Oncotarget

Vol 6, No 17

June 20, 2015

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About The Cover

Immunofluorescence confocal microscopy for FA-dependent human glioblastoma cell U87EGFRvIII targeting in vitro RNP (FA-free Alexa647-pRNA-3WJ). See Lee et al.

Table of Contents

Editorial

Efferocytosis: Burying cell corpses to regulate tolerance and immunity

Efferocytosis: Burying cell corpses to regulate tolerance and immunity

DOI: 10.18632/oncotarget.4402

Maziar Divangahi
14721-14722
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Reversing stem cell aging

Reversing stem cell aging

DOI: 10.18632/oncotarget.4403

Jiyung Shin, Mary Mohrin,  and Danica Chen
14723-14724
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Catalytically inactive telomerase in oncogenesis

Catalytically inactive telomerase in oncogenesis

DOI: 10.18632/oncotarget.4404

Vinay Tergaonkar
14725-14726
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Ubiquitin regulates dissociation of DNA repair factors from chromatin

Ubiquitin regulates dissociation of DNA repair factors from chromatin

DOI: 10.18632/oncotarget.4410

Petra Beli,  and Stephen P. Jackson
14727-14728
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ATM in senescence

ATM in senescence

DOI: 10.18632/oncotarget.4411

Katherine M. Aird,  and Rugang Zhang
14729-14730
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Peptide-siRNA nanotherapeutics in arthritis

Peptide-siRNA nanotherapeutics in arthritis

DOI: 10.18632/oncotarget.4439

Christine T.N. Pham, Hua Pan,  and Samuel A. Wickline
14731-14732
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Heme oxygenase-1: for better, for worse, in sickness and in health

Heme oxygenase-1: for better, for worse, in sickness and in health

DOI: 10.18632/oncotarget.4440

María Emilia Solano,  and Petra Clara Arck
14733-14734
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Reviews

Thyroid hormone and anti-apoptosis in tumor cells

Thyroid hormone and anti-apoptosis in tumor cells

DOI: 10.18632/oncotarget.4023

Hung-Yun Lin, Gennadi V. Glinsky, Shaker A. Mousa,  and Paul J. Davis
14735-14743
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Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies

Genetic heterogeneity in cholangiocarcinoma: a major challenge for targeted therapies

DOI: 10.18632/oncotarget.4539

Giovanni Brandi, Andrea Farioli, Annalisa Astolfi, Guido Biasco,  and Simona Tavolari
14744-14753
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Priority Research Papers

AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer

AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer

DOI: 10.18632/oncotarget.4474

Teraneh Z. Jhaveri, Juhyung Woo, Xiaobin Shang, Ben Ho Park,  and Edward Gabrielson
14754-14765
Abstract  |   PDF  |  HTML  |  Order a Reprint

RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model

RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model

DOI: 10.18632/oncotarget.3632

Tae Jin Lee, Farzin Haque, Dan Shu, Ji Young Yoo, Hui Li, Robert A. Yokel, Craig Horbinski, Tae Hyong Kim, Sung-Hak Kim, Chang-Hyuk Kwon, Ichiro Nakano, Balveen Kaur, Peixuan Guo,  and Carlo M. Croce
14766-14776
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

DOI: 10.18632/oncotarget.4401

Arianna De Luca, Marco Fiorillo, Maria Peiris-Pagès, Bela Ozsvari, Duncan L. Smith, Rosa Sanchez-Alvarez, Ubaldo E. Martinez-Outschoorn, Anna Rita Cappello, Vincenzo Pezzi, Michael P. Lisanti,  and Federica Sotgia
14777-14795
Abstract  |   PDF  |  HTML  |  Order a Reprint

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline

Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline

DOI: 10.18632/oncotarget.4193

Mary Pulvino, Luojing Chen, David Oleksyn, Jing Li, George Compitello, Randy Rossi, Stephen Spence, Vijaya Balakrishnan, Craig Jordan, Brian Poligone, Carla Casulo, Richard Burack, Joel L. Shapiro, Steven Bernstein, Jonathan W. Friedberg, Raymond J. Deshaies, Hartmut Land,  and Jiyong Zhao
14796-14813
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models

KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models

DOI: 10.18632/oncotarget.4530

Irene Riz, Teresa S. Hawley,  and Robert G. Hawley
14814-14831
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Pathology

The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo

The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo

DOI: 10.18632/oncotarget.4024

Johnny Suijker, Hans J. Baelde, Helene Roelofs, Anne-Marie Cleton-Jansen,  and Judith V.M.G. Bovée
14832-14842
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Gerotarget (Focus on Aging)

VGF expression by T lymphocytes in patients with Alzheimer’s disease

VGF expression by T lymphocytes in patients with Alzheimer’s disease

DOI: 10.18632/oncotarget.3569

Stefan Busse, Johann Steiner, Sarah Glorius, Henrik Dobrowolny, Sabrina Greiner-Bohl, Christian Mawrin, Ursula Bommhardt, Roland Hartig, Bernhard Bogerts,  and Mandy Busse
14843-14851
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Genomic instability and cellular stress in organ biopsies and peripheral blood lymphocytes from patients with colorectal cancer and predisposing pathologies

Genomic instability and cellular stress in organ biopsies and peripheral blood lymphocytes from patients with colorectal cancer and predisposing pathologies

DOI: 10.18632/oncotarget.4032

Sara Lombardi, Ilenia Fuoco, Giorgia di Fluri, Francesco Costa, Angelo Ricchiuti, Graziano Biondi, Vincenzo Nardini,  and Roberto Scarpato
14852-14864
Abstract  |   PDF  |  HTML  |  Order a Reprint

Prevalence and predictive factors of osteoporosis in systemic sclerosis patients: a case-control study

Prevalence and predictive factors of osteoporosis in systemic sclerosis patients: a case-control study

DOI: 10.18632/oncotarget.3806

Mathilde Marot, Antoine Valéry, Eric Esteve, Guido Bens, Adelheid Müller, Stéphanie Rist, Hechmi Toumi,  and Eric Lespessailles
14865-14873
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Zinc finger factor 521 enhances adipogenic differentiation of mouse multipotent cells and human bone marrow mesenchymal stem cells

Zinc finger factor 521 enhances adipogenic differentiation of mouse multipotent cells and human bone marrow mesenchymal stem cells

DOI: 10.18632/oncotarget.3900

Kuo-Yun Tseng,  and Shankung Lin
14874-14884
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers

Mitochondrial fission determines cisplatin sensitivity in tongue squamous cell carcinoma through the BRCA1–miR-593-5p–MFF axis

Mitochondrial fission determines cisplatin sensitivity in tongue squamous cell carcinoma through the BRCA1–miR-593-5p–MFF axis

DOI: 10.18632/oncotarget.3659

Song Fan, Bodu Liu, Lijuan Sun, Xiao-bin Lv, Zhaoyu Lin, Weixiong Chen, Weiliang Chen, Qionglan Tang, Youyuan Wang, Yuxiong Su, Shaowen Jin, Daming Zhang, Jianglong Zhong, Yilin Li, Bin Wen, Zhang Zhang, Pu Yang, Bin Zhou, Qixiang Liang, Xing Yu, Yinghua Zhu, Pengnan Hu, Junjun Chu, Wei Huang, Yuhuan Feng, Hongzhuang Peng, Qihong Huang, Erwei Song,  and Jinsong Li
14885-14904
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Human bone marrow niche chemoprotection mediated by cytochrome P450 enzymes

Human bone marrow niche chemoprotection mediated by cytochrome P450 enzymes

DOI: 10.18632/oncotarget.3614

Salvador Alonso, Meng Su, Jace W. Jones, Sudipto Ganguly, Maureen A. Kane, Richard J. Jones,  and Gabriel Ghiaur
14905-14912
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer

Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer

DOI: 10.18632/oncotarget.3818

Hao Liu, Yixue Gu, Hongsheng Wang, Jiang Yin, Guopei Zheng, Zhijie Zhang, Minyin Lu, Chenkun Wang,  and Zhimin He
14913-14925
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer

Cyclin-dependent kinase inhibitor dinaciclib potently synergizes with cisplatin in preclinical models of ovarian cancer

