Oncotarget

Vol 6, No 20

July 20, 2015

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About The Cover

Transcriptional analysis of human mesenchymal stem cells demonstrates changes in stem cell biological response to interleukin-2 upon replicative aging. See Niu et al.

Table of Contents

Editorial

Response to energy depletion: miR-451/AMPK loop

Response to energy depletion: miR-451/AMPK loop

https://doi.org/10.18632/oncotarget.4606

Agnieszka Bronisz, E. Antonio Chiocca,  and Jakub Godlewski
17851-17852
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Mitotic transformation of TRAMM/TrappC12

Mitotic transformation of TRAMM/TrappC12

https://doi.org/10.18632/oncotarget.4843

Miroslav P. Milev,  and Michael Sacher
17853-17854
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Trithorax group genes in hematopoiesis

Trithorax group genes in hematopoiesis

https://doi.org/10.18632/oncotarget.4882

Jennifer Chase, Jolanta Grembecka,  and Ivan Maillard
17855-17856
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Cell therapy - showing cells the way home

Cell therapy - showing cells the way home

https://doi.org/10.18632/oncotarget.4883

Martina Heinelt, Jeffrey M. Karp,  and Oren Levy
17857-17858
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Regulation of the polo kinase during cytokinesis

Regulation of the polo kinase during cytokinesis

https://doi.org/10.18632/oncotarget.4885

David Kachaner
17859-17860
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Repressing the repressor: Fra1 controls plasma cell generation

Repressing the repressor: Fra1 controls plasma cell generation

https://doi.org/10.18632/oncotarget.5015

Dirk Mielenz, Bettina Grötsch,  and Jean-Pierre David
17861-17862
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Editorial: Pathology

Trafficking of lymphocytes into the CNS

Trafficking of lymphocytes into the CNS

https://doi.org/10.18632/oncotarget.5014

Nicholas Schwab, Tilman Schneider-Hohendorf,  and Heinz Wiendl
17863-17864
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Editorial: Chromosome

“CRISPR” validation of recessive brain cancer genes in vivo

“CRISPR” validation of recessive brain cancer genes in vivo

https://doi.org/10.18632/oncotarget.4864

Marc Zuckermann, Daisuke Kawauchi,  and Jan Gronych
17865-17866
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Closing in on life: proximity dependent methods for life sciences

Closing in on life: proximity dependent methods for life sciences

https://doi.org/10.18632/oncotarget.4890

Björn Koos,  and Ola Söderberg
17867-17868
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Regnase-1 and Roquin regulate inflammatory mRNAs

Regnase-1 and Roquin regulate inflammatory mRNAs

https://doi.org/10.18632/oncotarget.4891

Takashi Mino,  and Osamu Takeuchi
17869-17870
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WISp39 and Hsp90: actin' together in cell migration

WISp39 and Hsp90: actin' together in cell migration

https://doi.org/10.18632/oncotarget.4934

Rati Fotedar,  and Robert L. Margolis
17871-17872
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Reviews

RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy

RB1 dual role in proliferation and apoptosis: cell fate control and implications for cancer therapy

https://doi.org/10.18632/oncotarget.4286

Paola Indovina, Francesca Pentimalli, Nadia Casini, Immacolata Vocca,  and Antonio Giordano
17873-17890
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Research Perspectives

Intron-based genomic editing: a highly efficient method for generating knockin zebrafish

Intron-based genomic editing: a highly efficient method for generating knockin zebrafish

https://doi.org/10.18632/oncotarget.4547

Jia Li, Baibing Zhang, Jiwen Bu,  and Jiulin Du
17891-17894
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Priority Research Papers

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma

Point mutations of the mTOR-RHEB pathway in renal cell carcinoma

https://doi.org/10.18632/oncotarget.4963

Arindam P. Ghosh, Christopher B. Marshall, Tatjana Coric, Eun-hee Shim, Richard Kirkman, Mary E. Ballestas, Mitsuhiko Ikura, Mary-Ann Bjornsti,  and Sunil Sudarshan
17895-17910
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Loss of TFF1 promotes Helicobacter pylori-induced β-catenin activation and gastric tumorigenesis

Loss of TFF1 promotes Helicobacter pylori-induced β-catenin activation and gastric tumorigenesis

https://doi.org/10.18632/oncotarget.3772

Mohammed Soutto, Judith Romero-Gallo, Uma Krishna, Blanca M. Piazuelo, Kay M. Washington, Abbes Belkhiri, Richard M. Peek,  and Wael El-Rifai
17911-17922
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Research Papers: Gerotarget (Focus on Aging)

Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice

Mitochondrial morphology is altered in atrophied skeletal muscle of aged mice

https://doi.org/10.18632/oncotarget.4235

Jean-Philippe Leduc-Gaudet, Martin Picard, Félix St-Jean Pelletier, Nicolas Sgarioto, Marie-Joëlle Auger, Joanne Vallée, Richard Robitaille, David H. St-Pierre,  and Gilles Gouspillou
17923-17937
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Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence

Transcriptional profiling of interleukin-2-primed human adipose derived mesenchymal stem cells revealed dramatic changes in stem cells response imposed by replicative senescence

https://doi.org/10.18632/oncotarget.4852

Ping Niu, Aibek Smagul, Lu Wang, Aiman Sadvakas, Ying Sha, Laura M. Pérez, Aliya Nussupbekova, Aday Amirbekov, Akan A. Akanov, Beatriz G. Gálvez, I. King Jordan,  and Victoria V. Lunyak
17938-17957
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Research Papers: Pathology

Elevated Th22 as well as Th17 cells associated with therapeutic outcome and clinical stage are potential targets in patients with multiple myeloma

Elevated Th22 as well as Th17 cells associated with therapeutic outcome and clinical stage are potential targets in patients with multiple myeloma

https://doi.org/10.18632/oncotarget.4641

Min Wang, Ping Chen, Yan Jia, Na He, Daqi Li, Chunyan Ji,  and Daoxin Ma
17958-17967
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Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice

Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice

https://doi.org/10.18632/oncotarget.4956

Amanda M. Goh, Yuezhen Xue, Marc Leushacke, Ling Li, Julin S. Wong, Poh Cheang Chiam, Siti Aishah Binte Rahmat, Michael B. Mann, Karen M. Mann, Nick Barker, Guillermina Lozano, Tamara Terzian,  and David P. Lane
17968-17980
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Research Papers

Identification of TAX2 peptide as a new unpredicted anti-cancer agent

Identification of TAX2 peptide as a new unpredicted anti-cancer agent

https://doi.org/10.18632/oncotarget.4025

Albin Jeanne, Emilie Sick, Jérôme Devy, Nicolas Floquet, Nicolas Belloy, Louis Theret, Camille Boulagnon-Rombi, Marie-Danièle Diebold, Manuel Dauchez, Laurent Martiny, Christophe Schneider,  and Stéphane Dedieu
17981-18000
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Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor

Targeting the sugar metabolism of tumors with a first-in-class 6-phosphofructo-2-kinase (PFKFB4) inhibitor

https://doi.org/10.18632/oncotarget.4534

Jason Chesney, Jennifer Clark, Lilibeth Lanceta, John O. Trent,  and Sucheta Telang
18001-18011
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The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis

The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis

https://doi.org/10.18632/oncotarget.4000

Tzu-Ting Huang, Yueh-Hsin Ping, An-Ming Wang, Chia-Chi Ke, Wen-Liang Fang, Kuo-Hung Huang, Hsin-Chen Lee, Chin-Wen Chi,  and Tien-Shun Yeh
18012-18026
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells

Curcumin suppresses cell growth and invasion and induces apoptosis by down-regulation of Skp2 pathway in glioma cells

https://doi.org/10.18632/oncotarget.4090

Lixia Wang, Xiantao Ye, Xingming Cai, Jingna Su, Renqiang Ma, Xuyuan Yin, Xiuxia Zhou, Huabin Li,  and Zhiwei Wang
18027-18037
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Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis

Torin2 targets dysregulated pathways in anaplastic thyroid cancer and inhibits tumor growth and metastasis

https://doi.org/10.18632/oncotarget.3833

Samira M. Sadowski, Myriem Boufraqech, Lisa Zhang, Amit Mehta, Payal Kapur, Yaqin Zhang, Zhuyin Li, Min Shen,  and Electron Kebebew
18038-18049
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XB130 translocation to microfilamentous structures mediates NNK-induced migration of human bronchial epithelial cells

XB130 translocation to microfilamentous structures mediates NNK-induced migration of human bronchial epithelial cells

https://doi.org/10.18632/oncotarget.3777

Qifei Wu, Jeya Nadesalingam, Serisha Moodley, Xiaohui Bai,  and Mingyao Liu
18050-18065
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Ultra-deep targeted sequencing of advanced oral squamous cell carcinoma identifies a mutation-based prognostic gene signature

Ultra-deep targeted sequencing of advanced oral squamous cell carcinoma identifies a mutation-based prognostic gene signature

https://doi.org/10.18632/oncotarget.3768

Shu-Jen Chen, Hsuan Liu, Chun-Ta Liao, Po-Jung Huang, Yi Huang, Ann Hsu, Petrus Tang, Yu-Sun Chang, Hua-Chien Chen,  and Tzu-Chen Yen
18066-18080
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lymphatic dysfunction attenuates tumor immunity through impaired antigen presentation

Lymphatic dysfunction attenuates tumor immunity through impaired antigen presentation

https://doi.org/10.18632/oncotarget.4018

Takayuki Kimura, Makoto Sugaya, Tomonori Oka, Andrew Blauvelt, Hitoshi Okochi,  and Shinichi Sato
18081-18093
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rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis

rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis

https://doi.org/10.18632/oncotarget.4093

Sandeep S. Negi,  and Patrick Brown
18094-18104
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of ATRX, associated with DNA methylation pattern of chromosome end, impacted biological behaviors of astrocytic tumors

