Oncotarget

Vol 6, No 25

August 28, 2015

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See Drusco et al. A differentially expressed set of microRNAs in cerebro-spinal fluid (CSF) can diagnose CNS malignancies

Table of Contents

Editorial

Rhino defines H3K9me3-marked piRNA clusters

Rhino defines H3K9me3-marked piRNA clusters

https://doi.org/10.18632/oncotarget.5178

Bowen Yu,  and Ying Huang
20740-20741
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Mitochondrial transport of protoporphyrinogen IX in erythroid cells

Mitochondrial transport of protoporphyrinogen IX in erythroid cells

https://doi.org/10.18632/oncotarget.5124

Yvette Y. Yien, Alessa R. Ringel,  and Barry H. Paw
20742-20743
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Lipid transport and epithelial barrier integrity

Lipid transport and epithelial barrier integrity

https://doi.org/10.18632/oncotarget.5233

Jill M. Fritz, Li Yang,  and Timothy E. Weaver
20744-20745
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RB in DNA repair

RB in DNA repair

https://doi.org/10.18632/oncotarget.5234

Paul H. Huang, Rebecca Cook,  and Sibylle Mittnacht
20746-20747
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Conversion of the CD8 lineage to CD4 T cells

Conversion of the CD8 lineage to CD4 T cells

https://doi.org/10.18632/oncotarget.5235

Maria P. Guzman,  and Zhibin Chen
20748-20749
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Editorial: Chromosome

Hedgehog fuels gut regeneration

Hedgehog fuels gut regeneration

https://doi.org/10.18632/oncotarget.4929

Aiguo Tian,  and Jin Jiang
20750-20751
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Editorial: Autophagy and Cell Death

Autophagy restricts HIV-1 infection

Autophagy restricts HIV-1 infection

https://doi.org/10.18632/oncotarget.5123

Coralie F. Daussy, Bruno Beaumelle,  and Lucile Espert
20752-20753
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Reviews

Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation, and autoimmunity

Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation, and autoimmunity

https://doi.org/10.18632/oncotarget.4537

Roman Uzhachenko, Anil Shanker, Alla V. Ivanova,  and Alla V. Ivanova
20754-20772
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Exercise for the heart: signaling pathways

Exercise for the heart: signaling pathways

https://doi.org/10.18632/oncotarget.4770

Lichan Tao, Yihua Bei, Haifeng Zhang, Junjie Xiao,  and Xinli Li
20773-20784
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Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance

Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance

https://doi.org/10.18632/oncotarget.4750

Markus Morkel, Pamela Riemer, Hendrik Bläker,  and Christine Sers
20785-20800
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Priority Research Papers

Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression

Cyclin-dependent kinase 2 is an ideal target for ovary tumors with elevated cyclin E1 expression

https://doi.org/10.18632/oncotarget.4600

Liu Yang, Dongdong Fang, Huijun Chen, Yiyu Lu, Zheng Dong, Han-Fei Ding, Qing Jing, Shi-Bing Su,  and Shuang Huang
20801-20812
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Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A

Aberrant amino acid signaling promotes growth and metastasis of hepatocellular carcinomas through Rab1A-dependent activation of mTORC1 by Rab1A

https://doi.org/10.18632/oncotarget.5175

Bi-Hong Xu, Xiao-Xing Li, Yang Yang, Mei-Yin Zhang, Hui-Lan Rao, Hui-Yun Wang,  and X.F. Steven Zheng
20813-20828
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A differentially expressed set of microRNAs in cerebro-spinal fluid (CSF) can diagnose CNS malignancies

A differentially expressed set of microRNAs in cerebro-spinal fluid (CSF) can diagnose CNS malignancies

https://doi.org/10.18632/oncotarget.4096

Alessandra Drusco, Arianna Bottoni, Alessandro Lagana', Mario Acunzo, Matteo Fassan, Luciano Cascione, Anna Antenucci, Prasanthi Kumchala, Caterina Vicentini, Marina P. Gardinam, Hansjuerg Alder, Mariantonia A. Carosi, Mario Ammirati, Stefano Gherardi, Marilena Luscri', Carmine Carapella, Nicola Zanesi,  and Carlo M. Croce
20829-20839
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Negative prognostic impact of regulatory T cell infiltration in surgically resected esophageal cancer post-radiochemotherapy

