Oncotarget

Vol 6, No 16

June 10, 2015

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Doxycycline targets mitochondrial biogenesis and DNA-repair, ultimately converging on ATP production and energy metabolism in cancer cells. See Lamb et al.

Table of Contents

Editorial

Yin-and-Yang of mTORC1/C2 in Angelman syndrome mice

Yin-and-Yang of mTORC1/C2 in Angelman syndrome mice

https://doi.org/10.18632/oncotarget.4298

Xiaoning Bi, Jiandong Sun,  and Michel Baudry
13844-13845
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A nutritional perspective on cellular rejuvenation

A nutritional perspective on cellular rejuvenation

https://doi.org/10.18632/oncotarget.4326

Patricia Huebbe, Anke Schloesser,  and Gerald Rimbach
13846-13847
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Digesting dietary miRNA therapeutics

Digesting dietary miRNA therapeutics

https://doi.org/10.18632/oncotarget.4357

Mark Yarmarkovich,  and Kendal D. Hirschi
13848-13849
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Δ113p53/Δ133p53: survival and integrity

Δ113p53/Δ133p53: survival and integrity

https://doi.org/10.18632/oncotarget.4371

Jun Chen,  and Jinrong Peng
13850-13851
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Plant and animal organelles in cell death

Plant and animal organelles in cell death

https://doi.org/10.18632/oncotarget.4386

Hong Yu,  and Jiayang Li
13852-13853
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Tumour modelling using viral vectors

Tumour modelling using viral vectors

https://doi.org/10.18632/oncotarget.4387

Ian J. Frew
13854-13855
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Long tails, short telomeres: Dyskeratosis congenita

Long tails, short telomeres: Dyskeratosis congenita

https://doi.org/10.18632/oncotarget.4388

Hemanth Tummala,  and Amanda J. Walne
13856-13857
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Reviews: Gerotarget (Focus on Aging)

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition

Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition

https://doi.org/10.18632/oncotarget.4030

Didier. Rémond, Danit R. Shahar, Doreen Gille, Paula Pinto, Josefa Kachal, Marie-Agnès Peyron, Claudia Nunes Dos Santos, Barbara Walther, Alessandra Bordoni, Didier Dupont, Lidia Tomás-Cobos,  and Guy Vergères
13858-13898
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Reviews

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened

https://doi.org/10.18632/oncotarget.4224

Annelies Gonnissen, Sofie Isebaert,  and Karin Haustermans
13899-13913
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MicroRNA expression and its implications for diagnosis and therapy of gallbladder cancer

MicroRNA expression and its implications for diagnosis and therapy of gallbladder cancer

https://doi.org/10.18632/oncotarget.4227

Zheng Li, Xin Yu, Jianxiong Shen, Priscilla T.Y. Law, Matthew T.V. Chan,  and William K.K. Wu
13914-13921
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DNA methylation and cognitive aging

DNA methylation and cognitive aging

https://doi.org/10.18632/oncotarget.4215

Xiangru Xu
13922-13932
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Priority Research Papers

Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma–is it necessary

Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma–is it necessary

https://doi.org/10.18632/oncotarget.4324

Chi Young Ok, Qing Ye, Ling Li, Ganiraju C. Manyam, Lijuan Deng, Rashmi R. Goswami, Xiaoxiao Wang, Santiago Montes-Moreno, Carlo Visco, Alexandar Tzankov, Karen Dybkaer, Li Zhang, Jeremy Abramson, Aliyah R. Sohani, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W.L. Choi, J. Han van Krieken, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Shanxiang Zhang, Ben M. Parsons, Mina Xu, Michael B. Møller, Jane N. Winter, Miguel A. Piris, Zijun Y. Xu-Monette, L. Jeffrey Medeiros,  and Ken H. Young
13933-13945
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miR-181c associates with tumor relapse of high grade osteosarcoma

miR-181c associates with tumor relapse of high grade osteosarcoma

https://doi.org/10.18632/oncotarget.3539

Federica Mori, Andrea Sacconi, Valeria Canu, Federica Ganci, Mariangela Novello, Vincenzo Anelli, Renato Covello, Virginia Ferraresi, Paola Muti, Roberto Biagini, Giovanni Blandino,  and Sabrina Strano
13946-13961
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AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis

AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis

https://doi.org/10.18632/oncotarget.3920

Wenting Mi, Qing Ye, Side Liu,  and Qing-Bai She
13962-13977
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

β-catenin activation drives thymoma initiation and progression in mice

β-catenin activation drives thymoma initiation and progression in mice

https://doi.org/10.18632/oncotarget.4368

Chih-Chia Liang, Tsai-Ling Lu, Yi-Ru Yu, Li-Ru You,  and Chun-Ming Chen
13978-13993
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P73 tumor suppressor and its targets, p21 and PUMA, are required for madin-darby canine kidney cell morphogenesis by maintaining an appropriate level of epithelial to mesenchymal transition

P73 tumor suppressor and its targets, p21 and PUMA, are required for madin-darby canine kidney cell morphogenesis by maintaining an appropriate level of epithelial to mesenchymal transition

https://doi.org/10.18632/oncotarget.4374

Yanhong Zhang, Ashley Young, Jin Zhang,  and Xinbin Chen
13994-14004
Abstract  |  PDF  |  HTML  |  Order a Reprint

Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy

Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy

https://doi.org/10.18632/oncotarget.4159

Rebecca Lamb, Marco Fiorillo, Amy Chadwick, Bela Ozsvari, Kimberly J. Reeves, Duncan L. Smith, Robert B. Clarke, Sacha J. Howell, Anna Rita Cappello, Ubaldo E. Martinez-Outschoorn, Maria Peiris-Pagès, Federica Sotgia,  and Michael P. Lisanti
14005-14025
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Soluble IL6R represents a miR-34a target: potential implications for the recently identified IL-6R/STAT3/miR-34a feed-back loop

Soluble IL6R represents a miR-34a target: potential implications for the recently identified IL-6R/STAT3/miR-34a feed-back loop

https://doi.org/10.18632/oncotarget.4334

Huihui Li, Matjaz Rokavec,  and Heiko Hermeking
14026-14032
Abstract  |  PDF  |  HTML  |  Order a Reprint

Research Papers: Pathology

The indirect NMDAR inhibitor flupirtine induces sustained post-ischemic recovery, neuroprotection and angioneurogenesis

The indirect NMDAR inhibitor flupirtine induces sustained post-ischemic recovery, neuroprotection and angioneurogenesis

https://doi.org/10.18632/oncotarget.4226

Hanna M. Jaeger, Jens R. Pehlke, Britta Kaltwasser, Ertugrul Kilic, Mathias Bähr, Dirk M. Hermann,  and Thorsten R. Doeppner
14033-14044
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Maintaining human fetal pancreatic stellate cell function and proliferation require β1 integrin and collagen I matrix interactions

Maintaining human fetal pancreatic stellate cell function and proliferation require β1 integrin and collagen I matrix interactions

https://doi.org/10.18632/oncotarget.4338

Bijun Chen, Jinming Li, George F. Fellows, Zilin Sun,  and Rennian Wang
14045-14059
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Paroxysmal supraventricular tachycardia as first manifestation of right atrial hemangioma during endovascular treatment of intracranial arteriovenous fistulas

Paroxysmal supraventricular tachycardia as first manifestation of right atrial hemangioma during endovascular treatment of intracranial arteriovenous fistulas

https://doi.org/10.18632/oncotarget.3781

Francesca Spanò, Alberto Cereda, Antonella Moreo, Edgardo Bonacina, Angelica Peritore, Alberto Roghi, Cristina Giannattasio,  and Patrizia Pedrotti
14060-14064
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Research Papers: Gerotarget (Focus on Aging)

Involvement of cellular metabolism in age-related LTP modifications in rat hippocampal slices

