Oncotarget

Vol 6, No 27

September 15, 2015

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About The Cover

See Duan et al. MHM, S4, and X2 cells were treated with vehicle (NT) or Nutlin (10 µM) for 24 hours. The cells were analyzed by a transmission microscope to visualize autophagic vacuoles (AVs). Representative images of early autophagic vacuoles (Avi, open arrow) and late autophagic vacuoles (Avd, filled arrow) were indicated.

Table of Contents

Editorial

HIF2a inhibitors for the treatment of VHL disease

HIF2a inhibitors for the treatment of VHL disease

https://doi.org/10.18632/oncotarget.4564

Ana Martins Metelo, Haley Noonan,  and Othon Iliopoulos
23036-23037
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How to wake a giant

How to wake a giant

https://doi.org/10.18632/oncotarget.5112

Ines Liebscher, Kelly R. Monk,  and Torsten Schöneberg
23038-23039
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Hyperinflammation, T cells, and endotoxemia

Hyperinflammation, T cells, and endotoxemia

https://doi.org/10.18632/oncotarget.5236

Makoto Inoue,  and Mari L. Shinohara
23040-23041
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Casp8p41 and HIV

Casp8p41 and HIV

https://doi.org/10.18632/oncotarget.5238

Nathan W. Cummins,  and Andrew D. Badley
23042-23043
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Targeting brain estrogen receptor for binge eating

Targeting brain estrogen receptor for binge eating

https://doi.org/10.18632/oncotarget.5239

Pingwen Xu, Xuehong Cao,  and Yong Xu
23044-23045
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Protection of muscle nuclei

Protection of muscle nuclei

https://doi.org/10.18632/oncotarget.5240

Talila Volk,  and Shuoshuo Wang
23046-23047
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HMGB1 and injury amplification

HMGB1 and injury amplification

https://doi.org/10.18632/oncotarget.5243

Peter Huebener, Celine Hernandez,  and Robert F. Schwabe
23048-23049
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Editorial: Gerotarget (Focus on Aging)

Rapid and simple detection of gero-suppressive agents

Rapid and simple detection of gero-suppressive agents

https://doi.org/10.18632/oncotarget.5455

Zbigniew Darzynkiewicz
23050-23051
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Research Perspectives

Dual mTORC1/C2 inhibitors: gerosuppressors with potential anti-aging effect

Dual mTORC1/C2 inhibitors: gerosuppressors with potential anti-aging effect

https://doi.org/10.18632/oncotarget.5563

Pedro Sousa-Victor, Laura García-Prat,  and Pura Muñoz-Cánoves
23052-23054
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Non-coding RNAs including miRNAs, piRNAs, and tRNAs in human cancer

Non-coding RNAs including miRNAs, piRNAs, and tRNAs in human cancer

https://doi.org/10.18632/oncotarget.5048

Mieke Heyns,  and Olga Kovalchuk
23055-23057
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Priority Reviews

Regulation of Bim in Health and Disease

Regulation of Bim in Health and Disease

https://doi.org/10.18632/oncotarget.5492

Ronit Vogt Sionov, Spiros A. Vlahopoulos,  and Zvi Granot
23058-23134
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Priority Research Papers

p53-regulated autophagy is controlled by glycolysis and determines cell fate

p53-regulated autophagy is controlled by glycolysis and determines cell fate

https://doi.org/10.18632/oncotarget.5218

Lei Duan, Ricardo E. Perez, Batzaya Davaadelger, Elena N. Dedkova, Lothar A. Blatter,  and Carl G. Maki
23135-23156
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Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma

Prognostic impact of c-Rel nuclear expression and REL amplification and crosstalk between c-Rel and the p53 pathway in diffuse large B-cell lymphoma

https://doi.org/10.18632/oncotarget.4319

Ling Li, Zijun Y. Xu-Monette, Chi Young Ok, Alexandar Tzankov, Ganiraju C. Manyam, Ruifan Sun, Carlo Visco, Mingzhi Zhang, Santiago Montes-Moreno, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W.L. Choi, J. Han van Krieken, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Michael B. Møller, Jinfeng Wang, Ben M. Parsons, Jane N. Winter, Miguel A. Piris, Lan V. Pham, L. Jeffrey Medeiros,  and Ken H. Young
23157-23180
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Gerotarget (Focus on Aging)

Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline

Epigenetic alterations in the suprachiasmatic nucleus and hippocampus contribute to age-related cognitive decline

https://doi.org/10.18632/oncotarget.4036

Scott H. Deibel, Erin L. Zelinski, Robin J. Keeley, Olga Kovalchuk,  and Robert J. McDonald
23181-23203
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Quantifying signaling pathway activation to monitor the quality of induced pluripotent stem cells

Quantifying signaling pathway activation to monitor the quality of induced pluripotent stem cells

https://doi.org/10.18632/oncotarget.4673

Eugene Makarev, Kristen Fortney, Maria Litovchenko, Karl H. Braunewell, Alex Zhavoronkov,  and Anthony Atala
23204-23212
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The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice

The effects of graded levels of calorie restriction: II. Impact of short term calorie and protein restriction on circulating hormone levels, glucose homeostasis and oxidative stress in male C57BL/6 mice

https://doi.org/10.18632/oncotarget.4003

Sharon E. Mitchell, Camille Delville, Penelope Konstantopedos, Jane Hurst, Davina Derous, Cara Green, Luonan Chen, Jackie J.D. Han, Yingchun Wang, Daniel E.L. Promislow, David Lusseau, Alex Douglas,  and John R. Speakman
23213-23237
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Research Papers: Pathology

Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program)

Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program)

https://doi.org/10.18632/oncotarget.4836

Olga V. Leontieva, Zoya N. Demidenko,  and Mikhail V. Blagosklonny
23238-23248
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Inhibition of muscle fibrosis results in increases in both utrophin levels and the number of revertant myofibers in Duchenne muscular dystrophy

