Oncotarget

Vol 6, No 14

May 20, 2015

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In vivo effect of fasting cycles in combination with chemotherapy on tumor glucose consumption and cancer growth. Patlak-map of a mouse, see Bianchi et al.

Table of Contents

Editorial

p53-induced autophagy and senescence

p53-induced autophagy and senescence

https://doi.org/10.18632/oncotarget.4170

Xinbing Sui, Weidong Han,  and Hongming Pan
11723-11724
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Reviews

The emerging role of CaMKII in cancer

The emerging role of CaMKII in cancer

https://doi.org/10.18632/oncotarget.3955

Yan-yang Wang, Ren Zhao,  and Hong Zhe
11725-11734
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Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry

Initiation and termination of DNA replication during S phase in relation to cyclins D1, E and A, p21WAF1, Cdt1 and the p12 subunit of DNA polymerase δ revealed in individual cells by cytometry

https://doi.org/10.18632/oncotarget.4149

Zbigniew Darzynkiewicz, Hong Zhao, Sufang Zhang, Marietta Y.W.T. Lee, Ernest Y.C. Lee,  and Zhongtao Zhang
11735-11750
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Priority Research Papers

Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition

Orthogonal targeting of EGFRvIII expressing glioblastomas through simultaneous EGFR and PLK1 inhibition

https://doi.org/10.18632/oncotarget.3996

Ying Shen, Jie Li, Masayuki Nitta, Diahnn Futalan, Tyler Steed, Jeffrey M. Treiber, Zack Taich, Deanna Stevens, Jill Wykosky, Hong-Zhuan Chen, Bob S. Carter, Oren J. Becher, Richard Kennedy, Fumiko Esashi, Jann N. Sarkaria, Frank B. Furnari, Webster K. Cavenee, Arshad Desai,  and Clark C. Chen
11751-11767
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HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells

HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells

https://doi.org/10.18632/oncotarget.4190

Lisha Xiang, Daniele M. Gilkes, Hongxia Hu, Weibo Luo, John W. Bullen, Houjie Liang,  and Gregg L. Semenza
11768-11778
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CSN6 deregulation impairs genome integrity in a COP1-dependent pathway

CSN6 deregulation impairs genome integrity in a COP1-dependent pathway

https://doi.org/10.18632/oncotarget.3151

Hyun Ho Choi, Chun-Hui Su, Lekun Fang, Jin Zhang, Sai-Ching J. Yeung,  and Mong-Hong Lee
11779-11793
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ERp19 contributes to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion

ERp19 contributes to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion

https://doi.org/10.18632/oncotarget.3649

Jing Wu, Xue-hua Chen, Xin-qiong Wang, Yi Yu, Jian-min Ren, Yuan Xiao, Tong Zhou, Pu Li,  and Chun-di Xu
11794-11805
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Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models

https://doi.org/10.18632/oncotarget.3688

Giovanna Bianchi, Roberto Martella, Silvia Ravera, Cecilia Marini, Selene Capitanio, Annamaria Orengo, Laura Emionite, Chiara Lavarello, Adriana Amaro, Andrea Petretto, Ulrich Pfeffer, Gianmario Sambuceti, Vito Pistoia, Lizzia Raffaghello,  and Valter D. Longo
11806-11819
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Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition

Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition

https://doi.org/10.18632/oncotarget.3689

Irene Caffa, Vito D’Agostino, Patrizia Damonte, Debora Soncini, Michele Cea, Fiammetta Monacelli, Patrizio Odetti, Alberto Ballestrero, Alessandro Provenzani, Valter D. Longo,  and Alessio Nencioni
11820-11832
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AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts

AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts

https://doi.org/10.18632/oncotarget.3738

Joffrey Pelletier, Danièle Roux, Benoit Viollet, Nathalie M. Mazure,  and Jacques Pouysségur
11833-11847
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RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development

RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development

https://doi.org/10.18632/oncotarget.4055

Direna Alonso-Curbelo, Lisa Osterloh, Estela Cañón, Tonantzin G. Calvo, Raúl Martínez-Herranz, Panagiotis Karras, Sonia Martínez, Erica Riveiro-Falkenbach, Pablo-Ortiz Romero, José Luis Rodríguez-Peralto, Joaquín Pastor,  and María S. Soengas
11848-11862
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c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression

c-Jun N-terminal kinase 2 prevents luminal cell commitment in normal mammary glands and tumors by inhibiting p53/Notch1 and breast cancer gene 1 expression

https://doi.org/10.18632/oncotarget.3787

Michael A. Cantrell, Nancy D. Ebelt, Adam D. Pfefferle, Charles M. Perou,  and Carla Lynn Van Den Berg
11863-11881
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Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy

Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy

https://doi.org/10.18632/oncotarget.3592

Hui Xu, Shervin Rahimpour, Cody L. Nesvick, Xu Zhang, Jingyun Ma, Min Zhang, Ge Zhang, Li Wang, Chunzhang Yang, Christopher S. Hong, Anand V. Germanwala, J. Bradley Elder, Abhik Ray-Chaudhury, Yu Yao, Mark R. Gilbert, Russell R. Lonser, John D. Heiss, Roscoe O. Brady, Ying Mao, Jianhua Qin,  and Zhengping Zhuang
11882-11893
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Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignancies

Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignancies

https://doi.org/10.18632/oncotarget.4180

Gautier Stoll, Gabriela Bindea, Bernhard Mlecnik, Jérôme Galon, Laurence Zitvogel,  and Guido Kroemer
11894-11909
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Cripto-1 as a novel therapeutic target for triple negative breast cancer

Cripto-1 as a novel therapeutic target for triple negative breast cancer

https://doi.org/10.18632/oncotarget.4182

Nadia P. Castro, Natalie D. Fedorova-Abrams, Anand S. Merchant, Maria Cristina Rangel, Tadahiro Nagaoka, Hideaki Karasawa, Malgorzata Klauzinska, Stephen M. Hewitt, Kajal Biswas, Shyam K. Sharan,  and David S. Salomon
11910-11929
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Research Papers: Pathology

Smad7 protects against chronic aristolochic acid nephropathy in mice

Smad7 protects against chronic aristolochic acid nephropathy in mice

https://doi.org/10.18632/oncotarget.3718

Xiao-Yu Dai, Li Zhou, Xiao-Ru Huang, Ping Fu,  and Hui-Yao Lan
11930-11944
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Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: novel HIF-1-mediated regulation of aquaporins in NP cells

Aquaporin 1 and 5 expression decreases during human intervertebral disc degeneration: novel HIF-1-mediated regulation of aquaporins in NP cells

https://doi.org/10.18632/oncotarget.3631

Zariel I. Johnson, Shilpa S. Gogate, Rebecca Day, Abbie Binch, Dessislava Z. Markova, Neil Chiverton, Ashley Cole, Matt Conner, Irving M. Shapiro, Christine L. Le Maitre,  and Makarand V. Risbud
11945-11958
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Research Papers: Gerotarget (Focus on Aging)

Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal

Systemic attenuation of the TGF-β pathway by a single drug simultaneously rejuvenates hippocampal neurogenesis and myogenesis in the same old mammal

https://doi.org/10.18632/oncotarget.3851

Hanadie Yousef, Michael J. Conboy, Adam Morgenthaler, Christina Schlesinger, Lukasz Bugaj, Preeti Paliwal, Christopher Greer, Irina M. Conboy,  and David Schaffer
11959-11978
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Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies

Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies

https://doi.org/10.18632/oncotarget.3979

Tyesha N. Burks, Ruth Marx, Laura Powell, Jasma Rucker, Djahida Bedja, Elisa Heacock, Barbara J. Smith, D. Brian Foster, David Kass, Brian O’Rourke, Jeremy D. Walston,  and Peter M. Abadir
11979-11993
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Research Papers

CRIPTO overexpression promotes mesenchymal differentiation in prostate carcinoma cells through parallel regulation of AKT and FGFR activities

CRIPTO overexpression promotes mesenchymal differentiation in prostate carcinoma cells through parallel regulation of AKT and FGFR activities

https://doi.org/10.18632/oncotarget.2740

Stéphane Terry, Ihsan Y. El-Sayed, Damien Destouches, Pascale Maillé, Nathalie Nicolaiew, Guillaume Ploussard, Fannie Semprez, Cynthia Pimpie, Himisha Beltran, Arturo Londono-Vallejo, Yves Allory, Alexandre de la Taille, David S. Salomon,  and Francis Vacherot
11994-12008
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Filamin A phosphorylation by Akt promotes cell migration in response to arsenic

Filamin A phosphorylation by Akt promotes cell migration in response to arsenic

https://doi.org/10.18632/oncotarget.3617

Lingzhi Li, Yongju Lu, Paul M. Stemmer,  and Fei Chen
12009-12019
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Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer

Therapeutic targeting of polo-like kinase 1 using RNA-interfering nanoparticles (iNOPs) for the treatment of non-small cell lung cancer

https://doi.org/10.18632/oncotarget.2664

Joshua A. McCarroll, Tanya Dwarte, Huricha Baigude, Jason Dang, Lu Yang, Rafael B. Erlich, Kathleen Kimpton, Joann Teo, Sharon M. Sagnella, Mia C. Akerfeldt, Jie Liu, Phoebe A. Phillips, Tariq M. Rana,  and Maria Kavallaris
12020-12034
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Epidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer

Epidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer

https://doi.org/10.18632/oncotarget.3574

Friederike Braig, Manuela März, Aneta Schieferdecker, Alexander Schulte, Mareike Voigt, Alexander Stein, Tobias Grob, Malik Alawi, Daniela Indenbirken, Malte Kriegs, Erik Engel, Udo Vanhoefer, Adam Grundhoff, Sonja Loges, Kristoffer Riecken, Boris Fehse, Carsten Bokemeyer,  and Mascha Binder
12035-12047
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CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21

CXCL12-induced VLA-4 activation is impaired in trisomy 12 chronic lymphocytic leukemia cells: a role for CCL21

https://doi.org/10.18632/oncotarget.3660

Sylvia Ganghammer, Evelyn Hutterer, Elisabeth Hinterseer, Gabriele Brachtl, Daniela Asslaber, Peter William Krenn, Tamara Girbl, Petra Berghammer, Roland Geisberger, Alexander Egle, Antonella Zucchetto, Anna Kruschinski, Valter Gattei, Alexandre Chigaev, Richard Greil,  and Tanja Nicole Hartmann
12048-12060
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TIMP-1 activated carcinoma-associated fibroblasts inhibit tumor apoptosis by activating SDF1/CXCR4 signaling in hepatocellular carcinoma

TIMP-1 activated carcinoma-associated fibroblasts inhibit tumor apoptosis by activating SDF1/CXCR4 signaling in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.3616

Tao Song, Changwei Dou, Yuli Jia, Kangsheng Tu,  and Xin Zheng
12061-12079
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Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis

Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis

https://doi.org/10.18632/oncotarget.3813

Karine Pozo, Antje Hillmann, Alexander Augustyn, Florian Plattner, Tao Hai, Tanvir Singh, Saleh Ramezani, Xiankai Sun, Roswitha Pfragner, John D. Minna, Gilbert J. Cote, Herbert Chen, James A. Bibb,  and Fiemu E. Nwariaku
12080-12093
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From the core to beyond the margin: a genomic picture of glioblastoma intratumor heterogeneity

From the core to beyond the margin: a genomic picture of glioblastoma intratumor heterogeneity

https://doi.org/10.18632/oncotarget.3297

Marc Aubry, Marie de Tayrac, Amandine Etcheverry, Anne Clavreul, Stéphan Saikali, Philippe Menei,  and Jean Mosser
12094-12109
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Comparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer?

Comparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer?

https://doi.org/10.18632/oncotarget.3661

Christiane Margue, Susanne Reinsbach, Demetra Philippidou, Nicolas Beaume, Casandra Walters, Jochen G. Schneider, Dorothée Nashan, Iris Behrmann,  and Stephanie Kreis
12110-12127
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Discovery of a small molecule targeting SET-PP2A interaction to overcome BCR-ABLT315I mutation of chronic myeloid leukemia

Discovery of a small molecule targeting SET-PP2A interaction to overcome BCR-ABLT315I mutation of chronic myeloid leukemia

https://doi.org/10.18632/oncotarget.3665

Shuzhen Wang, Weiquan Xie, Duowei Wang, Zhigang Peng, Yan Zheng, Nan Liu, Wen Dai, Yang Wang, Zongqiang Wang, Yong Yang,  and Yijun Chen
12128-12140
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma

The emerging role of NG2 in pediatric diffuse intrinsic pontine glioma

https://doi.org/10.18632/oncotarget.3716

Sridevi Yadavilli, Joseph Scafidi, Oren J. Becher, Amanda M. Saratsis, Rebecca L. Hiner, Madhuri Kambhampati, Santi Mariarita, Tobey J. MacDonald, Kari-Elise Codispoti, Suresh N. Magge, Jyoti K. Jaiswal, Roger J. Packer,  and Javad Nazarian
12141-12155
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tudor staphylococcal nuclease drives chemoresistance of non-small cell lung carcinoma cells by regulating S100A11

Tudor staphylococcal nuclease drives chemoresistance of non-small cell lung carcinoma cells by regulating S100A11

https://doi.org/10.18632/oncotarget.3495

Anna Zagryazhskaya, Olga Surova, Nadeem S. Akbar, Giulia Allavena, Katarina Gyuraszova, Irina B. Zborovskaya, Elena M. Tchevkina,  and Boris Zhivotovsky
12156-12173
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Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth

Ubiquitin E3 ligase MARCH7 promotes ovarian tumor growth

https://doi.org/10.18632/oncotarget.3650

Jianguo Hu, Ying Meng, Tinghe Yu, Lina Hu,  and Ming Mao
12174-12187
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-20b is up-regulated in brain metastases from primary breast cancers

miR-20b is up-regulated in brain metastases from primary breast cancers

https://doi.org/10.18632/oncotarget.3664

Aamir Ahmad, Kevin R. Ginnebaugh, Seema Sethi, Wei Chen, Rouba Ali, Sandeep Mittal,  and Fazlul H. Sarkar
12188-12195
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Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells

Hepatitis B virus X protein induces expression of alpha-fetoprotein and activates PI3K/mTOR signaling pathway in liver cells

https://doi.org/10.18632/oncotarget.2906

Mingyue Zhu, Junli Guo, Wei Li, Yan Lu, Shigan Fu, Xieju Xie, Hua Xia, Xu Dong, Yi Chen, Ming Quan, Shaojiang Zheng, Keping Xie,  and Mengsen Li
12196-12208
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FKBPL: a marker of good prognosis in breast cancer

FKBPL: a marker of good prognosis in breast cancer

https://doi.org/10.18632/oncotarget.3528

Laura Nelson, Hayley D. McKenn, Andrea Marshall, Laoighse Mulrane, Jane Starczynski, Sarah J. Storr, Fiona Lanigan, Christopher Byrne, Ken Arthur, Shauna Hegarty, Ahlam Abdunnabi Ali, Fiona Furlong, Helen McCarthy, Ian O. Ellis, Andrew R. Green, Emad Rakha, Leonie Young, Ian Kunkler, Jeremy Thomas, Wilma Jack, David Cameron, Karin Jirström, Anita Yakkundi, Lana McClements, Stewart G. Martin, William M. Gallagher, Janet Dunn, John Bartlett, Darran O’Connor,  and Tracy Robson
12209-12223
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Identification of a novel TGF-β-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis

Identification of a novel TGF-β-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis

https://doi.org/10.18632/oncotarget.3652

Chunxian Zeng, Yun-Long Wang, Chen Xie, Ye Sang, Tuan-Jie Li, Min Zhang, Ruizhi Wang, Qi Zhang, Limin Zheng,  and Shi-Mei Zhuang
12224-12233
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multi-platform profiling of over 2000 sarcomas: Identification of biomarkers and novel therapeutic targets

Multi-platform profiling of over 2000 sarcomas: Identification of biomarkers and novel therapeutic targets

https://doi.org/10.18632/oncotarget.3498

Sujana Movva, Wenhsiang Wen, Wangjuh Chen, Sherri Z. Millis, Zoran Gatalica, Sandeep Reddy, Margaret von Mehren,  and Brian A. Van Tine
12234-12247
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Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA damage and promotes mammary oncogenesis

Loss of the N-terminal methyltransferase NRMT1 increases sensitivity to DNA damage and promotes mammary oncogenesis

https://doi.org/10.18632/oncotarget.3653

Lindsay A. Bonsignore, Jill Sergesketter Butler, Carolyn M. Klinge,  and Christine E. Schaner Tooley
12248-12263
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Estrogen receptor (ER) was regulated by RNPC1 stabilizing mRNA in ER positive breast cancer

Estrogen receptor (ER) was regulated by RNPC1 stabilizing mRNA in ER positive breast cancer

https://doi.org/10.18632/oncotarget.3654

Liang Shi, Tian-Song Xia, Xiao-Long Wei, Wenbin Zhou, Jinqiu Xue, Lin Cheng, Peipei Lou, Chunlian Li, Ying Wang, Ji-Fu Wei,  and Qiang Ding
12264-12278
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype

Oncometabolic mutation IDH1 R132H confers a metformin-hypersensitive phenotype

https://doi.org/10.18632/oncotarget.3733

Elisabet Cuyàs, Salvador Fernández-Arroyo, Bruna Corominas-Faja, Esther Rodríguez-Gallego, Joaquim Bosch-Barrera, Begoña Martin-Castillo, Rafael De Llorens, Jorge Joven,  and Javier A. Menendez
12279-12296
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Molecular stratification of metastatic melanoma using gene expression profiling : Prediction of survival outcome and benefit from molecular targeted therapy

Molecular stratification of metastatic melanoma using gene expression profiling : Prediction of survival outcome and benefit from molecular targeted therapy

https://doi.org/10.18632/oncotarget.3655

Helena Cirenajwis, Henrik Ekedahl, Martin Lauss, Katja Harbst, Ana Carneiro, Jens Enoksson, Frida Rosengren, Linda Werner-Hartman, Therese Törngren, Anders Kvist, Erik Fredlund, Pär-Ola Bendahl, Karin Jirström, Lotta Lundgren, Jillian Howlin, Åke Borg, Sofia K. Gruvberger-Saal, Lao H. Saal, Kari Nielsen, Markus Ringnér, Hensin Tsao, Håkan Olsson, Christian Ingvar, Johan Staaf,  and Göran Jönsson
12297-12309
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Celecoxib increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation

Celecoxib increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation

https://doi.org/10.18632/oncotarget.3678

Roberta Venè, Francesca Tosetti, Simona Minghelli, Alessandro Poggi, Nicoletta Ferrari,  and Roberto Benelli
12310-12325
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Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a/androgen receptor (AR)/TGF-β1/Smad/MMP9 signals

Infiltrated pre-adipocytes increase prostate cancer metastasis via modulation of the miR-301a/androgen receptor (AR)/TGF-β1/Smad/MMP9 signals

https://doi.org/10.18632/oncotarget.3619

Hongjun Xie, Lei Li, Guodong Zhu, Qiang Dang, Zhenkun Ma, Dalin He, Luke Chang, Wenbing Song, Hong-Chiang Chang, John J. Krolewski, Kent L. Nastiuk, Shuyuan Yeh,  and Chawnshang Chang
12326-12339
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Sorafenib and DE605, a novel c-Met inhibitor, synergistically suppress hepatocellular carcinoma

Sorafenib and DE605, a novel c-Met inhibitor, synergistically suppress hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.3656

Xiufeng Jiang, Kang Feng, Ye Zhang, Zengyao Li, Fan Zhou, Huiqiang Dou,  and Tong Wang
12340-12356
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PAQR3 expression is downregulated in human breast cancers and correlated with HER2 expression

PAQR3 expression is downregulated in human breast cancers and correlated with HER2 expression

https://doi.org/10.18632/oncotarget.3657

Zhenghu Li, Zhi-Qiang Ling, Weiwei Guo, Xiao-Xiao Lu, Yi Pan, Zhenzhen Wang,  and Yan Chen
12357-12368
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Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer

Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer

https://doi.org/10.18632/oncotarget.3682

Inès Dufait, Julia Katharina Schwarze, Therese Liechtenstein, Wim Leonard, Heng Jiang, David Escors, Mark De Ridder,  and Karine Breckpot
12369-12382
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Loss of Wave1 gene defines a subtype of lethal prostate cancer

Loss of Wave1 gene defines a subtype of lethal prostate cancer

https://doi.org/10.18632/oncotarget.3564

Adam G. Sowalsky, Rebecca Sager, Rachel J. Schaefer, Gennady Bratslavsky, Pier Paolo Pandolfi, Steven P. Balk,  and Leszek Kotula
12383-12391
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TOPK is highly expressed in circulating tumor cells, enabling metastasis of prostate cancer

TOPK is highly expressed in circulating tumor cells, enabling metastasis of prostate cancer

https://doi.org/10.18632/oncotarget.3630

Huimin Sun, Lei Zhang, Changhong Shi, Peizhen Hu, Wei Yan, Zhe Wang, Qiuhong Duan, Fan Lu, Lipeng Qin, Tao Lu, Juanjuan Xiao, Yingmei Wang, Feng Zhu,  and Chen Shao
12392-12404
Abstract  |  PDF  |  HTML  |  Order a Reprint

NHE9 induces chemoradiotherapy resistance in esophageal squamous cell carcinoma by upregulating the Src/Akt/β-catenin pathway and Bcl-2 expression

NHE9 induces chemoradiotherapy resistance in esophageal squamous cell carcinoma by upregulating the Src/Akt/β-catenin pathway and Bcl-2 expression

https://doi.org/10.18632/oncotarget.3618

Junying Chen, Hong Yang, Jing Wen, Kongjia Luo, Qianwen Liu, Yijie Huang, Yuzhen Zheng, Zihui Tan, Qinyuan Huag,  and Jianhua Fu
12405-12420
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SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation

SRC family kinase (SFK) inhibition reduces rhabdomyosarcoma cell growth in vitro and in vivo and triggers p38 MAP kinase-mediated differentiation

https://doi.org/10.18632/oncotarget.3043

Nadia Casini, Iris Maria Forte, Gianmarco Mastrogiovanni, Francesca Pentimalli, Adriano Angelucci, Claudio Festuccia, Valentina Tomei, Elisa Ceccherini, Domenico Di Marzo, Silvia Schenone, Maurizio Botta, Antonio Giordano,  and Paola Indovina
12421-12435
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer

Photochemical activation of MH3-B1/rGel: a HER2-targeted treatment approach for ovarian cancer

https://doi.org/10.18632/oncotarget.3814

Bente Bull-Hansen, Maria B. Berstad, Kristian Berg, Yu Cao, Ellen Skarpen, Ane Sofie Fremstedal, Michael G. Rosenblum, Qian Peng,  and Anette Weyergang
12436-12451
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SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy

SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy

https://doi.org/10.18632/oncotarget.3611

Marta Mellai, Monica Cattaneo, Alessandra Maria Storaci, Laura Annovazzi, Paola Cassoni, Antonio Melcarne, Pasquale De Blasio, Davide Schiffer,  and Ida Biunno
12452-12467
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Targeting the inhibitory receptor CTLA-4 on T cells increased abscopal effects in murine mesothelioma model

Targeting the inhibitory receptor CTLA-4 on T cells increased abscopal effects in murine mesothelioma model

https://doi.org/10.18632/oncotarget.3487

Licun Wu, Matthew Onn Wu, Luis De la Maza, Zhihong Yun, Julie Yu, Yidan Zhao, John Cho,  and Marc de Perrot
12468-12480
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Combining TGF-β1 knockdown and miR200c administration to optimize antitumor efficacy of B16F10/GPI-IL-21 vaccine

Combining TGF-β1 knockdown and miR200c administration to optimize antitumor efficacy of B16F10/GPI-IL-21 vaccine

https://doi.org/10.18632/oncotarget.3722

Xiaoying Wang, Fengshu Zhao, Xiangfeng He, Jing Wang, Ying Zhang, Hongyi Zhang, Yaoyao Ni, Jianan Sun, Xiaobing Wang,  and Jun Dou
12493-12504
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Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines

Inhibition of mutant IDH1 decreases D-2-HG levels without affecting tumorigenic properties of chondrosarcoma cell lines

https://doi.org/10.18632/oncotarget.3723

Johnny Suijker, Jan Oosting, Annemarie Koornneef, Eduard A. Struys, Gajja S. Salomons, Frank G. Schaap, Cathelijn J.F. Waaijer, Pauline M. Wijers-Koster, Inge H. Briaire-de Bruijn, Lizette Haazen, Scott M. Riester, Amel Dudakovic, Erik Danen, Anne-Marie Cleton-Jansen, Andre J. van Wijnen,  and Judith V.M.G. Bovée
12505-12519
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Biological and clinical effects of abiraterone on anti-resorptive and anabolic activity in bone microenvironment

Biological and clinical effects of abiraterone on anti-resorptive and anabolic activity in bone microenvironment

https://doi.org/10.18632/oncotarget.3724

Michele Iuliani, Francesco Pantano, Consuelo Buttigliero, Marco Fioramonti, Valentina Bertaglia, Bruno Vincenzi, Alice Zoccoli, Giulia Ribelli, Marcello Tucci, Francesca Vignani, Alfredo Berruti, Giorgio Vittorio Scagliotti, Giuseppe Tonini,  and Daniele Santini
12520-12528
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling

Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling

https://doi.org/10.18632/oncotarget.3725

Yong Ryoul Yang, Dae Hyun Kim, Young-Kyo Seo, Dohyun Park, Hyun-Jun Jang, Soo Youn Choi, Yong Hwa Lee, Gyun Hui Lee, Kazuki Nakajima, Naoyuki Taniguchi, Jung-Min Kim, Eun-Jeong Choi, Hyo Youl Moon, Il Shin Kim, Jang Hyun Choi, Ho Lee, Sung Ho Ryu, Lucio Cocco,  and Pann-Ghill Suh
12529-12542
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miRNA-target network reveals miR-124as a key miRNA contributing to clear cell renal cell carcinoma aggressive behaviour by targeting CAV1 and FLOT1

miRNA-target network reveals miR-124as a key miRNA contributing to clear cell renal cell carcinoma aggressive behaviour by targeting CAV1 and FLOT1

https://doi.org/10.18632/oncotarget.3815

Henriett Butz, Peter M. Szabó, Heba W.Z. Khella, Roy Nofech-Mozes, Attila Patocs,  and George M. Yousef
12543-12557
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Tumor suppressive microRNA-137 negatively regulates Musashi-1 and colorectal cancer progression

Tumor suppressive microRNA-137 negatively regulates Musashi-1 and colorectal cancer progression

https://doi.org/10.18632/oncotarget.3726

Amber R. Smith, Rebecca T. Marquez, Wei-chung Tsao, Surajit Pathak, Alexandria Roy, Jie Ping, Bailey Wilkerson, Lan Lan, Wenjian Meng, Kristi L. Neufeld, Xiao-Feng Sun,  and Liang Xu
12558-12573
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5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair

5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair

https://doi.org/10.18632/oncotarget.3728

Upadhyayula Sai Srinivas, Jerzy Dyczkowski, Tim Beißbarth, Jochen Gaedcke, Wael Y. Mansour, Kerstin Borgmann,  and Matthias Dobbelstein
12574-12586
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Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer

Myc-dependent purine biosynthesis affects nucleolar stress and therapy response in prostate cancer

https://doi.org/10.18632/oncotarget.3494

Stefan J. Barfeld, Ladan Fazli, Margareta Persson, Lisette Marjavaara, Alfonso Urbanucci, Kirsi M. Kaukoniemi, Paul S. Rennie, Yvonne Ceder, Andrei Chabes, Tapio Visakorpi,  and Ian G. Mills
12587-12602
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Quercetin-induced apoptosis prevents EBV infection

Quercetin-induced apoptosis prevents EBV infection

https://doi.org/10.18632/oncotarget.3687

Minjung Lee, Myoungki Son, Eunhyun Ryu, Yu Su Shin, Jong Gwang Kim, Byung Woog Kang, Hyosun Cho,  and Hyojeung Kang
12603-12624
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MAP17 (PDZKIP1) as a novel prognostic biomarker for laryngeal cancer

MAP17 (PDZKIP1) as a novel prognostic biomarker for laryngeal cancer

https://doi.org/10.18632/oncotarget.3470

María-José de Miguel-Luken, Manuel Chaves-Conde, Verónica de Miguel-Luken, Sandra Muñoz-Galván, José Luis López-Guerra, Juan C. Mateos, Jerónimo Pachón, David Chinchón, Vladimir Suarez,  and Amancio Carnero
12625-12636
Abstract  |  PDF  |  HTML  |  Order a Reprint

A STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations

A STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations

https://doi.org/10.18632/oncotarget.3703

Claudia Canino, YuYing Luo, Paola Marcato, Giovanni Blandino, Harvey I. Pass,  and Mario Cioce
12637-12653
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High USP22 expression indicates poor prognosis in hepatocellular carcinoma

High USP22 expression indicates poor prognosis in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.3705

Bo Tang, Fang Tang, Bo Li, Shengguang Yuan, Qing Xu, Stephen Tomlinson, Junfei Jin, Wei Hu,  and Songqing He
12654-12667
Abstract  |  PDF  |  HTML  |  Order a Reprint

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner

Maritoclax and dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner

https://doi.org/10.18632/oncotarget.3706

Shankar Varadarajan, Paramasivan Poornima, Mateus Milani, Krishne Gowda, Shantu Amin, Hong-Gang Wang,  and Gerald M. Cohen
12668-12681
Abstract  |  PDF  |  HTML  |  Order a Reprint

Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells

Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells

https://doi.org/10.18632/oncotarget.3707

Riesa M. Burnett, Kelly E. Craven, Purna Krishnamurthy, Chirayu P. Goswami, Sunil Badve, Peter Crooks, William P. Mathews, Poornima Bhat-Nakshatri,  and Harikrishna Nakshatri
12682-12696
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC

FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC

https://doi.org/10.18632/oncotarget.3708

Francesco Morra, Chiara Luise, Francesco Merolla, Ina Poser, Roberta Visconti, Gennaro Ilardi, Simona Paladino, Hiroyuki Inuzuka, Gianluca Guggino, Roberto Monaco, David Colecchia, Guglielmo Monaco, Aniello Cerrato, Mario Chiariello, Krista Denning, Pier Paolo Claudio, Stefania Staibano,  and Angela Celetti
12697-12709
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genomic analysis of xCT-mediated regulatory network: identification of novel targets against AIDS-associated lymphoma

Genomic analysis of xCT-mediated regulatory network: identification of novel targets against AIDS-associated lymphoma

https://doi.org/10.18632/oncotarget.3710

Lu Dai, Yueyu Cao, Yihan Chen, Johnan A.R. Kaleeba, Jovanny Zabaleta,  and Zhiqiang Qin
12710-12722
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells

JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.3713

Bo Tang, Guangying Qi, Fang Tang, Shengguang Yuan, Zhenran Wang, Xingsi Liang, Bo Li, Shuiping Yu, Jie Liu, Qi Huang, Yangchao Wei, Run Zhai, Biao Lei, Hongping Yu, Xingyuan Jiao,  and Songqing He
12723-12739
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A standardized autopsy procurement allows for the comprehensive study of DIPG biology

A standardized autopsy procurement allows for the comprehensive study of DIPG biology

https://doi.org/10.18632/oncotarget.3374

Madhuri Kambhampati, Jennifer P. Perez, Sridevi Yadavilli, Amanda M. Saratsis, Ashley D. Hill, Cheng-Ying Ho, Eshini Panditharatna, Melissa Markel, Roger J. Packer,  and Javad Nazarian
12740-12747
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metformin potentiates rapamycin and cisplatin in gastric cancer in mice

