Oncotarget

Vol 6, No 12

April 30, 2015

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Confocal immunofluorescent images showing the nuclear localization of EGFR co-localize with Cyclin D1. See Pereira et al.

Table of Contents

Addendum

Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients

Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients

https://doi.org/10.18632/oncotarget.3998

Marina Bagnoli, Loris De Cecco, Anna Granata, Roberta Nicoletti, Edoardo Marchesi, Paola Alberti, Barbara Valeri, Massimo Libra, Mattia Barbareschi, Francesco Raspagliesi, Delia Mezzanzanica,  and Silvana Canevari
9643
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Editorial

MicroRNA-21, T helper lineage and autoimmunity

MicroRNA-21, T helper lineage and autoimmunity

https://doi.org/10.18632/oncotarget.3928

Gopal Murugaiyan, Lucien P. Garo,  and Howard L. Weiner
9644-9645
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Reviews

Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems

Polypharmacology of small molecules targeting the ubiquitin–proteasome and ubiquitin-like systems

https://doi.org/10.18632/oncotarget.3917

Ivano Amelio, Vivien Landré, Richard A. Knight, Andrey Lisitsa, Gerry Melino,  and Alexey V. Antonov
9646-9656
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Deubiquitinating enzymes as oncotargets

Deubiquitinating enzymes as oncotargets

https://doi.org/10.18632/oncotarget.3922

Urszula L. McClurg,  and Craig N. Robson
9657-9668
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Ecology meets cancer biology: the cancer swamp promotes the lethal cancer phenotype

Ecology meets cancer biology: the cancer swamp promotes the lethal cancer phenotype

https://doi.org/10.18632/oncotarget.3430

Sarah R. Amend,  and Amend J. Pienta
9669-9678
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Research Papers: Pathology

Nuclear localization of epidermal growth factor receptor (EGFR) in ameloblastomas

Nuclear localization of epidermal growth factor receptor (EGFR) in ameloblastomas

https://doi.org/10.18632/oncotarget.3919

Núbia Braga Pereira, Ana Carolina de Melo do Carmo, Marina Gonçalves Diniz, Ricardo Santiago Gomez, Dawidson Assis Gomes,  and Carolina Cavalieri Gomes
9679-9685
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Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARαPAC mice due to dysregulated bile acid synthesis

Forced expression of fibroblast growth factor 21 reverses the sustained impairment of liver regeneration in hPPARαPAC mice due to dysregulated bile acid synthesis

https://doi.org/10.18632/oncotarget.3531

Hui-Xin Liu, Ying Hu, Samuel W. French, Frank J. Gonzalez,  and Yu-Jui Yvonne Wan
9686-9700
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Research Papers: Gerotarget (Focus on Aging)

EGCG-mediated autophagy flux has a neuroprotection effect via a class III histone deacetylase in primary neuron cells

EGCG-mediated autophagy flux has a neuroprotection effect via a class III histone deacetylase in primary neuron cells

https://doi.org/10.18632/oncotarget.3832

Ju-Hee Lee, Ji-Hong Moon, Sung-Wook Kim, Jae-Kyo Jeong, Uddin MD. Nazim, You-Jin Lee, Jae-Won Seol,  and Sang-Youel Park
9701-9717
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Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats

Rapatar, a nanoformulation of rapamycin, decreases chemically-induced benign prostate hyperplasia in rats

https://doi.org/10.18632/oncotarget.3929

Ekaterina A. Lesovaya, Kirill I. Kirsanov, Elena E. Antoshina, Lubov S. Trukhanova, Tatiana G. Gorkova, Elena V. Shipaeva, Ramiz M. Salimov, Gennady A. Belitsky, Mikhail V. Blagosklonny, Marianna G. Yakubovskaya,  and Olga B. Chernova
9718-9727
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New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor

New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor

https://doi.org/10.18632/oncotarget.3303

Rosemeire M. Kanashiro-Takeuchi, Luca Szalontay, Andrew V. Schally, Lauro M. Takeuchi, Petra Popovics, Miklos Jaszberenyi, Irving Vidaurre, Marta Zarandi, Ren-Zhi Cai, Norman L. Block, Joshua M. Hare,  and Ferenc G. Rick
9728-9739
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Research Papers

Dual targeting of retinoid X receptor and histone deacetylase with DW22 as a novel antitumor approach