Inhibition of muscle fibrosis results in increases in both utrophin levels and the number of revertant myofibers in Duchenne muscular dystrophy

https://doi.org/10.18632/oncotarget.4021

Oshrat Levi, Olga Genin, Corrado Angelini, Orna Halevy,  and Mark Pines
23249-23260
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Conditional survival estimate of acute-on-chronic hepatitis B liver failure: a dynamic prediction based on a multicenter cohort

Conditional survival estimate of acute-on-chronic hepatitis B liver failure: a dynamic prediction based on a multicenter cohort

https://doi.org/10.18632/oncotarget.4666

Ming- Hua Zheng, Sheng-Jie Wu, Ke-Qing Shi, Hua-Dong Yan, Hai Li, Gui-Qi Zhu, Yao-Yao Xie, Fa-Ling Wu,  and Yong-Ping Chen
23261-23271
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Na+-induced Ca2+ influx through reverse mode of Na+-Ca2+ exchanger in mouse ventricular cardiomyocyte

Na+-induced Ca2+ influx through reverse mode of Na+-Ca2+ exchanger in mouse ventricular cardiomyocyte

https://doi.org/10.18632/oncotarget.4878

Zhen-Yu Yan, Tao Ban, Yao Fan, Wei-Ran Chen, Hong-Li Sun, Henying Chen, Quo-Fen Qiao,  and Bai-Yan Li
23272-23280
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AXL is an oncotarget in human colorectal cancer

AXL is an oncotarget in human colorectal cancer

https://doi.org/10.18632/oncotarget.3962

Erika Martinelli, Giulia Martini, Claudia Cardone, Teresa Troiani, Giuseppina Liguori, Donata Vitagliano, Stefania Napolitano, Floriana Morgillo, Barbara Rinaldi, Rosa Marina Melillo, Federica Liotti, Anna Nappi, Roberto Bianco, Liberato Berrin, Loreta Pia Ciuffreda, Davide Ciardiello, Vincenzo Iaffaioli, Gerardo Botti, Fiorella Ferraiolo,  and Fortunato Ciardiello
23281-23296
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Reviews

The role of MicroRNAs expression in laryngeal cancer

The role of MicroRNAs expression in laryngeal cancer

https://doi.org/10.18632/oncotarget.4195

Xin Yu,  and Zheng Li
23297-23305
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mouse models of liver cancer: Progress and recommendations

Mouse models of liver cancer: Progress and recommendations

https://doi.org/10.18632/oncotarget.4202

Li He, De-An Tian, Pei-Yuan Li,  and Xing-Xing He
23306-23322
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA in pancreatic adenocarcinoma: predictive/prognostic biomarkers or therapeutic targets?

MicroRNA in pancreatic adenocarcinoma: predictive/prognostic biomarkers or therapeutic targets?

https://doi.org/10.18632/oncotarget.4492

Oronzo Brunetti, Antonio Russo, Aldo Scarpa, Daniele Santini, Michele Reni, Alessandro Bittoni, Amalia Azzariti, Giuseppe Aprile, Sabina Delcuratolo, Michele Signorile, Antonio Gnoni, Loredana Palermo, Vito Lorusso, Stefano Cascinu,  and Nicola Silvestris
23323-23341
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Research Papers

Long non-coding RNA AOC4P suppresses hepatocellular carcinoma metastasis by enhancing vimentin degradation and inhibiting epithelial-mesenchymal transition

Long non-coding RNA AOC4P suppresses hepatocellular carcinoma metastasis by enhancing vimentin degradation and inhibiting epithelial-mesenchymal transition

https://doi.org/10.18632/oncotarget.4344

Tong-Hong Wang, Yong-Shiang Lin, Ying Chen, Chau-Ting Yeh, Yen-lin Huang, Tsung-Han Hsieh, Tzong-Ming Shieh, Chuen Hsueh,  and Tse-Ching Chen
23342-23357
Abstract  |  PDF  |  HTML  |  Order a Reprint

Androgen receptor splice variants circumvent AR blockade by microtubule-targeting agents

Androgen receptor splice variants circumvent AR blockade by microtubule-targeting agents

https://doi.org/10.18632/oncotarget.4396

Guanyi Zhang, Xichun Liu, Jianzhuo Li, Elisa Ledet, Xavier Alvarez, Yanfeng Qi, Xueqi Fu, Oliver Sartor, Yan Dong,  and Haitao Zhang
23358-23371
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma

TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.4281

Asuka Murata, Yoshifumi Baba, Takatsugu Ishimoto, Keisuke Miyake, Keisuke Kosumi, Kazuto Harada, Junji Kurashige, Shiro Iwagami, Yasuo Sakamoto, Yuji Miyamoto, Naoya Yoshida, Manabu Yamamoto, Shinya Oda, Masayuki Watanabe, Mitsuyoshi Nakao,  and Hideo Baba
23372-23382
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation

Extracellularly secreted APE1/Ref-1 triggers apoptosis in triple-negative breast cancer cells via RAGE binding, which is mediated through acetylation

https://doi.org/10.18632/oncotarget.4345

Yu Ran Lee, Ki Mo Kim, Byeong Hwa Jeon,  and Sunga Choi
23383-23398
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer

High copy number variation of cancer-related microRNA genes and frequent amplification of DICER1 and DROSHA in lung cancer

https://doi.org/10.18632/oncotarget.4351

Karol Czubak, Marzena Anna Lewandowska, Katarzyna Klonowska, Krzysztof Roszkowski, Janusz Kowalewski, Marek Figlerowicz,  and Piotr Kozlowski
23399-23416
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Spatiotemporal control of gene expression in bone-marrow derived cells of the tumor microenvironment induced by MRI guided focused ultrasound

Spatiotemporal control of gene expression in bone-marrow derived cells of the tumor microenvironment induced by MRI guided focused ultrasound

https://doi.org/10.18632/oncotarget.4288

Pierre-Yves Fortin, Matthieu Lepetit-Coiffé, Coralie Genevois, Christelle Debeissat, Bruno Quesson, Chrit T.W. Moonen, Jan Pieter Konsman,  and Franck Couillaud
23417-23426
Abstract  |  PDF  |  HTML  |  Order a Reprint

