Oncotarget

Vol 6, No 13

May 10, 2015

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Chemotherapy induces the catabolic tumour stroma phenotype. See Peiris-Pagès et al.

Table of Contents

Editorial

Growth hormone in adipose dysfunction and senescence

Growth hormone in adipose dysfunction and senescence

https://doi.org/10.18632/oncotarget.3997

Michael B. Stout, Tamara Tchkonia,  and James L. Kirkland
10667-10668
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iPSC-MSCs and islet allograft tolerance

iPSC-MSCs and islet allograft tolerance

https://doi.org/10.18632/oncotarget.4050

Tong-Song Wang, Pan-Pan Cheng,  and Zhong-Quan Qi
10669-10670
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Reviews

Genetic/molecular alterations of meningiomas and the signaling pathways targeted

Genetic/molecular alterations of meningiomas and the signaling pathways targeted

https://doi.org/10.18632/oncotarget.3870

Patrícia Domingues, María González-Tablas, Álvaro Otero, Daniel Pascual, Laura Ruiz, David Miranda, Pablo Sousa, Jesús María Gonçalves, María Celeste Lopes, Alberto Orfao,  and María Dolores Tabernero
10671-10688
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Mutations of c-Cbl in myeloid malignancies

Mutations of c-Cbl in myeloid malignancies

https://doi.org/10.18632/oncotarget.3986

Shulamit Katzav,  and M. Lienhard Schmitz
10689-10696
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EMT, CTCs and CSCs in tumor relapse and drug-resistance

EMT, CTCs and CSCs in tumor relapse and drug-resistance

https://doi.org/10.18632/oncotarget.4037

Abhisek Mitra, Lopa Mishra,  and Shulin Li
10697-10711
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Priority Research Papers

Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic

Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic

https://doi.org/10.18632/oncotarget.3544

Siddik Sarkar, Bridget A. Quinn, Xue-Ning Shen, Rupesh Dash, Swadesh K. Das, Luni Emdad, Alexander L. Klibanov, Xiang-Yang Wang, Maurizio Pellecchia, Devanand Sarkar,  and Paul B. Fisher
10712-10727
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells

Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells

https://doi.org/10.18632/oncotarget.3828

Maria Peiris-Pagès, Federica Sotgia,  and Michael P. Lisanti
10728-10745
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Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity

Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity

https://doi.org/10.18632/oncotarget.3628

Jessica Frankum, Pavel Moudry, Rachel Brough, Zdenek Hodny, Alan Ashworth, Jiri Bartek,  and Christopher J. Lord
10746-10758
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Research Papers: Pathology

Dysfunctional BLK in common variable immunodeficiency perturbs B-cell proliferation and ability to elicit antigen-specific CD4+ T-cell help

Dysfunctional BLK in common variable immunodeficiency perturbs B-cell proliferation and ability to elicit antigen-specific CD4+ T-cell help

https://doi.org/10.18632/oncotarget.3577

Ewoud B. Compeer, Willemijn Janssen, Annet van Royen-Kerkhof, Marielle van Gijn, Joris M. van Montfrans,  and Marianne Boes
10759-10771
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Experimental microembolism induces localized neuritic pathology in guinea pig cerebrum

Experimental microembolism induces localized neuritic pathology in guinea pig cerebrum

https://doi.org/10.18632/oncotarget.3599

Jian-Ming Li, Yan Cai, Fei Liu, La Yang, Xia Hu, Peter Patrylo Patrylo, Huaibin Cai, Xue-Gang Luo, Dong Xiao,  and Xiao-Xin Yan
10772-10785
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Global gene expression in pseudomyxoma peritonei, with parallel development of two immortalized cell lines

Global gene expression in pseudomyxoma peritonei, with parallel development of two immortalized cell lines

https://doi.org/10.18632/oncotarget.3198

Darren L. Roberts, Sarah T. O’Dwyer, Peter L. Stern,  and Andrew G. Renehan
10786-10800
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Research Papers: Gerotarget (Focus on Aging)

Ovariectomy shortens the life span of female mice

Ovariectomy shortens the life span of female mice

https://doi.org/10.18632/oncotarget.2984

Valeria Benedusi, Elisa Martini, Marinos Kallikourdis, Alessandro Villa, Clara Meda,  and Adriana Maggi
10801-10811
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A critical role of nicotinamide phosphoribosyltransferase in human telomerase reverse transcriptase induction by resveratrol in aortic smooth muscle cells