Negative prognostic impact of regulatory T cell infiltration in surgically resected esophageal cancer post-radiochemotherapy

https://doi.org/10.18632/oncotarget.4428

Erika Vacchelli, Michaela Semeraro, David P. Enot, Kariman Chaba, Vichnou Poirier Colame, Peggy Dartigues, Aurelie Perier, Irene Villa, Sylvie Rusakiewicz, Caroline Gronnier, Diane Goéré, Christophe Mariette, Laurence Zitvogel,  and Guido Kroemer
20840-20850
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Research Papers: Gerotarget (Focus on Aging)

Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice

Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice

https://doi.org/10.18632/oncotarget.4930

Fei Wang, Xueyan Shen, Shuping Li, Long Chen, Yanru Wang, Jie Qin, Guomin Zhou, Yuwen Peng, Xiaoyuan Feng, Ruixi Li,  and Chunmin Liang
20851-20862
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Research Papers: Pathology

Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility

Comprehensive molecular pathology analysis of small bowel adenocarcinoma reveals novel targets with potential for clinical utility

https://doi.org/10.18632/oncotarget.4576

Muhammad A Alvi, Darragh G McArt, Paul Kelly, Marc-Aurel Fuchs, Matthew Alderdice, Clare M McCabe, Victoria Bingham, Claire McGready, Shailesh Tripathi, Frank Emmert-Streib, Maurice B Loughrey, Stephen McQuaid, Perry Maxwell, Peter W Hamilton, Richard Turkington, Jacqueline A James, Richard H Wilson,  and Manuel Salto-Tellez
20863-20874
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PRDX6 controls multiple sclerosis by suppressing inflammation and blood brain barrier disruption

PRDX6 controls multiple sclerosis by suppressing inflammation and blood brain barrier disruption

https://doi.org/10.18632/oncotarget.5205

Hyung-Mun Yun, Kyung-Ran Park, Eun-Cheol Kim,  and Jin Tae Hong
20875-20884
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Combination genetic signature stratifies lower-grade gliomas better than histological grade

Combination genetic signature stratifies lower-grade gliomas better than histological grade

https://doi.org/10.18632/oncotarget.4928

Aden Ka-Yin Chan, Yu Yao, Zhenyu Zhang, Zhifeng Shi, Liang Chen, Nellie Yuk-Fei Chung, Joseph Shu-Ming Liu, Kay Ka-Wai Li, Danny Tat-Ming Chan, Wai Sang Poon, Liangfu Zhou,  and Ho-Keung Ng
20885-20901
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Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells

Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells

https://doi.org/10.18632/oncotarget.3939

Joao Paulo Oliveira-Costa, Alex Fiorini de Carvalho, Giorgia Gobbi da Silveira, Peter Amaya, Yongqi Wu, Kyoung-Joo Jenny Park, Mabel Pinilla Gigliola, Maryam Lustberg, Marcilei Eliza Cavicchioli Buim, Elisa Napolitano Ferreira, Luiz Paulo Kowalski, Jeffrey J. Chalmers, Fernando Augusto Soares, Dirce Maria Carraro,  and Alfredo Ribeiro-Silva
20902-20920
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Research Papers: Chromosome

Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy

Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy

https://doi.org/10.18632/oncotarget.4879

Ailsa Bennett, Beatrice Bechi, Anthony Tighe, Sarah Thompson, David J Procter,  and Stephen S Taylor
20921-20932
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Research Papers

The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis

The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis

https://doi.org/10.18632/oncotarget.3055

Christophe Chapard, Daniel Hohl,  and Marcel Huber
20933-20945
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Mechanical phenotype of cancer cells: cell softening and loss of stiffness sensing

Mechanical phenotype of cancer cells: cell softening and loss of stiffness sensing

https://doi.org/10.18632/oncotarget.4173

Hsi-Hui Lin, Hsiu-Kuan Lin, I-Hsuan Lin, Yu-Wei Chiou, Horn-Wei Chen, Ching-Yi Liu, Hans I-Chen Harn, Wen-Tai Chiu, Yang-Kao Wang, Meng-Ru Shen,  and Ming-Jer Tang
20946-20958
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Virus-Clip: a fast and memory-efficient viral integration site detection tool at single-base resolution with annotation capability

Virus-Clip: a fast and memory-efficient viral integration site detection tool at single-base resolution with annotation capability

https://doi.org/10.18632/oncotarget.4187

Daniel WH Ho, Karen MF Sze,  and Irene OL Ng
20959-20963
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Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma

Tensin4 is up-regulated by EGF-induced ERK1/2 activity and promotes cell proliferation and migration in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4122

Lo-Kong Chan, Yung-Tuen Chiu, Karen Man-Fong Sze,  and Irene Oi-Lin Ng
20964-20976
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TWIST-1 promotes cell growth, drug resistance and progenitor clonogenic capacities in myeloid leukemia and is a novel poor prognostic factor in acute myeloid leukemia