Involvement of cellular metabolism in age-related LTP modifications in rat hippocampal slices

https://doi.org/10.18632/oncotarget.4188

Dominika Drulis-Fajdasz, Tomasz Wójtowicz, Marcin Wawrzyniak, Jakub Wlodarczyk, Jerzy W. Mozrzymas,  and Dariusz Rakus
14065-14081
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APOε2 and education in cognitively normal older subjects with high levels of AD pathology at autopsy: findings from the Nun Study

APOε2 and education in cognitively normal older subjects with high levels of AD pathology at autopsy: findings from the Nun Study

https://doi.org/10.18632/oncotarget.4118

Diego Iacono, Peter Zandi, Myron Gross, William R. Markesbery, Olga Pletnikova, Gay Rudow,  and Juan C. Troncoso
14082-14091
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Dynamic self-guiding analysis of Alzheimer’s disease

Dynamic self-guiding analysis of Alzheimer’s disease

https://doi.org/10.18632/oncotarget.4221

Alexei Kurakin,  and Dale E. Bredesen
14092-14122
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Immunology

NF-κB, p38 MAPK, ERK1/2, mTOR, STAT3 and increased glycolysis regulate stability of paricalcitol/dexamethasone-generated tolerogenic dendritic cells in the inflammatory environment

NF-κB, p38 MAPK, ERK1/2, mTOR, STAT3 and increased glycolysis regulate stability of paricalcitol/dexamethasone-generated tolerogenic dendritic cells in the inflammatory environment

https://doi.org/10.18632/oncotarget.4234

Klára Dáňová, Anna Klapetková, Jana Kayserová, Anna Šedivá, Radek Špíšek,  and Lenka Palová Jelínková
14123-14138
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers

A simplified interventional mapping system (SIMS) for the selection of combinations of targeted treatments in non-small cell lung cancer

A simplified interventional mapping system (SIMS) for the selection of combinations of targeted treatments in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.3741

Vladimir Lazar, Eitan Rubin, Stephane Depil, Yudi Pawitan, Jean-François Martini, Jesus Gomez-Navarro, Antoine Yver, Zhengyin Kan, Jonathan R. Dry, Jeanne Kehren, Pierre Validire, Jordi Rodon, Philippe Vielh, Michel Ducreux, Susan Galbraith, Manfred Lehnert, Amir Onn, Raanan Berger, Marco A. Pierotti, Angel Porgador, CS Pramesh, Ding-wei Ye, Andre L. Carvalho, Gerald Batist, Thierry Le Chevalier, Philippe Morice, Benjamin Besse, Gilles Vassal, Andrew Mortlock, Johan Hansson, Ioana Berindan-Neagoe, Robert Dann, Joel Haspel, Alexandru Irimie A, Steve Laderman, Hovav Nechushtan, Amal S. Al Omari, Trent Haywood, Catherine Bresson, Khee Chee Soo, Gary Palmer, Ludovic Lacroix, Serge Koscielny, Karina Agda Eterovic, Jean-Yves Blay, Richard Buller, Alexander Eggermont, Richard L. Schilsky, John Mendelsohn, Jean-Charles Soria, Mace Rothenberg, Jean-Yves Scoazec, Waun Ki Hong,  and Razelle Kurzrock
14139-14152
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-221/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases

miR-221/222 induces pancreatic cancer progression through the regulation of matrix metalloproteinases

https://doi.org/10.18632/oncotarget.3686

Qinhong Xu, Pei Li, Xin Chen, Liang Zong, Zhengdong Jiang, Ligang Nan, Jianjun Lei, Wanxing Duan, Dong Zhang, Xuqi Li, Huanchen Sha, Zheng Wu, Qingyong Ma,  and Zheng Wang
14153-14164
Abstract  |  PDF  |  HTML  |  Order a Reprint

CXCL16/CXCR6 chemokine signaling mediates breast cancer progression by pERK1/2-dependent mechanisms

CXCL16/CXCR6 chemokine signaling mediates breast cancer progression by pERK1/2-dependent mechanisms

https://doi.org/10.18632/oncotarget.3690

Gang Xiao, Xiumin Wang, Jinglong Wang, Lidong Zu, Guangcun Cheng, Mingang Hao, Xueqing Sun, Yunjing Xue, Jinsong Lu,  and Jianhua Wang
14165-14178
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Infiltrating mast cells enhance prostate cancer invasion via altering LncRNA-HOTAIR/PRC2-androgen receptor (AR)-MMP9 signals and increased stem/progenitor cell population