A critical role of nicotinamide phosphoribosyltransferase in human telomerase reverse transcriptase induction by resveratrol in aortic smooth muscle cells

https://doi.org/10.18632/oncotarget.3580

Peixin Huang, Sean M. Riordan, Daniel P. Heruth, Dmitry N. Grigoryev, Li Qin Zhang,  and Shui Qing Ye
10812-10824
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Research Papers

A novel role for drebrin in regulating progranulin bioactivity in bladder cancer

A novel role for drebrin in regulating progranulin bioactivity in bladder cancer

https://doi.org/10.18632/oncotarget.3424

Shi-Qiong Xu, Simone Buraschi, Alaide Morcavallo, Marco Genua, Tomoaki Shirao, Stephen C. Peiper, Leonard G. Gomella, Ruth Birbe, Antonino Belfiore, Renato V. Iozzo,  and Andrea Morrione
10825-10839
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The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration

The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration

https://doi.org/10.18632/oncotarget.3450

Yating Cheng, Indira Jutooru, Gayathri Chadalapaka, Christopher J. Corton,  and Stephen Safe
10840-10852
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The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2

The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2

https://doi.org/10.18632/oncotarget.3414

Nicolas Skrypek, Romain Vasseur, Audrey Vincent, Bélinda Duchêne, Isabelle Van Seuningen,  and Nicolas Jonckheere
10853-10867
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microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer

microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer

https://doi.org/10.18632/oncotarget.3451

Dong-liang Chen, Dong-sheng Zhang, Yun-xin Lu, Le-zong Chen, Zhao-lei Zeng, Ming-ming He, Feng-hua Wang, Yu-hong Li, Hui-zhong Zhang, Helene Pelicano, Wei Zhang,  and Rui-hua Xu
10868-10879
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PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma

PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.3534

Carmen Oi-ning Leung, Carmen Chak-lui Wong, Dorothy Ngo-yin Fan, Alan Ka-lun Kai, Edmund Kwok-kwan Tung, Iris Ming-jing Xu, Irene Oi-lin Ng,  and Regina Cheuk-lam Lo
10880-10892
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Hypoxia-inducible factor 1α (HIF-1α) and reactive oxygen species (ROS) mediates radiation-induced invasiveness through the SDF-1α/CXCR4 pathway in non-small cell lung carcinoma cells

Hypoxia-inducible factor 1α (HIF-1α) and reactive oxygen species (ROS) mediates radiation-induced invasiveness through the SDF-1α/CXCR4 pathway in non-small cell lung carcinoma cells

https://doi.org/10.18632/oncotarget.3535

Qing Gu, Yan He, Jianfeng Ji, Yifan Yao, Wenhao Shen, Jialin Luo, Wei Zhu, Han Cao, Yangyang Geng, Jing Xu, Shuyu Zhang, Jianping Cao,  and Wei-Qun Ding
10893-10907
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction

Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction

https://doi.org/10.18632/oncotarget.3434

Zaid Al-Wahab, Ismail Mert, Calvin Tebbe, Jasdeep Chhina, Miriana Hijaz, Robert T. Morris, Rouba Ali-Fehmi, Shailendra Giri, Adnan R. Munkarah,  and Ramandeep Rattan
10908-10923
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Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood

Quantitative phosphoproteome analysis of embryonic stem cell differentiation toward blood

https://doi.org/10.18632/oncotarget.3454

Manuela Piazzi, Andrew Williamson, Chia-Fang Lee, Stella Pearson, Georges Lacaud, Valerie Kouskoff, James A. McCubrey, Lucio Cocco,  and Anthony D. Whetton
10924-10939
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LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy

LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy

https://doi.org/10.18632/oncotarget.3458

Mingxin Zuo, Chenglong Li, Jiayuh Lin,  and Milind Javle
10940-10949
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Controlled release microspheres loaded with BMP7 suppress primary tumors from human glioblastoma

