Oncotarget

Vol 6, No 21

July 30, 2015

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Partial response in a 63-year-old patient with prostate cancer treated with 400 mg AMG 208 (18F-FLT-PET and CT scans). See Hong et al.

Table of Contents

Editorial

CNVs in neurodevelopmental disorders

CNVs in neurodevelopmental disorders

https://doi.org/10.18632/oncotarget.4853

Chun-Ting Lee, William J. Freed,  and Deborah C. Mash
18238-18239
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USP8 mutation in Cushing’s disease

USP8 mutation in Cushing’s disease

https://doi.org/10.18632/oncotarget.4856

Chuanxin Huang, Yongyong Shi,  and Yao Zhao
18240-18241
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Hyper-activated PI3K-δ in immunodeficiency

Hyper-activated PI3K-δ in immunodeficiency

https://doi.org/10.18632/oncotarget.4884

Lucie Heurtier, Marie-Céline Deau,  and Sven Kracker
18242-18243
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Targeting interleukin-17 receptors

Targeting interleukin-17 receptors

https://doi.org/10.18632/oncotarget.4892

Wen-Hwa Lee, Heng-Hsiung Wu,  and Chun-Kai Huang
18244-18245
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PlGF, immune system and hypertension

PlGF, immune system and hypertension

https://doi.org/10.18632/oncotarget.4914

Daniela Carnevale,  and Giuseppe Lembo
18246-18247
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Editorial: Chromosome

Plasticity of coral physiology under ocean acidification

Plasticity of coral physiology under ocean acidification

https://doi.org/10.18632/oncotarget.4983

Alexander Ashley Venn, Eric Tambutté,  and Sylvie Tambutté
18248-18249
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Reviews

Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder

Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder

https://doi.org/10.18632/oncotarget.4213

Anindya Chatterjee, Joydeep Ghosh,  and Reuben Kapur
18250-18264
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Long noncoding RNAs and neuroblastoma

Long noncoding RNAs and neuroblastoma

https://doi.org/10.18632/oncotarget.4251

Gaurav Kumar Pandey,  and Chandrasekhar Kanduri
18265-18275
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Research Perspectives

The joining of the Hsp90 and Hsp70 chaperone cycles yields transient interactions and stable intermediates: insights from mass spectrometry

The joining of the Hsp90 and Hsp70 chaperone cycles yields transient interactions and stable intermediates: insights from mass spectrometry

https://doi.org/10.18632/oncotarget.4954

Carla Schmidt, Victoria Beilsten-Edmands,  and Carol V. Robinson
18276-18281
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Priority Research Papers

Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions

Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions

https://doi.org/10.18632/oncotarget.4957

Rajarshi Sengupta, Amy Barone, Jayne Marasa, Sara Taylor, Erin Jackson, Nicole M. Warrington, Shyam Rao, Albert H. Kim, Jeffrey R. Leonard, David Piwnica-Worms,  and Joshua B. Rubin
18282-18292
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Research Papers: Gerotarget (Focus on Aging)

Exercise-mimetic AICAR transiently benefits brain function

Exercise-mimetic AICAR transiently benefits brain function

https://doi.org/10.18632/oncotarget.4715

Davide Guerrieri,  and Henriette van Praag
18293-18313
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The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse

The effects of graded levels of calorie restriction: III. Impact of short term calorie and protein restriction on mean daily body temperature and torpor use in the C57BL/6 mouse

https://doi.org/10.18632/oncotarget.4506

Sharon E. Mitchell, Camille Delville, Penelope Konstantopedos, Davina Derous, Cara L. Green, Luonan Chen, Jing-Dong J. Han, Yingchun Wang, Daniel E.L. Promislow, Alex Douglas, David Lusseau,  and John R. Speakman
18314-18337
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Research Papers: Pathology

Class 3 semaphorins expression and association with innervation and angiogenesis within the degenerate human intervertebral disc

