Oncotarget

Vol 6, No 26

September 8, 2015

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About The Cover

See Miyakawa et al. HepG2 cells were transfected with plasmids encoding SHBs-FLAG and HA-tetherin. After 24 h, the cells were fixed, permeabilized, and stained with anti-FLAG (green) and anti-HA (red), followed by confocal microscopic analysis. Scale bar, 10 μm.

Table of Contents

Editorial: Immunology

The herpesvirus stealth program

The herpesvirus stealth program

https://doi.org/10.18632/oncotarget.5261

Teng Huang,  and Nikolaus Osterrieder
21761-21762
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LOX-1 boosts immunity

LOX-1 boosts immunity

https://doi.org/10.18632/oncotarget.4756

SangKon Oh,  and HyeMee Joo
21763-21764
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Fatty acid synthesis and NLRP3-inflammasome

Fatty acid synthesis and NLRP3-inflammasome

https://doi.org/10.18632/oncotarget.4781

Jong-Seok Moon, Kiichi Nakahira,  and Augustine M.K. Choi
21765-21766
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A Hrd way for MHC-II expression

A Hrd way for MHC-II expression

https://doi.org/10.18632/oncotarget.4799

Johanna Melo-Cardenas, Sinyi Kong,  and Deyu Fang
21767-21768
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Complementing regeneration

Complementing regeneration

https://doi.org/10.18632/oncotarget.4844

Ali Alawieh, Aarti Narang,  and Stephen Tomlinson
21769-21770
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IDO-GCN2 and autophagy in inflammation

IDO-GCN2 and autophagy in inflammation

https://doi.org/10.18632/oncotarget.4846

Tracy L. McGaha
21771-21772
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TCR signals fuel Treg cells

TCR signals fuel Treg cells

https://doi.org/10.18632/oncotarget.4881

Christoph Drees, J. Christoph Vahl,  and Marc Schmidt-Supprian
21773-21774
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IL-37 restrains autoimmune diseases

IL-37 restrains autoimmune diseases

https://doi.org/10.18632/oncotarget.4887

Liang Ye,  and Huang Zhong
21775-21776
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Thymic involution beyond T-cell insufficiency

Thymic involution beyond T-cell insufficiency

https://doi.org/10.18632/oncotarget.4970

Brandon Coder,  and Dong-Ming Su
21777-21778
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OX40/OX40L axis: not a friend in autoimmunity

OX40/OX40L axis: not a friend in autoimmunity

https://doi.org/10.18632/oncotarget.4973

Hideki Ueno,  and Patrick Blanco
21779-21780
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Protein conformation in a vaccine matters

Protein conformation in a vaccine matters

https://doi.org/10.18632/oncotarget.5102

Trudy G. Morrison
21781-21782
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PD-1: Dual guard for immunopathology

PD-1: Dual guard for immunopathology

https://doi.org/10.18632/oncotarget.4787

Hye Ryun Kim, Hyo Jin Park,  and Sang-Jun Ha
21783-21784
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Regulation of T follicular helper cells by ICOS

Regulation of T follicular helper cells by ICOS

https://doi.org/10.18632/oncotarget.4798

Andreas Hutloff
21785-21786
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Notch controls effector CD8+ T cell differentiation

Notch controls effector CD8+ T cell differentiation

https://doi.org/10.18632/oncotarget.4886

Frédéric Duval, Mélissa Mathieu,  and Nathalie Labrecque
21787-21788
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TPL2 mediates IL-17R signaling in neuroinflammation

TPL2 mediates IL-17R signaling in neuroinflammation

https://doi.org/10.18632/oncotarget.4888

Yichuan Xiao,  and Shao-Cong Sun
21789-21790
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Uncovering HIV-1-infected cells

Uncovering HIV-1-infected cells

https://doi.org/10.18632/oncotarget.4974

Maxime Veillette, Jonathan Richard,  and Andrés Finzi
21791-21792
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RUNX1 as a recombinase cofactor

RUNX1 as a recombinase cofactor

https://doi.org/10.18632/oncotarget.5488

Agata Cieslak, Dominique Payet-Bornet,  and Vahid Asnafi
21793-21794
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Natural Th1 cells: escape from neglect

Natural Th1 cells: escape from neglect

https://doi.org/10.18632/oncotarget.5489

Seong Hoe Park
21795-21796
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NK cell exhaustion: bad news for chronic disease?

NK cell exhaustion: bad news for chronic disease?

https://doi.org/10.18632/oncotarget.5490

Jamie L. Schafer, Michaela C. Müller-Trutwin,  and R. Keith Reeves
21797-21798
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Research Perspectives

Cdk5 and Foxc2 – a new relationship in the lymphatic vasculature

Cdk5 and Foxc2 – a new relationship in the lymphatic vasculature

https://doi.org/10.18632/oncotarget.4848

Johanna Liebl
21799-21801
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Priority Research Papers

MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7

MicroRNA-224 is implicated in lung cancer pathogenesis through targeting caspase-3 and caspase-7

https://doi.org/10.18632/oncotarget.5224

Ri Cui, Taewan Kim, Matteo Fassan, Wei Meng, Hui-Lung Sun, Young-Jun Jeon, Caterina Vicentini, Esmerina Tili, Yong Peng, Aldo Scarpa, Guang Liang, Yong Kui Zhang, Arnab Chakravarti,  and Carlo M. Croce
21802-21815
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Perifosine as a potential novel anti-telomerase therapy

Perifosine as a potential novel anti-telomerase therapy

https://doi.org/10.18632/oncotarget.5200

Brody Holohan, Moriah M. Hagiopian, Tsung-Po Lai, Ejun Huang, Daphne R. Friedman, Woodring E. Wright,  and Jerry W. Shay
21816-21826
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In vivo hematopoietic Myc activation directs a transcriptional signature in endothelial cells within the bone marrow microenvironment

In vivo hematopoietic Myc activation directs a transcriptional signature in endothelial cells within the bone marrow microenvironment

https://doi.org/10.18632/oncotarget.5217

Katharina Franke, Baiba Vilne, Olivia Prazeres da Costa, Martina Rudelius, Christian Peschel, Robert A.J. Oostendorp,  and Ulrich Keller
21827-21839
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Research Papers: Immunology