Controlled release microspheres loaded with BMP7 suppress primary tumors from human glioblastoma

https://doi.org/10.18632/oncotarget.3459

Pilar González-Gómez, Jose Crecente-Campo, Cristina Zahonero, Maria de la Fuente, Aurelio Hernández-Laín, Helena Mira, Pilar Sánchez-Gómez,  and Marcos Garcia-Fuentes
10950-10963
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miR-942 promotes cancer stem cell-like traits in esophageal squamous cell carcinoma through activation of Wnt/β-catenin signalling pathway

miR-942 promotes cancer stem cell-like traits in esophageal squamous cell carcinoma through activation of Wnt/β-catenin signalling pathway

https://doi.org/10.18632/oncotarget.3696

Chunlei Ge, Shikai Wu, Weiwei Wang, Zhimin Liu, Jianhua Zhang, Zhenyu Wang, Ruilei Li, Zhiwei Zhang, Zhen Li, Suwei Dong, Ying Wang, Yuanbo Xue, Jinyan Yang, Qinghua Tan, Ziping Wang,  and Xin Song
10964-10977
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of new biomarkers for human papillary thyroid carcinoma employing NanoString analysis

Identification of new biomarkers for human papillary thyroid carcinoma employing NanoString analysis

https://doi.org/10.18632/oncotarget.3452

Zhanna Chitikova, Marc Pusztaszeri, Anne-Marie Makhlouf, Margaret Berczy, Celine Delucinge-Vivier, Frederic Triponez, Patrick Meyer, Jacques Philippe,  and Charna Dibner
10978-10993
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway

Oncogenic KRAS sensitizes premalignant, but not malignant cells, to Noxa-dependent apoptosis through the activation of the MEK/ERK pathway

https://doi.org/10.18632/oncotarget.3552

Annalisa Conti, Maria Teresa Majorini, Richard Elliott, Alan Ashworth, Christopher J. Lord, Carlotta Cancelliere, Alberto Bardelli, Pierfausto Seneci, Henning Walczak, Domenico Delia,  and Daniele Lecis
10994-11008
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Leucine-rich α-2-glycoprotein promotes TGFβ1-mediated growth suppression in the Lewis lung carcinoma cell lines

Leucine-rich α-2-glycoprotein promotes TGFβ1-mediated growth suppression in the Lewis lung carcinoma cell lines

https://doi.org/10.18632/oncotarget.3557

Norihiko Takemoto, Satoshi Serada, Minoru Fujimoto, Honda Hiromi, Tomoharu Ohkawara, Tsuyoshi Takahashi, Shintaro Nomura, Hidenori Inohara,  and Tetsuji Naka
11009-11022
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MicroRNA-146a modulates B-cell oncogenesis by regulating Egr1

MicroRNA-146a modulates B-cell oncogenesis by regulating Egr1

https://doi.org/10.18632/oncotarget.3433

Jorge R. Contreras, Jayanth Kumar Palanichamy, Tiffany M. Tran, Thilini R. Fernando, Norma I. Rodriguez-Malave, Neha Goswami, Valerie A. Arboleda, David Casero,  and Dinesh S. Rao
11023-11037
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Low thyroid hormone levels improve survival in murine model for ocular melanoma

Low thyroid hormone levels improve survival in murine model for ocular melanoma

https://doi.org/10.18632/oncotarget.3566

Ido Didi Fabian, Mordechai Rosner, Ina Fabian, Vicktoria Vishnevskia-Dai, Ofira Zloto, Elena Shinderman Maman, Keren Cohen, Martin Ellis, Hung-Yun Lin, Aleck Hercbergs, Paul J. Davis,  and Osnat Ashur-Fabian
11038-11046
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Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis

Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis

https://doi.org/10.18632/oncotarget.3567

Evgeniy Stoyanov, Guy Ludwig, Lina Mizrahi, Devorah Olam, Temima Schnitzer-Perlman, Elena Tasika, Gabriele Sass, Gisa Tiegs, Yong Jiang, Ting Nie, James Kohler, Raymond F. Schinazi, Paula M. Vertino, Howard Cedar, Eithan Galun,  and Daniel Goldenberg
11047-11060
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: resistance reversal with WNT inhibitor

The pan-PI3K inhibitor GDC-0941 activates canonical WNT signaling to confer resistance in TNBC cells: resistance reversal with WNT inhibitor

https://doi.org/10.18632/oncotarget.3568

Huey-En Tzeng, Lixin Yang, Kemin Chen, Yafan Wang, Yun-Ru Liu, Shiow-Lin Pan, Shikha Gaur, Shuya Hu,  and Yun Yen
11061-11073
Abstract  |  PDF  |  HTML  |  Order a Reprint

Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression

Pygopus-2 promotes invasion and metastasis of hepatic carcinoma cell by decreasing E-cadherin expression

https://doi.org/10.18632/oncotarget.3570

Sheng Zhang, Jie Li, Pingguo Liu, Jianfeng Xu, Wenxiu Zhao, Chengrong Xie, Zhenyu Yin,  and Xiaomin Wang
11074-11086
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Claudin-4 is required for vasculogenic mimicry formation in human breast cancer cells

Claudin-4 is required for vasculogenic mimicry formation in human breast cancer cells

https://doi.org/10.18632/oncotarget.3571

Yong-Feng Cui, An-Heng Liu, Dai-Zhi An, Ru-Bao Sun, Yun Shi, Yun-Xiang Shi, Miao Shi, Qiang Zhang, Li-Li Wang, Qiong Feng, Gui-Lan Pan,  and Qiang Wang
11087-11097
Abstract  |  PDF  |  HTML  |  Order a Reprint

Targeting of surface alpha-enolase inhibits the invasiveness of pancreatic cancer cells

Targeting of surface alpha-enolase inhibits the invasiveness of pancreatic cancer cells

https://doi.org/10.18632/oncotarget.3572

Moitza Principe, Patrizia Ceruti, Neng-Yao Shih, Michelle S. Chattaragada, Simona Rolla, Laura Conti, Marco Bestagno, Lorena Zentilin, Sheng-Hui Yang, Paola Migliorini, Paola Cappello, Oscar Burrone,  and Francesco Novelli
11098-11113
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer

RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer

https://doi.org/10.18632/oncotarget.3573

Chengcheng Guo, Chuncheng Hao, RuPing Shao, Bingliang Fang, Arlene M. Correa, Wayne L. Hofstetter, Jack A. Roth, Carmen Behrens, Neda Kalhor, Ignacio I. Wistuba, Stephen G. Swisher,  and Apar Pataer
11114-11124
Abstract  |  PDF  |  HTML  |  Order a Reprint

High expression of small GTPase Rab3D promotes cancer progression and metastasis

High expression of small GTPase Rab3D promotes cancer progression and metastasis

https://doi.org/10.18632/oncotarget.3575

Jian Yang, Wei Liu, Xin’an Lu, Yan Fu, Lin Li,  and Yongzhang Luo
11125-11138
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma

Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma

https://doi.org/10.18632/oncotarget.3576

Yong Feng, Jacson Shen, Yan Gao, Yunfei Liao, Gregory Cote, Edwin Choy, Ivan Chebib, Henry Mankin, Francis Hornicek,  and Zhenfeng Duan
11139-11149
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Combined inhibition of EGFR and c-ABL suppresses the growth of triple-negative breast cancer growth through inhibition of HOTAIR

Combined inhibition of EGFR and c-ABL suppresses the growth of triple-negative breast cancer growth through inhibition of HOTAIR

https://doi.org/10.18632/oncotarget.3441

Yuan-Liang Wang, Anne-Marie Overstreet, Min-Shan Chen, Jiang Wang, Hua-Jun Zhao, Po-Chun Ho, Molly Smith,  and Shao-Chun Wang
11150-11161
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration

Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration

https://doi.org/10.18632/oncotarget.3578

FuiBoon Kai, James P. Fawcett,  and Roy Duncan
11162-11174
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin

Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin

https://doi.org/10.18632/oncotarget.3579

Lahiru Gangoda, Shivakumar Keerthikumar, Pamali Fonseka, Laura E. Edgington, Ching-Seng Ang, Cemil Ozcitti, Matthew Bogyo, Belinda S. Parker,  and Suresh Mathivanan
11175-11190
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Low spinophilin expression enhances aggressive biological behavior of breast cancer

Low spinophilin expression enhances aggressive biological behavior of breast cancer

https://doi.org/10.18632/oncotarget.3586

Daniela Schwarzenbacher, Verena Stiegelbauer, Alexander Deutsch, Anna Lena Ress, Ariane Aigelsreiter, Silvia Schauer, Karin Wagner, Tanja Langsenlehner, Margit Resel, Armin Gerger, Hui Ling, Cristina Ivan, George Adrian Calin, Gerald Hoefler, Beate Rinner,  and Martin Pichler
11191-11202
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Esophageal adenocarcinoma and obesity: peritumoral adipose tissue plays a role in lymph node invasion

