Oncotarget

Vol 6, No 10

April 10, 2015

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Deregulation of differentiation markers in PDXs after chemotherapy. See Molejon et al.

Table of Contents

Errata

Erratum: Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms

Erratum: Drug resistance in multiple myeloma: latest findings and new concepts on molecular mechanisms

https://doi.org/10.18632/oncotarget.3810

Jahangir Abdi, Guoan Chen,  and Hong Chang
7364
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Reviews

Targeting AMPK for cancer prevention and treatment

Targeting AMPK for cancer prevention and treatment

https://doi.org/10.18632/oncotarget.3629

Weidong Li, Shakir M. Saud, Matthew R. Young, Guohong Chen,  and Baojin Hua
7365-7378
Abstract  |  PDF  |  HTML  |  Order a Reprint

Priority Research Papers

Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma

Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma

https://doi.org/10.18632/oncotarget.3132

Boris Ratnikov, Pedro Aza-Blanc, Ze’ev A. Ronai, Jeffrey W. Smith, Andrei L. Osterman,  and David A. Scott
7379-7389
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The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients

The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients

https://doi.org/10.18632/oncotarget.3506

Rainer Fagerholm, Marjanka K. Schmidt, Sofia Khan, Sajjad Rafiq, William Tapper, Kristiina Aittomäki, Dario Greco, Tuomas Heikkinen, Taru A. Muranen, Peter A. Fasching, Wolfgang Janni, Richard Weinshilboum, Christian R. Loehberg, John L. Hopper, Melissa C. Southey, Renske Keeman, Annika Lindblom, Sara Margolin, Arto Mannermaa, Vesa Kataja, Georgia Chenevix-Trench, kConFab Investigators, Diether Lambrechts, Hans Wildiers, Jenny Chang-Claude, Petra Seibold, Fergus J. Couch, Janet E. Olson, Irene L. Andrulis, Julia A. Knight, Montserrat García-Closas, Jonine Figueroa, Maartje J. Hooning, Agnes Jager, Mitul Shah, Barbara J. Perkins, Robert Luben, Ute Hamann, Maria Kabisch, Kamila Czene, Per Hall, Douglas F. Easton, Paul D.P. Pharoah, Jianjun Liu, Diana Eccles, Carl Blomqvist,  and Heli Nevanlinna
7390-7407
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Deciphering the cellular source of tumor relapse identifies CD44 as a major therapeutic target in pancreatic adenocarcinoma

Deciphering the cellular source of tumor relapse identifies CD44 as a major therapeutic target in pancreatic adenocarcinoma

https://doi.org/10.18632/oncotarget.3510

Maria Inés Molejon, Juan Ignacio Tellechea, Celine Loncle, Odile Gayet, Marine Gilabert, Pauline Duconseil, Maria Belen Lopez-Millan, Vincent Moutardier, Mohamed Gasmi, Stephane Garcia, Olivier Turrini, Mehdi Ouaissi, Flora Poizat, Nelson Dusetti,  and Juan Iovanna
7408-7423
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Research Papers: Gerotarget (Focus on Aging)

Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins

Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins

https://doi.org/10.18632/oncotarget.3232

Camilla Evangelisti, Pia Bernasconi, Paola Cavalcante, Cristina Cappelletti, Maria Rosaria D’Apice, Paolo Sbraccia, Giuseppe Novelli, Sabino Prencipe, Silvia Lemma, Nicola Baldini, Sofia Avnet, Stefano Squarzoni, Alberto M. Martelli,  and Giovanna Lattanzi
7424-7437
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Research Papers

Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1

Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1

https://doi.org/10.18632/oncotarget.3476

Hyeongsun Moon, Jayde E. Ruelcke, Eunju Choi, Laura J. Sharpe, Zeyad D. Nassar, Helle Bielefeldt-Ohmann, Marie-Odile Parat, Anup Shah, Mathias Francois, Kerry L. Inder, Andrew J. Brown, Pamela J. Russell, Robert G. Parton,  and Michelle M. Hill
7438-7453
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-34a suppresses amphiregulin and tumor metastatic potential of head and neck squamous cell carcinoma (HNSCC)