DOI: 10.18632/oncotarget.3717

Xiu-Xiu Chen, Feng-Feng Xie, Xiu-Jie Zhu, Feng Lin, Shi-Shi Pan, Li-Hua Gong, Jian-Ge Qiu, Wen-Ji Zhang, Qi-Wei Jiang, Xiao-Long Mei, You-Qiu Xue, Wu-Ming Qin, Zhi Shi,  and Xiao-Jian Yan
14926-14939
Abstract  |   PDF  |  HTML  |  Order a Reprint

Foretinib inhibits angiogenesis, lymphangiogenesis and tumor growth of pancreatic cancer in vivo by decreasing VEGFR-2/3 and TIE-2 signaling

Foretinib inhibits angiogenesis, lymphangiogenesis and tumor growth of pancreatic cancer in vivo by decreasing VEGFR-2/3 and TIE-2 signaling

DOI: 10.18632/oncotarget.3613

Hsiu-Mei Chen, Chia-Hua Tsai,  and Wen-Chun Hung
14940-14952
Abstract  |   PDF  |  HTML  |  Order a Reprint

Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms

Targeting Notch1 and proteasome as an effective strategy to suppress T-cell lymphoproliferative neoplasms

DOI: 10.18632/oncotarget.3621

Lujun Yang, Shuangfeng Zhang, Suraj Konnath George, Rong Teng, Xuefen You, Mengqi Xu, Hong Liu, Xiaoping Sun, Hesham M. Amin,  and Wenyu Shi
14953-14969
Abstract  |   PDF  |  HTML  |  Order a Reprint

Essential role for cyclic-AMP responsive element binding protein 1 (CREB) in the survival of acute lymphoblastic leukemia

Essential role for cyclic-AMP responsive element binding protein 1 (CREB) in the survival of acute lymphoblastic leukemia

DOI: 10.18632/oncotarget.3911

Naomi E. van der Sligte, Kim R. Kampen, Arja ter Elst, Frank J.G. Scherpen, Tiny G.J. Meeuwsen-de Boer, Victor Guryev, Frank N. van Leeuwen, Steven M. Kornblau,  and Eveline S.J.M. de Bont
14970-14981
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RRAD inhibits the Warburg effect through negative regulation of the NF-κB signaling

RRAD inhibits the Warburg effect through negative regulation of the NF-κB signaling

DOI: 10.18632/oncotarget.3719

Juan Liu, Cen Zhang, Rui Wu, Meihua Lin, Yingjian Liang, Jia Liu, Xiaolong Wang, Bo Yang,  and Zhaohui Feng
14982-14992
Abstract  |   PDF  |  HTML  |  Order a Reprint

MicroRNA-451 regulates stemness of side population cells via PI3K/Akt/mTOR signaling pathway in multiple myeloma

MicroRNA-451 regulates stemness of side population cells via PI3K/Akt/mTOR signaling pathway in multiple myeloma

DOI: 10.18632/oncotarget.3802

Juan Du, Shuyan Liu, Jie He, Xi Liu, Ying Qu, Wenqing Yan, Jianling Fan, Rong Li, Hao Xi, Weijun Fu, Chunyang Zhang, Jing Yang,  and Jian Hou
14993-15007
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression

PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression

DOI: 10.18632/oncotarget.3634

Germano Mariano, Maria Rosaria Ricciardi, Daniela Trisciuoglio, Michele Zampieri, Fabio Ciccarone, Tiziana Guastafierro, Roberta Calabrese, Elisabetta Valentini, Agostino Tafuri, Donatella Del Bufalo, Paola Caiafa,  and Anna Reale
15008-15021
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer

Fibulin-5 inhibits Wnt/β-catenin signaling in lung cancer

DOI: 10.18632/oncotarget.3609

Xiaojun Chen, Xiaomeng Song, Wen Yue, Dongshi Chen, Jian Yu, Zhi Yao,  and Lin Zhang
15022-15034
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-21 plays an oncogenic role by targeting FOXO1 and activating the PI3K/AKT pathway in diffuse large B-cell lymphoma

MicroRNA-21 plays an oncogenic role by targeting FOXO1 and activating the PI3K/AKT pathway in diffuse large B-cell lymphoma