Class 3 semaphorins expression and association with innervation and angiogenesis within the degenerate human intervertebral disc

https://doi.org/10.18632/oncotarget.4274

Abbie L.A. Binch, Ashley A. Cole, Lee M. Breakwell, Anthony L.R. Michael, Neil Chiverton, Laura B. Creemers, Alison K. Cross,  and Christine L. Le Maitre
18338-18354
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Human saliva as route of inter-human infection for mouse mammary tumor virus

Human saliva as route of inter-human infection for mouse mammary tumor virus

https://doi.org/10.18632/oncotarget.4567

Chiara Maria Mazzanti, Francesca Lessi, Ivana Armogida, Katia Zavaglia, Sara Franceschi, Mohammad A.L. Hamad, Manuela Roncella, Matteo Ghilli, Antonio Boldrini, Giovanni Fanelli, Ivo Marchetti, Cristian Scatena, Jacob Hochman, Antonio Giuseppe Naccarato,  and Generoso Bevilacqua
18355-18363
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Redox process is crucial for inhibitory properties of aurintricarboxylic acid against activity of YopH: virulence factor of Yersinia pestis

Redox process is crucial for inhibitory properties of aurintricarboxylic acid against activity of YopH: virulence factor of Yersinia pestis

https://doi.org/10.18632/oncotarget.4625

Kuban-Jankowska Alicja, Sahu Kamlesh K, Niedzialkowski Pawel, Gorska Magdalena, Tuszynski Jack A, Ossowski Tadeusz,  and Wozniak Michal
18364-18373
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Research Papers

MYC or BCL2 copy number aberration is a strong predictor of outcome in patients with diffuse large B-cell lymphoma

MYC or BCL2 copy number aberration is a strong predictor of outcome in patients with diffuse large B-cell lymphoma

https://doi.org/10.18632/oncotarget.4073

Ting-Xun Lu, Lei Fan, Li Wang, Jia-Zhu Wu, Kou-Rong Miao, Jin-Hua Liang, Qi-Xing Gong, Zhen Wang, Ken H. Young, Wei Xu, Zhi-Hong Zhang,  and Jian-Yong Li
18374-18388
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MiR-101 targets DUSP1 to regulate the TGF-β secretion in sorafenib inhibits macrophage-induced growth of hepatocarcinoma

MiR-101 targets DUSP1 to regulate the TGF-β secretion in sorafenib inhibits macrophage-induced growth of hepatocarcinoma

https://doi.org/10.18632/oncotarget.4089

Xufu Wei, Chengyong Tang, Xiuxian Lu, Rui Liu, Mi Zhou, Diao He, Daofeng Zheng, Chao Sun,  and Zhongjun Wu
18389-18405
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AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer

AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer

https://doi.org/10.18632/oncotarget.4074

Shao-hua Fan, Yan-yan Wang, Zhi-yong Wu, Zi-feng Zhang, Jun Lu, Meng-qiu Li, Qun Shan, Dong-mei Wu, Chun-hui Sun, Bin Hu,  and Yuan-lin Zheng
18406-18417
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Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines

Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines

https://doi.org/10.18632/oncotarget.4099

Paul D. Hanavan, Chad R. Borges, Benjamin A. Katchman, Douglas O. Faigel, Thai H. Ho, Chen-Ting Ma, Eduard A. Sergienko, Nathalie Meurice, Joachim L. Petit,  and Douglas F. Lake
18418-18428
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miR-29b attenuates tumorigenicity and stemness maintenance in human glioblastoma multiforme by directly targeting BCL2L2

miR-29b attenuates tumorigenicity and stemness maintenance in human glioblastoma multiforme by directly targeting BCL2L2

https://doi.org/10.18632/oncotarget.4384

Hyun Joo Chung, Young Eun Choi, Eun Sook Kim, Young-Hoon Han, Myung-Jin Park,  and In Hwa Bae
18429-18444
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YM155, a survivin suppressant, triggers PARP-dependent cell death (parthanatos) and inhibits esophageal squamous-cell carcinoma xenografts in mice