Infiltrating mast cells enhance prostate cancer invasion via altering LncRNA-HOTAIR/PRC2-androgen receptor (AR)-MMP9 signals and increased stem/progenitor cell population

https://doi.org/10.18632/oncotarget.3651

Lei Li, Qiang Dang, Hongjun Xie, Zhao Yang, Dalin He, Liang Liang, Wenbing Song, Shuyuan Yeh,  and Chawnshang Chang
14179-14190
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EFEMP1 promotes the migration and invasion of osteosarcoma via MMP-2 with induction by AEG-1 via NF-κB signaling pathway

EFEMP1 promotes the migration and invasion of osteosarcoma via MMP-2 with induction by AEG-1 via NF-κB signaling pathway

https://doi.org/10.18632/oncotarget.3691

Zhuo Wang, Chuang-Jie Cao, Lei-Lei Huang, Zun-Fu Ke, Can-Jiao Luo, Zhong-Wei Lin, Fen Wang, Yuan-Qi Zhang,  and Lian-Tang Wang
14191-14208
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs

The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs

https://doi.org/10.18632/oncotarget.3694

Yanna Tang, Wenfeng Fang, Yaxiong Zhang, Shaodong Hong, Shiyang Kang, Yue Yan, Nan Chen, Jianhua Zhan, Xiaobo He, Tao Qin, Ge Li, Wenyi Tang, Peijian Peng,  and Li Zhang
14209-14219
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Kras activation in p53-deficient myoblasts results in high-grade sarcoma formation with impaired myogenic differentiation

Kras activation in p53-deficient myoblasts results in high-grade sarcoma formation with impaired myogenic differentiation

https://doi.org/10.18632/oncotarget.3856

Timothy McKinnon, Rosemarie Venier, Brendan C. Dickson, Leah Kabaroff, Manon Alkema, Li Chen, Jack F. Shern, Marielle E. Yohe, Javed Khan,  and Rebecca A. Gladdy
14220-14232
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lemur Tyrosine Kinase 2, a novel target in prostate cancer therapy

Lemur Tyrosine Kinase 2, a novel target in prostate cancer therapy

https://doi.org/10.18632/oncotarget.3899

Kalpit Shah,  and Neil A. Bradbury
14233-14246
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models

Necrosis targeted radiotherapy with iodine-131-labeled hypericin to improve anticancer efficacy of vascular disrupting treatment in rabbit VX2 tumor models

https://doi.org/10.18632/oncotarget.3679

Haibo Shao, Jian Zhang, Ziping Sun, Feng Chen, Xu Dai, Yaming Li, Yicheng Ni,  and Ke Xu
14247-14259
Abstract  |  PDF  |  HTML  |  Order a Reprint

uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery

uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery

https://doi.org/10.18632/oncotarget.3680

Martin C. Boonstra, Pieter B.A.A van Driel, Danny M. van Willigen, Marieke A. Stammes, Hendrica A.J.M. Prevoo, Quirijn R.J.G. Tummers, Andrew P. Mazar, Freek J. Beekman, Peter J.K. Kuppen, Cornelis J.H. van de Velde, Clemens W.G.M. Löwik, John V. Frangioni, Fijs W.B. van Leeuwen, Cornelis F.M. Sier,  and Alexander L. Vahrmeijer
14260-14273
Abstract  |  PDF  |  HTML  |  Order a Reprint

NKX2-1-mediated p53 expression modulates lung adenocarcinoma progression via modulating IKKβ/NF-κB activation

NKX2-1-mediated p53 expression modulates lung adenocarcinoma progression via modulating IKKβ/NF-κB activation

https://doi.org/10.18632/oncotarget.3695

Po-Ming Chen, Tzu-Chin Wu, Ya-Wen Cheng, Chih-Yi Chen,  and Huei Lee
14274-14289
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Deltex-3-like (DTX3L) stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway

Deltex-3-like (DTX3L) stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway

https://doi.org/10.18632/oncotarget.3742

Nguyen Dinh Thang, Ichiro Yajima, Mayuko Y. Kumasaka, Machiko Iida, Tamio Suzuki,  and Masashi Kato
14290-14299
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fibroblast surface-associated FGF-2 promotes contact-dependent colorectal cancer cell migration and invasion through FGFR-SRC signaling and integrin αvβ5-mediated adhesion

Fibroblast surface-associated FGF-2 promotes contact-dependent colorectal cancer cell migration and invasion through FGFR-SRC signaling and integrin αvβ5-mediated adhesion

https://doi.org/10.18632/oncotarget.3883

Sarah Knuchel, Pascale Anderle, Patricia Werfelli, Eva Diamantis,  and Curzio Rüegg
14300-14317
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts

Trop-2 is up-regulated in invasive prostate cancer and displaces FAK from focal contacts

https://doi.org/10.18632/oncotarget.3960

Marco Trerotola, Kirat K. Ganguly, Ladan Fazli, Carmine Fedele, Huimin Lu, Anindita Dutta, Qin Liu, Tiziana De Angelis, Luke W. Riddell, Natalia A. Riobo, Martin E. Gleave, Amina Zoubeidi, Richard G. Pestell, Dario C. Altieri,  and Lucia R. Languino
14318-14328
Abstract  |  PDF  |  HTML  |  Order a Reprint

JAK2 inhibitor TG101348 overcomes erlotinib-resistance in non-small cell lung carcinoma cells with mutated EGF receptor

JAK2 inhibitor TG101348 overcomes erlotinib-resistance in non-small cell lung carcinoma cells with mutated EGF receptor

https://doi.org/10.18632/oncotarget.3685

Fu-quan Zhang, Wen-tao Yang, Shan-zhou Duan, Ying-chen Xia, Rong-ying Zhu,  and Yong-bing Chen
14329-14343
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Frequent amplification of AIB1, a critical oncogene modulating major signaling pathways, is associated with poor survival in gastric cancer

Frequent amplification of AIB1, a critical oncogene modulating major signaling pathways, is associated with poor survival in gastric cancer

https://doi.org/10.18632/oncotarget.3852

Jing Shi, Wei Liu, Fang Sui, Rong Lu, Qingyuan He, Qi Yang, Hongjun Lv, Bingyin Shi,  and Peng Hou
14344-14359
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Highly effective NK cells are associated with good prognosis in patients with metastatic prostate cancer

Highly effective NK cells are associated with good prognosis in patients with metastatic prostate cancer

https://doi.org/10.18632/oncotarget.3965

Christine Pasero, Gwenaëlle Gravis, Samuel Granjeaud, Mathilde Guerin, Jeanne Thomassin-Piana, Palma Rocchi, Naji Salem, Jochen Walz, Alessandro Moretta,  and Daniel Olive
14360-14373
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Ectopic expression of a novel CD22 splice-variant regulates survival and proliferation in malignant T cells from cutaneous T cell lymphoma (CTCL) patients.

Ectopic expression of a novel CD22 splice-variant regulates survival and proliferation in malignant T cells from cutaneous T cell lymphoma (CTCL) patients.

https://doi.org/10.18632/oncotarget.3720

Ieva Bagdonaite, Hans H. Wandall, Ivan V. Litvinov, Claudia Nastasi, Jürgen C. Becker, Sally Dabelsteen, Carsten Geisler, Charlotte M. Bonefeld, Qian Zhang, Mariusz A. Wasik, Youwen Zhou, Denis Sasseville, Niels Ødum,  and Anders Woetmann
14374-14384
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancer

PUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancer

https://doi.org/10.18632/oncotarget.3775

Huanan Wang, Lingling Zhang, Xu Yang, Yipeng Jin, Shimin Pei, Di Zhang, Hong Zhang, Bin Zhou, Yingjie Zhang,  and Degui Lin
14385-14398
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors

The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors

https://doi.org/10.18632/oncotarget.3882

Kerstin Mock, Bogdan-Tiberius Preca, Tilman Brummer, Simone Brabletz, Marc P. Stemmler,  and Thomas Brabletz
14399-14412
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anticancer activity of halofuginone in a preclinical model of osteosarcoma: inhibition of tumor growth and lung metastases

Anticancer activity of halofuginone in a preclinical model of osteosarcoma: inhibition of tumor growth and lung metastases

https://doi.org/10.18632/oncotarget.3891

Audrey Lamora, Mathilde Mullard, Jérôme Amiaud, Régis Brion, Dominique Heymann, Françoise Redini,  and Franck Verrecchia
14413-14427
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment

Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment

https://doi.org/10.18632/oncotarget.3982

Yue Cheng, Yee Peng Phoon, Xiwan Jin, Shing Yee Steffi Chong, Joseph Chok Yan Ip, Bonnie Wing Yan Wong,  and Maria Li Lung
14428-14439
Abstract  |  PDF  |  HTML  |  Order a Reprint

MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine

MicroRNA-33a-mediated downregulation of Pim-3 kinase expression renders human pancreatic cancer cells sensitivity to gemcitabine

https://doi.org/10.18632/oncotarget.3885

Chen Liang, Xian-Jun Yu, Xiao-Zhong Guo, Meng-Hong Sun, Zhen Wang, Yao Song, Quan-Xing Ni, Hong-Yu Li, Naofumi Mukaida,  and Ying-Yi Li
14440-14455
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pit-1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment

Pit-1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment

https://doi.org/10.18632/oncotarget.3894

Samuel Seoane, Efigenia Arias, Rita Sigueiro, Juan Sendon-Lago, Anxo Martinez-Ordoñez, Esteban Castelao, Noemí Eiró, Tomás Garcia-Caballero, Manuel Macia, Rafael Lopez-Lopez, Miguel Maestro, Francisco Vizoso, Antonio Mouriño,  and Roman Perez-Fernandez
14456-14471
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells

Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells

https://doi.org/10.18632/oncotarget.3991

Chengguang Zhao, Hui Xiao, Xiaojuan Wu, Chenglong Li, Guang Liang, Shulin Yang,  and Jiayuh Lin
14472-14487
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Reactive stroma component COL6A1 is upregulated in castration-resistant prostate cancer and promotes tumor growth

Reactive stroma component COL6A1 is upregulated in castration-resistant prostate cancer and promotes tumor growth

https://doi.org/10.18632/oncotarget.3697

Yi-Ping Zhu, Fang-Ning Wan, Yi-Jun Shen, Hong-Kai Wang, Gui-Ming Zhang,  and Ding-Wei Ye
14488-14496
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

C-Jun recruits the NSL complex to regulate its target gene expression by modulating H4K16 acetylation and promoting the release of the repressive NuRD complex

C-Jun recruits the NSL complex to regulate its target gene expression by modulating H4K16 acetylation and promoting the release of the repressive NuRD complex

https://doi.org/10.18632/oncotarget.3988

Yan Liu, Yuehong Long, Zhaobin Xing,  and Daoyong Zhang
14497-14506
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo

Combined inhibition of Bcl-2/Bcl-xL and Usp9X/Bag3 overcomes apoptotic resistance in glioblastoma in vitro and in vivo

https://doi.org/10.18632/oncotarget.3993

Georg Karpel-Massler, Chang Shu, Lily Chau, Matei Banu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Yulian Ramirez, Alonzo H. Ross, Jeffrey N. Bruce, Peter Canoll,  and Markus D. Siegelin
14507-14521
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Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics

Destabilisation of dimeric 14-3-3 proteins as a novel approach to anti-cancer therapeutics

https://doi.org/10.18632/oncotarget.3995

Joanna M. Woodcock, Carl Coolen, Katy L. Goodwin, Dong Jae Baek, Robert Bittman, Michael S. Samuel, Stuart M. Pitson,  and Angel F. Lopez
14522-14536
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Perioperative cerebral ischemia promote infiltrative recurrence in glioblastoma