Molecular dissection of HBV evasion from restriction factor tetherin: A new perspective for antiviral cell therapy

Molecular dissection of HBV evasion from restriction factor tetherin: A new perspective for antiviral cell therapy

https://doi.org/10.18632/oncotarget.4808

Kei Miyakawa, Satoko Matsunaga, Koichi Watashi, Masaya Sugiyama, Hirokazu Kimura, Naoki Yamamoto, Masashi Mizokami, Takaji Wakita,  and Akihide Ryo
21840-21852
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Human CD4+ T cells require exogenous cystine for glutathione and DNA synthesis

Human CD4+ T cells require exogenous cystine for glutathione and DNA synthesis

https://doi.org/10.18632/oncotarget.5213

Trine B. Levring, Martin Kongsbak, Anna K. O. Rode, Anders Woetmann, Niels Ødum, Charlotte Menné Bonefeld,  and Carsten Geisler
21853-21864
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Research Papers

The potential utility of acetyltanshinone IIA in the treatment of HER2-overexpressed breast cancer: Induction of cancer cell death by targeting apoptotic and metabolic signaling pathways

The potential utility of acetyltanshinone IIA in the treatment of HER2-overexpressed breast cancer: Induction of cancer cell death by targeting apoptotic and metabolic signaling pathways

https://doi.org/10.18632/oncotarget.4156

Mounia Guerram, Zhen-Zhou Jiang, Bashir Alsiddig Yousef, Aida Mejda Hamdi, Hozeifa Mohamed Hassan, Zi-Qiao Yuan, Hou-Wei Luo, Xiong Zhu,  and Lu-Yong Zhang
21865-21877
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The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer

The pioneer factor PBX1 is a novel driver of metastatic progression in ERα-positive breast cancer

https://doi.org/10.18632/oncotarget.4243

Luca Magnani, Darren K. Patten, Van T. M. Nguyen, Sung-Pil Hong, Jennifer H. Steel, Naina Patel, Ylenia Lombardo, Monica Faronato, Ana R. Gomes, Laura Woodley, Karen Page, David Guttery, Lindsay Primrose, Daniel Fernandez Garcia, Jacqui Shaw, Patrizia Viola, Andrew Green, Christopher Nolan, Ian O. Ellis, Emad A. Rakha, Sami Shousha, Eric W.-F. Lam, Balázs Győrffy, Mathieu Lupien,  and Charles R. Coombes
21878-21891
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Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells

Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells

https://doi.org/10.18632/oncotarget.5260

Rebecca Lamb, Bela Ozsvari, Gloria Bonuccelli, Duncan L. Smith, Richard G. Pestell, Ubaldo E. Martinez-Outschoorn, Robert B. Clarke, Federica Sotgia,  and Michael P. Lisanti
21892-21905
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Regulation of sensitivity of tumor cells to antitubulin drugs by Cdk1-TAZ signalling

Regulation of sensitivity of tumor cells to antitubulin drugs by Cdk1-TAZ signalling

https://doi.org/10.18632/oncotarget.4259

Yulei Zhao,  and Xiaolong Yang
21906-21917
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth: a possible role for exosomal disposal of miR-21

Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth: a possible role for exosomal disposal of miR-21

https://doi.org/10.18632/oncotarget.4204

Simona Taverna, Marco Giallombardo, Marzia Pucci, Anna Flugy, Mauro Manno, Samuele Raccosta, Christian Rolfo, Giacomo De Leo,  and Riccardo Alessandro
21918-21933
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326

Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326

https://doi.org/10.18632/oncotarget.4290

Jing Ke, Yi-long Yao, Jian Zheng, Ping Wang, Yun-hui Liu, Jun Ma, Zhen Li, Xiao-bai Liu, Zhi-qing Li, Zhen-hua Wang,  and Yi-xue Xue
21934-21949
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Predominant Rab-GTPase amplicons contributing to oral squamous cell carcinoma progression to metastasis

Predominant Rab-GTPase amplicons contributing to oral squamous cell carcinoma progression to metastasis

https://doi.org/10.18632/oncotarget.4277

Sabrina Daniela da Silva, Fabio Albuquerque Marchi, Bin Xu, Krikor Bijian, Faisal Alobaid, Alex Mlynarek, Silvia Regina Rogatto, Michael Hier, Luiz Paulo Kowalski,  and Moulay A. Alaoui-Jamali
21950-21963
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DNA repair prognostic index modelling reveals an essential role for base excision repair in influencing clinical outcomes in ER negative and triple negative breast cancers

DNA repair prognostic index modelling reveals an essential role for base excision repair in influencing clinical outcomes in ER negative and triple negative breast cancers

https://doi.org/10.18632/oncotarget.4157

Tarek M.A. Abdel-Fatah, Arvind Arora, Paul M. Moseley, Christina Perry, Emad A. Rakha, Andrew R. Green, Stephen Y.T. Chan, Ian O. Ellis,  and Srinivasan Madhusudan
21964-21978
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpressed tryptophanyl-tRNA synthetase, an angiostatic protein, enhances oral cancer cell invasiveness

Overexpressed tryptophanyl-tRNA synthetase, an angiostatic protein, enhances oral cancer cell invasiveness

https://doi.org/10.18632/oncotarget.4273

Chien-Wei Lee, Kai-Ping Chang, Yan-Yu Chen, Ying Liang, Chuen Hsueh, Jau-Song Yu, Yu-Sun Chang,  and Chia-Jung Yu
21979-21992
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EGFR blockade prevents glioma escape from BRAFV600E targeted therapy

EGFR blockade prevents glioma escape from BRAFV600E targeted therapy

https://doi.org/10.18632/oncotarget.4014

Tsun-Wen Yao, Jie Zhang, Michael Prados, William A. Weiss, C. David James,  and Theodore Nicolaides
21993-22005
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-153/Nrf-2/GPx1 pathway regulates radiosensitivity and stemness of glioma stem cells via reactive oxygen species