YM155, a survivin suppressant, triggers PARP-dependent cell death (parthanatos) and inhibits esophageal squamous-cell carcinoma xenografts in mice

https://doi.org/10.18632/oncotarget.4315

Nan Zhao, Yousheng Mao, Gaijing Han, Qiang Ju, Lanping Zhou, Fang Liu, Yang Xu,  and Xiaohang Zhao
18445-18459
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Prognostic significance of the TREK-1 K2P potassium channels in prostate cancer

Prognostic significance of the TREK-1 K2P potassium channels in prostate cancer

https://doi.org/10.18632/oncotarget.3782

Gui-Ming Zhang, Fang-Ning Wan, Xiao-Jian Qin, Da-Long Cao, Hai-Liang Zhang, Yao Zhu, Bo Dai, Guo-Hai Shi,  and Ding-Wei Ye
18460-18468
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PP2A inhibitors arrest G2/M transition through JNK/Sp1- dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21

PP2A inhibitors arrest G2/M transition through JNK/Sp1- dependent down-regulation of CDK1 and autophagy-dependent up-regulation of p21

https://doi.org/10.18632/oncotarget.4063

Fei-Ran Gong, Meng-Yao Wu, Meng Shen, Qiaoming Zhi, Ze-Kuan Xu, Rong Wang, Wen-Jie Wang, Yang Zong, Zeng-Liang Li, Yadi Wu, Binhua P. Zhou, Kai Chen, Min Tao,  and Wei Li
18469-18483
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Factors involved in CLL pathogenesis and cell survival are disrupted by differentiation of CLL B-cells into antibody-secreting cells

Factors involved in CLL pathogenesis and cell survival are disrupted by differentiation of CLL B-cells into antibody-secreting cells

https://doi.org/10.18632/oncotarget.3941

Hussein Ghamlouch, Walaa Darwiche, Ahmed Hodroge, Hakim Ouled-Haddou, Sébastien Dupont, Amrathlal Rabbind Singh, Caroline Guignant, Stéphanie Trudel, Bruno Royer, Brigitte Gubler,  and Jean-Pierre Marolleau
18484-18503
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Liposome encapsulated curcumin-difluorinated (CDF) inhibits the growth of cisplatin resistant head and neck cancer stem cells

Liposome encapsulated curcumin-difluorinated (CDF) inhibits the growth of cisplatin resistant head and neck cancer stem cells

https://doi.org/10.18632/oncotarget.4181

Saroj K. Basak, Alborz Zinabadi, Arthur W. Wu, Natarajan Venkatesan, Victor M. Duarte, James J. Kang, Clifton L. Dalgard, Meera Srivastava, Fazlul H. Sarkar, Marilene B. Wang,  and Eri S. Srivatsan
18504-18517
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Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors

Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors

https://doi.org/10.18632/oncotarget.3934

Meriam Ayadi, Anaïs Bouygues, Djamila Ouaret, Nathalie Ferrand, Salem Chouaib, Jean-Paul Thiery, Christian Muchardt, Michèle Sabbah,  and Annette K. Larsen
18518-18533
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

C/EBPα-p30 protein induces expression of the oncogenic long non-coding RNA UCA1 in acute myeloid leukemia

C/EBPα-p30 protein induces expression of the oncogenic long non-coding RNA UCA1 in acute myeloid leukemia

https://doi.org/10.18632/oncotarget.4069

James M. Hughes, Ivano Legnini, Beatrice Salvatori, Silvia Masciarelli, Marcella Marchioni, Francesco Fazi, Mariangela Morlando, Irene Bozzoni,  and Alessandro Fatica
18534-18544
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fasting cycles potentiate the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models

Fasting cycles potentiate the efficacy of gemcitabine treatment in in vitro and in vivo pancreatic cancer models

https://doi.org/10.18632/oncotarget.4186

Martina D’Aronzo, Manlio Vinciguerra, Tommaso Mazza, Concetta Panebianco, Chiara Saracino, Stephen P. Pereira, Paolo Graziano,  and Valerio Pazienza
18545-18557
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism

Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism

https://doi.org/10.18632/oncotarget.4061

Stefano J. Mandriota, Linda J. Valentijn, Laurence Lesne, David R. Betts, Denis Marino, Mary Boudal-Khoshbeen, Wendy B. London, Anne-Laure Rougemont, Edward F. Attiyeh, John M. Maris, Michael D. Hogarty, Jan Koster, Jan J. Molenaar, Rogier Versteeg, Marc Ansari,  and Fabienne Gumy-Pause
18558-18576
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion

Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion

https://doi.org/10.18632/oncotarget.4094

Yuan-Na Lin, Ridhirama Bhuwania, Kira Gromova, Antonio Virgilio Failla, Tobias Lange, Kristoffer Riecken, Stefan Linder, Matthias Kneussel, Jakob R. Izbicki,  and Sabine Windhorst
18577-18589
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anticancer activity of MPT0G157, a derivative of indolylbenzenesulfonamide, inhibits tumor growth and angiogenesis

Anticancer activity of MPT0G157, a derivative of indolylbenzenesulfonamide, inhibits tumor growth and angiogenesis

https://doi.org/10.18632/oncotarget.4068

Yen-Chia Huang, Fang-I Huang, Samir Mehndiratta, Ssu-Chia Lai, Jing-Ping Liou,  and Chia-Ron Yang
18590-18601
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

DDX3 as a strongest prognosis marker and its downregulation promotes metastasis in colorectal cancer

DDX3 as a strongest prognosis marker and its downregulation promotes metastasis in colorectal cancer

https://doi.org/10.18632/oncotarget.4329

Chia-Yi Su, Tsung-Chieh Lin, Yuan-Feng Lin, Ming-Huang Chen, Chien-Hsin Lee, Hsuan-Yao Wang, Yu-Chieh Lee, Yu-Peng Liu, Chi-Long Chen,  and Michael Hsiao
18602-18612
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-451: epithelial-mesenchymal transition inhibitor and prognostic biomarker of hepatocelluar carcinoma

MicroRNA-451: epithelial-mesenchymal transition inhibitor and prognostic biomarker of hepatocelluar carcinoma

https://doi.org/10.18632/oncotarget.4317

Jia-Yuan Huang, Kai Zhang, Dong-Qin Chen, Jing Chen, Bing Feng, Haizhu Song, Yitian Chen, Ziman Zhu, Lei Lu, Wei De, Rui Wang,  and Long-Bang Chen
18613-18630
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Serum miR-26a as a diagnostic and prognostic biomarker in cholangiocarcinoma

Serum miR-26a as a diagnostic and prognostic biomarker in cholangiocarcinoma

https://doi.org/10.18632/oncotarget.4072

Li-Juan Wang, Kai-Liang Zhang, Ning Zhang, Xiang-Wei Ma, Su-Wen Yan, Dong-Hua Cao,  and Sheng-Jia Shi
18631-18640
Abstract  |  PDF  |  HTML  |  Order a Reprint

Survival of patients with structurally-grouped TP53 mutations in ovarian and breast cancers

Survival of patients with structurally-grouped TP53 mutations in ovarian and breast cancers

https://doi.org/10.18632/oncotarget.4080

Brandon-Luke L. Seagle, Kevin H. Eng, Monica Dandapani, Judy Y. Yeh, Kunle Odunsi,  and Shohreh Shahabi
18641-18652
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epstein-Barr virus DNA load in chronic lymphocytic leukemia is an independent predictor of clinical course and survival

Epstein-Barr virus DNA load in chronic lymphocytic leukemia is an independent predictor of clinical course and survival

https://doi.org/10.18632/oncotarget.4418

Carlo Visco, Erika Falisi, Ken H. Young, Michela Pascarella, Omar Perbellini, Giuseppe Carli, Elisabetta Novella, Davide Rossi, Ilaria Giaretta, Chiara Cavallini, Maria Teresa Scupoli, Anita De Rossi, Emanuele Stefano Giovanni D’Amore, Mario Rassu, Gianluca Gaidano, Giovanni Pizzolo, Achille Ambrosetti,  and Francesco Rodeghiero
18653-18663
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

The prognosis of hepatocellular carcinoma after curative hepatectomy in young patients