The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition

The endoplasmic reticulum mitochondrial calcium cross talk is downregulated in malignant pleural mesothelioma cells and plays a critical role in apoptosis inhibition

https://doi.org/10.18632/oncotarget.4370

Simone Patergnani, Carlotta Giorgi, Stefania Maniero, Sonia Missiroli, Pio Maniscalco, Ilaria Bononi, Fernanda Martini, Giorgio Cavallesco, Mauro Tognon,  and Paolo Pinton
23427-23444
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer

Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer

https://doi.org/10.18632/oncotarget.4352

Moloy T. Goswami, Guoan Chen, Balabhadrapatruni V. S. K. Chakravarthi, Satya S. Pathi, Sharath K. Anand, Shannon L. Carskadon, Thomas J. Giordano, Arul M. Chinnaiyan, Dafydd G. Thomas, Nallasivam Palanisamy, David G. Beer,  and Sooryanarayana Varambally
23445-23461
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A pancreatic tumor-specific biomarker characterized in humans and mice as an immunogenic onco-glycoprotein is efficient in dendritic cell vaccination

A pancreatic tumor-specific biomarker characterized in humans and mice as an immunogenic onco-glycoprotein is efficient in dendritic cell vaccination

https://doi.org/10.18632/oncotarget.4359

Aurélie Collignon, Adriana Teodora Perles-Barbacaru, Stéphane Robert, Françoise Silvy, Emmanuelle Martinez, Isabelle Crenon, Sébastien Germain, Stéphane Garcia, Angèle Viola, Dominique Lombardo, Eric Mas,  and Evelyne Béraud
23462-23479
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma

miR-193a-3p is a potential tumor suppressor in malignant pleural mesothelioma

https://doi.org/10.18632/oncotarget.4346

Marissa Williams, Michaela B. Kirschner, Yuen Yee Cheng, Jacky Hanh, Jocelyn Weiss, Nancy Mugridge, Casey M. Wright, Anthony Linton, Steven C. Kao, J James B. Edelman, Michael P. Vallely, Brian C. McCaughan, Wendy Cooper, Sonja Klebe, Ruby C.Y. Lin, Himanshu Brahmbhatt, Jennifer MacDiarmid, Nico van Zandwijk,  and Glen Reid
23480-23495
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Embigin, regulated by HOXC8, plays a suppressive role in breast tumorigenesis

Embigin, regulated by HOXC8, plays a suppressive role in breast tumorigenesis

https://doi.org/10.18632/oncotarget.4360

Fengmei Chao, Jun Zhang, Yang Zhang, Houli Liu, Chenchen Yang, Juan Wang, Yanjun Guo, Xiaohong Wen, Kaiye Zhang, Bei Huang, Daihai Liu,  and Yong Li
23496-23509
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cisplatin inhibits MEK1/2

Cisplatin inhibits MEK1/2

https://doi.org/10.18632/oncotarget.4355

Tetsu Yamamoto, Igor F. Tsigelny, Andreas W. Götz,  and Stephen B. Howell
23510-23522
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

pHLIP-mediated targeting of truncated tissue factor to tumor vessels causes vascular occlusion and impairs tumor growth

pHLIP-mediated targeting of truncated tissue factor to tumor vessels causes vascular occlusion and impairs tumor growth

https://doi.org/10.18632/oncotarget.4395

Suping Li, Yanhua Tian, Ying Zhao, Yinlong Zhang, Shishuai Su, Jing Wang, Meiyu Wu, Quanwei Shi, Gregory J Anderson, Johannes Thomsen, Ruifang Zhao, Tianjiao Ji, Jie Wang,  and Guangjun Nie
23523-23532
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-93/miR-106b/miR-375-CIC-CRABP1: a novel regulatory axis in prostate cancer progression

miR-93/miR-106b/miR-375-CIC-CRABP1: a novel regulatory axis in prostate cancer progression

https://doi.org/10.18632/oncotarget.4372

Nahyun Choi, Jongmin Park, Jeon-Soo Lee, Jeehyun Yoe, Guk Yeol Park, Eunjeong Kim, Hyeongrin Jeon, Yong Mee Cho, Tae-Young Roh,  and Yoontae Lee
23533-23547
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer

Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer

https://doi.org/10.18632/oncotarget.4556

Lacey M. Litchfield, Abir Mukherjee, Mark A. Eckert, Alyssa Johnson, Kathryn A. Mills, Shawn Pan, Viji Shridhar, Ernst Lengyel,  and Iris L. Romero
23548-23560
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2

A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2

https://doi.org/10.18632/oncotarget.4452

Ammara Abdullah, Sanam Sane, Kate A. Branick, Jessica L Freeling, Hongmin Wang, Dong Zhang,  and Khosrow Rezvani
23561-23581
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer

Long non-coding RNA UCA1 induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/mTOR pathway in EGFR-mutant non-small cell lung cancer

https://doi.org/10.18632/oncotarget.4361

Ningning Cheng, Weijing Cai, Shengxiang Ren, Xuefei Li, Qi Wang, Hui Pan, Mingchuan Zhao, Jiayu Li, Yishi Zhang, Chao Zhao, Xiaoxia Chen, Ke Fei, Caicun Zhou,  and Fred R. Hirsch
23582-23593
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma

Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma

https://doi.org/10.18632/oncotarget.4335

Ming-Huang Chen, Chueh-Chuan Yen, Chi-Tung Cheng, Ren-Chin Wu, Shih-Chiang Huang, Chung-Shan Yu, Yi-Hsiu Chung, Chun-Yu Liu, Peter Mu-Hsin Chang, Yee Chao, Ming-Han Chen, Yu-Fen Chen, Kun-Chun Chiang, Ta-Sen Yeh, Tzu Chi Chen, Chi-Ying F. Huang,  and Chun-Nan Yeh
23594-23608
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma

The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma

https://doi.org/10.18632/oncotarget.4603

Cinzia Fionda, Maria Pia Abruzzese, Alessandra Zingoni, Francesca Cecere, Elisabetta Vulpis, Giovanna Peruzzi, Alessandra Soriani, Rosa Molfetta, Rossella Paolini, Maria Rosaria Ricciardi, Maria Teresa Petrucci, Angela Santoni,  and Marco Cippitelli
23609-23630
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies

A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies

https://doi.org/10.18632/oncotarget.4604

Mary E. Irwin, Blake P. Johnson, Roxsan Manshouri, Hesham M. Amin,  and Joya Chandra
23631-23646
Abstract  |  PDF  |  HTML  |  Order a Reprint

Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells

Glioma-derived plasminogen activator inhibitor-1 (PAI-1) regulates the recruitment of LRP1 positive mast cells

https://doi.org/10.18632/oncotarget.4640

Ananya Roy, Antoine Coum, Voichita D. Marinescu, Jelena Põlajeva, Anja Smits, Sven Nelander, Lene Uhrbom, Bengt Westermark, Karin Forsberg-Nilsson, Fredrik Pontén,  and Elena Tchougounova
23647-23661
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models

CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models

https://doi.org/10.18632/oncotarget.4282

Ji-Feng Xu, Xiao-Hong Pan, Shui-Jun Zhang, Chen Zhao, Bin-Song Qiu, Hai-Feng Gu, Jian-Fei Hong, Li Cao, Yu Chen, Bing Xia, Qin Bi,  and Ya-Ping Wang
23662-23670
Abstract  |  PDF  |  HTML  |  Order a Reprint

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis

https://doi.org/10.18632/oncotarget.4409

Carrie A Duckworth, Scott E Guimond, Paulina Sindrewicz, Ashley J Hughes, Neil S French, Lu-Yun Lian, Edwin A Yates, D Mark Pritchard, Jonathan M Rhodes, Jeremy E Turnbull,  and Lu-Gang Yu
23671-23687
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Time-course gene profiling and networks in demethylated retinoblastoma cell line

Time-course gene profiling and networks in demethylated retinoblastoma cell line

https://doi.org/10.18632/oncotarget.4644

Federico Malusa, Monia Taranta, Nazar Zaki, Caterina Cinti,  and Enrico Capobianco
23688-23707
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TRIM66 overexpresssion contributes to osteosarcoma carcinogenesis and indicates poor survival outcome

TRIM66 overexpresssion contributes to osteosarcoma carcinogenesis and indicates poor survival outcome

https://doi.org/10.18632/oncotarget.4291

Yu Chen, Yongfei Guo, Haisong Yang, Guodong Shi, Guohua Xu, Jiangang Shi, Na Yin,  and Deyu Chen
23708-23719
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance

Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance

https://doi.org/10.18632/oncotarget.4690

Anil Belur Nagaraj, Peronne Joseph, Olga Kovalenko, Sareena Singh, Amy Armstrong, Raymond Redline, Kimberly Resnick, Kristine Zanotti, Steven Waggoner,  and Analisa DiFeo
23720-23734
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Retargeted human avidin-CAR T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging

Retargeted human avidin-CAR T cells for adoptive immunotherapy of EGFRvIII expressing gliomas and their evaluation via optical imaging

https://doi.org/10.18632/oncotarget.4362

Kaiyu Liu, Xujie Liu, Zhiping Peng, Haojie Sun, Mingzhi Zhang, Jianning Zhang, Shuang Liu, Limin Hao, Guoqiu Lu, Kangcheng Zheng, Xikui Gong, Di Wu, Fan Wang,  and Li Shen
23735-23747
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

COL11A1 confers chemoresistance on ovarian cancer cells through the activation of Akt/c/EBPβ pathway and PDK1 stabilization

COL11A1 confers chemoresistance on ovarian cancer cells through the activation of Akt/c/EBPβ pathway and PDK1 stabilization

https://doi.org/10.18632/oncotarget.4250

Yi-Hui Wu, Tzu-Hao Chang, Yu-Fang Huang, Chien-Chin Chen,  and Cheng-Yang Chou
23748-23763
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer

Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer

https://doi.org/10.18632/oncotarget.4350

Wei Song, Wei Li, Lingyu Li, Shilin Zhang, Xu Yan, Xue Wen, Xiaoying Zhang, Huimin Tian, Ailing Li, Ji-Fan Hu,  and Jiuwei Cui
23764-23775
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling

3'3-Diindolylmethane inhibits migration, invasion and metastasis of hepatocellular carcinoma by suppressing FAK signaling

https://doi.org/10.18632/oncotarget.4196

Wen-Xue Li, Li-Ping Chen, Min-Ying Sun, Jun-Tao Li, Hua-Zhang Liu,  and Wei Zhu
23776-23792
Abstract  |  PDF  |  HTML  |  Order a Reprint

MiR-26b/KPNA2 axis inhibits epithelial ovarian carcinoma proliferation and metastasis through downregulating OCT4

MiR-26b/KPNA2 axis inhibits epithelial ovarian carcinoma proliferation and metastasis through downregulating OCT4

https://doi.org/10.18632/oncotarget.4363

Jiaxin Lin, Lan Zhang, He Huang, Yongwen Huang, Long Huang, Jianhua Wang, Shuting Huang, Li He, Yun Zhou, Weihua Jia, Jingping Yun, Rongzhen Luo,  and Min Zheng
23793-23806
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma

Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4278

Huei-Yue Dai, Hui-Yu Chen, Wei-Chen Lai, Mien-Chie Hung,  and Long-Yuan Li
23807-23819
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LINE-1 hypomethylation in normal colon mucosa is associated with poor survival in Chinese patients with sporadic colon cancer

LINE-1 hypomethylation in normal colon mucosa is associated with poor survival in Chinese patients with sporadic colon cancer

https://doi.org/10.18632/oncotarget.4450

Changhua Zhuo, Qingguo Li, Yuchen Wu, Yiwei Li, Jia Nie, Dawei Li, Junjie Peng, Peng Lian, Bin Li, Guoxiang Cai, Xinxiang Li,  and Sanjun Cai
23820-23836
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Direct regulation of E-cadherin by targeted histone methylation of TALE-SET fusion protein in cancer cells