MiR-34a suppresses amphiregulin and tumor metastatic potential of head and neck squamous cell carcinoma (HNSCC)

https://doi.org/10.18632/oncotarget.3148

Jiali Zhang, Yu Wang, Xinming Chen, Yi Zhou, Fangyan Jiang, Jirong Chen, Li Wang,  and Wen-Feng Zhang
7454-7469
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

YB-1 and MTA1 protein levels and not DNA or mRNA alterations predict for prostate cancer recurrence

YB-1 and MTA1 protein levels and not DNA or mRNA alterations predict for prostate cancer recurrence

https://doi.org/10.18632/oncotarget.3477

Christine Moore Sheridan, Tristan R. Grogan, Hao G. Nguyen, Colette Galet, Matthew B. Rettig, Andrew C. Hsieh,  and Davide Ruggero
7470-7480
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MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation

MUTYH mediates the toxicity of combined DNA 6-thioguanine and UVA radiation

https://doi.org/10.18632/oncotarget.3037

Francesca Grasso, Vitalba Ruggieri, Gabriele De Luca, Paola Leopardi, Maria Teresa Mancuso, Ida Casorelli, Pietro Pichierri, Peter Karran,  and Margherita Bignami
7481-7492
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Intratumoral diversity of telomere length in individual neuroblastoma tumors

Intratumoral diversity of telomere length in individual neuroblastoma tumors

https://doi.org/10.18632/oncotarget.2115

Annalisa Pezzolo, Angela Pistorio, Claudio Gambini, Riccardo Haupt, Manuela Ferraro, Giovanni Erminio, Bruno De Bernardi, Alberto Garaventa,  and Vito Pistoia
7493-7503
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TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis

TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis

https://doi.org/10.18632/oncotarget.3233

Jesse Gore, Kelly E. Craven, Julie L. Wilson, Gregory A. Cote, Monica Cheng, Hai V. Nguyen, Harvey M. Cramer, Stuart Sherman,  and Murray Korc
7504-7521
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Nutrient/serum starvation derived TRIP-Br3 down-regulation accelerates apoptosis by destabilizing XIAP

Nutrient/serum starvation derived TRIP-Br3 down-regulation accelerates apoptosis by destabilizing XIAP

https://doi.org/10.18632/oncotarget.3112

Chengping Li, Samil Jung, Soonduck Lee, Dongjun Jeong, Young Yang, Keun-Il Kim, Jong-Seok Lim, Chung-Il Cheon, Changjin Kim, Young-Sook Kang,  and Myeong-Sok Lee
7522-7535
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Adrenomedullin blockade induces regression of tumor neovessels through interference with vascular endothelial-cadherin signalling

Adrenomedullin blockade induces regression of tumor neovessels through interference with vascular endothelial-cadherin signalling

https://doi.org/10.18632/oncotarget.3167

Ghizlane Khalfaoui-Bendriss, Nadège Dussault, Samantha Fernandez-Sauze, Caroline Berenguer-Daizé, Romain Sigaud, Christine Delfino, Mylène Cayol, Philippe Metellus, Olivier Chinot, Kamel Mabrouk, Pierre-Marie Martin,  and L’Houcine Ouafik
7536-7553
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Anti-tumour effects of antibodies targeting the extracellular cysteine-rich region of the receptor tyrosine kinase EphB4

Anti-tumour effects of antibodies targeting the extracellular cysteine-rich region of the receptor tyrosine kinase EphB4

https://doi.org/10.18632/oncotarget.3199

Sally-Anne Stephenson, Evelyn L. Douglas, Inga Mertens-Walker, Jessica E. Lisle, Mohanan SN Maharaj,  and Adrian C. Herington
7554-7569
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Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and neck squamous cell carcinomas

Elevated Src family kinase activity stabilizes E-cadherin-based junctions and collective movement of head and neck squamous cell carcinomas

https://doi.org/10.18632/oncotarget.3071

Laurence Veracini, Dominique Grall, Sébastien Schaub, Stéphanie Beghelli-de la Forest Divonne, Marie-Christine Etienne-Grimaldi, Gérard Milano, Alexandre Bozec, Emmanuel Babin, Anne Sudaka, Juliette Thariat,  and Ellen Van Obberghen-Schilling
7570-7583
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NDRG4, a novel candidate tumor suppressor, is a predictor of overall survival of colorectal cancer patients