Dual targeting of retinoid X receptor and histone deacetylase with DW22 as a novel antitumor approach

https://doi.org/10.18632/oncotarget.3149

Lihui Wang, Guoliang Chen, Kang Chen, Yong Ren, Huahuan Li, Xiaorui Jiang, Lina Jia, Shiyuan Fu, Yi Li, Xinwei Liu, Shuang Wang, Jingyu Yang,  and Chunfu Wu
9740-9755
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Silencing of R-Spondin1 increases radiosensitivity of glioma cells

Silencing of R-Spondin1 increases radiosensitivity of glioma cells

https://doi.org/10.18632/oncotarget.3395

Xuefeng Gu, Xuefeng Wang, Hong Xiao, Guoda Ma, Lili Cui, You Li, Haihong Zhou, Wandong Liang, Bin Zhao,  and Keshen Li
9756-9765
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EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF

EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF

https://doi.org/10.18632/oncotarget.2870

Farah Khayati, Laura Pérez-Cano, Kamel Maouche, Aurélie Sadoux, Zineb Boutalbi, Marie-Pierre Podgorniak, Uwe Maskos, Niclas Setterblad, Anne Janin, Fabien Calvo, Céleste Lebbé, Suzanne Menashi, Juan Fernandez-Recio,  and Samia Mourah
9766-9780
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Flotillin-2 promotes nasopharyngeal carcinoma metastasis and is necessary for the epithelial-mesenchymal transition induced by transforming growth factor-β

Flotillin-2 promotes nasopharyngeal carcinoma metastasis and is necessary for the epithelial-mesenchymal transition induced by transforming growth factor-β

https://doi.org/10.18632/oncotarget.3382

Liang Zhao, Li Lin, Changqie Pan, Min Shi, Yulin Liao, Jianping Bin,  and Wangjun Liao
9781-9793
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Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer

Netrin-4 as a biomarker promotes cell proliferation and invasion in gastric cancer

https://doi.org/10.18632/oncotarget.3400

Bin Lv, Chunhua Song, Lijun Wu, Qi Zhang, Daisen Hou, Ping Chen, Shunji Yu, Zhicheng Wang, Yiwei Chu, Jun Zhang, Dongqin Yang,  and Jie Liu
9794-9806
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NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib

NGF-induced TrkA/CD44 association is involved in tumor aggressiveness and resistance to lestaurtinib

https://doi.org/10.18632/oncotarget.3227

Léo Aubert, Matthieu Guilbert, Cyril Corbet, Elisabeth Génot, Eric Adriaenssens, Thierry Chassat, François Bertucci, Thomas Daubon, Nicolas Magné, Xuefen Le Bourhis,  and Robert-Alain Toillon
9807-9819
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Hypoxia/reoxygenation-experienced cancer cell migration and metastasis are regulated by Rap1- and Rac1-GTPase activation via the expression of thymosin beta-4

Hypoxia/reoxygenation-experienced cancer cell migration and metastasis are regulated by Rap1- and Rac1-GTPase activation via the expression of thymosin beta-4

https://doi.org/10.18632/oncotarget.3218

Jae-Wook Lee, Yun-Kyoung Ryu, Young-Hoon Ji, Joo Hyun Kang,  and Eun-Yi Moon
9820-9833
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Cordycepin (3’-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b

Cordycepin (3’-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b

https://doi.org/10.18632/oncotarget.3383

Pu Zhang, Changjin Huang, Changliang Fu, Yang Tian, Yijuan Hu, Bochu Wang, Amy Strasner, Yang Song,  and Erqun Song
9834-9853
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Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation

Dietary compound isoliquiritigenin prevents mammary carcinogenesis by inhibiting breast cancer stem cells through WIF1 demethylation

https://doi.org/10.18632/oncotarget.3396

Neng Wang, Zhiyu Wang, Yu Wang, Xiaoming Xie, Jiangang Shen, Cheng Peng, Jieshu You, Fu Peng, Hailin Tang, Xinyuan Guan,  and Jianping Chen
9854-9876
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PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis

PAK1-mediated MORC2 phosphorylation promotes gastric tumorigenesis

https://doi.org/10.18632/oncotarget.3185

Guiling Wang, Yanyan Song, Tong Liu, Chunyu Wang, Qing Zhang, Furong Liu, Xinze Cai, Zhifeng Miao, Hongde Xu, Huimian Xu, Liu Cao,  and Feng Li
9877-9886
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Cisplatin fails to induce puma mediated apoptosis in mucosal melanomas