Esophageal adenocarcinoma and obesity: peritumoral adipose tissue plays a role in lymph node invasion

https://doi.org/10.18632/oncotarget.3587

Elisabetta Trevellin, Marco Scarpa, Amedeo Carraro, Francesca Lunardi, Andromachi Kotsafti, Andrea Porzionato, Luca Saadeh, Matteo Cagol, Rita Alfieri, Umberto Tedeschi, Fiorella Calabrese, Carlo Castoro,  and Roberto Vettor
11203-11215
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma

Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma

https://doi.org/10.18632/oncotarget.3589

Anna Granata, Roberta Nicoletti, Paola Perego, Egidio Iorio, Balaji Krishnamachary, Fabio Benigni, Alessandro Ricci, Franca Podo, Zaver M. Bhujwalla, Silvana Canevari, Marina Bagnoli,  and Delia Mezzanzanica
11216-11230
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Resistin and interleukin-6 exhibit racially-disparate expression in breast cancer patients, display molecular association and promote growth and aggressiveness of tumor cells through STAT3 activation

Resistin and interleukin-6 exhibit racially-disparate expression in breast cancer patients, display molecular association and promote growth and aggressiveness of tumor cells through STAT3 activation

https://doi.org/10.18632/oncotarget.3591

Sachin K. Deshmukh, Sanjeev K. Srivastava, Arun Bhardwaj, Ajay P. Singh, Nikhil Tyagi, Saravanakumar Marimuthu, Donna L. Dyess, Valeria Dal Zotto, James E. Carter,  and Seema Singh
11231-11241
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma

New somatic mutations and WNK1-B4GALNT3 gene fusion in papillary thyroid carcinoma

https://doi.org/10.18632/oncotarget.3593

Valerio Costa, Roberta Esposito, Carmela Ziviello, Romina Sepe, Larissa Valdemarin Bim, Nunzio Antonio Cacciola, Myriam Decaussin-Petrucci, Pierlorenzo Pallante, Alfredo Fusco,  and Alfredo Ciccodicola
11242-11251
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells

E2F1 enhances glycolysis through suppressing Sirt6 transcription in cancer cells

https://doi.org/10.18632/oncotarget.3594

Minghui Wu, Edward Seto,  and Jingsong Zhang
11252-11263
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Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment

Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment

https://doi.org/10.18632/oncotarget.3595

Laura Brohée, Stéphane Demine, Jérome Willems, Thierry Arnould, Alain C. Colige,  and Christophe F. Deroanne
11264-11280
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FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway

FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway

https://doi.org/10.18632/oncotarget.3596

Guanzhen Yu, Aidong Zhou, Jianfei Xue, Chen Huang, Xia Zhang, Shin-Hyuk Kang, Wen-Tai Chiu, Christina Tan, Keping Xie, Jiejun Wang,  and Suyun Huang
11281-11294
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Sunitinib but not VEGF blockade inhibits cancer stem cell endothelial differentiation

Sunitinib but not VEGF blockade inhibits cancer stem cell endothelial differentiation

https://doi.org/10.18632/oncotarget.3123

Alessia Brossa, Cristina Grange, Letizia Mancuso, Laura Annaratone, Maria Antonietta Satolli, Massimiliano Mazzone, Giovanni Camussi,  and Benedetta Bussolati
11295-11309
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Targeting myeloid cells in the tumor microenvironment enhances vaccine efficacy in murine epithelial ovarian cancer