NDRG4, a novel candidate tumor suppressor, is a predictor of overall survival of colorectal cancer patients

https://doi.org/10.18632/oncotarget.3170

Dake Chu, Zixi Zhang, Yi Zhou, Yunming Li, Shaojun Zhu, Jian Zhang, Qingchuan Zhao, Gang Ji, Weizhong Wang,  and Jianyong Zheng
7584-7596
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Genomic differences between pure ductal carcinoma in situ and synchronous ductal carcinoma in situ with invasive breast cancer

Genomic differences between pure ductal carcinoma in situ and synchronous ductal carcinoma in situ with invasive breast cancer

https://doi.org/10.18632/oncotarget.3162

Shinn Young Kim, Seung- Hyun Jung, Min Sung Kim, In-Pyo Baek, Sung Hak Lee, Tae-Min Kim, Yeun-Jun Chung,  and Sug Hyung Lee
7597-7607
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

BRCA1 regulates PIG3-mediated apoptosis in a p53-dependent manner

BRCA1 regulates PIG3-mediated apoptosis in a p53-dependent manner

https://doi.org/10.18632/oncotarget.3263

Wenwen Zhang, Jiayan Luo, Fengxia Chen, Fang Yang, Wei Song, Aiyu Zhu,  and Xiaoxiang Guan
7608-7618
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Kidney-type glutaminase (GLS1) is a biomarker for pathologic diagnosis and prognosis of hepatocellular carcinoma

Kidney-type glutaminase (GLS1) is a biomarker for pathologic diagnosis and prognosis of hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.3196

Decai Yu, Xianbiao Shi, Gang Meng, Jun Chen, Chen Yan, Yong Jiang, Jiwu Wei,  and Yitao Ding
7619-7631
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo

Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo

https://doi.org/10.18632/oncotarget.2939

Noelia Purroy, Pau Abrisqueta, Júlia Carabia, Cecilia Carpio, Carles Palacio, Francesc Bosch,  and Marta Crespo
7632-7643
Abstract  |  PDF  |  HTML  |  Order a Reprint

HDAC9 promotes glioblastoma growth via TAZ-mediated EGFR pathway activation

HDAC9 promotes glioblastoma growth via TAZ-mediated EGFR pathway activation

https://doi.org/10.18632/oncotarget.3223

Rui Yang, Yanan Wu, Mei Wang, Zhongfeng Sun, Jiahua Zou, Yundong Zhang,  and Hongjuan Cui
7644-7656
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A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide

A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide

https://doi.org/10.18632/oncotarget.3150

Marta Pojo, Céline S. Gonçalves, Ana Xavier-Magalhães, Ana Isabel Oliveira, Tiago Gonçalves, Sara Correia, Ana J. Rodrigues, Sandra Costa, Luísa Pinto, Afonso A. Pinto, José M. Lopes, Rui M. Reis, Miguel Rocha, Nuno Sousa,  and Bruno M. Costa
7657-7674
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-145 mediates the antiproliferative and gene regulatory effects of vitamin D3 by directly targeting E2F3 in gastric cancer cells

miR-145 mediates the antiproliferative and gene regulatory effects of vitamin D3 by directly targeting E2F3 in gastric cancer cells

https://doi.org/10.18632/oncotarget.3048

Su’e Chang, Ling Gao, Yang Yang, Dongdong Tong, Bo Guo, Liying Liu, Zongfang Li, Tusheng Song,  and Chen Huang
7675-7685
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells

A dual yet opposite growth-regulating function of miR-204 and its target XRN1 in prostate adenocarcinoma cells and neuroendocrine-like prostate cancer cells

https://doi.org/10.18632/oncotarget.3480

Miao Ding, Biaoyang Lin, Tao Li, Yuanyuan Liu, Yuhua Li, Xiaoyu Zhou, Maohua Miao, Jinfa Gu, Hongjie Pan, Fen Yang, Tianqi Li, Xin Yuan Liu,  and Runsheng Li
7686-7700
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identifying the determinants of response to MDM2 inhibition