Cisplatin fails to induce puma mediated apoptosis in mucosal melanomas

https://doi.org/10.18632/oncotarget.3195

Marie Kristin Fritsche, Veronika Metzler, Karen Becker, Christian Plettenberg, Clemens Heiser, Benedikt Hofauer,  and Andreas Knopf
9887-9896
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Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma

Targeting Toll-like receptor 2 inhibits growth of head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.3393

Lovisa Farnebo, Arash Shahangian, Yunqin Lee, June Ho Shin, Ferenc A. Scheeren,  and John B. Sunwoo
9897-9907
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Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis

Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis

https://doi.org/10.18632/oncotarget.3532

Veronica De Simone, Giulia Ronchetti, Eleonora Franzè, Alfredo Colantoni, Angela Ortenzi, Massimo C. Fantini, Angelamaria Rizzo, Giuseppe S. Sica, Pierpaolo Sileri, Piero Rossi, Thomas T. MacDonald, Francesco Pallone, Giovanni Monteleone,  and Carmine Stolfi
9908-9923
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HSPA12B: a novel facilitator of lung tumor growth

HSPA12B: a novel facilitator of lung tumor growth

https://doi.org/10.18632/oncotarget.3533

He Ma, Ting Lu, Xiaojin Zhang, Chuanfu Li, Jingwei Xiong, Lei Huang, Ping Liu, Yuehua Li, Li Liu,  and Zhengnian Ding
9924-9936
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A suppressive role of ionizing radiation-responsive miR-29c in the development of liver carcinoma via targeting WIP1

A suppressive role of ionizing radiation-responsive miR-29c in the development of liver carcinoma via targeting WIP1

https://doi.org/10.18632/oncotarget.3157

Bo Wang, Dongping Li, Corinne Sidler, Rocio Rodriguez-Juarez, Natasha Singh, Mieke Heyns, Yaroslav Ilnytskyy, Roderick T. Bronson,  and Olga Kovalchuk
9937-9950
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Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo

Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo

https://doi.org/10.18632/oncotarget.3179

Niu Zhanfeng, Li Yanhui, Fei Zhou, Hao Shaocai, Li Guangxing,  and Xia Hechun
9951-9958
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Valproic acid promotes radiosensitization in meningioma stem-like cells

Valproic acid promotes radiosensitization in meningioma stem-like cells

https://doi.org/10.18632/oncotarget.3692

Hsin-Ying Clair Chiou, Wen-Kuo Lai, Li-Chun Huang, Shih-Ming Huang, Sheau-Huei Chueh, Hsin-I Ma,  and Dueng-Yuan Hueng
9959-9969
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Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage

Delphinidin sensitizes prostate cancer cells to TRAIL-induced apoptosis, by inducing DR5 and causing caspase-mediated HDAC3 cleavage

https://doi.org/10.18632/oncotarget.3667

Hyeonseok Ko, Mi-Hyeon Jeong, Hyelin Jeon, Gi-Jun Sung, Youngsin So, InKi Kim, JaeKyoung Son, Sang-wook Lee, Ho-Geun Yoon,  and Kyung-Chul Choi
9970-9984
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CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases

CXCR6 expression in non-small cell lung carcinoma supports metastatic process via modulating metalloproteinases

https://doi.org/10.18632/oncotarget.3194

Hina Mir, Rajesh Singh, Goetz H. Kloecker, James W. Lillard Jr.,  and Shailesh Singh
9985-9998
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Aspirin counteracts cancer stem cell features, desmoplasia and gemcitabine resistance in pancreatic cancer

Aspirin counteracts cancer stem cell features, desmoplasia and gemcitabine resistance in pancreatic cancer

https://doi.org/10.18632/oncotarget.3171

Yiyao Zhang, Li Liu, Pei Fan, Nathalie Bauer, Jury Gladkich, Eduard Ryschich, Alexandr V. Bazhin, Nathalia A. Giese, Oliver Strobel, Thilo Hackert, Ulf Hinz, Wolfgang Gross, Franco Fortunato,  and Ingrid Herr
9999-10015
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Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells

Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells

https://doi.org/10.18632/oncotarget.3540

Hsueh-Te Lee, Jianfei Xue, Ping-Chieh Chou, Aidong Zhou, Phillip Yang, Charles A. Conrad, Kenneth D. Aldape, Waldemar Priebe, Cam Patterson, Raymond Sawaya, Keping Xie,  and Suyun Huang
10016-10029
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase

Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase

https://doi.org/10.18632/oncotarget.3192

Ke Li, Jun Pang, Huaiyan Cheng, Wei-Peng Liu, Jin-Ming Di, Heng-Jun Xiao, Yun Luo, Hao Zhang, Wen-Tao Huang, Ming-Kun Chen, Liao-Yuan Li, Chun-Kui Shao, Ying-Hong Feng,  and Xin Gao
10030-10044
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Vasorin is a potential serum biomarker and drug target of hepatocarcinoma screened by subtractive-EMSA-SELEX to clinic patient serum

Vasorin is a potential serum biomarker and drug target of hepatocarcinoma screened by subtractive-EMSA-SELEX to clinic patient serum

https://doi.org/10.18632/oncotarget.3541

Shaohua Li, Hui Li, Xiqin Yang, Wei Wang, Aixue Huang, Jie Li, Xingliang Qin, Fei Li, Guanyi Lu, Hongmei Ding, Xueting Su, Lvbin Hou, Wei Xia, Ming Shi, Hongwen Zhang, Qiang Zhao, Jie Dong, Xingfeng Ge, Leqiao Sun, Chenjun Bai, Chaonan Wang, Xuelian Shen, Tao Fang, Fusheng Wang, Heqiu Zhang,  and Ningsheng Shao
10045-10059
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

XPC inhibits NSCLC cell proliferation and migration by enhancing E-Cadherin expression

XPC inhibits NSCLC cell proliferation and migration by enhancing E-Cadherin expression

https://doi.org/10.18632/oncotarget.3542

Tiantian Cui, Amit Kumar Srivastava, Chunhua Han, Linlin Yang, Ran Zhao, Ning Zou, Meihua Qu, Wenrui Duan, Xiaoli Zhang,  and Qi-En Wang
10060-10072
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NF2 blocks Snail-mediated p53 suppression in mesothelioma

NF2 blocks Snail-mediated p53 suppression in mesothelioma

https://doi.org/10.18632/oncotarget.3543

Jung-Hyun Cho, Su-Jin Lee, Ah-Young Oh, Min-Ho Yoon, Tae-Geun Woo,  and Bum-Joon Park
10073-10085
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MET receptor is a potential therapeutic target in high grade cervical cancer

MET receptor is a potential therapeutic target in high grade cervical cancer

https://doi.org/10.18632/oncotarget.3161

Katarzyna Miekus, Marta Pawlowska, Małgorzata Sekuła, Grazyna Drabik, Zbigniew Madeja, Dariusz Adamek,  and Marcin Majka
10086-10101
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Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver

Co-activation of PIK3CA and Yap promotes development of hepatocellular and cholangiocellular tumors in mouse and human liver

https://doi.org/10.18632/oncotarget.3546

Xiaolei Li, Junyan Tao, Antonio Cigliano, Marcella Sini, Julien Calderaro, Daniel Azoulay, Chunmei Wang, Yan Liu, Lijie Jiang, Katja Evert, Maria I. Demartis, Silvia Ribback, Kirsten Utpatel, Frank Dombrowski, Matthias Evert, Diego F. Calvisi,  and Xin Chen
10102-10115
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways

Connexin32 regulates hepatoma cell metastasis and proliferation via the p53 and Akt pathways

https://doi.org/10.18632/oncotarget.2687

Bixing Zhao, Wenxiu Zhao, Yu Wang, Yaping Xu, Jianfeng Xu, Kai Tang, Sheng Zhang, Zhenyu Yin, Qiao Wu,  and Xiaomin Wang
10116-10133
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Glucose starvation-mediated inhibition of salinomycin induced autophagy amplifies cancer cell specific cell death

Glucose starvation-mediated inhibition of salinomycin induced autophagy amplifies cancer cell specific cell death

https://doi.org/10.18632/oncotarget.3548

Jaganmohan R. Jangamreddy, Mayur V. Jain, Anna-Lotta Hallbeck, Karin Roberg, Kourosh Lotfi,  and Marek J. Łos
10134-10145
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Targeting the degradation of AXL receptor tyrosine kinase to overcome resistance in gefitinib-resistant non-small cell lung cancer

Targeting the degradation of AXL receptor tyrosine kinase to overcome resistance in gefitinib-resistant non-small cell lung cancer

https://doi.org/10.18632/oncotarget.3380

Song Yi Bae, Ji-Young Hong, Hye-Jung Lee, Hyen Joo Park,  and Sang Kook Lee
10146-10160
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Critical role of gap junction communication, calcium and nitric oxide signaling in bystander responses to focal photodynamic injury