Targeting myeloid cells in the tumor microenvironment enhances vaccine efficacy in murine epithelial ovarian cancer

https://doi.org/10.18632/oncotarget.3597

Anm Nazmul H. Khan, Nonna Kolomeyevskaya, Kelly L. Singel, Melissa J. Grimm, Kirsten B. Moysich, Sayeema Daudi, Kassondra S. Grzankowski, Sashikant Lele, Lourdes Ylagan, Gill A. Webster, Scott I. Abrams, Kunle Odunsi,  and Brahm H. Segal
11310-11326
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Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

https://doi.org/10.18632/oncotarget.3598

Valentina R. Minciacchi, Sungyong You, Cristiana Spinelli, Samantha Morley, Mandana Zandian, Paul-Joseph Aspuria, Lorenzo Cavallini, Chiara Ciardiello, Mariana Reis Sobreiro, Matteo Morello, Geetanjali Kharmate, Su Chul Jang, Dae-Kyum Kim, Elham Hosseini-Beheshti, Emma Tomlinson Guns, Martin Gleave, Yong Song Gho, Suresh Mathivanan, Wei Yang, Michael R. Freeman,  and Dolores Di Vizio
11327-11341
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma

The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma

https://doi.org/10.18632/oncotarget.3604

Yasuto Kinose, Kenjiro Sawada, Koji Nakamura, Ikuko Sawada, Aska Toda, Erika Nakatsuka, Kae Hashimoto, Seiji Mabuchi, Kazuhiro Takahashi, Hirohisa Kurachi, Ernst Lengyel,  and Tadashi Kimura
11342-11356
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone

Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone

https://doi.org/10.18632/oncotarget.3605

Shigeru Kawabata, M. Christine Hollander, Jeeva P. Munasinghe, Lauren R. Brinster, José R. Mercado-Matos, Jie Li, Lucia Regales, William Pao, Pasi A. Jänne, Kwok-Kin Wong, John A. Butman, Russell R. Lonser, Marlan R. Hansen, Richard K. Gurgel, Alexander O. Vortmeyer,  and Phillip A. Dennis
11357-11368
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice

Intraperitoneal administration of tumor-targeting Salmonella typhimurium A1-R inhibits disseminated human ovarian cancer and extends survival in nude mice

https://doi.org/10.18632/oncotarget.3607

Yasunori Matsumoto, Shinji Miwa, Yong Zhang, Ming Zhao, Shuya Yano, Fuminari Uehara, Mako Yamamoto, Yukihiko Hiroshima, Makoto Toneri, Michael Bouvet, Hisahiro Matsubara, Hiroyuki Tsuchiya,  and Robert M. Hoffman
11369-11377
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B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3

B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3

https://doi.org/10.18632/oncotarget.3409

Fei Fei, Eun Ji Joo, Somayeh S. Tarighat, Isabelle Schiffer, Helicia Paz, Muller Fabbri, Hisham Abdel-Azim, John Groffen,  and Nora Heisterkamp
11378-11394
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism

Distinct von Hippel-Lindau gene and hypoxia-regulated alterations in gene and protein expression patterns of renal cell carcinoma and their effects on metabolism

https://doi.org/10.18632/oncotarget.3456

Sandra Leisz, Kristin Schulz, Susanne Erb, Peter Oefner, Katja Dettmer, Dimitrios Mougiakakos, Ena Wang, Francesco M. Marincola, Franziska Stehle,  and Barbara Seliger
11395-11406
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Population analysis of microsatellite genotypes reveals a signature associated with ovarian cancer

Population analysis of microsatellite genotypes reveals a signature associated with ovarian cancer

https://doi.org/10.18632/oncotarget.2933

Natalie C. Fonville, Zalman Vaksman, Lauren J. McIver,  and Harold R. Garner
11407-11420
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Loss of β-catenin in adrenocortical cancer cells causes growth inhibition and reversal of epithelial-to-mesenchymal transition

Loss of β-catenin in adrenocortical cancer cells causes growth inhibition and reversal of epithelial-to-mesenchymal transition

https://doi.org/10.18632/oncotarget.3222

Aude Salomon, Michelle Keramidas, Cécile Maisin,  and Michaël Thomas
11421-11433
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Reduction in gap junction intercellular communication promotes glioma migration

Reduction in gap junction intercellular communication promotes glioma migration

https://doi.org/10.18632/oncotarget.3407

Qurratulain Aftab, Wun-Chey Sin,  and Christian C. Naus
11447-11464
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD44 increases the efficiency of distant metastasis of breast cancer