TWIST-1 promotes cell growth, drug resistance and progenitor clonogenic capacities in myeloid leukemia and is a novel poor prognostic factor in acute myeloid leukemia

https://doi.org/10.18632/oncotarget.4007

Nan Wang, Dan Guo, YangYang Zhao, ChengYa Dong, XiaoYan Liu, BinXia Yang, ShuWei Wang, Lin Wang, QingGuo Liu, Qian Ren, YongMin Lin,  and XiaoTong Ma
20977-20992
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Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis

Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis

https://doi.org/10.18632/oncotarget.3663

Jiguang Ma, Wanxing Duan, Suxia Han, Jianjun Lei, Qinhong Xu, Xin Chen, Zhengdong Jiang, Ligang Nan, Jiahui Li, Ke Chen, Liang Han, Zheng Wang, Xuqi Li, Erxi Wu,  and Xiongwei Huo
20993-21003
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ANGPTL2/LILRB2 signaling promotes the propagation of lung cancer cells

ANGPTL2/LILRB2 signaling promotes the propagation of lung cancer cells

https://doi.org/10.18632/oncotarget.4217

Xiaoye Liu, Xiaoting Yu, Jingjing Xie, Mengna Zhan, Zhuo Yu, Li Xie, Hongxiang Zeng, Feifei Zhang, Guoqiang Chen, Xianghua Yi,  and Junke Zheng
21004-21015
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mitochondrial ribosomal protein S18-2 evokes chromosomal instability and transforms primary rat skin fibroblasts

Mitochondrial ribosomal protein S18-2 evokes chromosomal instability and transforms primary rat skin fibroblasts

https://doi.org/10.18632/oncotarget.4123

Suhas D. Darekar, Muhammad Mushtaq, Sreeharsha Gurrapu, Larysa Kovalevska, Catherine Drummond, Maria Petruchek, Luca Tirinato, Enzo Di Fabrizio, Ennio Carbone,  and Elena Kashuba
21016-21028
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Down regulation of Akirin-2 increases chemosensitivity in human glioblastomas more efficiently than Twist-1

Down regulation of Akirin-2 increases chemosensitivity in human glioblastomas more efficiently than Twist-1

https://doi.org/10.18632/oncotarget.3763

Sebastian Krossa, Anne Dorothée Schmitt, Kirsten Hattermann, Jürgen Fritsch, Axel J. Scheidig, Hubertus Maximilian Mehdorn,  and Janka Held-Feindt
21029-21045
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MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4

MicroRNA-301a-3p promotes pancreatic cancer progression via negative regulation of SMAD4

https://doi.org/10.18632/oncotarget.4124

Xiang Xia, Kundong Zhang, Gang Cen, Tao Jiang, Jun Cao, Kejian Huang, Chen Huang, Qian Zhao,  and Zhengjun Qiu
21046-21063
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High RAD54B expression: an independent predictor of postoperative distant recurrence in colorectal cancer patients

High RAD54B expression: an independent predictor of postoperative distant recurrence in colorectal cancer patients

https://doi.org/10.18632/oncotarget.4222

Yuzo Nagai, Yoko Yamamoto, Takaaki Yasuhara, Keisuke Hata, Takeshi Nishikawa, Toshiaki Tanaka, Junichiro Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Hiroaki Nozawa, Shinsuke Kazama, Hironori Yamaguchi, Soichiro Ishihara, Eiji Sunami, Takeharu Yamanaka, Kiyoshi Miyagawa,  and Toshiaki Watanabe
21064-21073
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Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells

Pharmacological inactivation of CHK1 and WEE1 induces mitotic catastrophe in nasopharyngeal carcinoma cells

https://doi.org/10.18632/oncotarget.4020

Joyce P.Y. Mak, Wing Yu Man, Jeremy P.H. Chow, Hoi Tang Ma,  and Randy Y.C. Poon
21074-21084
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Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

https://doi.org/10.18632/oncotarget.3912

Imayavaramban Lakshmanan, Parthasarathy Seshacharyulu, Dhanya Haridas, Satyanarayana Rachagani, Suprit Gupta, Suhasini Joshi, Chittibabu Guda, Ying Yan, Maneesh Jain, Apar K. Ganti, Moorthy P. Ponnusamy,  and Surinder K. Batra
21085-21099
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women

Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women

https://doi.org/10.18632/oncotarget.4228

Sumie Kato, Lorena Abarzua-Catalan, César Trigo, Ana Delpiano, Cristobal Sanhueza, Karen García, Carolina Ibañez, Katherine Hormazábal, Daniela Diaz, Jorge Brañes, Enrique Castellón, Erasmo Bravo, Gareth Owen,  and Mauricio A. Cuello
21100-21119
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer

By inhibiting snail signaling and miR-23a-3p, osthole suppresses the EMT-mediated metastatic ability in prostate cancer

https://doi.org/10.18632/oncotarget.4229

Yu-Ching Wen, Wei-Jiunn Lee, Peng Tan, Shun-Fa Yang, Michael Hsiao, Liang-Ming Lee,  and Ming-Hsien Chien
21120-21136
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A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model

A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model

https://doi.org/10.18632/oncotarget.4121

Kai Guo, Peng Huang, Naijin Xu, Peng Xu, Haruki Kaku, Shaobo Zheng, Abai Xu, Eiji Matsuura, Chunxiao Liu,  and Hiromi Kumon
21137-21147
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Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer

Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer

https://doi.org/10.18632/oncotarget.4125

Peng Wang, Chao-feng Zhu, Ming-zhe Ma, Gang Chen, Ming Song, Zhao-lei Zeng, Wen-hua Lu, Jing Yang, Shijun Wen, Paul J. Chiao, Yumin Hu,  and Peng Huang
21148-21158
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Bcl-2high mantle cell lymphoma cells are sensitized to acadesine with ABT-199

Bcl-2high mantle cell lymphoma cells are sensitized to acadesine with ABT-199

https://doi.org/10.18632/oncotarget.4230

Arnau Montraveta, Sílvia Xargay-Torrent, Laia Rosich, Mònica López-Guerra, Jocabed Roldán, Vanina Rodríguez, Eriong Lee-Vergés, Mercè de Frías, Clara Campàs, Elias Campo, Gaël Roué,  and Dolors Colomer
21159-21172
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Ca2+ influx-mediated dilation of the endoplasmic reticulum and c-FLIPL downregulation trigger CDDO-Me-induced apoptosis in breast cancer cells

Ca2+ influx-mediated dilation of the endoplasmic reticulum and c-FLIPL downregulation trigger CDDO-Me-induced apoptosis in breast cancer cells

https://doi.org/10.18632/oncotarget.4065

Soo Ah Jeong, In Young Kim, A Reum Lee, Mi Jin Yoon, Hyeseong Cho, Jong-Soo Lee,  and Kyeong Sook Choi
21173-21192
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Validation of an IGF-CTP scoring system for assessing hepatic reserve in egyptian patients with hepatocellular carcinoma

Validation of an IGF-CTP scoring system for assessing hepatic reserve in egyptian patients with hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.4176

Reham Abdel-Wahab, Samir Shehata, Manal M. Hassan, Lianchun Xiao, Ju-Seog Lee, Sheree Cheung, Hoda H. Essa, Hesham M. Hassabo, Ahmed S. Shalaby, Eman Mosad, Kanwal Raghav, Asif Rashid, Robert A. Wolff, Jeffrey S. Morris, Hesham M. Amin,  and Ahmed O. Kaseb
21193-21207
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Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2

Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2

https://doi.org/10.18632/oncotarget.4126

Wen Yue, Xi Zheng, Yong Lin, Chung S. Yang, Qing Xu, Darren Carpizo, Huarong Huang, Robert S. DiPaola,  and Xiang-Lin Tan
21208-21224
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TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is a potential prognostic biomarker in lung cancer

TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is a potential prognostic biomarker in lung cancer

https://doi.org/10.18632/oncotarget.4237

Wen-bin Liu, Fei Han, Xiao Jiang, Hong-qiang Chen, Huan Zhao, Yong Liu, Yong-hong Li, Chuanshu Huang, Jia Cao,  and Jin-yi Liu
21225-21239
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p53 attenuates AKT signaling by modulating membrane phospholipid composition

p53 attenuates AKT signaling by modulating membrane phospholipid composition

https://doi.org/10.18632/oncotarget.4067

Natalia Rueda-Rincon, Katarzyna Bloch, Rita Derua, Rajesh Vyas, Amy Harms, Thomas Hankemeier, Niamat Ali Khan, Jonas Dehairs, Muralidhararao Bagadi, Maria Mercedes Binda, Etienne Waelkens, Jean-Christophe Marine,  and Johannes V. Swinnen
21240-21254
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Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening

Spontaneously-forming spheroids as an in vitro cancer cell model for anticancer drug screening

https://doi.org/10.18632/oncotarget.4013

Maria A. Theodoraki, Celso O. Rezende Jr., Oraphin Chantarasriwong, Adriana D. Corben, Emmanuel A. Theodorakis,  and Mary L. Alpaugh
21255-21267
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Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting epidermal growth factor receptor