Identifying the determinants of response to MDM2 inhibition

https://doi.org/10.18632/oncotarget.3116

Anne Y. Saiki, Sean Caenepeel, Elissa Cosgrove, Cheng Su, Michael Boedigheimer,  and Jonathan D. Oliner
7701-7712
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

Adipose-derived stem cells promote tumor initiation and accelerate tumor growth by interleukin-6 production

https://doi.org/10.18632/oncotarget.3481

Hong-Jian Wei, Rong Zeng, Jui-Hua Lu, Wen-Fu T. Lai, Wei-Hong Chen, Hen-Yu Liu, Ya-Ting Chang,  and Win-Ping Deng
7713-7726
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome

TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome

https://doi.org/10.18632/oncotarget.3115

Sebastian Ribi, Daniel Baumhoer, Kristy Lee, Edison ., Audrey S.M. Teo, Babita Madan, Kang Zhang, Wendy K. Kohlmann, Fei Yao, Wah Heng Lee, Qiangze Hoi, Shaojiang Cai, Xing Yi Woo, Patrick Tan, Gernot Jundt, Jan Smida, Michaela Nathrath, Wing-Kin Sung, Joshua D. Schiffman, David M. Virshup,  and Axel M. Hillmer
7727-7740
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PTX3 gene activation in EGF-induced head and neck cancer cell metastasis

PTX3 gene activation in EGF-induced head and neck cancer cell metastasis

https://doi.org/10.18632/oncotarget.3482

Wei-Chiao Chang, Shuo-Lun Wu, Wan-Chen Huang, Jinn-Yuan Hsu, Shih-Hung Chan, Ju-Ming Wang, Jhih-Peng Tsai,  and Ben-Kuen Chen
7741-7757
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium

Skeletal muscle atrophy is attenuated in tumor-bearing mice under chemotherapy by treatment with fish oil and selenium

https://doi.org/10.18632/oncotarget.3483

Hang Wang, Tsung-Lin Li, Simon Hsia, I-Li Su, Yi-Lin Chan,  and Chang-Jer Wu
7758-7773
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Loss of miR-200c up-regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma

Loss of miR-200c up-regulates CYP1B1 and confers docetaxel resistance in renal cell carcinoma

https://doi.org/10.18632/oncotarget.3484

Inik Chang, Yozo Mitsui, Shinichiro Fukuhara, Ankurpreet Gill, Darryn K. Wong, Soichiro Yamamura, Varahram Shahryari, Z. Laura Tabatabai, Rajvir Dahiya, Dong Min Shin,  and Yuichiro Tanaka
7774-7787
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Gluconeogenesis, lipogenesis, and HBV replication are commonly regulated by PGC-1α-dependent pathway

Gluconeogenesis, lipogenesis, and HBV replication are commonly regulated by PGC-1α-dependent pathway

https://doi.org/10.18632/oncotarget.3050

Hong-Jhih Jhuang, Wei-Hsiang Hsu, Kuan-Ting Lin, Shih-Lan Hsu, Feng-Sheng Wang, Chen-Kung Chou, Kuen-Haur Lee, Ann-Ping Tsou, Jin-Mei Lai, Sheau-Farn Yeh,  and Chi-Ying F. Huang
7788-7803
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

AP-1-mediated chromatin looping regulates ZEB2 transcription: new insights into TNFα-induced epithelial–mesenchymal transition in triple-negative breast cancer

AP-1-mediated chromatin looping regulates ZEB2 transcription: new insights into TNFα-induced epithelial–mesenchymal transition in triple-negative breast cancer

https://doi.org/10.18632/oncotarget.3158

Yichun Qiao, Chiou-Nan Shiue, Jian Zhu, Ting Zhuang, Philip Jonsson, Anthony P.H. Wright, Chunyan Zhao,  and Karin Dahlman-Wright
7804-7814
Abstract  |  PDF  |  HTML  |  Order a Reprint

Inhibition of tumor growth by a newly-identified activator for epidermal fatty acid binding protein