CD44 increases the efficiency of distant metastasis of breast cancer

https://doi.org/10.18632/oncotarget.3410

Suzanne McFarlane, Jonathan A. Coulter, Paul Tibbits, Anthony O’Grady, Cheryl McFarlane, Nicola Montgomery, Ashleigh Hill, Helen O. McCarthy, Leonie S. Young, Elaine W. Kay, Clare M. Isacke,  and David J.J. Waugh
11465-11476
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High frequency of loss of PTEN expression in human solid salivary adenoid cystic carcinoma and its implication for targeted therapy

High frequency of loss of PTEN expression in human solid salivary adenoid cystic carcinoma and its implication for targeted therapy

https://doi.org/10.18632/oncotarget.3411

Han Liu, Li Du, Ru Wang, Chao Wei, Bo Liu, Lei Zhu, Pixu Liu, Qiang Liu, Jiang Li, Shi-Long Lu,  and Jing Xiao
11477-11491
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metastasis-associated in colon cancer-1 promotes vasculogenic mimicry in gastric cancer by upregulating TWIST1/2

Metastasis-associated in colon cancer-1 promotes vasculogenic mimicry in gastric cancer by upregulating TWIST1/2

https://doi.org/10.18632/oncotarget.3416

Lin Wang, Li Lin, Xi Chen, Li Sun, Yulin Liao, Na Huang,  and Wangjun Liao
11492-11506
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AMPK-mediated energy homeostasis and associated metabolic effects on cancer cell response and resistance to cetuximab

AMPK-mediated energy homeostasis and associated metabolic effects on cancer cell response and resistance to cetuximab

https://doi.org/10.18632/oncotarget.3432

Xinqun Li, Yang Lu, Haiquan Lu, Jingtao Luo, Yun Hong,  and Zhen Fan
11507-11518
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MTH1 expression is required for effective transformation by oncogenic HRAS

MTH1 expression is required for effective transformation by oncogenic HRAS

https://doi.org/10.18632/oncotarget.3447

Maria G. Giribaldi, Anisleidys Monoz, Katherine Halvorsen, Asmita Patel,  and Priyamvada Rai
11519-11529
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Down-regulation of ARNT promotes cancer metastasis by activating the fibronectin/integrin β1/FAK axis

Down-regulation of ARNT promotes cancer metastasis by activating the fibronectin/integrin β1/FAK axis

https://doi.org/10.18632/oncotarget.3448

Chi-Ruei Huang, Chung-Ta Lee, Kwang-Yu Chang, Wen-Chang Chang, Yao-Wen Liu, Jenq-Chang Lee,  and Ben-Kuen Chen
11530-11546
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU

Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU

https://doi.org/10.18632/oncotarget.3413

Xin Li, Jie Yu, Malcolm V. Brock, Qian Tao, James G. Herman, Ping Liang,  and Mingzhou Guo
11547-11560
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of β-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear β-Catenin/TCF-1 complex: critical role of STAT-3

Inhibition of β-Catenin signaling suppresses pancreatic tumor growth by disrupting nuclear β-Catenin/TCF-1 complex: critical role of STAT-3

https://doi.org/10.18632/oncotarget.3427

Kartick C. Pramanik, Neel M. Fofaria, Parul Gupta, Alok Ranjan, Sung-Hoon Kim,  and Sanjay K. Srivastava
11561-11574
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Autoimmune response to PARP and BRCA1/BRCA2 in cancer

Autoimmune response to PARP and BRCA1/BRCA2 in cancer

https://doi.org/10.18632/oncotarget.3428

Qing Zhu, Su-Xia Han, Cong-Ya Zhou, Meng-Jiao Cai, Li-Ping Dai,  and Jian-Ying Zhang
11575-11584
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TMEM16A overexpression contributes to tumor invasion and poor prognosis of human gastric cancer through TGF-β signaling

TMEM16A overexpression contributes to tumor invasion and poor prognosis of human gastric cancer through TGF-β signaling

https://doi.org/10.18632/oncotarget.3412

Fang Liu, Qing-Hua Cao, De-Jian Lu, Bin Luo, Xiao-Fang Lu, Rong-Cheng Luo,  and Xiao-Guang Wang
11585-11599
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of AKR1C1/ERβ induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity

Activation of AKR1C1/ERβ induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity

https://doi.org/10.18632/oncotarget.3417

Huiyoung Yun, Jianping Xie, Aria F. Olumi, Rita Ghosh,  and Addanki P. Kumar
11600-11613
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells

FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells

https://doi.org/10.18632/oncotarget.3426

Seon Min Woo, Bo Ram Seo, Kyoung-jin Min,  and Taeg Kyu Kwon
11614-11626
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ψ-Bufarenogin, a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling

ψ-Bufarenogin, a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling

https://doi.org/10.18632/oncotarget.3435

Jin Ding, Wen Wen, Daimin Xiang, Peipei Yin, Yanfang Liu, Chang Liu, Guoping He, Zhuo Cheng, Jianpeng Yin, Chunquan Sheng, Wen Zhang, Fajun Nan, Wencai Ye, Xiuli Zhang,  and Hongyang Wang
11627-11639
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration

Connexin 43 expression is associated with increased malignancy in prostate cancer cell lines and functions to promote migration

https://doi.org/10.18632/oncotarget.3449

Ao Zhang, Masahiro Hitomi, Noah Bar-Shain, Zafardjan Dalimov, Leigh Ellis, Kiran K. Velpula, Gail C. Fraizer, Robert G. Gourdie,  and Justin D. Lathia
11640-11651
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer

LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer

https://doi.org/10.18632/oncotarget.3457

Sheng-Jia Shi, Li-Juan Wang, Bo Yu, Yun-Hui Li, Yong Jin,  and Xiao-Zhong Bai
11652-11663
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathway

Recurrence of glioblastoma after radio-chemotherapy is associated with an angiogenic switch to the CXCL12-CXCR4 pathway

https://doi.org/10.18632/oncotarget.3256

Emeline Tabouret, Aurelie Tchoghandjian, Emilie Denicolai, Christine Delfino, Philippe Metellus, Thomas Graillon, Celine Boucard, Isabelle Nanni, Laetitia Padovani, L’Houcine Ouafik, Dominique Figarella-Branger,  and Olivier Chinot
11664-11675
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype

MicroRNA profiling of Chinese primary glioblastoma reveals a temozolomide-chemoresistant subtype

https://doi.org/10.18632/oncotarget.3258

Wei Yan, Yanwei Liu, Pei Yang, Zheng Wang, Yongping You,  and Tao Jiang
11676-11682
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Independent replication of a melanoma subtype gene signature and evaluation of its prognostic value and biological correlates in a population cohort

Independent replication of a melanoma subtype gene signature and evaluation of its prognostic value and biological correlates in a population cohort

https://doi.org/10.18632/oncotarget.3549

Jérémie Nsengimana, Jon Laye, Anastasia Filia, Christy Walker, Rosalyn Jewell, Joost J. Van den Oord, Pascal Wolter, Poulam Patel, Antje Sucker, Dirk Schadendorf, Göran B. Jönsson, D. Timothy Bishop,  and Julia Newton-Bishop
11683-11693
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High mesothelin expression in advanced lung adenocarcinoma is associated with KRAS mutations and a poor prognosis

High mesothelin expression in advanced lung adenocarcinoma is associated with KRAS mutations and a poor prognosis

https://doi.org/10.18632/oncotarget.3429

Anish Thomas, Yuanbin Chen, Seth M. Steinberg, Ji Luo, Svetlana Pack, Mark Raffeld, Zied Abdullaev, Christine Alewine, Arun Rajan, Giuseppe Giaccone, Ira Pastan, Markku Miettinen,  and Raffit Hassan
11694-11703
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tyrosine-protein phosphatase non-receptor type 12 expression is a good prognostic factor in resectable non-small cell lung cancer

Tyrosine-protein phosphatase non-receptor type 12 expression is a good prognostic factor in resectable non-small cell lung cancer

https://doi.org/10.18632/oncotarget.3588

Xun Cao, Yan-Zhen Chen, Ruo-Zhen Luo, Lin Zhang, Song-Liang Zhang, Jun Zeng, Yu-Chuan Jiang, Yu-Jing Han,  and Zhe-Sheng Wen
11704-11713
Abstract  |  PDF  |  HTML  |  Order a Reprint

Implications for selecting local excision in locally advanced rectal cancer after preoperative chemoradiation

Implications for selecting local excision in locally advanced rectal cancer after preoperative chemoradiation

https://doi.org/10.18632/oncotarget.3418

Juefeng Wan, Kaitai Liu, Ji Zhu, Guichao Li,  and Zhen Zhang
11714-11722
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