Direct regulation of E-cadherin by targeted histone methylation of TALE-SET fusion protein in cancer cells

https://doi.org/10.18632/oncotarget.4340

Hyun-Soo Cho, Jeong Gu Kang, Jae-Hye Lee, Jeong-Ju Lee, Seong Kook Jeon, Jeong-Heon Ko, Dae-Soo Kim, Kun-Hyang Park, Yong-Sam Kim,  and Nam-Soon Kim
23837-23844
Abstract  |  PDF  |  HTML  |  Order a Reprint

Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling

Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling

https://doi.org/10.18632/oncotarget.4313

Wan-Chen Tsai, Chien-Lin Chen,  and Hong-Chen Chen
23845-23856
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo

Lovastatin overcomes gefitinib resistance through TNF-α signaling in human cholangiocarcinomas with different LKB1 statuses in vitro and in vivo

https://doi.org/10.18632/oncotarget.4408

Sheng-Huei Yang, Hung-Yun Lin, Vincent H.S. Chang, Chien-Chung Chen, Yun-Ru Liu, Jinghan Wang, Keqiang Zhang, Xiaoqing Jiang,  and Yun Yen
23857-23873
Abstract  |  PDF  |  HTML  |  Order a Reprint

miR-200c dampens cancer cell migration via regulation of protein kinase A subunits

miR-200c dampens cancer cell migration via regulation of protein kinase A subunits

https://doi.org/10.18632/oncotarget.4381

Florian Christoph Sigloch, Ulrike Christina Burk, Martin Lothar Biniossek, Thomas Brabletz,  and Oliver Schilling
23874-23889
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α- and AP-1-mediated VEGFa transcription

NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α- and AP-1-mediated VEGFa transcription

https://doi.org/10.18632/oncotarget.4341

Li Qin, Yan Xu, Yixiang Xu, Gang Ma, Lan Liao, Yelin Wu, Yi Li, Xian Wang, Xiaosong Wang, Jun Jiang, Jin Wang,  and Jianming Xu
23890-23904
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular profiling of lung adenosquamous carcinoma: hybrid or genuine type?

Molecular profiling of lung adenosquamous carcinoma: hybrid or genuine type?

https://doi.org/10.18632/oncotarget.4163

Erik Vassella, Stephanie Langsch, Matthias S. Dettmer, Cornelia Schlup, Maja Neuenschwander, Milo Frattini, Mathias Gugger,  and Stephan C. Schäfer
23905-23916
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor

Multifaceted interactions and regulation between antizyme and its interacting proteins cyclin D1, ornithine decarboxylase and antizyme inhibitor

https://doi.org/10.18632/oncotarget.4469

Yen-Chin Liu, Chien-Yun Lee, Chi-Li Lin, Hui-Yi Chen, Guang-Yaw Liu,  and Hui-Chih Hung
23917-23929
Abstract  |  PDF  |  HTML  |  Order a Reprint

E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines

E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines

https://doi.org/10.18632/oncotarget.4525

Liming Li, Cui Xu, Jia Long, Danbei Shen, Wuqing Zhou, Qiyan Zhou, Jia Yang,  and Mingjun Jiang
23930-23943
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis

Differential involvement of RASSF2 hypermethylation in breast cancer subtypes and their prognosis

https://doi.org/10.18632/oncotarget.4062

Noemi Perez-Janices, Idoia Blanco-Luquin, Natalia Torrea, Therese Liechtenstein, David Escors, Alicia Cordoba, Francisco Vicente-Garcia, Isabel Jauregui, Susana De La Cruz, José Juan Illarramendi, Valle Coca, Maria Berdasco, Grazyna Kochan, Berta Ibañez, José Miguel Lera,  and David Guerrero-Setas
23944-23958
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells

Systematic dissection of phenotypic, functional, and tumorigenic heterogeneity of human prostate cancer cells

https://doi.org/10.18632/oncotarget.4260

Xin Liu, Xin Chen, Kiera Rycaj, Hsueh-Ping Chao, Qu Deng, Collene Jeter, Can Liu, Sofia Honorio, Hangwen Li, Tammy Davis, Mahipal Suraneni, Brian Laffin, Jichao Qin, Qiuhui Li, Tao Yang, Pamela Whitney, Jianjun Shen, Jiaoti Huang,  and Dean G. Tang
23959-23986
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistant cancers

Targeting chemotherapy-induced PTX3 in tumor stroma to prevent the progression of drug-resistant cancers

https://doi.org/10.18632/oncotarget.4364

Jhih-Ying Chi, Yu-Wei Hsiao, Chien-Feng Li, Yu-Chih Lo, Zu-Yau Lin, Jhen-Yi Hong, Yang-Ming Liu, Xiu Han, Shao-Ming Wang, Ben-Kuen Chen, Kelvin K. Tsai,  and Ju-Ming Wang
23987-24001
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas

Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas

https://doi.org/10.18632/oncotarget.4365

Yu-Chao Chang, Chia-Ing Jan, Chih-Yu Peng, Yu-Chi Lai, Fang-Wei Hu,  and Cheng-Chia Yu
24002-24016
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway

MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway

https://doi.org/10.18632/oncotarget.4447

Yun-Li Chang, Pei-Jie Zhou, Lianzi Wei, Wang Li, Zhongzhong Ji, Yu-Xiang Fang,  and Wei-Qiang Gao
24017-24031
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma

Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastoma

https://doi.org/10.18632/oncotarget.4429

Jui-Ling Hsu, Fan-Lun Liu, Lih-Ching Hsu, Hsun-Shuo Chang, Wohn-Jenn Leu, Chia-Chun Yu, Wei-Ling Chang, Ih-Sheng Chen, Fan-Lu Kung,  and Jih-Hwa Guh
24032-24046
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Humanized anti-hepatocyte growth factor (HGF) antibody suppresses innate irinotecan (CPT-11) resistance induced by fibroblast-derived HGF