Critical role of gap junction communication, calcium and nitric oxide signaling in bystander responses to focal photodynamic injury

https://doi.org/10.18632/oncotarget.3553

Bianca Calì, Stefano Ceolin, Federico Ceriani, Mario Bortolozzi, Andrielly H.R. Agnellini, Veronica Zorzi, Andrea Predonzani, Vincenzo Bronte, Barbara Molon,  and Fabio Mammano
10161-10174
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Yes-mediated phosphorylation of focal adhesion kinase at tyrosine 861 increases metastatic potential of prostate cancer cells

Yes-mediated phosphorylation of focal adhesion kinase at tyrosine 861 increases metastatic potential of prostate cancer cells

https://doi.org/10.18632/oncotarget.3391

Tanushree Chatterji, Andreas S. Varkaris, Nila U. Parikh, Jian H. Song, Chien-Jui Cheng, Rebecca E. Schweppe, Stephanie Alexander, John W. Davis, Patricia Troncoso, Peter Friedl, Jian Kuang, Sue-Hwa Lin,  and Gary E. Gallick
10175-10194
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer

The miR-193a-3p-regulated ING5 gene activates the DNA damage response pathway and inhibits multi-chemoresistance in bladder cancer

https://doi.org/10.18632/oncotarget.3555

Yang Li, Hui Deng, Lei Lv, Cheng Zhang, Liting Qian, Jun Xiao, Weidong Zhao, Qi Liu, Daming Zhang, Yingwei Wang, Jun Yan, Hongyu Zhang, Yinghua He,  and Jingde Zhu
10195-10206
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma

Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma

https://doi.org/10.18632/oncotarget.3504

Lindi Chen, Raphaël F. Rousseau, Steven A. Middleton, Gwen L. Nichols, David R. Newell, John Lunec,  and Deborah A. Tweddle
10207-10221
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Lung tumorigenesis induced by human vascular endothelial growth factor (hVEGF)-A165 overexpression in transgenic mice and amelioration of tumor formation by miR-16

Lung tumorigenesis induced by human vascular endothelial growth factor (hVEGF)-A165 overexpression in transgenic mice and amelioration of tumor formation by miR-16

https://doi.org/10.18632/oncotarget.3390

Yu-Tang Tung, Pin-Wu Huang, Yu-Ching Chou, Cheng-Wei Lai, Hsiu-Po Wang, Heng-Chien Ho, Chih-Ching Yen, Chih-Yen Tu, Tung-Chou Tsai, Dah-Cherng Yeh, Jiun-Long Wang, Chuan-Mu Chen,  and Chuan-Mu Chen
10222-10238
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis

WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis

https://doi.org/10.18632/oncotarget.3518

Li Qin, Yan-Tao Yin, Fang-Jing Zheng, Li-Xia Peng, Chang-Fu Yang, Ying-Na Bao, Ying-Ying Liang, Xin-Jian Li, Yan-Qun Xiang, Rui Sun, An-Hua Li, Ru-Hai Zou, Xiao-Qing Pei, Bi-Jun Huang, Tie-Bang Kang, Duan-Fang Liao, Yi-Xin Zeng, Bart O. Williams,  and Chao-Nan Qian
10239-10252
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Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer

Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer

https://doi.org/10.18632/oncotarget.3520

Nicolas Bovy, Benoît Blomme, Pierre Frères, Stella Dederen, Olivier Nivelles, Michelle Lion, Oriane Carnet, Joseph A. Martial, Agnès Noël, Marc Thiry, Guy Jérusalem, Claire Josse, Vincent Bours, Sébastien P. Tabruyn,  and Ingrid Struman
10253-10266
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Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells

Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells

https://doi.org/10.18632/oncotarget.3522

Dominique Thuringer, Kevin Berthenet, Laurent Cronier, Gaetan Jego, Eric Solary,  and Carmen Garrido
10267-10283
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MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer

MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer

https://doi.org/10.18632/oncotarget.3581

Catherine Olesch, Weixiao Sha, Carlo Angioni, Lisa Katharina Sha, Elias Açaf, Paola Patrignani, Per-Johan Jakobsson, Heinfried H. Radeke, Sabine Grösch, Gerd Geisslinger, Andreas von Knethen, Andreas Weigert,  and Bernhard Brüne
10284-10296
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MicroRNA-144 suppresses osteosarcoma growth and metastasis by targeting ROCK1 and ROCK2