MicroRNA-153/Nrf-2/GPx1 pathway regulates radiosensitivity and stemness of glioma stem cells via reactive oxygen species

https://doi.org/10.18632/oncotarget.4292

Wei Yang, Yueming Shen, Jing Wei,  and Fenju Liu
22006-22027
Abstract  |  PDF  |  HTML  |  Order a Reprint

Mutational and gene fusion analyses of primary large cell and large cell neuroendocrine lung cancer

Mutational and gene fusion analyses of primary large cell and large cell neuroendocrine lung cancer

https://doi.org/10.18632/oncotarget.4314

Anna Karlsson, Hans Brunnström, Kajsa Ericson Lindquist, Karin Jirström, Mats Jönsson, Frida Rosengren, Christel Reuterswärd, Helena Cirenajwis, Åke Borg, Per Jönsson, Maria Planck, Göran Jönsson,  and Johan Staaf
22028-22037
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

‘Cut from the same cloth’: Shared microsatellite variants among cancers link to ectodermal tissues-neural tube and crest cells

‘Cut from the same cloth’: Shared microsatellite variants among cancers link to ectodermal tissues-neural tube and crest cells

https://doi.org/10.18632/oncotarget.4194

Enusha Karunasena, Lauren J. McIver, Jasmin H. Bavarva, Xiaowei Wu, Hongxiao Zhu,  and Harold R. Garner
22038-22047
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A contrasting function for miR-137 in embryonic mammogenesis and adult breast carcinogenesis

A contrasting function for miR-137 in embryonic mammogenesis and adult breast carcinogenesis

https://doi.org/10.18632/oncotarget.4218

Jong-Min Lee, Kyoung-Won Cho, Eun-Jung Kim, Qinghuang Tang, Kye-Seong Kim, Cheryll Tickle,  and Han-Sung Jung
22048-22059
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass

Downregulation of c-SRC kinase CSK promotes castration resistant prostate cancer and pinpoints a novel disease subclass

https://doi.org/10.18632/oncotarget.4279

Chih-Cheng Yang, Ladan Fazli, Salvatore Loguercio, Irina Zharkikh, Pedro Aza-Blanc, Martin E. Gleave,  and Dieter A. Wolf
22060-22071
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combination of body mass index and oxidized low density lipoprotein receptor 1 in prognosis prediction of patients with squamous non-small cell lung cancer

Combination of body mass index and oxidized low density lipoprotein receptor 1 in prognosis prediction of patients with squamous non-small cell lung cancer

https://doi.org/10.18632/oncotarget.4299

Long Jiang, Shanshan Jiang, Yongbin Lin, Han Yang, Zerui Zhao, Zehua Xie, Yaobin Lin,  and Hao Long
22072-22080
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression

Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression

https://doi.org/10.18632/oncotarget.4203

María Laura Polo, Marina Riggio, María May, María Jimena Rodríguez, María Cecilia Perrone, Melody Stallings-Mann, Diego Kaen, Marlene Frost, Matthew Goetz, Judy Boughey, Claudia Lanari, Derek Radisky,  and Virginia Novaro
22081-22097
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)

Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)

https://doi.org/10.18632/oncotarget.4300

Ruby Yun-Ju Huang, Kuee Theng Kuay, Tuan Zea Tan, Mohammad Asad, Hei Mui Tang, Aloysius Hsien Chun Ng, Jieru Ye, Vin Yee Chung,  and Jean Paul Thiery
22098-22113
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy

Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy

https://doi.org/10.18632/oncotarget.4294

Kei Mitsuhashi, Itaru Yamamoto, Hiroyoshi Kurihara, Shinichi Kanno, Miki Ito, Hisayoshi Igarashi, Keisuke Ishigami, Yasutaka Sukawa, Mami Tachibana, Hiroaki Takahashi, Takashi Tokino, Reo Maruyama, Hiromu Suzuki, Kohzoh Imai, Yasuhisa Shinomura, Hiroyuki Yamamoto,  and Katsuhiko Nosho
22114-22125
Abstract  |  PDF  |  HTML  |  Order a Reprint

Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth

Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth

https://doi.org/10.18632/oncotarget.4244

Yan Dong, Baoping Cao, Meiying Zhang, Weidong Han, James G. Herman, François Fuks, Yali Zhao,  and Mingzhou Guo
22126-22138
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anti-cancer effect of snake venom toxin through down regulation of AP-1 mediated PRDX6 expression

Anti-cancer effect of snake venom toxin through down regulation of AP-1 mediated PRDX6 expression

https://doi.org/10.18632/oncotarget.4192

Hye Lim Lee, Mi Hee Park, Dong Ju Son, Ho Sub Song, Jung Hyun Kim, Seong Cheol Ko, Min Jong Song, Won Hyoung Lee, Joo Hee Yoon, Young Wan Ham, Sang Bae Han,  and Jin Tae Hong
22139-22151
Abstract  |  PDF  |  HTML  |  Order a Reprint

Discovery of benzo[e]pyridoindolones as kinase inhibitors that disrupt mitosis exit while erasing AMPK-Thr172 phosphorylation on the spindle

Discovery of benzo[e]pyridoindolones as kinase inhibitors that disrupt mitosis exit while erasing AMPK-Thr172 phosphorylation on the spindle

https://doi.org/10.18632/oncotarget.4158

Ly-Thuy-Tram Le, Morgane Couvet, Bertrand Favier, Jean-Luc Coll, Chi-Hung Nguyen,  and Annie Molla
22152-22166
Abstract  |  PDF  |  HTML  |  Order a Reprint

Tivantinib (ARQ 197) affects the apoptotic and proliferative machinery downstream of c-MET: role of Mcl-1, Bcl-xl and Cyclin B1

Tivantinib (ARQ 197) affects the apoptotic and proliferative machinery downstream of c-MET: role of Mcl-1, Bcl-xl and Cyclin B1

https://doi.org/10.18632/oncotarget.4240

Shuai Lu, Helga-Paula Török, Eike Gallmeier, Frank T. Kolligs, Antonia Rizzani, Sabrina Arena, Burkhard Göke, Alexander L. Gerbes,  and Enrico N. De Toni
22167-22178
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels

Genome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels

https://doi.org/10.18632/oncotarget.4246

Byungho Lim, Jihyeob Mun, Jeong-Hwan Kim, Chan Wook Kim, Seon Ae Roh, Dong-Hyung Cho, Yong Sung Kim, Seon-Young Kim,  and Jin Cheon Kim
22179-22190
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Endothelial-like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor-derived angiogenic response

Endothelial-like malignant glioma cells in dynamic three dimensional culture identifies a role for VEGF and FGFR in a tumor-derived angiogenic response

https://doi.org/10.18632/oncotarget.4339

Stuart J. Smith, Jennifer H. Ward, Christopher Tan, Richard G. Grundy,  and Ruman Rahman
22191-22205
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Upfront molecular testing in patients with advanced gastro-esophageal cancer: Is it time yet?