Humanized anti-hepatocyte growth factor (HGF) antibody suppresses innate irinotecan (CPT-11) resistance induced by fibroblast-derived HGF

https://doi.org/10.18632/oncotarget.4369

Jong Kyu Woo, Ju-Hee Kang, BoRa Kim, Byung Hee Park, Kum-Joo Shin, Seong-Won Song, Jung Ju Kim, Hwan-Mook Kim, Sang-Jin Lee,  and Seung Hyun Oh
24047-24060
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread

Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread

https://doi.org/10.18632/oncotarget.4448

Elisa Giannoni, Maria Letizia Taddei, Andrea Morandi, Giuseppina Comito, Maura Calvani, Francesca Bianchini, Barbara Richichi, Giovanni Raugei, Nicholas Wong, Damu Tang,  and Paola Chiarugi
24061-24074
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells

Doxorubicin induces apoptosis by targeting Madcam1 and AKT and inhibiting protein translation initiation in hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.4373

Jiayi Wang, Lifang Ma, Xun Tang, Xiao Zhang, Yongxia Qiao, Yuling Shi, Yanfeng Xu, Zhongyong Wang, Yongchun Yu,  and Fenyong Sun
24075-24091
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer

eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer

https://doi.org/10.18632/oncotarget.4483

Min-Wu Chao, Li-Ting Wang, Chin-Yu Lai, Xiao-Ming Yang, Ya-Wen Cheng, Kuo-Hsiung Lee, Shiow-Lin Pan,  and Che-Ming Teng
24092-24104
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oxidized low-density lipoprotein is a common risk factor for cardiovascular diseases and gastroenterological cancers via epigenomical regulation of microRNA-210

Oxidized low-density lipoprotein is a common risk factor for cardiovascular diseases and gastroenterological cancers via epigenomical regulation of microRNA-210

https://doi.org/10.18632/oncotarget.4152

Ku-Chung Chen, Yi-Chu Liao, Jaw-Yuan Wang, Ying-Chu Lin, Chung-Ho Chen,  and Suh-Hang H. Juo
24105-24118
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DNMT1-dependent suppression of microRNA424 regulates tumor progression in human bladder cancer

DNMT1-dependent suppression of microRNA424 regulates tumor progression in human bladder cancer

https://doi.org/10.18632/oncotarget.4431

Chun-Te Wu, Wei-Yu Lin, Ying-Hsu Chang, Paul-Yang Lin, Wen-Cheng Chen,  and Miao-Fen Chen
24119-24131
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Upregulation of FAM83D affects the proliferation and invasion of hepatocellular carcinoma

Upregulation of FAM83D affects the proliferation and invasion of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4432

Weijia Liao, Weilong Liu, Xing Liu, Qing Yuan, Ying Ou, Yao Qi, Wanqiu Huang, Yun Wang,  and Jian Huang
24132-24147
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism

Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism

https://doi.org/10.18632/oncotarget.4376

Guo-Qing Chen, Cheng-Fang Tang, Xiao-Ke Shi, Cheng-Yuan Lin, Sarwat Fatima, Xiao-Hua Pan, Da-Jian Yang, Ge Zhang, Ai-Ping Lu, Shu-Hai Lin,  and Zhao-Xiang Bian
24148-24162
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TACC3 promotes stemness and is a potential therapeutic target in hepatocellular carcinoma

TACC3 promotes stemness and is a potential therapeutic target in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4643

Dong-Sheng Zhou, Hong-Bo Wang, Zhong-Guo Zhou, Yao-Jun Zhang, Qian Zhong, Li Xu, Yue-Hua Huang, Sai-Ching Yeung, Min-Shan Chen,  and Mu-Sheng Zeng
24163-24177
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure

Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure

https://doi.org/10.18632/oncotarget.4680

Xuebing Ding, Mingming Ma, Junfang Teng, Robert K.F. Teng, Shuang Zhou, Jingzheng Yin, Ekokobe Fonkem, Jason H. Huang, Erxi Wu,  and Xuejing Wang
24178-24191
Abstract  |  PDF  |  HTML  |  Order a Reprint

Suppression of Rituximab-resistant B-cell lymphoma with a novel multi-component anti-CD20 mAb nanocluster

Suppression of Rituximab-resistant B-cell lymphoma with a novel multi-component anti-CD20 mAb nanocluster

https://doi.org/10.18632/oncotarget.4206

Huafei Li, Ge Zhang, Cheng Jiang, Fulei Zhang, Changhong Ke, He Zhao, Yun Sun, Mengxin Zhao, Di Chen, Xiandi Zhu, Li Zhang, Bohua Li, Jianxin Dai,  and Wei Li
24192-24204
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular spectrum of BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias: implication for MEK-ERK pathway activation

Molecular spectrum of BRAF, NRAS and KRAS gene mutations in plasma cell dyscrasias: implication for MEK-ERK pathway activation

https://doi.org/10.18632/oncotarget.4434

Marta Lionetti, Marzia Barbieri, Katia Todoerti, Luca Agnelli, Simona Marzorati, Sonia Fabris, Gabriella Ciceri, Serena Galletti, Giulia Milesi, Martina Manzoni, Mara Mazzoni, Angela Greco, Giovanni Tonon, Pellegrino Musto, Luca Baldini,  and Antonino Neri
24205-24217
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma

Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma

https://doi.org/10.18632/oncotarget.4523

Yi Li, Yuhuan Zheng, Tianshu Li, Qiang Wang, Jianfei Qian, Yong Lu, Mingjun Zhang, Enguang Bi, Maojie Yang, Frederic Reu, Qing Yi,  and Zhen Cai
24218-24229
Abstract  |  PDF  |  HTML  |  Order a Reprint

The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior

The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior

https://doi.org/10.18632/oncotarget.4353

Olga Bornachea, Fernando F. López-Calderón, Marta Dueñas, Carmen Segrelles, Corina Lorz, Cristian Suárez-Cabrera, María Marañón, Beatriz Paradela-Dobarro, Mirentxu Santos,  and Jesús M. Paramio
24230-24245
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression

Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression

https://doi.org/10.18632/oncotarget.4759

Lu Dai, Jimena Trillo-Tinoco, Aiping Bai, Yihan Chen, Jacek Bielawski, Luis Del Valle, Charles D. Smith, Augusto C. Ochoa, Zhiqiang Qin,  and Chris Parsons
24246-24260
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Requirement of novel amino acid fragments of orphan nuclear receptor TR3/Nur77 for its functions in angiogenesis

Requirement of novel amino acid fragments of orphan nuclear receptor TR3/Nur77 for its functions in angiogenesis

https://doi.org/10.18632/oncotarget.4637

Yan Li, Pierre M. Bourbon, Marianne A. Grant, Jin Peng, Taiyang Ye, Dezheng Zhao,  and Huiyan Zeng
24261-24276
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents

Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents

https://doi.org/10.18632/oncotarget.4493

Yun-Kai Zhang, Hengyuan Zhang, Guan-Nan Zhang, Yi-Jun Wang, Rishil J. Kathawala, Rui Si, Bhargav A. Patel, Jinyi Xu,  and Zhe-Sheng Chen
24277-24290
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EBV-encoded RNA via TLR3 induces inflammation in nasopharyngeal carcinoma

EBV-encoded RNA via TLR3 induces inflammation in nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.4552

Zhi Li, Yumei Duan, Shiyue Cheng, Yan Chen, Yanxin Hu, Lu Zhang, Jiang He, Qiong Liao, Lifang Yang,  and Lun-Quan Sun
24291-24303
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells

The antidiabetic compound 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione, isolated from averrhoa carambola L., demonstrates significant antitumor potential against human breast cancer cells

https://doi.org/10.18632/oncotarget.4475

Ying Gao, Renbin Huang, Yixuan Gong, Hyo Sim Park, Qingwei Wen, Nadin Marwan Almosnid, Uma D. Chippada-Venkata, Najlaa Abdulrhman Hosain, Eric Vick, Anthony Farone,  and Elliot Altman
24304-24319
Abstract  |  PDF  |  HTML  |  Order a Reprint

Detection of novel and potentially actionable anaplastic lymphoma kinase (ALK) rearrangement in colorectal adenocarcinoma by immunohistochemistry screening

Detection of novel and potentially actionable anaplastic lymphoma kinase (ALK) rearrangement in colorectal adenocarcinoma by immunohistochemistry screening

https://doi.org/10.18632/oncotarget.4462

Jeeyun Lee, Hee Cheol Kim, Jung Yong Hong, Kai Wang, Sun Young Kim, Jiryeon Jang, Seung Tae Kim, Joon Oh Park, Ho Yeong Lim, Won Ki Kang, Young Suk Park, Jiyun Lee, Woo Yong Lee, Yoon Ah Park, Jung Wook Huh, Seong Hyeon Yun, In-Gu Do, Seok Hyung Kim, Sohail Balasubramanian, Philip J. Stephens, Jeffrey S. Ross, Gang Gary Li, Zachary Hornby, Siraj M. Ali, Vincent A. Miller, Kyoung-Mee Kim,  and Sai-Hong Ignatius Ou
24320-24332
Abstract  |  PDF  |  HTML  |  Order a Reprint

5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme

5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme

https://doi.org/10.18632/oncotarget.4476

Fabio Ciccarone, Elisabetta Valentini, Michele Zampieri,  and Paola Caiafa
24333-24347
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CCR7 enhances TGF-β1-induced epithelial-mesenchymal transition and is associated with lymph node metastasis and poor overall survival in gastric cancer

CCR7 enhances TGF-β1-induced epithelial-mesenchymal transition and is associated with lymph node metastasis and poor overall survival in gastric cancer

https://doi.org/10.18632/oncotarget.4484

Huiying Ma, Lingling Gao, Shichao Li, Jie Qin, Long Chen, Xinzhou Liu, Pingping Xu, Fei Wang, Honglei Xiao, Shuang Zhou, Qiang Gao, Binbin Liu, Yihong Sun,  and Chunmin Liang
24348-24360
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

eIF3 controls cell size independently of S6K1-activity

eIF3 controls cell size independently of S6K1-activity

https://doi.org/10.18632/oncotarget.4458

Katharina Schipany, Margit Rosner, Loredana Ionce, Markus Hengstschläger,  and Boris Kovacic
24361-24375
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer

Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer

https://doi.org/10.18632/oncotarget.4463

James Kalmuk, Margaret Folaron, Julian Buchinger, Roberto Pili,  and Mukund Seshadri
24376-24392
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

https://doi.org/10.18632/oncotarget.5162

Min-Young Kwon, Eunhee Park, Seon-Jin Lee,  and Su Wol Chung
24393-24403
Abstract  |  PDF  |  HTML  |  Order a Reprint

Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions

Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions

https://doi.org/10.18632/oncotarget.4380

Ana-Rita Pedrosa, Alexandre Trindade, Catarina Carvalho, José Graça, Sandra Carvalho, Maria C. Peleteiro, Ralf H. Adams,  and António Duarte
24404-24423
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq technology

Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq technology

https://doi.org/10.18632/oncotarget.4420

Xiao-Han Tang, Alison M. Urvalek, Kwame Osei-Sarfo, Tuo Zhang, Theresa Scognamiglio,  and Lorraine J. Gudas
24424-24435
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Human stromal cells are required for an anti-breast cancer effect of zoledronic acid

Human stromal cells are required for an anti-breast cancer effect of zoledronic acid

https://doi.org/10.18632/oncotarget.4421

Hilde H. Nienhuis, Marlous Arjaans, Hetty Timmer-Bosscha, Elisabeth G.E. de Vries,  and Carolina P. Schröder
24436-24447
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR

miRNA-99b-5p suppresses liver metastasis of colorectal cancer by down-regulating mTOR

https://doi.org/10.18632/oncotarget.4423

Wenhua Li, Jinjia Chang, Shanshan Wang, Xinyang Liu, Junjie Peng, Dan Huang, Menghong Sun, Zhiyu Chen, Wen Zhang, Weijian Guo,  and Jin Li
24448-24462
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of miR-215 mediated targets/pathways via translational immunoprecipitation expression analysis (TrIP-chip)