Perioperative cerebral ischemia promote infiltrative recurrence in glioblastoma

https://doi.org/10.18632/oncotarget.3994

Anna-Luisa Thiepold, Sebastian Luger, Marlies Wagner, Natalie Filmann, Michael W. Ronellenfitsch, Patrick N. Harter, Anne K. Braczynski, Stephan Dützmann, Elke Hattingen, Joachim P. Steinbach, Christian Senft, Johannes Rieger,  and Oliver Bähr
14537-14544
Abstract  |  PDF  |  HTML  |  Order a Reprint

Absolute quantification of cell-free microRNAs in cancer patients

Absolute quantification of cell-free microRNAs in cancer patients

https://doi.org/10.18632/oncotarget.3859

Manuela Ferracin, Laura Lupini, Irene Salamon, Elena Saccenti, Maria Vittoria Zanzi, Andrea Rocchi, Lucia Da Ros, Barbara Zagatti, Gentian Musa, Cristian Bassi, Alessandra Mangolini, Giorgio Cavallesco, Antonio Frassoldati, Stefano Volpato, Paolo Carcoforo, Alan B. Hollingsworth,  and Massimo Negrini
14545-14555
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tumor promotion by γ and suppression by β non-muscle actin isoforms

Tumor promotion by γ and suppression by β non-muscle actin isoforms

https://doi.org/10.18632/oncotarget.3989

Vera Dugina, Natalya Khromova, Vera Rybko, Oleg Blizniukov, Galina Shagieva, Christine Chaponnier, Boris Kopnin,  and Pavel Kopnin
14556-14571
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Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma

Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma

https://doi.org/10.18632/oncotarget.3990

Stefano Amente, Giorgio Milazzo, Maria Cristina Sorrentino, Susanna Ambrosio, Giacomo Di Palo, Luigi Lania, Giovanni Perini,  and Barbara Majello
14572-14583
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Proteomic profiling of high risk medulloblastoma reveals functional biology

Proteomic profiling of high risk medulloblastoma reveals functional biology

https://doi.org/10.18632/oncotarget.3927

Jerome A. Staal, Ling San Lau, Huizhen Zhang, Wendy J. Ingram, Andrew R. Hallahan, Paul A. Northcott, Stefan M. Pfister, Robert J. Wechsler-Reya, Jessica M. Rusert, Michael D. Taylor, Yoon-Jae Cho, Roger J. Packer, Kristy J. Brown,  and Brian R. Rood
14584-14595
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Endoplasmic reticulum targeting in Ewing’s sarcoma by the alkylphospholipid analog edelfosine

Endoplasmic reticulum targeting in Ewing’s sarcoma by the alkylphospholipid analog edelfosine

https://doi.org/10.18632/oncotarget.4053

Ximena Bonilla, EL-Habib Dakir, Faustino Mollinedo,  and Consuelo Gajate
14596-14613
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Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics

Cytogenomic profiling of breast cancer brain metastases reveals potential for repurposing targeted therapeutics

https://doi.org/10.18632/oncotarget.3786

Aliccia Bollig-Fischer, Sharon K. Michelhaugh, Priyanga Wijesinghe, Greg Dyson, Adele Kruger, Nallasivam Palanisamy, Lydia Choi, Baraa Alosh, Rouba Ali-Fehmi,  and Sandeep Mittal
14614-14624
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comparison of the selective targeting efficacy of Salmonella typhimurium A1-R and VNP20009 on the Lewis lung carcinoma in nude mice

Comparison of the selective targeting efficacy of Salmonella typhimurium A1-R and VNP20009 on the Lewis lung carcinoma in nude mice

https://doi.org/10.18632/oncotarget.3342

Yong Zhang, Nan Zhang, Ming Zhao,  and Robert M. Hoffman
14625-14631
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RPPA-based protein profiling reveals eIF4G overexpression and 4E-BP1 serine 65 phosphorylation as molecular events that correspond with a pro-survival phenotype in chronic lymphocytic leukemia