Inhibition of tumor growth by a newly-identified activator for epidermal fatty acid binding protein

https://doi.org/10.18632/oncotarget.3485

Enyu Rao, Puja Singh, Xiuhong Zhai, Yan Li, Ganqian Zhu, Yuwen Zhang, Jiaqing Hao, Young-In Chi, Rhoderick E. Brown, Margot P. Cleary,  and Bing Li
7815-7827
Abstract  |  PDF  |  HTML  |  Order a Reprint

Knockdown of CD44 inhibits the invasion and metastasis of hepatocellular carcinoma both in vitro and in vivo by reversing epithelial-mesenchymal transition

Knockdown of CD44 inhibits the invasion and metastasis of hepatocellular carcinoma both in vitro and in vivo by reversing epithelial-mesenchymal transition

https://doi.org/10.18632/oncotarget.3488

Yuan Gao, Bai Ruan, Weihui Liu, Jianlin Wang, Xisheng Yang, Zhuochao Zhang, Xia Li, Juanli Duan, Fuqing Zhang, Rui Ding, Kaishan Tao,  and Kefeng Dou
7828-7837
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Gold nano-particles (AuNPs) carrying anti-EBV-miR-BART7-3p inhibit growth of EBV-positive nasopharyngeal carcinoma

Gold nano-particles (AuNPs) carrying anti-EBV-miR-BART7-3p inhibit growth of EBV-positive nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.3046

Longmei Cai, Jinbang Li, Xiaona Zhang, Yaoyong Lu, Jianguo Wang, Xiaoming Lyu, Yuxiang Chen, Jinkun Liu, Hongbing Cai, Ying Wang,  and Xin Li
7838-7850
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase

Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase

https://doi.org/10.18632/oncotarget.3490

Marta Lualdi, Edoardo Pedrini, Katia Rea, Laura Monti, Debora Scaldaferri, Marzia Gariboldi, Annalisa Camporeale, Paolo Ghia, Elena Monti, Antonella Tomassetti, Francesco Acquati,  and Roberto Taramelli
7851-7865
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Downregulation of miR-432 activates Wnt/β-catenin signaling and promotes human hepatocellular carcinoma proliferation

Downregulation of miR-432 activates Wnt/β-catenin signaling and promotes human hepatocellular carcinoma proliferation

https://doi.org/10.18632/oncotarget.3492

Nan Jiang, Wen-Jie Chen, Jian-Wen Zhang, Chi Xu, Xian-Cheng Zeng, Tong Zhang, Yang Li,  and Guo-Ying Wang
7866-7879
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Vasohibin-1 suppresses colon cancer

Vasohibin-1 suppresses colon cancer

https://doi.org/10.18632/oncotarget.3493

Shuai Liu, Bing Han, Qunyuan Zhang, Jie Dou, Fang Wang, Wenli Lin, Yuping Sun,  and Guangyong Peng
7880-7898
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway

Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway

https://doi.org/10.18632/oncotarget.3219

Feng Wang, Hou-Qun Ying, Bang-Shun He, Yu-Qin Pan, Qi-Wen Deng, Hui-Ling Sun, Jie Chen, Xian Liu,  and Shu-Kui Wang
7899-7917
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2

MicroRNA-200a suppresses metastatic potential of side population cells in human hepatocellular carcinoma by decreasing ZEB2

https://doi.org/10.18632/oncotarget.3486

Xisheng Yang, Jianlin Wang, Shibin Qu, Hongtao Zhang, Bai Ruan, Yuan Gao, Ben Ma, Xing Wang, Nan Wu, Xiaolei Li, Kefeng Dou,  and Haimin Li
7918-7929
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MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells

MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells

https://doi.org/10.18632/oncotarget.3181

Xiaoping Liu, Qianqian Lei, Zhibin Yu, Gang Xu, Hailin Tang, Wei Wang, Zeyou Wang, Guiyuan Li,  and Minghua Wu
7930-7943
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death

Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death

https://doi.org/10.18632/oncotarget.3501

Enyu Rao, Yuwen Zhang, Ganqian Zhu, Jiaqing Hao, Xuan-Mai T. Persson, Nejat K. Egilmez, Jill Suttles,  and Bing Li
7944-7958
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Extracellular vesicles derived from renal cancer stem cells induce a pro-tumorigenic phenotype in mesenchymal stromal cells