DOI: 10.18632/oncotarget.3729

Heounjeong Go, Ji-Young Jang, Pil-Jong Kim, Young-Goo Kim, Soo Jeong Nam, Jin Ho Paik, Tae Min Kim, Dae Seog Heo, Chul-Woo Kim,  and Yoon Kyung Jeon
15035-15049
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Thyroid hormone-mediated regulation of lipocalin 2 through the Met/FAK pathway in liver cancer

Thyroid hormone-mediated regulation of lipocalin 2 through the Met/FAK pathway in liver cancer

DOI: 10.18632/oncotarget.3670

I-Hsiao Chung, Cheng-Yi Chen, Yang-Hsiang Lin, Hsiang-Cheng Chi, Pei-ju Tai, Chia-Jung Liao, Chung-Ying Tsai, Syuan-Ling Lin, Meng-Han Wu, Ching-Ying Chen,  and Kwang-Huei Lin
15050-15064
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer

HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer

DOI: 10.18632/oncotarget.3527

Hanna Styczen, Iris Nagelmeier, Tim Beissbarth, Manuel Nietert, Kia Homayounfar, Thilo Sprenger, Ute Boczek, Kathrin Stanek, Julia Kitz, Hendrik A. Wolff, Michael B. Ghadimi, Peter Middel, Torsten Liersch, Josef Rüschoff,  and Lena-Christin Conradi
15065-15076
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis

Loss of CX3CR1 increases accumulation of inflammatory monocytes and promotes gliomagenesis

DOI: 10.18632/oncotarget.3730

Xi Feng, Frank Szulzewsky, Alexan Yerevanian, Zhihong Chen, David Heinzmann, Rikke Darling Rasmussen, Virginia Alvarez-Garcia, Yeonghwan Kim, Bingcheng Wang, Ilaria Tamagno, Hao Zhou, Xiaoxia Li, Helmut Kettenmann, Richard M. Ransohoff,  and Dolores Hambardzumyan
15077-15094
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Upregulation of spondin-2 predicts poor survival of colorectal carcinoma patients

Upregulation of spondin-2 predicts poor survival of colorectal carcinoma patients

DOI: 10.18632/oncotarget.3822

Qian Zhang, Xiao-Qing Wang, Jie Wang, Shu-Jian Cui, Xiao-Min Lou, Bing Yan, Jie Qiao, Ying-Hua Jiang, Li-Jun Zhang, Peng-Yuan Yang,  and Feng Liu
15095-15110
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue

Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue

DOI: 10.18632/oncotarget.3615

Ying Gu, Hong Zhou, Yichao Gan, Jiawei Zhang, Jianghua Chen, Xiaoxian Gan, Hongzhi Li, Weiwei Zheng, Zhipeng Meng, Xiaoxiao Ma, Xichun Wang, Xiaohua Xu, Ganyu Xu, Xiaoya Lu, Yun Liang, Xuzhao Zhang, Xinliang Lu, Wendong Huang,  and Rongzhen Xu
15111-15121
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Irreversible dual inhibitory mode: the novel Btk inhibitor PLS-123 demonstrates promising anti-tumor activity in human B-cell lymphoma

Irreversible dual inhibitory mode: the novel Btk inhibitor PLS-123 demonstrates promising anti-tumor activity in human B-cell lymphoma

DOI: 10.18632/oncotarget.3824

Ning Ding, Xitao Li, Yunfei Shi, Lingyan Ping, Lina Wu, Kai Fu, Lixia Feng, Xiaohui Zheng, Yuqin Song, Zhengying Pan,  and Jun Zhu
15122-15136
Abstract  |   PDF  |  HTML  |  Order a Reprint

Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN

Silencing of PMEPA1 accelerates the growth of prostate cancer cells through AR, NEDD4 and PTEN

DOI: 10.18632/oncotarget.3526

Hua Li, Ahmed A. Mohamed, Shashwat Sharad, Elizabeth Umeda, Yingjie Song, Denise Young, Gyorgy Petrovics, David G. McLeod, Isabell A. Sesterhenn, Taduru Sreenath, Albert Dobi,  and Shiv Srivastava
15137-15149
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Insulin-like growth factor binding protein-3 inhibits cell adhesion via suppression of integrin β4 expression

Insulin-like growth factor binding protein-3 inhibits cell adhesion via suppression of integrin β4 expression