Honokiol inhibits the growth of head and neck squamous cell carcinoma by targeting epidermal growth factor receptor

https://doi.org/10.18632/oncotarget.4178

Tripti Singh, Nirzari A. Gupta, Su Xu, Ram Prasad, Sadanandan E. Velu,  and Santosh K. Katiyar
21268-21282
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Down-regulation of α-L-fucosidase 1 expression confers inferior survival for triple-negative breast cancer patients by modulating the glycosylation status of the tumor cell surface

Down-regulation of α-L-fucosidase 1 expression confers inferior survival for triple-negative breast cancer patients by modulating the glycosylation status of the tumor cell surface

https://doi.org/10.18632/oncotarget.4238

Tzu-Chun Cheng, Shih-Hsin Tu, Li-Ching Chen, Ming-Yao Chen, Wen-Ye Chen, Yen-Kuang Lin, Chi-Tang Ho, Shyr-Yi Lin, Chih-Hsiung Wu,  and Yuan-Soon Ho
21283-21300
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The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells

The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells

https://doi.org/10.18632/oncotarget.4019

Jared Ching, Stephanie Amiridis, Stanley S. Stylli, Andrew R. Bjorksten, Nicole Kountouri, Thomas Zheng, Lucy Paradiso, Rodney B. Luwor, Andrew P. Morokoff, Terence J. O’Brien,  and Andrew H. Kaye
21301-21314
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CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis

CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis

https://doi.org/10.18632/oncotarget.4066

Muhammad Noman Khan, Bing Wang, Jing Wei, Yingqiu Zhang, Qiang Li, Xuelin Luan, Jya-Wei Cheng, John R. Gordon, Fang Li,  and Han Liu
21315-21327
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K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis

K-Ras stabilization by estrogen via PKCδ is involved in endometrial tumorigenesis

https://doi.org/10.18632/oncotarget.4049

Kyoung-Hwa Koo, Woo-Jeong Jeong, Yong-Hee Cho, Jong-Chan Park, Do Sik Min,  and Kang-Yell Choi
21328-21340
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ZD6474, a new treatment strategy for human osteosarcoma, and its potential synergistic effect with celecoxib

ZD6474, a new treatment strategy for human osteosarcoma, and its potential synergistic effect with celecoxib

https://doi.org/10.18632/oncotarget.4179

Jiani Liu, Jiangxue Wu, Ling Zhou, Changchuan Pan, Yi Zhou, Wuying Du, Jie-min Chen, Xiaofeng Zhu, Jingnan Shen, Shuai Chen, Ran-yi Liu,  and Wenlin Huang
21341-21352
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Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer

Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer

https://doi.org/10.18632/oncotarget.3860

Andrew J. Wilson, Oluwole Fadare, Alicia Beeghly-Fadiel, Deok-Soo Son, Qi Liu, Shilin Zhao, Jeanette Saskowski, Md. Jashim Uddin, Cristina Daniel, Brenda Crews, Brian D. Lehmann, Jennifer A. Pietenpol, Marta A. Crispens, Lawrence J. Marnett,  and Dineo Khabele
21353-21368
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Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)

Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)

https://doi.org/10.18632/oncotarget.4128

Fei Ge, Wenlin Chen, Junying Qin, Zhongmei Zhou, Rong Liu, Linlin Liu, Jing Tan, Tianning Zou, Hongyuan Li, Guosheng Ren,  and Ceshi Chen
21369-21378
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Oral nano-delivery of anticancer ginsenoside 25-OCH3-PPD, a natural inhibitor of the MDM2 oncogene: Nanoparticle preparation, characterization, in vitro and in vivo anti-prostate cancer activity, and mechanisms of action

Oral nano-delivery of anticancer ginsenoside 25-OCH3-PPD, a natural inhibitor of the MDM2 oncogene: Nanoparticle preparation, characterization, in vitro and in vivo anti-prostate cancer activity, and mechanisms of action

https://doi.org/10.18632/oncotarget.4091

Sukesh Voruganti, Jiang-Jiang Qin, Sushanta Sarkar, Subhasree Nag, Ismail A. Walbi, Shu Wang, Yuqing Zhao, Wei Wang,  and Ruiwen Zhang
21379-21394
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BEX1 acts as a tumor suppressor in acute myeloid leukemia