Upfront molecular testing in patients with advanced gastro-esophageal cancer: Is it time yet?

https://doi.org/10.18632/oncotarget.4247

Sameh Mikhail, Kristen Ciombor, Anne Noonan, Christina Wu, Richard Goldberg, Weiqiang Zhao, Lai Wei, Kristina Mathey, Melissa Yereb, Cynthia Timmers,  and Tanios Bekaii-Saab
22206-22213
Abstract  |  PDF  |  HTML  |  Order a Reprint

PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop

PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop

https://doi.org/10.18632/oncotarget.4257

Michael Selitrennik,  and Sima Lev
22214-22226
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Stathmin and phospho-stathmin protein signature is associated with survival outcomes of breast cancer patients

Stathmin and phospho-stathmin protein signature is associated with survival outcomes of breast cancer patients

https://doi.org/10.18632/oncotarget.4276

Xia-Ying Kuang, Li Chen, Zhi-Jie Zhang, Yi-Rong Liu, Yi-Zi Zheng, Hong Ling, Feng Qiao, Shan Li, Xin Hu,  and Zhi-Ming Shao
22227-22238
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Osteopontin (OPN/SPP1) isoforms collectively enhance tumor cell invasion and dissemination in esophageal adenocarcinoma

Osteopontin (OPN/SPP1) isoforms collectively enhance tumor cell invasion and dissemination in esophageal adenocarcinoma

https://doi.org/10.18632/oncotarget.4161

Jules Lin, Amy L. Myers, Zhuwen Wang, Derek J. Nancarrow, Daysha Ferrer-Torres, Amy Handlogten, Kimmy Leverenz, Julia Bao, Dafydd G. Thomas, Thomas D. Wang, Mark B. Orringer, Rishindra M. Reddy, Andrew C. Chang, David G. Beer,  and Lin Lin
22239-22257
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Neoplastic human embryonic stem cells as a model of radiation resistance of human cancer stem cells

Neoplastic human embryonic stem cells as a model of radiation resistance of human cancer stem cells

https://doi.org/10.18632/oncotarget.4165

Steve Dingwall, Jung Bok Lee, Borhane Guezguez, Aline Fiebig, Jamie McNicol, Douglas Boreham, Tony J. Collins,  and Mick Bhatia
22258-22269
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AS1411-conjugated gold nanospheres and their potential for breast cancer therapy

AS1411-conjugated gold nanospheres and their potential for breast cancer therapy

https://doi.org/10.18632/oncotarget.4207

Mohammad T. Malik, Martin G. O’Toole, Lavona K. Casson, Shelia D. Thomas, Gina T. Bardi, Elsa Merit Reyes-Reyes, Chin K. Ng, Kyung A. Kang,  and Paula J. Bates
22270-22281
Abstract  |  PDF  |  HTML  |  Order a Reprint

Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of patched and increase chemotherapy efficiency on melanoma cells

Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of patched and increase chemotherapy efficiency on melanoma cells

https://doi.org/10.18632/oncotarget.4162

Laura Fiorini, Marie-Aude Tribalat, Lucy Sauvard, Julie Cazareth, Enzo Lalli, Isabelle Broutin, Olivier P. Thomas,  and Isabelle Mus-Veteau
22282-22297
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma

Targeting TRAP1 as a downstream effector of BRAF cytoprotective pathway: a novel strategy for human BRAF-driven colorectal carcinoma

https://doi.org/10.18632/oncotarget.4263

Valentina Condelli, Francesca Maddalena, Lorenza Sisinni, Giacomo Lettini, Danilo Swann Matassa, Annamaria Piscazzi, Giuseppe Palladino, Maria Rosaria Amoroso, Franca Esposito,  and Matteo Landriscina
22298-22309
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F

Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F

https://doi.org/10.18632/oncotarget.4208

Spela Magister, Han-Ching Tseng, Vickie T. Bui, Janko Kos,  and Anahid Jewett
22310-22327
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeting Bcl-2 stability to sensitize cells harboring oncogenic ras

Targeting Bcl-2 stability to sensitize cells harboring oncogenic ras

https://doi.org/10.18632/oncotarget.4084

Bo Peng, Suthakar Ganapathy, Ling Shen, Junchi Huang, Bo Yi, Xiaodong Zhou, Wei Dai,  and Changyan Chen
22328-22337
Abstract  |  PDF  |  HTML  |  Order a Reprint

Anti-G-CSF treatment induces protective tumor immunity in mouse colon cancer by promoting protective NK cell, macrophage and T cell responses

Anti-G-CSF treatment induces protective tumor immunity in mouse colon cancer by promoting protective NK cell, macrophage and T cell responses

https://doi.org/10.18632/oncotarget.4169

Katherine T. Morris, Eliseo F. Castillo, Anita L. Ray, Lea L. Weston, Robert A. Nofchissey, Joshua A. Hanson, Von G. Samedi, Irina V. Pinchuk, Laurie G. Hudson,  and Ellen J. Beswick
22338-22347
Abstract  |  PDF  |  HTML  |  Order a Reprint

ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma

ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma

https://doi.org/10.18632/oncotarget.4255

Katherine E. Hutchinson, Douglas B. Johnson, Adam S. Johnson, Violeta Sanchez, Maria Kuba, Pengcheng Lu, Xi Chen, Mark C. Kelley, Qingguo Wang, Zhongming Zhao, Mark Kris, Michael F. Berger, Jeffrey A. Sosman,  and William Pao
22348-22360
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CRISPR/Cas9-mediated gene knockout of NANOG and NANOGP8 decreases the malignant potential of prostate cancer cells