DOI: 10.18632/oncotarget.3825

Hyo-Jong Lee, Ji-Sun Lee, Su Jung Hwang,  and Ho-Young Lee
15150-15163
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MMP3-mediated tumor progression is controlled transcriptionally by a novel IRF8-MMP3 interaction

MMP3-mediated tumor progression is controlled transcriptionally by a novel IRF8-MMP3 interaction

DOI: 10.18632/oncotarget.3897

Debarati Banik, Colleen S. Netherby, Paul N. Bogner,  and Scott I. Abrams
15164-15179
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Upregulation of miR-572 transcriptionally suppresses SOCS1 and p21 and contributes to human ovarian cancer progression

Upregulation of miR-572 transcriptionally suppresses SOCS1 and p21 and contributes to human ovarian cancer progression

DOI: 10.18632/oncotarget.3737

Xin Zhang, Junling Liu, Dan Zang, Shu Wu, Aibin Liu, Jinrong Zhu, Geyan Wu, Jun Li,  and Lili Jiang
15180-15193
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Elevated MARCKS phosphorylation contributes to unresponsiveness of breast cancer to paclitaxel treatment

Elevated MARCKS phosphorylation contributes to unresponsiveness of breast cancer to paclitaxel treatment

DOI: 10.18632/oncotarget.3827

Ching-Hsien Chen, Chun-Ting Cheng, Yuan Yuan, Jing Zhai, Muhammad Arif, Lon Wolf R. Fong, Reen Wu,  and David K. Ann
15194-15208
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Accelerated hepatocellular carcinoma development in CUL4B transgenic mice

Accelerated hepatocellular carcinoma development in CUL4B transgenic mice

DOI: 10.18632/oncotarget.3829

Jupeng Yuan, Baichun Jiang, Aizhen Zhang, Yanyan Qian, Haining Tan, Jiangang Gao, Changshun Shao,  and Yaoqin Gong
15209-15221
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by targeting ZEB2 and MACC1/Met/Akt signaling

MiR-338-3p inhibits epithelial-mesenchymal transition in gastric cancer cells by targeting ZEB2 and MACC1/Met/Akt signaling

DOI: 10.18632/oncotarget.3835

Na Huang, Zhenzhen Wu, Li Lin, Minyu Zhou, Lin Wang, Huanrong Ma, Jianling Xia, Jianping Bin, Yulin Liao,  and Wangjun Liao
15222-15234
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma

Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma

DOI: 10.18632/oncotarget.3837

Britt Lauenborg, Louise Christensen, Ulrik Ralfkiaer, Katharina L. Kopp, Lars Jønson, Sally Dabelsteen, Charlotte M. Bonefeld, Carsten Geisler, Lise Mette R. Gjerdrum, Qian Zhang, Mariusz A. Wasik, Elisabeth Ralfkiaer, Niels Ødum,  and Anders Woetmann
15235-15249
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors

The c-Jun/RHOB/AKT pathway confers resistance of BRAF-mutant melanoma cells to MAPK inhibitors

DOI: 10.18632/oncotarget.3888

Audrey Delmas, Julia Cherier, Magdalena Pohorecka, Claire Medale-Giamarchi, Nicolas Meyer, Anne Casanova, Olivier Sordet, Laurence Lamant, Ariel Savina, Anne Pradines,  and Gilles Favre
15250-15264
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2’-deoxycytidine in human leukemic KG1 cells

Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2’-deoxycytidine in human leukemic KG1 cells

DOI: 10.18632/oncotarget.3317

Stéphane Vispé, Arthur Deroide, Emeline Davoine, Cécile Desjobert, Fabrice Lestienne, Lucie Fournier, Natacha Novosad, Sophie Bréand, Jérôme Besse, Florence Busato, Jörg Tost, Luc De Vries, Didier Cussac, Joëlle Riond,  and Paola B. Arimondo
15265-15282
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Selective killing of breast cancer cells expressing activated CD44 using CD44 ligand-coated nanoparticles in vitro and in vivo

Selective killing of breast cancer cells expressing activated CD44 using CD44 ligand-coated nanoparticles in vitro and in vivo