BEX1 acts as a tumor suppressor in acute myeloid leukemia

https://doi.org/10.18632/oncotarget.4095

Oscar Lindblad, Tianfeng Li, Xianwei Su, Jianmin Sun, Nuzhat N. Kabir, Fredrik Levander, Hui Zhao, Gang Lu, Lars Rönnstrand,  and Julhash U. Kazi
21395-21405
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PinX1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis by suppressing MMP-2 via NF-κB-dependent transcription

PinX1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis by suppressing MMP-2 via NF-κB-dependent transcription

https://doi.org/10.18632/oncotarget.4011

Hai-Long Li, Li Han, Hai-Rong Chen, Fei Meng, Qing-Hua Liu, Zhen-Qiang Pan, Jin Bai,  and Jun-Nian Zheng
21406-21420
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Annexin A3 is a mammary marker and a potential neoplastic breast cell therapeutic target

Annexin A3 is a mammary marker and a potential neoplastic breast cell therapeutic target

https://doi.org/10.18632/oncotarget.4070

Bashar Zeidan, Thomas R. Jackson, Samantha E.T. Larkin, Ramsey I. Cutress, Gary R. Coulton, Margaret Ashton-Key, Nick Murray, Graham Packham, Vassilis Gorgoulis, Spiros D. Garbis,  and Paul A. Townsend
21421-21427
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Identification of epidermal growth factor receptor and its inhibitory microRNA141 as novel targets of Krüppel-like factor 8 in breast cancer

Identification of epidermal growth factor receptor and its inhibitory microRNA141 as novel targets of Krüppel-like factor 8 in breast cancer

https://doi.org/10.18632/oncotarget.4077

Tianshu Li, Heng Lu, Debarati Mukherjee, Satadru K. Lahiri, Chao Shen, Lin Yu,  and Jihe Zhao
21428-21442
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NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells

NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells

https://doi.org/10.18632/oncotarget.4167

Yi Zhu, Minmin Shi, Hao Chen, Jiangning Gu, Jiaqiang Zhang, Baiyong Shen, Xiaxing Deng, Junjie Xie, Xi Zhan,  and Chenghong Peng
21443-21451
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Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium

Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium

https://doi.org/10.18632/oncotarget.4087

Chong Xu, Hai Zhang, Chunxiao Liu, Yu Zhu, Xiaoxue Wang, Wei Gao, Shile Huang,  and Long Chen
21452-21467
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Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-β2 and Ran GTPase in human glioblastoma cells

Nuclear translocation of fibroblast growth factor-2 (FGF2) is regulated by Karyopherin-β2 and Ran GTPase in human glioblastoma cells

https://doi.org/10.18632/oncotarget.4097

Feng Wang, Lijun Yang, Lin Shi, Qian Li, Gengshen Zhang, Jianliang Wu, Jun Zheng,  and Baohua Jiao
21468-21478
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MDM2 mediates p73 ubiquitination: a new molecular mechanism for suppression of p73 function

MDM2 mediates p73 ubiquitination: a new molecular mechanism for suppression of p73 function

https://doi.org/10.18632/oncotarget.4086

Hong Wu,  and Roger P. Leng
21479-21492
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Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic

Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic

https://doi.org/10.18632/oncotarget.4085

Zhuang Miao, Lin Wu, Ming Lu, Xianzhi Meng, Bo Gao, Xin Qiao, Weihui Zhang,  and Dongbo Xue
21493-21506
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Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling

Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling

https://doi.org/10.18632/oncotarget.4242

Anja Heinemann, Carleen Cullinane, Ricardo De Paoli-Iseppi, James S. Wilmott, Dilini Gunatilake, Jason Madore, Dario Strbenac, Jean Y. Yang, Kavitha Gowrishankar, Jessamy C. Tiffen, Rab K. Prinjha, Nicholas Smithers, Grant A. McArthur, Peter Hersey,  and Stuart J. Gallagher
21507-21521
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Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies

Patient-derived bladder cancer xenografts in the preclinical development of novel targeted therapies

https://doi.org/10.18632/oncotarget.3974

Wolfgang Jäger, Hui Xue, Tetsutaro Hayashi, Claudia Janssen, Shannon Awrey, Alexander W. Wyatt, Shawn Anderson, Igor Moskalev, Anne Haegert, Mohammed Alshalalfa, Nicholas Erho, Elai Davicioni, Ladan Fazli, Estelle Li, Colin Collins, Yuzhuo Wang,  and Peter C. Black
21522-21532
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A fully human chimeric antigen receptor with potent activity against cancer cells but reduced risk for off-tumor toxicity