CRISPR/Cas9-mediated gene knockout of NANOG and NANOGP8 decreases the malignant potential of prostate cancer cells

https://doi.org/10.18632/oncotarget.4293

Norihiko Kawamura, Keisuke Nimura, Hiromichi Nagano, Sohei Yamaguchi, Norio Nonomura,  and Yasufumi Kaneda
22361-22374
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis

Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis

https://doi.org/10.18632/oncotarget.4296

Joan Manils, Diana Gómez, Mercè Salla-Martret, Heinz Fischer, Jason M. Fye, Elena Marzo, Laura Marruecos, Inma Serrano, Rocío Salgado, Juan P. Rodrigo, Juana M. Garcia-Pedrero, Anna M. Serafin, Xavier Cañas, Carmen Benito, Agustí Toll, Sònia-Vanina Forcales, Fred W. Perrino, Leopold Eckhart,  and Concepció Soler
22375-22396
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

siRNA knockdown of mitochondrial thymidine kinase 2 (TK2) sensitizes human tumor cells to gemcitabine

siRNA knockdown of mitochondrial thymidine kinase 2 (TK2) sensitizes human tumor cells to gemcitabine

https://doi.org/10.18632/oncotarget.4272

Christine Di Cresce, Rene Figueredo, Mateusz Rytelewski, Saman Maleki Vareki, Colin Way, Peter J. Ferguson, Mark D. Vincent,  and James Koropatnick
22397-22409
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MIF, secreted by human hepatic sinusoidal endothelial cells, promotes chemotaxis and outgrowth of colorectal cancer in liver prometastasis

MIF, secreted by human hepatic sinusoidal endothelial cells, promotes chemotaxis and outgrowth of colorectal cancer in liver prometastasis

https://doi.org/10.18632/oncotarget.4198

Chun-Ting Hu, Li-Li Guo, Na Feng, Lei Zhang, Na Zhou, Li-Li Ma, Lan Shen, Gui-hui Tong, Qian-Wen Yan, Shi-jie Zhu, Xiu-Wu Bian, Mao-De Lai, Yong-Jian Deng,  and Yan-Qing Ding
22410-22423
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids

Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids

https://doi.org/10.18632/oncotarget.4211

Teresa Peart, Yudith Ramos Valdes, Rohann J. M. Correa, Elena Fazio, Monique Bertrand, Jacob McGee, Michel Préfontaine, Akira Sugimoto, Gabriel E. DiMattia,  and Trevor G. Shepherd
22424-22438
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-620 promotes tumor radioresistance by targeting 15-hydroxyprostaglandin dehydrogenase (HPGD)

miR-620 promotes tumor radioresistance by targeting 15-hydroxyprostaglandin dehydrogenase (HPGD)

https://doi.org/10.18632/oncotarget.4210

Xiaoyong Huang, Samira Taeb, Sahar Jahangiri, Elina Korpela, Ivan Cadonic, Nancy Yu, Sergey Krylov, Emmanouil Fokas, Paul C. Boutros,  and Stanley K. Liu
22439-22451
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14

miRNA-337-3p suppresses neuroblastoma progression by repressing the transcription of matrix metalloproteinase 14

https://doi.org/10.18632/oncotarget.4311

Xuan Xiang, Hong Mei, Xiang Zhao, Jiarui Pu, Dan Li, Hongxia Qu, Wanju Jiao, Jihe Zhao, Kai Huang, Liduan Zheng,  and Qiangsong Tong
22452-22466
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation

DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation

https://doi.org/10.18632/oncotarget.4164

Monica Faronato, Van T.M. Nguyen, Darren K. Patten, Ylenia Lombardo, Jennifer H. Steel, Naina Patel, Laura Woodley, Sami Shousha, Giancarlo Pruneri, R. Charles Coombes,  and Luca Magnani
22467-22479
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Modulation of cerebral endothelial cell function by TGF-β in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition

Modulation of cerebral endothelial cell function by TGF-β in glioblastoma: VEGF-dependent angiogenesis versus endothelial mesenchymal transition

https://doi.org/10.18632/oncotarget.4310

Shanmugarajan Krishnan, Emese Szabo, Isabel Burghardt, Karl Frei, Ghazaleh Tabatabai,  and Michael Weller
22480-22495
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC)*

Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC)*

https://doi.org/10.18632/oncotarget.4318

David M. Goldenberg, Thomas M. Cardillo, Serengulam V. Govindan, Edmund A. Rossi,  and Robert M. Sharkey
22496-22512
Abstract  |  PDF  |  HTML  |  Order a Reprint

The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer

The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer

https://doi.org/10.18632/oncotarget.4154

Wei-Cheng Liang, Wei-Ming Fu, Cheuk-Wa Wong, Yan Wang, Wei-Mao Wang, Guo-Xin Hu, Li Zhang, Li-Jia Xiao, David Chi-Cheong Wan, Jin-Fang Zhang,  and Mary Miu-Yee Waye
22513-22525
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The transcriptome and miRNome profiling of glioblastoma tissues and peritumoral regions highlights molecular pathways shared by tumors and surrounding areas and reveals differences between short-term and long-term survivors

The transcriptome and miRNome profiling of glioblastoma tissues and peritumoral regions highlights molecular pathways shared by tumors and surrounding areas and reveals differences between short-term and long-term survivors

https://doi.org/10.18632/oncotarget.4151

Barbara Fazi, Armando Felsani, Luigi Grassi, Anna Moles, Daniel D’Andrea, Nicola Toschi, Daria Sicari, Pasquale De Bonis, Carmelo Anile, Maria Giovanna Guerrisi, Emilia Luca, Maria Giulia Farace, Giulio Maira, Silvia Anna Ciafré,  and Annunziato Mangiola
22526-22552
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Alternative splicing of synuclein gamma in endometrial cancer: identification of a novel isoform