DOI: 10.18632/oncotarget.3681

Cuixia Yang, Yiqing He, Huizhen Zhang, Yiwen Liu, Wenjuan Wang, Yan Du,  and Feng Gao
15283-15296
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion

A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion

DOI: 10.18632/oncotarget.3812

Amanda M. Butler, Michele L. Scotti Buzhardt, Eda Erdogan, Shuhua Li, Kristin S. Inman, Alan P. Fields,  and Nicole R. Murray
15297-15310
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population

Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population

DOI: 10.18632/oncotarget.3840

Chao Yang, Ran Tang, Xiang Ma, Younan Wang, Dakui Luo, Zekuan Xu, Yi Zhu,  and Li Yang
15311-15320
Abstract  |   PDF  |  HTML  |  Order a Reprint

Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells

Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells

DOI: 10.18632/oncotarget.4148

Nitu Bansal, Prasun J. Mishra, Mark Stein, Robert S. DiPaola,  and Joseph R. Bertino
15321-15331
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo

Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo

DOI: 10.18632/oncotarget.3684

Chetna Sharon, Somesh Baranwal, Nirmita J. Patel, Daniel Rodriguez-Agudo, William M. Pandak, Adhip P. N. Majumdar, Geoffrey Krystal,  and Bhaumik B. Patel
15332-15347
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer

Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer

DOI: 10.18632/oncotarget.3610

Meichun Hu, Shihong Peng, Yundong He, Min Qin, Xiaonan Cong, Yajing Xing, Mingyao Liu,  and Zhengfang Yi
15348-15361
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The intrinsic stiffness of human trabecular meshwork cells increases with senescence

The intrinsic stiffness of human trabecular meshwork cells increases with senescence

DOI: 10.18632/oncotarget.3798

Joshua T. Morgan, Vijay Krishna Raghunathan, Yow-Ren Chang, Christopher J. Murphy,  and Paul Russell
15362-15374
Abstract  |   PDF  |  HTML  |  Order a Reprint

Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes

Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes

DOI: 10.18632/oncotarget.3801

Shivakumar Keerthikumar, Lahiru Gangoda, Michael Liem, Pamali Fonseka, Ishara Atukorala, Cemil Ozcitti, Adam Mechler, Christopher G. Adda, Ching-Seng Ang,  and Suresh Mathivanan
15375-15396
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TR4 nuclear receptor increases prostate cancer invasion via decreasing the miR-373-3p expression to alter TGFβR2/p-Smad3 signals

TR4 nuclear receptor increases prostate cancer invasion via decreasing the miR-373-3p expression to alter TGFβR2/p-Smad3 signals

DOI: 10.18632/oncotarget.3778

Xiaofu Qiu, Jin Zhu, Yin Sun, Kun Fan, Dong-Rong Yang, Gonghui Li, Guosheng Yang,  and Chawnshang Chang
15397-15409
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Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma

Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myeloma

DOI: 10.18632/oncotarget.3795

Prahlad V. Raninga, Giovanna Di Trapani, Slavica Vuckovic, Maneet Bhatia,  and Kathryn F. Tonissen
15410-15424
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Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors

Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors

DOI: 10.18632/oncotarget.3908

Melanie Schwermer, Sangkyun Lee, Johannes Köster, Tom van Maerken, Harald Stephan, Angelika Eggert, Katharina Morik, Johannes H. Schulte,  and Alexander Schramm
15425-15435
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OVOL guides the epithelial-hybrid-mesenchymal transition

OVOL guides the epithelial-hybrid-mesenchymal transition

DOI: 10.18632/oncotarget.3623

Dongya Jia, Mohit Kumar Jolly, Marcelo Boareto, Princy Parsana, Steven M. Mooney, Kenneth J. Pienta, Herbert Levine,  and Eshel Ben-Jacob
15436-15448
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DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol

DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol

DOI: 10.18632/oncotarget.3913

Magdalena Gorska, Alicja Kuban-Jankowska, Michal Zmijewski, Antonella Marino Gammazza, Francesco Cappello, Maciej Wnuk, Monika Gorzynik, Iwona Rzeszutek, Agnieszka Daca, Anna Lewinska,  and Michal Wozniak
15449-15463
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Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients’ cells