A fully human chimeric antigen receptor with potent activity against cancer cells but reduced risk for off-tumor toxicity

https://doi.org/10.18632/oncotarget.4071

De-Gang Song, Qunrui Ye, Mathilde Poussin, Lin Liu, Mariangela Figini,  and Daniel J. Powell Jr.
21533-21546
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Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001

Nrf2 activity as a potential biomarker for the pan-epigenetic anticancer agent, RRx-001

https://doi.org/10.18632/oncotarget.4249

Shoucheng Ning, Thillai Veerapazham Sekar, Jan Scicinski, Bryan Oronsky, Donna M. Peehl, Susan J. Knox,  and Ramasamy Paulmurugan
21547-21556
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Inhibition of Bcl-xL overcomes polyploidy resistance and leads to apoptotic cell death in acute myeloid leukemia cells

Inhibition of Bcl-xL overcomes polyploidy resistance and leads to apoptotic cell death in acute myeloid leukemia cells

https://doi.org/10.18632/oncotarget.4306

Weihua Zhou, Jie Xu, Elise Gelston, Xing Wu, Zhengzhi Zou, Bin Wang, Yunxin Zeng, Hua Wang, Anwen Liu, Lingzhi Xu,  and Quentin Liu
21557-21571
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Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization

Distinct effects of TRAIL on the mitochondrial network in human cancer cells and normal cells: role of plasma membrane depolarization

https://doi.org/10.18632/oncotarget.4268

Yoshihiro Suzuki-Karasaki, Kyoko Fujiwara, Kosuke Saito, Miki Suzuki-Karasaki, Toyoko Ochiai,  and Masayoshi Soma
21572-21588
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A dominant-negative F-box deleted mutant of E3 ubiquitin ligase, β-TrCP1/FWD1, markedly reduces myeloma cell growth and survival in mice

A dominant-negative F-box deleted mutant of E3 ubiquitin ligase, β-TrCP1/FWD1, markedly reduces myeloma cell growth and survival in mice

https://doi.org/10.18632/oncotarget.4120

Ramaswamy Sharma, Paul J. Williams, Anjana Gupta, Brandon McCluskey, Shylesh Bhaskaran, Steve Muñoz,  and Babatunde O. Oyajobi
21589-21602
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siRNAs with decreased off-target effect facilitate the identification of essential genes in cancer cells

siRNAs with decreased off-target effect facilitate the identification of essential genes in cancer cells

https://doi.org/10.18632/oncotarget.4269

Chunyan Li, Zhenzhen Liu, Fang Yang, Wensheng Liu, Di Wang, Encheng Dong, Yu Wang, Chung-I Wu,  and Xuemei Lu
21603-21613
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Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients

Effects of TGF-beta signalling inhibition with galunisertib (LY2157299) in hepatocellular carcinoma models and in ex vivo whole tumor tissue samples from patients

https://doi.org/10.18632/oncotarget.4308

Maria Serova, Annemilaï Tijeras-Raballand, Célia Dos Santos, Miguel Albuquerque, Valerie Paradis, Cindy Neuzillet, Karim A. Benhadji, Eric Raymond, Sandrine Faivre,  and Armand de Gramont
21614-21627
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Intravesical administration of exogenous microRNA-145 as a therapy for mouse orthotopic human bladder cancer xenograft

Intravesical administration of exogenous microRNA-145 as a therapy for mouse orthotopic human bladder cancer xenograft

https://doi.org/10.18632/oncotarget.4129

Teruo Inamoto, Kohei Taniguchi, Kiyoshi Takahara, Ayako Iwatsuki, Tomoaki Takai, Kazumasa Komura, Yuki Yoshikawa, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Junko Kouno, Koichiro Minami, Hirofumi Uehara, Hajime Hirano, Hayahito Nomi, Satoshi Kiyama, Yukihiro Akao,  and Haruhito Azuma
21628-21635
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Targeted DNA and RNA sequencing of fine-needle biopsy FFPE specimens in patients with unresectable hepatocellular carcinoma treated with sorafenib

Targeted DNA and RNA sequencing of fine-needle biopsy FFPE specimens in patients with unresectable hepatocellular carcinoma treated with sorafenib

https://doi.org/10.18632/oncotarget.4270

Kazuko Sakai, Haruhiko Takeda, Norihiro Nishijima, Etsuro Orito, Kouji Joko, Yasushi Uchida, Namiki Izumi, Kazuto Nishio,  and Yukio Osaki
21636-21644
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Expression of miR-27a-3p is an independent predictive factor for recurrence in clear cell renal cell carcinoma