Loss of ATRX, associated with DNA methylation pattern of chromosome end, impacted biological behaviors of astrocytic tumors

https://doi.org/10.18632/oncotarget.3906

Jinquan Cai, Jing Chen, Wei Zhang, Pei Yang, Chuanbao Zhang, Mingyang Li, Kun Yao, Hongjun Wang, Qingbin Li, Chuanlu Jiang,  and Tao Jiang
18105-18115
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion

Discovery of new small molecules inhibiting 67 kDa laminin receptor interaction with laminin and cancer cell invasion

https://doi.org/10.18632/oncotarget.4016

Ada Pesapane, Carmen Di Giovanni, Francesca Wanda Rossi, Daniela Alfano, Luigi Formisano, Pia Ragno, Carmine Selleri, Nunzia Montuori,  and Antonio Lavecchia
18116-18133
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Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion

Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion

https://doi.org/10.18632/oncotarget.4017

Claudio Pulito, Federica Mori, Andrea Sacconi, Luca Casadei, Maria Ferraiuolo, Maria Cristina Valerio, Raffaela Santoro, Frauke Goeman, Anna Maidecchi, Luisa Mattoli, Cesare Manetti, Silvia Di Agostino, Paola Muti, Giovanni Blandino,  and Sabrina Strano
18134-18150
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Clinical Research Papers

Optimal adjuvant therapy for resected hepatocellular carcinoma: a systematic review with network meta-analysis

Optimal adjuvant therapy for resected hepatocellular carcinoma: a systematic review with network meta-analysis

https://doi.org/10.18632/oncotarget.4098

Gui-Qi Zhu, Ke-Qing Shi, Hua-Jian Yu, Sun-Yue He, Martin Braddock, Meng-Tao Zhou, Yong-Ping Chen,  and Ming-Hua Zheng
18151-18161
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Erlotinib is effective in pancreatic cancer with epidermal growth factor receptor mutations: a randomized, open-label, prospective trial

Erlotinib is effective in pancreatic cancer with epidermal growth factor receptor mutations: a randomized, open-label, prospective trial

https://doi.org/10.18632/oncotarget.4216

Jack P. Wang, Chen-Yi Wu, Yi-Cheng Yeh, Yi-Ming Shyr, Ying-Ying Wu, Chen-Yu Kuo, Yi-Ping Hung, Ming-Huang Chen, Wei-Ping Lee, Jiing-Chyuan Luo, Yee Chao,  and Chung-Pin Li
18162-18173
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Progesterone receptor loss identifies luminal-type local advanced breast cancer with poor survival in patients who fail to achieve a pathological complete response to neoadjuvant chemotherapy

Progesterone receptor loss identifies luminal-type local advanced breast cancer with poor survival in patients who fail to achieve a pathological complete response to neoadjuvant chemotherapy

https://doi.org/10.18632/oncotarget.4225

Sheng Chen, Liang Huang, Can-Ming Chen,  and Zhi-Ming Shao
18174-18182
Abstract  |  PDF  |  HTML  |  Order a Reprint

Dose coverage of axillary level I-III areas during whole breast irradiation with simplified intensity modulated radiation therapy in early stage breast cancer patients

Dose coverage of axillary level I-III areas during whole breast irradiation with simplified intensity modulated radiation therapy in early stage breast cancer patients

https://doi.org/10.18632/oncotarget.4301

Li Zhang, Zhao-zhi Yang, Xing-xing Chen, Jeffrey Tuan, Jin-li Ma, Xin Mei, Xiao-li Yu, Zhi-rui Zhou, Zhi-min Shao, Guang-yu Liu,  and Xiao-mao Guo
18183-18191
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Phase I/II clinical trial of dendritic-cell based immunotherapy (DCVAC/PCa) combined with chemotherapy in patients with metastatic, castration-resistant prostate cancer

Phase I/II clinical trial of dendritic-cell based immunotherapy (DCVAC/PCa) combined with chemotherapy in patients with metastatic, castration-resistant prostate cancer

https://doi.org/10.18632/oncotarget.4145

Michal Podrazil, Rudolf Horvath, Etienne Becht, Daniela Rozkova, Pavla Bilkova, Hana Hromadkova, Jana Kayserova, Katerina Vavrova, Jan Lastovicka, Petra Vrabcova, Katerina Kubackova, Zdenka Gasova, Ladislav Jarolim, Marek Babjuk, Radek Spisek, Jirina Bartunkova,  and Jitka Fucikova
18192-18205
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Are VEGFR-TKIs effective or safe for patients with advanced non-small cell lung cancer?

Are VEGFR-TKIs effective or safe for patients with advanced non-small cell lung cancer?

https://doi.org/10.18632/oncotarget.4524

Shuai Wang, Zhe Yang,  and Zhou Wang
18206-18223
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity

Targeted next generation sequencing of parotid gland cancer uncovers genetic heterogeneity

https://doi.org/10.18632/oncotarget.4015

Inga Grünewald, Claudia Vollbrecht, Jeannine Meinrath, Moritz F. Meyer, Lukas C. Heukamp, Uta Drebber, Alexander Quaas, Dirk Beutner, Karl-Bernd Hüttenbrink, Eva Wardelmann, Wolfgang Hartmann, Reinhard Büttner, Margarete Odenthal,  and Markus Stenner
18224-18237
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