Extracellular vesicles derived from renal cancer stem cells induce a pro-tumorigenic phenotype in mesenchymal stromal cells

https://doi.org/10.18632/oncotarget.3503

Rafael Soares Lindoso, Federica Collino,  and Giovanni Camussi
7959-7969
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells

Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells

https://doi.org/10.18632/oncotarget.3419

Germana Rappa, Toni M. Green, Jana Karbanová, Denis Corbeil,  and Aurelio Lorico
7970-7991
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells

Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells

https://doi.org/10.18632/oncotarget.3505

Ting Liu, Qiuxu Men, Guixian Wu, Chunrong Yu, Zan Huang, Xin Liu,  and Wenhua Li
7992-8006
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UV irradiation/cold shock-mediated apoptosis is switched to bubbling cell death at low temperatures

UV irradiation/cold shock-mediated apoptosis is switched to bubbling cell death at low temperatures

https://doi.org/10.18632/oncotarget.3153

Szu-Jung Chen, Pei-Wen Lin, Hsin-Ping Lin, Sheng-Shyang Huang, Feng-Jie Lai, Hamm-Ming Sheu, Li-Jin Hsu,  and Nan-Shan Chang
8007-8018
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Computational prediction and experimental validation of a novel synthesized pan-PIM inhibitor PI003 and its apoptosis-inducing mechanisms in cervical cancer

Computational prediction and experimental validation of a novel synthesized pan-PIM inhibitor PI003 and its apoptosis-inducing mechanisms in cervical cancer

https://doi.org/10.18632/oncotarget.3139

Zhongyu Liu, Weihua He, Jianglin Gao, Junhua Luo, Xian Huang,  and Chunfang Gao
8019-8035
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The oncogenic role of JC virus T antigen in lens tumors without cell specificity of alternative splicing of its intron

The oncogenic role of JC virus T antigen in lens tumors without cell specificity of alternative splicing of its intron

https://doi.org/10.18632/oncotarget.3507

Wen-feng Gou, Shuang Zhao, Dao-fu Shen, Xue-feng Yang, Yun-peng Liu, Hong-zhi Sun, Jun-sheng Luo,  and Hua-chuan Zheng
8036-8045
Abstract  |  PDF  |  HTML  |  Order a Reprint

Ku80 cooperates with CBP to promote COX-2 expression and tumor growth

Ku80 cooperates with CBP to promote COX-2 expression and tumor growth

https://doi.org/10.18632/oncotarget.3508

Yao Xiao, Jingshu Wang, Yu Qin, Yang Xuan, Yunlu Jia, Wenxian Hu, Wendan Yu, Meng Dai, Zhenglin Li, Canhui Yi, Shilei Zhao, Mei Li, Sha Du, Wei Cheng, Xiangsheng Xiao, Yiming Chen, Taihua Wu, Songshu Meng, Yuhui Yuan, Quentin Liu, Wenlin Huang, Wei Guo, Shusen Wang,  and Wuguo Deng
8046-8061
Abstract  |  PDF  |  HTML  |  Order a Reprint

Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinase

Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinase

https://doi.org/10.18632/oncotarget.3509

Marco Colamonici, Gavin Blyth, Diana Saleiro, Amy Szilard, Meghan Bliss-Moreau, Francis J. Giles, Jessica K. Altman, Elspeth M. Beauchamp,  and Leonidas C. Platanias
8062-8070
Abstract  |  PDF  |  HTML  |  Order a Reprint

Systems biology network-based discovery of a small molecule activator BL-AD008 targeting AMPK/ZIPK and inducing apoptosis in cervical cancer

Systems biology network-based discovery of a small molecule activator BL-AD008 targeting AMPK/ZIPK and inducing apoptosis in cervical cancer

https://doi.org/10.18632/oncotarget.3513

Leilei Fu, Shouyue Zhang, Lan Zhang, Xupeng Tong, Jin Zhang, Yonghui Zhang, Liang Ouyang, Bo Liu,  and Jian Huang
8071-8088
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-31 functions as a tumor suppressor by regulating cell cycle and epithelial-mesenchymal transition regulatory proteins in liver cancer