MicroRNA-144 suppresses osteosarcoma growth and metastasis by targeting ROCK1 and ROCK2

https://doi.org/10.18632/oncotarget.3305

Wei Wang, Xin Zhou,  and Min Wei
10297-10308
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Chorein addiction in VPS13A overexpressing rhabdomyosarcoma cells

Chorein addiction in VPS13A overexpressing rhabdomyosarcoma cells

https://doi.org/10.18632/oncotarget.3582

Sabina Honisch, Willi Yu, Guilai Liu, Ioana Alesutan, Syeda T. Towhid, Anna Tsapara, Sabine Schleicher, Rupert Handgretinger, Christos Stournaras,  and Florian Lang
10309-10319
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity

HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity

https://doi.org/10.18632/oncotarget.3583

Davide Valente, Gianluca Bossi, Alice Moncada, Mara Tornincasa, Stefania Indelicato, Salvatore Piscuoglio, Eva Diamantis Karamitopoulou, Armando Bartolazzi, Giovanna Maria Pierantoni, Alfredo Fusco, Silvia Soddu,  and Cinzia Rinaldo
10320-10334
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach

Molecular signatures of sanguinarine in human pancreatic cancer cells: A large scale label-free comparative proteomics approach

https://doi.org/10.18632/oncotarget.3231

Chandra K. Singh, Satwinderjeet Kaur, Jasmine George, Minakshi Nihal, Molly C. Pellitteri Hahn, Cameron O. Scarlett,  and Nihal Ahmad
10335-10349
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation

Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation

https://doi.org/10.18632/oncotarget.3585

Yue Zhou, Chao Liang, Fei Xue, Wei Chen, Xiao Zhi, Xinhua Feng, Xueli Bai,  and Tingbo Liang
10350-10365
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Triple negative breast cancers comprise a highly tumorigenic cell subpopulation detectable by its high responsiveness to a Sox2 regulatory region 2 (SRR2) reporter

Triple negative breast cancers comprise a highly tumorigenic cell subpopulation detectable by its high responsiveness to a Sox2 regulatory region 2 (SRR2) reporter

https://doi.org/10.18632/oncotarget.3590

Karen Jung, Nidhi Gupta, Peng Wang, Jamie T. Lewis, Keshav Gopal, Fang Wu, Xiaoxia Ye, Abdulraheem Alshareef, Bassam S. Abdulkarim, Donna N. Douglas, Norman M. Kneteman,  and Raymond Lai
10366-10373
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells

Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: two saturable mechanisms of Dp44mT uptake by cells

https://doi.org/10.18632/oncotarget.3606

Angelica M. Merlot, Sumit Sahni, Darius J.R. Lane, Ashleigh M. Fordham, Namfon Pantarat, David E. Hibbs, Vera Richardson, Munikumar R. Doddareddy, Jennifer A. Ong, Michael L.H. Huang, Des R. Richardson,  and Danuta S. Kalinowski
10374-10398
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors

PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors

https://doi.org/10.18632/oncotarget.3295

Annalisa Lonetti, Alessandra Cappellini, Antonino Maria Spartà, Francesca Chiarini, Francesca Buontempo, Camilla Evangelisti, Cecilia Evangelisti, Ester Orsini, James A. McCubrey,  and Alberto Maria Martelli
10399-10414
Abstract  |  PDF  |  HTML  |  Order a Reprint

IL-8 confers resistance to EGFR inhibitors by inducing stem cell properties in lung cancer

IL-8 confers resistance to EGFR inhibitors by inducing stem cell properties in lung cancer

https://doi.org/10.18632/oncotarget.3389

Yi-Nan Liu, Tzu-Hua Chang, Meng-Feng Tsai, Shang-Gin Wu, Tzu-Hsiu Tsai, Hsuan-Yu Chen, Sung-Liang Yu, James Chih-Hsin Yang,  and Jin-Yuan Shih
10415-10431
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness

Dysregulation of the miR-34a-SIRT1 axis inhibits breast cancer stemness

https://doi.org/10.18632/oncotarget.3394

Wei Ma, Gary Guishan Xiao, Jun Mao, Ying Lu, Bo Song, Lihui Wang, Shujun Fan, Panhong Fan, Zhenhuan Hou, Jiazhi Li, Xiaotang Yu, Bo Wang, Huan Wang, Honghai Wang, Fei Xu, Yan Li, Qiang Liu,  and Lianhong Li
10432-10444
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Novel agents that downregulate EGFR, HER2, and HER3 in parallel