Identification of miR-215 mediated targets/pathways via translational immunoprecipitation expression analysis (TrIP-chip)

https://doi.org/10.18632/oncotarget.4425

Andrew Fesler, Xiao Xu, Xiao Zheng, Xiaodong Li, Jingting Jiang, James J. Russo,  and Jingfang Ju
24463-24473
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks

Gastric cancer associated variant of DNA polymerase beta (Leu22Pro) promotes DNA replication associated double strand breaks

https://doi.org/10.18632/oncotarget.4426

Jenna Rozacky, Antoni A. Nemec, Joann B. Sweasy,  and Dawit Kidane
24474-24487
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Clinical Research Papers

Morphological and immunohistochemical identification of epithelial-to-mesenchymal transition in clinical prostate cancer

Morphological and immunohistochemical identification of epithelial-to-mesenchymal transition in clinical prostate cancer

https://doi.org/10.18632/oncotarget.4177

Kimberley Kolijn, Esther I. Verhoef,  and Geert J.L.H. van Leenders
24488-24498
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Molecular characterization of patients with pathologic complete response or early failure after neoadjuvant chemotherapy for locally advanced breast cancer using next generation sequencing and nCounter assay

Molecular characterization of patients with pathologic complete response or early failure after neoadjuvant chemotherapy for locally advanced breast cancer using next generation sequencing and nCounter assay

https://doi.org/10.18632/oncotarget.4119

Kyunghee Park, Moon Ki Choi, Hae Hyun Jung, In-Gu Do, Kwang Hee Lee, TaeJin Ahn, Won Ho Kil, Seok Won Kim, Jeong Eon Lee, Seok Jin Nam, Duk-Hwan Kim, Jin Seok Ahn, Young-Hyuck Im,  and Yeon Hee Park
24499-24510
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Distant metastasis risk and patterns of nasopharyngeal carcinoma in the era of IMRT: long-term results and benefits of chemotherapy

Distant metastasis risk and patterns of nasopharyngeal carcinoma in the era of IMRT: long-term results and benefits of chemotherapy

https://doi.org/10.18632/oncotarget.4312

An-Chuan Li, Wei-Wei Xiao, Guan-Zhu Shen, Lin Wang, An-An Xu, Yan-Qing Cao, Shao-Min Huang, Cheng-Guang Lin, Fei Han, Xiao-Wu Deng,  and Chong Zhao
24511-24521
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Functional intronic ERCC1 polymorphism from regulomeDB can predict survival in lung cancer after surgery

Functional intronic ERCC1 polymorphism from regulomeDB can predict survival in lung cancer after surgery

https://doi.org/10.18632/oncotarget.4083

Shin Yup Lee, Mi Jeong Hong, Hyo-Sung Jeon, Yi Young Choi, Jin Eun Choi, Hyo-Gyoung Kang, Deuk Kju Jung, Chengcheng Jin, Sook Kyung Do, Seung Soo Yoo, Yangki Seok, Eung Bae Lee, Kyung Min Shin, Ji Yun Jeong, Won Kee Lee, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Young Tae Kim, Sanghoon Jheon,  and Jae Yong Park
24522-24532
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Optimal drug regimens for primary biliary cirrhosis: a systematic review and network meta-analysis

Optimal drug regimens for primary biliary cirrhosis: a systematic review and network meta-analysis

https://doi.org/10.18632/oncotarget.4528

Gui-Qi Zhu, Sha Huang, Gui-Qian Huang, Li-Ren Wang, Yi-Qian Lin, Yi-Ming Wu, Ke-Qing Shi, Jiang-Tao Wang, Zhi-Rui Zhou, Martin Braddock, Yong-Ping Chen, Meng-Tao Zhou,  and Ming-Hua Zheng
24533-24549
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Sorafenib continuation or discontinuation in patients with unresectable hepatocellular carcinoma after a complete response

Sorafenib continuation or discontinuation in patients with unresectable hepatocellular carcinoma after a complete response

https://doi.org/10.18632/oncotarget.4076

Yingqiang Zhang, Wenzhe Fan, Kangshun Zhu, Ligong Lu, Sirui Fu, Jinhua Huang, Yu Wang, Jianyong Yang, Yonghui Huang, Wang Yao,  and Jiaping Li
24550-24559
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RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients

RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients

https://doi.org/10.18632/oncotarget.4183

Talia Golan, Elina Zorde Khvalevsky, Ayala Hubert, Rachel Malka Gabai, Naama Hen, Amiel Segal, Abraham Domb, Gil Harari, Eliel Ben David, Stephen Raskin, Yuri Goldes, Eran Goldin, Rami Eliakim, Maor Lahav, Yael Kopleman, Alain Dancour, Amotz Shemi,  and Eithan Galun
24560-24570
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Reproductive factors and hormone receptor status among very young (<35 years) breast cancer patients

Reproductive factors and hormone receptor status among very young (<35 years) breast cancer patients

https://doi.org/10.18632/oncotarget.4698

Xiaoqing Jia, Guangyu Liu, Miao Mo, Jingyi Cheng, Zhenzhou Shen,  and Zhimin Shao
24571-24580
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Errata

Erratum: Actionable mutations in plasma cell-free DNA in patients with advanced cancers referred for experimental targeted therapies

Erratum: Actionable mutations in plasma cell-free DNA in patients with advanced cancers referred for experimental targeted therapies

https://doi.org/10.18632/oncotarget.5663

Filip Janku, Philipp Angenendt, Apostolia M. Tsimberidou, Siqing Fu, Aung Naing, Gerald S. Falchook, David S. Hong, Veronica R. Holley, Goran Cabrilo, Jennifer J. Wheler, Sarina A. Piha-Paul, Ralph G. Zinner, Agop Y. Bedikian, Michael J. Overman, Bryan K. Kee, Kevin B. Kim, E. Scott Kopetz, Rajyalakshmi Luthra, Frank Diehl, Funda Meric-Bernstam,  and Razelle Kurzrock
24581-24581
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