The prognosis of hepatocellular carcinoma after curative hepatectomy in young patients

https://doi.org/10.18632/oncotarget.4330

Sang Yun Ha, Insuk Sohn, Soo Hyun Hwang, Jung Wook Yang,  and Cheol-Keun Park
18664-18673
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High EGFR and low p-Akt expression is associated with better outcome after nimotuzumab-containing treatment in esophageal cancer patients: preliminary clinical result and testable hypothesis

High EGFR and low p-Akt expression is associated with better outcome after nimotuzumab-containing treatment in esophageal cancer patients: preliminary clinical result and testable hypothesis

https://doi.org/10.18632/oncotarget.4367

Chun-yu Wang, Jia-ying Deng, Xu-wei Cai, Xiao-long Fu, Yuan Li, Xiao-yan Zhou, Xiang-hua Wu, Xi-chun Hu, Min Fan, Jia-qing Xiang, Ya-wei Zhang, Hai-quan Chen, Rolando Perez, Guo-liang Jiang,  and Kuai-le Zhao
18674-18682
Abstract  |  PDF  |  HTML  |  Order a Reprint

Efficacy and safety analysis of trastuzumab and paclitaxel based regimen plus carboplatin or epirubicin as neoadjuvant therapy for clinical stage II-III, HER2-positive breast cancer patients: a phase 2, open-label, multicenter, randomized trial

Efficacy and safety analysis of trastuzumab and paclitaxel based regimen plus carboplatin or epirubicin as neoadjuvant therapy for clinical stage II-III, HER2-positive breast cancer patients: a phase 2, open-label, multicenter, randomized trial

https://doi.org/10.18632/oncotarget.4337

Liang Huang, Sheng Chen, Wentao Yang, Binghe Xu, Tao Huang, Hongjian Yang, Hong Zheng, Yongsheng Wang, Erwei Song, Jin Zhang, Shude Cui, Da Pang, Lili Tang, Yutao Lei, Cuizhi Geng,  and Zhiming Shao
18683-18692
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A first-in-human study of AMG 208, an oral MET inhibitor, in adult patients with advanced solid tumors

A first-in-human study of AMG 208, an oral MET inhibitor, in adult patients with advanced solid tumors

https://doi.org/10.18632/oncotarget.4472

David S. Hong, Peter Rosen, A. Craig Lockhart, Siqing Fu, Filip Janku, Razelle Kurzrock, Rabia Khan, Benny Amore, Isaac Caudillo, Hongjie Deng, Yuying C. Hwang, Robert Loberg, Gataree Ngarmchamnanrith, Darrin M. Beaupre,  and Peter Lee
18693-18706
Abstract  |  PDF  |  HTML  |  Order a Reprint

Long-term results of a randomized phase III trial of TPF induction chemotherapy followed by surgery and radiation in locally advanced oral squamous cell carcinoma

Long-term results of a randomized phase III trial of TPF induction chemotherapy followed by surgery and radiation in locally advanced oral squamous cell carcinoma

https://doi.org/10.18632/oncotarget.4531

Lai-ping Zhong, Chen-ping Zhang, Guo-xin Ren, Wei Guo, William N. William Jr, Christopher S. Hong, Jian Sun, Han-guang Zhu, Wen-yong Tu, Jiang Li, Yi-li Cai, Qiu-ming Yin, Li-zhen Wang, Zhong-he Wang, Yong-jie Hu, Tong Ji, Wen-jun Yang, Wei-min Ye, Jun Li, Yue He, Yan-an Wang, Li-qun Xu, Zhengping Zhuang, J. Jack Lee, Jeffrey N. Myers,  and Zhi-yuan Zhang
18707-18714
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Hepatic resection versus transarterial chemoembolization for the initial treatment of hepatocellular carcinoma: A systematic review and meta-analysis

Hepatic resection versus transarterial chemoembolization for the initial treatment of hepatocellular carcinoma: A systematic review and meta-analysis

https://doi.org/10.18632/oncotarget.4134

Xingshun Qi, Diya Wang, Chunping Su, Hongyu Li,  and Xiaozhong Guo
18715-18733
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


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