Novel agents that downregulate EGFR, HER2, and HER3 in parallel

https://doi.org/10.18632/oncotarget.3398

Renan Barroso Ferreira, Mary Elizabeth Law, Stephan Christopher Jahn, Bradley John Davis, Coy Don Heldermon, Mary Reinhard, Ronald Keith Castellano,  and Brian Keith Law
10445-10459
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/STAT3

Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/STAT3

https://doi.org/10.18632/oncotarget.3399

Shicong Zhu, Zhihua Wang, Zijian Li, Hongling Peng, Yunya Luo, Mingyang Deng, Ruijuan Li, Chongwen Dai, Yunxiao Xu, Sufang Liu,  and Guangsen Zhang
10460-10472
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Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion

Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion

https://doi.org/10.18632/oncotarget.3401

Séverine Roselli, Jay Pundavela, Yohann Demont, Sam Faulkner, Sheridan Keene, John Attia, Chen Chen Jiang, Xu Dong Zhang, Marjorie M. Walker,  and Hubert Hondermarck
10473-10486
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Rampant centrosome amplification underlies more aggressive disease course of triple negative breast cancers

Rampant centrosome amplification underlies more aggressive disease course of triple negative breast cancers

https://doi.org/10.18632/oncotarget.3402

Vaishali Pannu, Karuna Mittal, Guilherme Cantuaria, Michelle D. Reid, Xiaoxian Li, Shashikiran Donthamsetty, Michelle McBride, Sergey Klimov, Remus Osan, Meenakshi V. Gupta, Padmashree C.G. Rida,  and Ritu Aneja
10487-10497
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy

Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy

https://doi.org/10.18632/oncotarget.3403

Wei An, Scott A. Nadeau, Bhopal C. Mohapatra, Dan Feng, Neha Zutshi, Matthew D. Storck, Priyanka Arya, James E. Talmadge, Jane L. Meza, Vimla Band,  and Hamid Band
10498-10509
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status

HDACi inhibits liposarcoma via targeting of the MDM2-p53 signaling axis and PTEN, irrespective of p53 mutational status

https://doi.org/10.18632/oncotarget.3230

Wen-Bin Ou, Jiaqing Zhu, Grant Eilers, Xuhui Li, Ye Kuang, Li Liu, Adrián Mariño-Enríquez, Ziqin Yan, Hailong Li, Fanguo Meng, Haimeng Zhou, Qing Sheng,  and Jonathan A. Fletcher
10510-10520
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Integrated genomic analysis identifies subclasses and prognosis signatures of kidney cancer

Integrated genomic analysis identifies subclasses and prognosis signatures of kidney cancer

https://doi.org/10.18632/oncotarget.3294

Yann Christinat,  and Wilhelm Krek
10521-10531
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Multiple myeloma induces Mcl-1 expression and survival of myeloid-derived suppressor cells

Multiple myeloma induces Mcl-1 expression and survival of myeloid-derived suppressor cells

https://doi.org/10.18632/oncotarget.3300

Kim De Veirman, Jo A. Van Ginderachter, Susanne Lub, Nathan De Beule, Kris Thielemans, Ivan Bautmans, Babatunde O. Oyajobi, Elke De Bruyne, Eline Menu, Miguel Lemaire, Ivan Van Riet, Karin Vanderkerken,  and Els Van Valckenborgh
10532-10547
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment

Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment

https://doi.org/10.18632/oncotarget.3307

Laura R. H. Ip, George Poulogiannis, Felipe Cia Viciano, Junko Sasaki, Satoshi Kofuji, Victoria J. Spanswick, Daniel Hochhauser, John A. Hartley, Takehiko Sasaki,  and Christina A. Gewinner
10548-10562
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models

Powerful anti-tumor and anti-angiogenic activity of a new anti-vascular endothelial growth factor receptor 1 peptide in colorectal cancer models

https://doi.org/10.18632/oncotarget.3384

Valeria Cicatiello, Ivana Apicella, Laura Tudisco, Valeria Tarallo, Luigi Formisano, Annamaria Sandomenico, Younghee Kim, Ana Bastos-Carvalho, Augusto Orlandi, Jayakrishna Ambati, Menotti Ruvo, Roberto Bianco,  and Sandro De Falco
10563-10576
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability

ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability

https://doi.org/10.18632/oncotarget.3387

Matthias Scheffler, Anne Schultheis, Cristina Teixido, Sebastian Michels, Daniela Morales-Espinosa, Santiago Viteri, Wolfgang Hartmann, Sabine Merkelbach-Bruse, Rieke Fischer, Hans-Ulrich Schildhaus, Jana Fassunke, Martin Sebastian, Monika Serke, Britta Kaminsky, Winfried Randerath, Ulrich Gerigk, Yon-Dschun Ko, Stefan Krüger, Roland Schnell, Achim Rothe, Cornelia Kropf-Sanchen, Lukas Heukamp, Rafael Rosell, Reinhard Büttner,  and Jürgen Wolf
10577-10585
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Deregulation of dicer and mir-155 expression in liposarcoma

Deregulation of dicer and mir-155 expression in liposarcoma

https://doi.org/10.18632/oncotarget.3201

Bruno Vincenzi, Michele Iuliani, Alice Zoccoli, Francesco Pantano, Marco Fioramonti, Delia De Lisi, Anna Maria Frezza, Carla Rabitti, Giuseppe Perrone, Andrea Onetti Muda, Antonio Russo, Antonio Giordano, Daniele Santini, Angelo Paolo Dei Tos,  and Giuseppe Tonini
10586-10591
Abstract  |  PDF  |  HTML  |  Order a Reprint

CD163+ tumor-associated macrophage is a prognostic biomarker and is associated with therapeutic effect on malignant pleural effusion of lung cancer patients

CD163+ tumor-associated macrophage is a prognostic biomarker and is associated with therapeutic effect on malignant pleural effusion of lung cancer patients

https://doi.org/10.18632/oncotarget.3547

Li Yang, Fei Wang, Liping Wang, Lan Huang, Jing Wang, Bin Zhang,  and Yi Zhang
10592-10603
Abstract  |  PDF  |  HTML  |  Order a Reprint

Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer

Molecular profiling of peripheral blood is associated with circulating tumor cells content and poor survival in metastatic castration-resistant prostate cancer

https://doi.org/10.18632/oncotarget.3550

Mercedes Marín-Aguilera, Òscar Reig, Juan José Lozano, Natalia Jiménez, Susana García-Recio, Nadina Erill, Lydia Gaba, Andrea Tagliapietra, Vanesa Ortega, Gemma Carrera, Anna Colomer, Pedro Gascón,  and Begoña Mellado
10604-10616
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TERT promoter mutations and telomere length in adult malignant gliomas and recurrences

TERT promoter mutations and telomere length in adult malignant gliomas and recurrences

https://doi.org/10.18632/oncotarget.3329

Barbara Heidenreich, Sivaramakrishna P. Rachakonda, Ismail Hosen, Florian Volz, Kari Hemminki, Astrid Weyerbrock,  and Rajiv Kumar
10617-10633
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Increased angiogenesis is associated with a 32-gene expression signature and 6p21 amplification in aggressive endometrial cancer

Increased angiogenesis is associated with a 32-gene expression signature and 6p21 amplification in aggressive endometrial cancer

https://doi.org/10.18632/oncotarget.3521

Ingunn M. Stefansson, Maria Raeder, Elisabeth Wik, Monica Mannelqvist, Kanthida Kusonmano, Gøril Knutsvik, Ingfrid Haldorsen, Jone Trovik, Anne M. Øyan, Karl-H. Kalland, Anne Cathrine Staff, Helga B. Salvesen,  and Lars A. Akslen
10634-10645
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High expression of cAMP-responsive element-binding protein 1 (CREB1) is associated with metastasis, tumor stage and poor outcome in gastric cancer

High expression of cAMP-responsive element-binding protein 1 (CREB1) is associated with metastasis, tumor stage and poor outcome in gastric cancer

https://doi.org/10.18632/oncotarget.3392

Ya-Wen Wang, Xu Chen, Ji-Wei Gao, Hui Zhang, Ran-Ran Ma, Zu-Hua Gao,  and Peng Gao
10646-10657
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Expression and clinicopathological significance of FSIP1 in breast cancer

Expression and clinicopathological significance of FSIP1 in breast cancer

https://doi.org/10.18632/oncotarget.3381

Hao Zhang, Minna Luo, Zining Jin, Dan Wang, Ming Sun, Xinhan Zhao, Zuowei Zhao, Haixin Lei, Man Li,  and Caigang Liu
10658-10666
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