Cannabinoid receptor CB1 regulates STAT3 activity and its expression dictates the responsiveness to SR141716 treatment in human glioma patients’ cells

DOI: 10.18632/oncotarget.3895

Elena Ciaglia, Giovanni Torelli, Simona Pisanti, Paola Picardi, Alba D’Alessandro, Chiara Laezza, Anna Maria Malfitano, Donatella Fiore, Antonio Christian Pagano Zottola, Maria Chiara Proto, Giuseppe Catapano, Patrizia Gazzerro,  and Maurizio Bifulco
15464-15481
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells but scarcely by microglia

Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells but scarcely by microglia

DOI: 10.18632/oncotarget.3855

Eva Rietkötter, Annalen Bleckmann, Michaela Bayerlová, Kerstin Menck, Han-Ning Chuang, Britta Wenske, Hila Schwartz, Neta Erez, Claudia Binder, Uwe-Karsten Hanisch,  and Tobias Pukrop
15482-15493
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Trametinib modulates cancer multidrug resistance by targeting ABCB1 transporter

Trametinib modulates cancer multidrug resistance by targeting ABCB1 transporter

DOI: 10.18632/oncotarget.3820

Jian-Ge Qiu, Yao-Jun Zhang, Yong Li, Jin-Ming Zhao, Wen-Ji Zhang, Qi-Wei Jiang, Xiao-Long Mei, You-Qiu Xue, Wu-Ming Qin, Yang Yang, Di-Wei Zheng, Yao Chen, Meng-Ning Wei,  and Zhi Shi
15494-15509
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma

MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma

DOI: 10.18632/oncotarget.3732

Diana T. Lau, Claudia L. Flemming, Samuele Gherardi, Giovanni Perini, André Oberthuer, Matthias Fischer, Dilafruz Juraeva, Benedikt Brors, Chengyuan Xue, Murray D. Norris, Glenn M. Marshall, Michelle Haber, Jamie I. Fletcher,  and Lesley J. Ashton
15510-15523
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Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression

Targeting pancreatitis blocks tumor-initiating stem cells and pancreatic cancer progression

DOI: 10.18632/oncotarget.3499

Altaf Mohammed, Naveena B. Janakiram, Venkateshwar Madka, Misty Brewer, Rebekah L. Ritchie, Stan Lightfoot, Gaurav Kumar, Michael Sadeghi, Jagan Mohan R. Patlolla, Hiroshi Y. Yamada, Zobeida Cruz-Monserrate, Randal May, Courtney W. Houchen, Vernon E. Steele,  and Chinthalapally V. Rao
15524-15539
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Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70

Anchoring of both PKA-RIIα and 14-3-3θ regulates retinoic acid induced 16 mediated phosphorylation of heat shock protein 70

DOI: 10.18632/oncotarget.3702

Cui-Ling Ding, Gang Xu, Hai-Lin Tang, Shi-Ying Zhu, Lan-Juan Zhao, Hao Ren, Ping Zhao, Zhong-Tian Qi,  and Wen Wang
15540-15550
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance

Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance

DOI: 10.18632/oncotarget.3902

Jesús García-Cano, Gorbatchev Ambroise, Raquel Pascual-Serra, M Carmen Carrión, Leticia Serrano-Oviedo, Marta Ortega-Muelas, Francisco J. Cimas, Sebastià Sabater, María José Ruiz-Hidalgo, Isabel Sanchez Perez, Antonio Mas, Félix A. Jalón, Aimé Vazquez,  and Ricardo Sánchez-Prieto
15551-15565
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Gap junctions modulate glioma invasion by direct transfer of microRNA

Gap junctions modulate glioma invasion by direct transfer of microRNA

DOI: 10.18632/oncotarget.3904

Xiaoting Hong, Wun Chey Sin, Andrew L. Harris,  and Christian C. Naus
15566-15577
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy

Short-term expansion of breast circulating cancer cells predicts response to anti-cancer therapy

DOI: 10.18632/oncotarget.3903

Bee Luan Khoo, Soo Chin Lee, Prashant Kumar, Tuan Zea Tan, Majid Ebrahimi Warkiani, Samuel GW Ow, Sayantani Nandi, Chwee Teck Lim,  and Jean Paul Thiery
15578-15593
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PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion

PBK/TOPK enhances aggressive phenotype in prostate cancer via β-catenin-TCF/LEF-mediated matrix metalloproteinases production and invasion

DOI: 10.18632/oncotarget.3709

Joshua D. Brown-Clay, Deepika N. Shenoy, Olga Timofeeva, Bhaskar V. Kallakury, Asit K. Nandi,  and Partha P. Banerjee
15594-15609
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Enolase-1 is a therapeutic target in endometrial carcinoma

Enolase-1 is a therapeutic target in endometrial carcinoma

DOI: 10.18632/oncotarget.3639

Mengyang Zhao, Weiyi Fang, Yan Wang, Suiqun Guo, Luyun Shu, Lijing Wang, YiYu Chen, Qiaofen Fu, Yan Liu, Shengni Hua, Yue Fan, Yiyi Liu, Xiaojie Deng, Rongcheng Luo, Zhong Mei, Qinping Jiang,  and Zhen Liu
15610-15627
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ccdc6 knock-in mice develop thyroid hyperplasia associated to an enhanced CREB1 activity

Ccdc6 knock-in mice develop thyroid hyperplasia associated to an enhanced CREB1 activity

DOI: 10.18632/oncotarget.3858

Vincenza Leone, Concetta Langella, Francesco Esposito, Claudio Arra, Giuseppe Palma, Domenica Rea, Orlando Paciello, Francesco Merolla, Davide De Biase, Serenella Papparella, Angela Celetti,  and Alfredo Fusco
15628-15638
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Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model

Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model

DOI: 10.18632/oncotarget.3712

Jiahua Jiang, Daisy Dandan Wang, Mengmeng Yang, Dawei Chen, Liang Pang, Sheng Guo, Jie Cai, Jean-Pierre Wery, Linda Li, Henry Qixiang Li,  and Peter Ping Lin
15639-15651
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Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells

Metformin-induced energy deficiency leads to the inhibition of lipogenesis in prostate cancer cells

DOI: 10.18632/oncotarget.3404

Camille Loubière, Thomas Goiran, Kathiane Laurent, Zied Djabari, Jean-François Tanti,  and Frédéric Bost
15652-15661
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Clinical Research Papers

Prognostic value of a 92-probe signature in breast cancer

Prognostic value of a 92-probe signature in breast cancer

DOI: 10.18632/oncotarget.3525

Salima Akter, Tae Gyu Choi, Minh Nam Nguyen, Abel Matondo, Jin-Hwan Kim, Yong Hwa Jo, Ara Jo, Muhammad Shahid, Dae Young Jun, Ji Youn Yoo, Yen Ngoc Nguyen Ngo, Seong-Wook Seo, Liaquat Ali, Ju-Seog Lee, Kyung-Sik Yoon, Wonchae Choe, Insug Kang, Joohun Ha, Jayoung Kim,  and Sung Soo Kim
15662-15680
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RAS testing in metastatic colorectal cancer: excellent reproducibility amongst 17 Dutch pathology centers

RAS testing in metastatic colorectal cancer: excellent reproducibility amongst 17 Dutch pathology centers

DOI: 10.18632/oncotarget.3804

Annemarie Boleij, Bastiaan B.J. Tops, Paul D.M. Rombout, Elizabeth M. Dequeker, Marjolijn J.L. Ligtenberg, J. Han van Krieken,  and Dutch RAS EQA Initiative
15681-15689
Abstract  |   PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical evaluation of stereotactic radiation therapy for recurrent or second primary mediastinal lymph node metastases originating from non-small cell lung cancer

Clinical evaluation of stereotactic radiation therapy for recurrent or second primary mediastinal lymph node metastases originating from non-small cell lung cancer

DOI: 10.18632/oncotarget.3704

Mao-Bin Meng, Huan-Huan Wang, Nicholas G. Zaorsky, Xian-Zhi Zhao, Zhi-Qiang Wu, Bo Jiang, Yong-Chun Song, Hong-Qing Zhuang, Feng-Tong Li, Lu-Jun Zhao, Chang-Li Wang, Kai Li, Ping Wang,  and Zhi-Yong Yuan
15690-15703
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