Alternative splicing of synuclein gamma in endometrial cancer: identification of a novel isoform

https://doi.org/10.18632/oncotarget.4155

Kathrin Schaal, Marc Hirschfeld, Peter Bronsert, Hannah Füllgraf, Markus Jäger, Bettina Herde, Claudia Nöthling, Sebastian Mayer, Thalia Erbes,  and Elmar Stickeler
22553-22563
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Regulation of migration and invasion by Toll-like receptor-9 signaling network in prostate cancer

Regulation of migration and invasion by Toll-like receptor-9 signaling network in prostate cancer

https://doi.org/10.18632/oncotarget.4197

Yun Luo, Qi-Wei Jiang, Jie-Ying Wu, Jian-Ge Qiu, Wen-Ji Zhang, Xiao-Long Mei, Zhi Shi,  and Jin-Ming Di
22564-22574
Abstract  |  PDF  |  HTML  |  Order a Reprint

Enhanced nucleotide excision repair capacity in lung cancer cells by preconditioning with DNA-damaging agents

Enhanced nucleotide excision repair capacity in lung cancer cells by preconditioning with DNA-damaging agents

https://doi.org/10.18632/oncotarget.4610

Ji Ye Choi, Jeong-Min Park, Joo Mi Yi, Sun-Hee Leem,  and Tae-Hong Kang
22575-22586
Abstract  |  PDF  |  HTML  |  Order a Reprint

EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression

EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression

https://doi.org/10.18632/oncotarget.4088

Shibao Li, Yingyu Ma, Chongwei Xie, Zhiyuan Wu, Zhihua Kang, Zujun Fang, Bing Su,  and Ming Guan
22587-22597
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosis

Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosis

https://doi.org/10.18632/oncotarget.4200

Ping Wang, Peiguo Wang, Becky Liu, Jing Zhao, Qingsong Pang, Samir G. Agrawal, Li Jia,  and Feng-Ting Liu
22598-22612
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model

Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model

https://doi.org/10.18632/oncotarget.4209

Adi Binder Gallimidi, Stuart Fischman, Brurya Revach, Raanan Bulvik, Alina Maliutina, Ariel M. Rubinstein, Gabriel Nussbaum,  and Michael Elkin
22613-22623
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells

Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells

https://doi.org/10.18632/oncotarget.4168

Silvia Bruno, Bernardetta Ledda, Claudya Tenca, Silvia Ravera, Anna Maria Orengo, Andrea Nicola Mazzarello, Elisa Pesenti, Salvatore Casciaro, Omar Racchi, Fabio Ghiotto, Cecilia Marini, Gianmario Sambuceti, Andrea DeCensi,  and Franco Fais
22624-22640
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Role of PAR-4 in ovarian cancer

Role of PAR-4 in ovarian cancer

https://doi.org/10.18632/oncotarget.4010

Sonia Meynier, Marianne Kramer, Pascale Ribaux, Jean Christophe Tille, Florence Delie, Patrick Petignat,  and Marie Cohen
22641-22652
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis

https://doi.org/10.18632/oncotarget.4248

Richard L. Carpenter, Ivy Paw, Hu Zhu, Sherona Sirkisoon, Fei Xing, Kounosuke Watabe, Waldemar Debinski,  and Hui-Wen Lo
22653-22665
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer

The MDM2-inhibitor Nutlin-3 synergizes with cisplatin to induce p53 dependent tumor cell apoptosis in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.4433

Christophe Deben, An Wouters, Ken Op de Beeck, Jolien van Den Bossche, Julie Jacobs, Karen Zwaenepoel, Marc Peeters, Jan Van Meerbeeck, Filip Lardon, Christian Rolfo, Vanessa Deschoolmeester,  and Patrick Pauwels
22666-22679
Abstract  |  PDF  |  HTML  |  Order a Reprint

RTVP-1 promotes mesenchymal transformation of glioma via a STAT-3/IL-6-dependent positive feedback loop

RTVP-1 promotes mesenchymal transformation of glioma via a STAT-3/IL-6-dependent positive feedback loop

https://doi.org/10.18632/oncotarget.4205

Nis David Giladi, Amotz Ziv-Av, Hae Kyung Lee, Susan Finniss, Simona Cazacu, Cunli Xiang, Hiba Ben-Asher, Ana deCarvalho, Tom Mikkelsen, Laila Poisson,  and Chaya Brodie
22680-22697
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MYC amplifications in myeloma cell lines: correlation with MYC-inhibitor efficacy

MYC amplifications in myeloma cell lines: correlation with MYC-inhibitor efficacy

https://doi.org/10.18632/oncotarget.4245

Toril Holien, Kristine Misund, Oddrun Elise Olsen, Katarzyna Anna Baranowska, Glenn Buene, Magne Børset, Anders Waage,  and Anders Sundan
22698-22705
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenetic inactivation of the candidate tumor suppressor gene ASC/TMS1 in human renal cell carcinoma and its role as a potential therapeutic target

Epigenetic inactivation of the candidate tumor suppressor gene ASC/TMS1 in human renal cell carcinoma and its role as a potential therapeutic target

https://doi.org/10.18632/oncotarget.4256

Qianling Liu, Jie Jin, Jianming Ying, Yun Cui, Mengkui Sun, Lian Zhang, Yu Fan, Ben Xu,  and Qian Zhang
22706-22723
Abstract  |  PDF  |  HTML  |  Order a Reprint

Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma

Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma

https://doi.org/10.18632/oncotarget.4261

Gabriela Resende Vieira de Sousa, Tamaya C. Ribeiro, Andre M. Faria, Beatriz M. P. Mariani, Antonio M. Lerario, Maria Claudia N. Zerbini, Iberê C. Soares, Alda Wakamatsu, Venancio A. F. Alves, Berenice B. Mendonca, Maria Candida B. V. Fragoso, Ana Claudia Latronico,  and Madson Q. Almeida
22724-22733
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia

The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia

https://doi.org/10.18632/oncotarget.4212

Sílvia Xargay-Torrent, Mónica López-Guerra, Laia Rosich, Arnau Montraveta, Jocabed Roldán, Vanina Rodríguez, Neus Villamor, Marta Aymerich, Chandraiah Lagisetti, Thomas R. Webb, Carlos López-Otín, Elias Campo,  and Dolors Colomer
22734-22749
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A retrospective analysis of cisplatin, pemetrexed, and bevacizumab in previously treated non-small-cell lung cancer

A retrospective analysis of cisplatin, pemetrexed, and bevacizumab in previously treated non-small-cell lung cancer

https://doi.org/10.18632/oncotarget.4262

Ke-Jun Liu,  and Hai-Ying Wu
22750-22757
Abstract  |  PDF  |  HTML  |  Order a Reprint

β-catenin stabilization enhances SS18-SSX2-driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition

β-catenin stabilization enhances SS18-SSX2-driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition

https://doi.org/10.18632/oncotarget.4283

Jared J. Barrott, Benjamin E. Illum, Huifeng Jin, Ju-Fen Zhu, Tim Mosbruger, Michael J. Monument, Kyllie Smith-Fry, Matthew G. Cable, Yanliang Wang, Allie H. Grossmann, Mario R. Capecchi,  and Kevin B. Jones
22758-22766
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression

F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression

https://doi.org/10.18632/oncotarget.4082

Xin Tian, Shundong Dai, Jing Sun, Guojiang Jin, Shenyi Jiang, Fandong Meng, Yan Li, Di Wu,  and Youhong Jiang
22767-22775
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nanovehicles as a novel target strategy for hyperthermic intraperitoneal chemotherapy: a multidisciplinary study of peritoneal carcinomatosis

Nanovehicles as a novel target strategy for hyperthermic intraperitoneal chemotherapy: a multidisciplinary study of peritoneal carcinomatosis

https://doi.org/10.18632/oncotarget.4309

Maciej Nowacki, Marek Wisniewski, Karolina Werengowska-Ciecwierz, Katarzyna Roszek, Joanna Czarnecka, I. Łakomska, Tomasz Kloskowski, Dominik Tyloch, Robert Debski, Katarzyna Pietkun, Marta Pokrywczynska, Dariusz Grzanka, Rafał Czajkowski, Gerard Drewa, A. Jundziłł, Joseph K. Agyin, Samy L. Habib, Artur P. Terzyk,  and Tomasz Drewa
22776-22798
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3

Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3

https://doi.org/10.18632/oncotarget.4332

Baolai Zhang, Shuhong Dong, Ruiming Zhu, Chunyan Hu, Jing Hou, Yan Li, Qian Zhao, Xue Shao, Qian Bu, Hongyu Li, Yongjie Wu, Xiaobo Cen,  and Yinglan Zhao
22799-22811
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Next-generation sequencing of FLT3 internal tandem duplications for minimal residual disease monitoring in acute myeloid leukemia

Next-generation sequencing of FLT3 internal tandem duplications for minimal residual disease monitoring in acute myeloid leukemia

https://doi.org/10.18632/oncotarget.4333

Jean-Emmanuel Bibault, Martin Figeac, Nathalie Hélevaut, Céline Rodriguez, Sabine Quief, Shéhérazade Sebda, Aline Renneville, Olivier Nibourel, Philippe Rousselot, Bérengère Gruson, Hervé Dombret, Sylvie Castaigne,  and Claude Preudhomme
22812-22821
Abstract  |  PDF  |  HTML  |  Order a Reprint

Anti-tumor effect of inhibition of IL-6 signaling in mucoepidermoid carcinoma

Anti-tumor effect of inhibition of IL-6 signaling in mucoepidermoid carcinoma

https://doi.org/10.18632/oncotarget.4477

Daiki Mochizuki, April Adams, Kristy A. Warner, Zhaocheng Zhang, Alexander T. Pearson, Kiyoshi Misawa, Scott A. McLean, Gregory T. Wolf,  and Jacques E. Nör
22822-22835
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation

Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation

https://doi.org/10.18632/oncotarget.4479

Isabel R. Schlaepfer, Dhanya K. Nambiar, Anand Ramteke, Rahul Kumar, Deepanshi Dhar, Chapla Agarwal, Bryan Bergman, Michael Graner, Paul Maroni, Rana P. Singh, Rajesh Agarwal,  and Gagan Deep
22836-22856
Abstract  |  PDF  |  HTML  |  Order a Reprint

Macrophage depletion reduces postsurgical tumor recurrence and metastatic growth in a spontaneous murine model of melanoma

Macrophage depletion reduces postsurgical tumor recurrence and metastatic growth in a spontaneous murine model of melanoma

https://doi.org/10.18632/oncotarget.3127

Muly Tham, Karen Khoo, Kim Pin Yeo, Masashi Kato, Amelle Prevost-Blondel, Veronique Angeli,  and Jean-Pierre Abastado
22857-22868
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

p53 controls colorectal cancer cell invasion by inhibiting the NF-κB-mediated activation of Fascin

p53 controls colorectal cancer cell invasion by inhibiting the NF-κB-mediated activation of Fascin

https://doi.org/10.18632/oncotarget.5137

Xinbing Sui, Jing Zhu, Haimei Tang, Chan Wang, Jichun Zhou, Weidong Han, Xian Wang, Yong Fang, Yinghua Xu, Da Li, Rui Chen, Junhong Ma, Zhao Jing, Xidong Gu, Hongming Pan,  and Chao He
22869-22879
Abstract  |  PDF  |  HTML  |  Order a Reprint

Co-expression of CXCL8 and HIF-1α is associated with metastasis and poor prognosis in hepatocellular carcinoma

Co-expression of CXCL8 and HIF-1α is associated with metastasis and poor prognosis in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4412

Xian-Peng Li, Xiao-Yu Yang, Ewelina Biskup, Jiang Zhou, Hong-Liang Li, Yi-Feng Wu, Ming-Liang Chen,  and Feng Xu
22880-22889
Abstract  |  PDF  |  HTML  |  Order a Reprint

Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis

Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis

https://doi.org/10.18632/oncotarget.4413

Michael W. Pickup, Laura D. Hover, Yan Guo, Agnieszka E. Gorska, Anna Chytil, Sergey V. Novitskiy, Harold L. Moses,  and Philip Owens
22890-22904
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