Metformin potentiates rapamycin and cisplatin in gastric cancer in mice

https://doi.org/10.18632/oncotarget.3327

Guanzhen Yu, Wenzhang Fang, Tian Xia, Ying Chen, Yunshu Gao, Xiaodong Jiao, Suyun Huang, Zhaosheng Li, Jiejun Wang,  and Keping Xie
12748-12762
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers

The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers

https://doi.org/10.18632/oncotarget.3497

Chee Wee Ong, Pei Yi Chong, Darragh G. McArt, Jason Yongsheng Chan, Hwee Tong Tan, Alan Prem Kumar, Maxey C. M. Chung, Marie-Véronique Clément, Richie Soong, Sandra Van Schaeybroeck, David J. J. Waugh, Patrick G. Johnston, Philip D. Dunne,  and Manuel Salto-Tellez
12763-12773
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differences in breast cancer characteristics and outcomes between Caucasian and Chinese women in the US

Differences in breast cancer characteristics and outcomes between Caucasian and Chinese women in the US

https://doi.org/10.18632/oncotarget.3666

Dan-Na Chen, Chuan-Gui Song, Qian-Wen Ouyang, Yi-Zhou Jiang, Fu-Gui Ye, Fang-Jing Ma, Rong-Cheng Luo,  and Zhi-Ming Shao
12774-12782
Abstract  |  PDF  |  HTML  |  Order a Reprint

Molecular heterogeneity assessment by next-generation sequencing and response to gefitinib of EGFR mutant advanced lung adenocarcinoma

Molecular heterogeneity assessment by next-generation sequencing and response to gefitinib of EGFR mutant advanced lung adenocarcinoma

https://doi.org/10.18632/oncotarget.3727

Emilio Bria, Sara Pilotto, Eliana Amato, Matteo Fassan, Silvia Novello, Umberto Peretti, Tiziana Vavalà, Stefania Kinspergher, Luisella Righi, Antonio Santo, Matteo Brunelli, Vincenzo Corbo, Eliana Giglioli, Isabella Sperduti, Michele Milella, Marco Chilosi, Aldo Scarpa,  and Giampaolo Tortora
12783-12795
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dual targeting of HER1/EGFR and HER2 with cetuximab and trastuzumab in patients with metastatic pancreatic cancer after gemcitabine failure: results of the “THERAPY”phase 1-2 trial

Dual targeting of HER1/EGFR and HER2 with cetuximab and trastuzumab in patients with metastatic pancreatic cancer after gemcitabine failure: results of the “THERAPY”phase 1-2 trial

https://doi.org/10.18632/oncotarget.3473

Eric Assenat, David Azria, Caroline Mollevi, Rosine Guimbaud, Nicole Tubiana-Mathieu, Denis Smith, Jean-Pierre Delord, Emmanuelle Samalin, Fabienne Portales, Christel Larbouret, Bruno Robert, Frédéric Bibeau, Jean-Pierre Bleuse, Evelyne Crapez, Marc Ychou,  and André Pèlegrin
12796-12808
Abstract  |  PDF  |  HTML  |  Order a Reprint

Actionable mutations in plasma cell-free DNA in patients with advanced cancers referred for experimental targeted therapies

Actionable mutations in plasma cell-free DNA in patients with advanced cancers referred for experimental targeted therapies

https://doi.org/10.18632/oncotarget.3373

Filip Janku, Philipp Angenendt, Apostolia M. Tsimberidou, Siqing Fu, Aung Naing, Gerald S. Falchook, David S. Hong, Veronica R. Holley, Goran Cabrilo, Jennifer J. Wheler, Sarina A. Piha-Paul, Ralph G. Zinner, Agop Y. Bedikian, Michael J. Overman, Bryan K. Kee, Kevin B. Kim, Scott E. Kopetz, Rajyalakshmi Luthra, Frank Diehl, Funda Meric-Bernstam,  and Razelle Kurzrock
12809-12821
Abstract  |  PDF  |  HTML  |  Order a Reprint

HOXB13 overexpression is an independent predictor of early PSA recurrence in prostate cancer treated by radical prostatectomy

HOXB13 overexpression is an independent predictor of early PSA recurrence in prostate cancer treated by radical prostatectomy

https://doi.org/10.18632/oncotarget.3431

Cristina Villares Zabalza, Meike Adam, Christoph Burdelski, Waldemar Wilczak, Corina Wittmer, Stefan Kraft, Till Krech, Stefan Steurer, Christina Koop, Claudia Hube-Magg, Markus Graefen, Hans Heinzer, Sarah Minner, Ronald Simon, Guido Sauter, Thorsten Schlomm,  and Maria Christina Tsourlakis
12822-12834
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