RPPA-based protein profiling reveals eIF4G overexpression and 4E-BP1 serine 65 phosphorylation as molecular events that correspond with a pro-survival phenotype in chronic lymphocytic leukemia

https://doi.org/10.18632/oncotarget.4104

Austin Y. Shull, Satish K. Noonepalle, Farrukh T. Awan, Jimei Liu, Lirong Pei, Roni J. Bollag, Huda Salman, Zhiyong Ding,  and Huidong Shi
14632-14645
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Role of TGF-β signaling in uterine carcinosarcoma

Role of TGF-β signaling in uterine carcinosarcoma

https://doi.org/10.18632/oncotarget.3711

Shailendra Kumar Dhar Dwivedi, Scott D. McMeekin, Katrina Slaughter,  and Resham Bhattacharya
14646-14655
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dynamic treatment effect (DTE) curves reveal the mode of action for standard and experimental cancer therapies

Dynamic treatment effect (DTE) curves reveal the mode of action for standard and experimental cancer therapies

https://doi.org/10.18632/oncotarget.4141

Kingshuk Roy Choudhury, Stephen T. Keir, Kathleen A. Ashcraft, Mary-Keara Boss,  and Mark W. Dewhirst
14656-14668
Abstract  |  PDF  |  HTML  |  Order a Reprint

IPP51, a chalcone acting as a microtubule inhibitor with in vivo antitumor activity against bladder carcinoma

IPP51, a chalcone acting as a microtubule inhibitor with in vivo antitumor activity against bladder carcinoma

https://doi.org/10.18632/oncotarget.4144

Véronique Martel-Frachet, Michelle Keramidas, Alessandra Nurisso, Salvatore DeBonis, Claire Rome, Jean-Luc Coll, Ahcène Boumendjel, Dimitrios A. Skoufias,  and Xavier Ronot
14669-14686
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment

Monocytes and macrophages, implications for breast cancer migration and stem cell-like activity and treatment

https://doi.org/10.18632/oncotarget.4189

Rebecca Ward, Andrew H. Sims, Alexander Lee, Christina Lo, Luke Wynne, Humza Yusuf, Hannah Gregson, Michael P. Lisanti, Federica Sotgia, Göran Landberg,  and Rebecca Lamb
14687-14699
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Assessment of folate receptor-β expression in human neoplastic tissues

Assessment of folate receptor-β expression in human neoplastic tissues

https://doi.org/10.18632/oncotarget.3739

Jiayin Shen, Karson S. Putt, Daniel W. Visscher, Linda Murphy, Cynthia Cohen, Sunil Singhal, George Sandusky, Feng Yang, Dimitri S. Dimitrov,  and Philip S. Low
14700-14709
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Secondary bladder cancer after anticancer therapy for prostate cancer: reduced comorbidity after androgen-deprivation therapy

Secondary bladder cancer after anticancer therapy for prostate cancer: reduced comorbidity after androgen-deprivation therapy

https://doi.org/10.18632/oncotarget.3817

Masaki Shiota, Akira Yokomizo, Ario Takeuchi, Kenjiro Imada, Keijiro Kiyoshima, Junichi Inokuchi, Katsunori Tatsugami, Saiji Ohga, Katsumasa Nakamura, Hiroshi Honda,  and Seiji Naito
14710-14719
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Errata

Erratum: Clinical and biological significance of de novo CD5+ diffuse large B-cell lymphoma in Western countries

Erratum: Clinical and biological significance of de novo CD5+ diffuse large B-cell lymphoma in Western countries

https://doi.org/10.18632/oncotarget.4464

Zijun Y. Xu-Monette, Meifeng Tu, Kausar J. Jabbar, Xin Cao, Alexandar Tzankov, Carlo Visco, Lalitha Nagarajan, Qinging Cai, Santiago Montes-Moreno, Yuji An, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W.L. Choi, J. Han van Krieken, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Xiaoying Zhao, Michael B. Møller, John P. Farnen, Jane N. Winter, Miguel A. Piris, Roberto N. Miranda, L. Jeffrey Medeiros,  and Ken H. Young
14720
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