downregulation through MDM2 proteasomal degradation

Selective inhibition of histone deacetylase 2 induces p53-dependent survivin downregulation through MDM2 proteasomal degradation

https://doi.org/10.18632/oncotarget.3100

Sung-Keum Seo, Chang-Sun Hwang, Tae-Boo Choe, Seok-Il Hong, Jae Youn Yi, Sang-Gu Hwang, Hyun-Gyu Lee, Sang Taek Oh, Yun-Han Lee,  and In-Chul Park
26528-26540
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


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