Expression of miR-27a-3p is an independent predictive factor for recurrence in clear cell renal cell carcinoma

https://doi.org/10.18632/oncotarget.4064

Wataru Nakata, Motohide Uemura, Mototaka Sato, Kazutoshi Fujita, Kentaro Jingushi, Yuko Ueda, Kaori Kitae, Kazutake Tsujikawa,  and Norio Nonomura
21645-21654
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Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels

Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels

https://doi.org/10.18632/oncotarget.4130

Seo Hee Nam, Doyeun Kim, Mi-Sook Lee, Doohyung Lee, Tae Kyoung Kwak, Minkyung Kang, Jihye Ryu, Hye-Jin Kim, Haeng Eun Song, Jungeun Choi, Gyu-Ho Lee, Sang-Yeob Kim, Song Hwa Park, Dae Gyu Kim, Nam Hoon Kwon, Tai Young Kim, Jean Paul Thiery, Sunghoon Kim,  and Jung Weon Lee
21655-21674
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Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer

Epigenetic and oncogenic regulation of SLC16A7 (MCT2) results in protein over-expression, impacting on signalling and cellular phenotypes in prostate cancer

https://doi.org/10.18632/oncotarget.4328

Nelma Pertega-Gomes, Jose R. Vizcaino, Sergio Felisbino, Anne Y. Warren, Greg Shaw, Jonathan Kay, Hayley Whitaker, Andy G. Lynch, Lee Fryer, David E. Neal,  and Charles E. Massie
21675-21684
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Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer

Expression profiling of nuclear receptors in breast cancer identifies TLX as a mediator of growth and invasion in triple-negative breast cancer

https://doi.org/10.18632/oncotarget.3942

Meng-Lay Lin, Hetal Patel, Judit Remenyi, Christopher R. S. Banerji, Chun-Fui Lai, Manikandan Periyasamy, Ylenia Lombardo, Claudia Busonero, Silvia Ottaviani, Alun Passey, Philip R. Quinlan, Colin A. Purdie, Lee B. Jordan, Alastair M. Thompson, Richard S. Finn, Oscar M. Rueda, Carlos Caldas, Jesus Gil, Charles R. Coombes, Frances V. Fuller-Pace, Andrew E. Teschendorff, Laki Buluwela,  and Simak Ali
21685-21703
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ERα inhibits epithelial-mesenchymal transition by suppressing Bmi1 in breast cancer

ERα inhibits epithelial-mesenchymal transition by suppressing Bmi1 in breast cancer

https://doi.org/10.18632/oncotarget.3966

Xiao-Long Wei, Xiao-Wei Dou, Jing-Wen Bai, Xiang-Rong Luo, Si-Qi Qiu, Di-Di Xi, Wen-He Huang, Cai-Wen Du, Kwan Man,  and Guo-Jun Zhang
21704-21717
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Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma

Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma

https://doi.org/10.18632/oncotarget.4304

Claudia C. Faria, Sameer Agnihotri, Stephen C. Mack, Brian J. Golbourn, Roberto J. Diaz, Samantha Olsen, Melissa Bryant, Matthew Bebenek, Xin Wang, Kelsey C. Bertrand, Michelle Kushida, Renee Head, Ian Clark, Peter Dirks, Christian A. Smith, Michael D. Taylor,  and James T. Rutka
21718-21729
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Identification of novel long non-coding RNAs in triple-negative breast cancer

Identification of novel long non-coding RNAs in triple-negative breast cancer

https://doi.org/10.18632/oncotarget.4419

Xiaokun Shen, Bojian Xie, Zhaosheng Ma, Wenjie Yu, Wenmin Wang, Dong Xu, Xinqiang Yan, Beibei Chen, Longyao Yu, Jicheng Li, Xiaobing Chen, Kan Ding,  and Feilin Cao
21730-21739
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Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel

Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel

https://doi.org/10.18632/oncotarget.3226

Pedram Kharaziha, Dimitris Chioureas, Dorothea Rutishauser, George Baltatzis, Lena Lennartsson, Pedro Fonseca, Alireza Azimi, Kjell Hultenby, Roman Zubarev, Anders Ullén, Jeffrey Yachnin, Sten Nilsson,  and Theocharis Panaretakis
21740-21754
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Clinical Research Papers

Dyskerin and TERC expression may condition survival in lung cancer patients

Dyskerin and TERC expression may condition survival in lung cancer patients

https://doi.org/10.18632/oncotarget.4580

Marianna Penzo, Vienna Ludovini, Davide Trerè, Annamaria Siggillino, Jacopo Vannucci, Guido Bellezza, Lucio Crinò,  and Lorenzo Montanaro
21755-21760
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