In vivo selection for spine-derived highly metastatic lung cancer cells is associated with increased migration, inflammation and decreased adhesion

In vivo selection for spine-derived highly metastatic lung cancer cells is associated with increased migration, inflammation and decreased adhesion

https://doi.org/10.18632/oncotarget.4416

Xiaopan Cai, Jian Luo, Xinghai Yang, Huayun Deng, Jishen Zhang, Shichang Li, Haifeng Wei, Cheng Yang, Leqin Xu, Rongrong Jin, Zhenxi Li, Wang Zhou, JianDong Ding, Jianjun Chu, Lianshun Jia, Qi Jia, Chengjun Tan, Mingyao Liu,  and Jianru Xiao
22905-22917
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis

The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis

https://doi.org/10.18632/oncotarget.4382

Lingyun Zhang, Yuee Teng, Yibo Fan, Yan Wang, Wei Li, Jing Shi, Yanju Ma, Ce Li, Xiaonan Shi, Xiujuan Qu,  and Yunpeng Liu
22918-22933
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition

Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition

https://doi.org/10.18632/oncotarget.4473

Hanbing An, Sydney L. Stoops, Natasha G. Deane, Jing Zhu, Jinghuan Zi, Connie Weaver, Alex G. Waterson, Andries Zijlstra, Craig W. Lindsley,  and Robert Daniel Beauchamp
22934-22948
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular analysis of ovarian mucinous carcinoma reveals different cell of origins

Molecular analysis of ovarian mucinous carcinoma reveals different cell of origins

https://doi.org/10.18632/oncotarget.5146

Yihong Wang, Lauren Ende Shwartz, Derek Anderson, Ming-Tseh Lin, Lisa Haley, Ren-chin Wu, Russell Vang, Ie-ming Shih,  and Robert J. Kurman
22949-22958
Abstract  |  PDF  |  HTML  |  Order a Reprint

Clinical Research Papers

Tissue specific expression of extracellular microRNA in human breast cancers and normal human breast tissue in vivo

Tissue specific expression of extracellular microRNA in human breast cancers and normal human breast tissue in vivo

https://doi.org/10.18632/oncotarget.4038

Annelie Abrahamsson,  and Charlotta Dabrosin
22959-22969
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association of the intermediate filament nestin with cancer stage: a meta-analysis based on 223 positive/high nestin cases and 460 negative/low case-free controls

Association of the intermediate filament nestin with cancer stage: a meta-analysis based on 223 positive/high nestin cases and 460 negative/low case-free controls

https://doi.org/10.18632/oncotarget.4042

Beilong Zhong, Tao Wang, Jianyong Zou, Fangfang Zheng, Rijiao Huang, Xiaobin Zheng, Weilin Yang,  and Zhenguang Chen
22970-22977
Abstract  |  PDF  |  HTML  |  Order a Reprint

Influence of age on predictiveness of genetic risk score for prostate cancer in a Chinese hospital-based biopsy cohort

Influence of age on predictiveness of genetic risk score for prostate cancer in a Chinese hospital-based biopsy cohort

https://doi.org/10.18632/oncotarget.3938

Yao Zhu, Cheng-Tao Han, Hai-Tao Chen, Fang Liu, Gui-Ming Zhang, Wei-Yi Yang, Jian-Feng Xu,  and Ding-Wei Ye
22978-22984
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Effect of tumor size on breast cancer-specific survival stratified by joint hormone receptor status in a SEER population-based study

Effect of tumor size on breast cancer-specific survival stratified by joint hormone receptor status in a SEER population-based study

https://doi.org/10.18632/oncotarget.3945

Yi-Zi Zheng, Lei Wang, Xin Hu,  and Zhi-Ming Shao
22985-22995
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-143 is a putative predictive factor for the response to fluoropyrimidine-based chemotherapy in patients with metastatic colorectal cancer

MicroRNA-143 is a putative predictive factor for the response to fluoropyrimidine-based chemotherapy in patients with metastatic colorectal cancer

https://doi.org/10.18632/oncotarget.4035

Femke Simmer, Sabine Venderbosch, Jeroen R. Dijkstra, Elisa M. Vink-Börger, Claudius Faber, Leonie J. Mekenkamp, Miriam Koopman, Anton F. De Haan, Cornelis J. Punt,  and Iris D. Nagtegaal
22996-23007
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Maintenance chemotherapy in children with ALL exerts metronomic-like thrombospondin-1 associated anti-endothelial effect

Maintenance chemotherapy in children with ALL exerts metronomic-like thrombospondin-1 associated anti-endothelial effect

https://doi.org/10.18632/oncotarget.3984

Nicolas Andre, Sylvie Cointe, Vincent Barlogis, Laurent Arnaud, Romaric Lacroix, Eddy Pasquier, Françoise Dignat-George, Gérard Michel,  and Florence Sabatier
23008-23014
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Prognostic value of HPV-mRNA in sentinel lymph nodes of cervical cancer patients with pN0-status

Prognostic value of HPV-mRNA in sentinel lymph nodes of cervical cancer patients with pN0-status

https://doi.org/10.18632/oncotarget.4132

Matthias Dürst, Heike Hoyer, Christoph Altgassen, Christiane Greinke, Norman Häfner, Alba Fishta, Mieczyslaw Gajda, Ute Mahnert, Peter Hillemanns, Thomas Dimpfl, Miriam Lenhard, K. Ulrich Petry, Ingo B. Runnebaum,  and Achim Schneider
23015-23025
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Loss of tumor suppressors KAI1 and p27 identifies a unique subgroup of primary melanoma patients with poor ­­prognosis

Loss of tumor suppressors KAI1 and p27 identifies a unique subgroup of primary melanoma patients with poor ­­prognosis

https://doi.org/10.18632/oncotarget.4854

Guohong Zhang, Yabin Cheng, Guangdi Chen, Yun Tang, Gholamreza Ardekani, Anand Rotte, Magdalena Martinka, Kevin McElwee, Xuezhu Xu, Qi Wang,  and Youwen Zhou
23026-23035
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