MicroRNA-31 functions as a tumor suppressor by regulating cell cycle and epithelial-mesenchymal transition regulatory proteins in liver cancer

https://doi.org/10.18632/oncotarget.3512

Hyung Seok Kim, Kyo Sun Lee, Hyun Jin Bae, Jung Woo Eun, Qingyu Shen, Se Jin Park, Woo Chan Shin, Hee Doo Yang, Mijung Park, Won Sang Park, Yong-Koo Kang,  and Suk Woo Nam
8089-8102
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Secreted uPAR isoform 2 (uPAR7b) is a novel direct target of miR-221

Secreted uPAR isoform 2 (uPAR7b) is a novel direct target of miR-221

https://doi.org/10.18632/oncotarget.3516

Natalie Falkenberg, Nataša Anastasov, Annalisa Schaub, Vanja Radulovic, Manfred Schmitt, Viktor Magdolen,  and Michaela Aubele
8103-8114
Abstract  |  PDF  |  HTML  |  Order a Reprint

Oncogenic mutations of thyroid hormone receptor β

Oncogenic mutations of thyroid hormone receptor β

https://doi.org/10.18632/oncotarget.3466

Jeong Won Park, Li Zhao, Mark Willingham,  and Sheue-yann Cheng
8115-8131
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Silencing of voltage-gated potassium channel KV9.3 inhibits proliferation in human colon and lung carcinoma cells

Silencing of voltage-gated potassium channel KV9.3 inhibits proliferation in human colon and lung carcinoma cells

https://doi.org/10.18632/oncotarget.3517

Jeong-Ha Lee, Jun-Won Park, Jun Kyu Byun, Hark Kyun Kim, Pan Dong Ryu, So Yeong Lee,  and Dae-Yong Kim
8132-8143
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mitogen-activated protein kinase binding protein 1 (MAPKBP1) is an unfavorable prognostic biomarker in cytogenetically normal acute myeloid leukemia

Mitogen-activated protein kinase binding protein 1 (MAPKBP1) is an unfavorable prognostic biomarker in cytogenetically normal acute myeloid leukemia

https://doi.org/10.18632/oncotarget.3519

Lin Fu, Jinlong Shi, Kai Hu, Jijun Wang, Weidong Wang,  and Xiaoyan Ke
8144-8154
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process

Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process

https://doi.org/10.18632/oncotarget.2692

Nicola Alessio, Stefania Del Gaudio, Stefania Capasso, Giovanni Di Bernardo, Salvatore Cappabianca, Marilena Cipollaro, Gianfranco Peluso,  and Umberto Galderisi
8155-8166
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells

Activation of NRF2 by p62 and proteasome reduction in sphere-forming breast carcinoma cells

https://doi.org/10.18632/oncotarget.3047

In-geun Ryoo, Bo-hyun Choi,  and Mi-Kyoung Kwak
8167-8184
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FOXM1: A novel drug target in gastroenteropancreatic neuroendocrine tumors

FOXM1: A novel drug target in gastroenteropancreatic neuroendocrine tumors

https://doi.org/10.18632/oncotarget.3600

Franziska Briest, Erika Berg, Irina Grass, Helma Freitag, Daniel Kaemmerer, Florentine Lewens, Friederike Christen, Ruza Arsenic, Annelore Altendorf-Hofmann, Almut Kunze, Jörg Sänger, Thomas Knösel, Britta Siegmund, Michael Hummel,  and Patricia Grabowski
8185-8199
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Marine compounds inhibit growth of multiple myeloma in vitro and in vivo

Marine compounds inhibit growth of multiple myeloma in vitro and in vivo

https://doi.org/10.18632/oncotarget.3362

Normann Steiner, Domenico Ribatti, Wolfgang Willenbacher, Karin Jöhrer, Johann Kern, Christian Marinaccio, Miguel Aracil, Luis F. García-Fernández, Guenther Gastl, Gerold Untergasser,  and Eberhard Gunsilius
8200-8209
Abstract  |  PDF  |  HTML  |  Order a Reprint

Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma

Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma

https://doi.org/10.18632/oncotarget.3601

Zhi-Qiang Ling, Ming-Hua Ge, Xiao-Xiao Lu, Jin Han, Yi-Chen Wu, Xiang Liu, Xin Zhu,  and Lian-Lian Hong
8210-8225
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition

MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition

https://doi.org/10.18632/oncotarget.3364

Marta Kovatcheva, David D. Liu, Mark A. Dickson, Mary E. Klein, Rachael O’Connor, Fatima O. Wilder, Nicholas D. Socci, William D. Tap, Gary K. Schwartz, Samuel Singer, Aimee M. Crago,  and Andrew Koff
8226-8243
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

NF-κB-mediated miR-124 suppresses metastasis of non-small-cell lung cancer by targeting MYO10

NF-κB-mediated miR-124 suppresses metastasis of non-small-cell lung cancer by targeting MYO10

https://doi.org/10.18632/oncotarget.3135

Yingjia Sun, Xinghao Ai, Shengping Shen,  and Shun Lu
8244-8254
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic factors of survival in patients treated with nab-paclitaxel plus gemcitabine regimen for advanced or metastatic pancreatic cancer: A single institutional experience

Prognostic factors of survival in patients treated with nab-paclitaxel plus gemcitabine regimen for advanced or metastatic pancreatic cancer: A single institutional experience

https://doi.org/10.18632/oncotarget.3143

Giovanni Lo Re, Davide A Santeufemia, Luisa Foltran, Ettore Bidoli, Stefano M.M. Basso,  and Franco Lumachi
8255-8260
Abstract  |  PDF  |  HTML  |  Order a Reprint

Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients

Peripheral myeloid-derived suppressor and T regulatory PD-1 positive cells predict response to neoadjuvant short-course radiotherapy in rectal cancer patients

https://doi.org/10.18632/oncotarget.3014

Maria Napolitano, Crescenzo D'Alterio, Eleonora Cardone, Anna Maria Trotta, Biagio Pecori, Daniela Rega, Ugo Pace, Dario Scala, Giosuè Scognamiglio, Fabiana Tatangelo, Carmela Cacciapuoti, Roberto Pacelli, Paolo Delrio,  and Stefania Scala
8261-8270
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells

A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells

https://doi.org/10.18632/oncotarget.3186

Chih-Chien Chou, Hsaio-Ching Chuang, Santosh B. Salunke, Samuel K. Kulp,  and Ching-Shih Chen
8271-8285
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-93 promotes cell proliferation in gliomas through activation of PI3K/Akt signaling pathway

miR-93 promotes cell proliferation in gliomas through activation of PI3K/Akt signaling pathway

https://doi.org/10.18632/oncotarget.3221

Lili Jiang, Chanjuan Wang, Fangyong Lei, Longjuan Zhang, Xin Zhang, Aibin Liu, Geyan Wu, Jinrong Zhu,  and Libing Song
8286-8299
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Low molecular weight protein tyrosine phosphatase (LMWPTP) upregulation mediates malignant potential in colorectal cancer

Low molecular weight protein tyrosine phosphatase (LMWPTP) upregulation mediates malignant potential in colorectal cancer

https://doi.org/10.18632/oncotarget.3224

Elmer Hoekstra, Liudmila L. Kodach, Asha M. Das, Roberta R. Ruela-de-Sousa, Carmen V. Ferreira, James C. Hardwick, C. Janneke van der Woude, Maikel P. Peppelenbosch, Timo L.M. ten Hagen,  and Gwenny M. Fuhler
8300-8312
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD133 initiates tumors, induces epithelial-mesenchymal transition and increases metastasis in pancreatic cancer

CD133 initiates tumors, induces epithelial-mesenchymal transition and increases metastasis in pancreatic cancer

https://doi.org/10.18632/oncotarget.3228

Alice Nomura, Sulagna Banerjee, Rohit Chugh, Vikas Dudeja, Masato Yamamoto, Selwyn M. Vickers,  and Ashok K. Saluja
8313-8322
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Zipper-interacting protein kinase promotes epithelial-mesenchymal transition, invasion and metastasis through AKT and NF-kB signaling and is associated with metastasis and poor prognosis in gastric cancer patients

Zipper-interacting protein kinase promotes epithelial-mesenchymal transition, invasion and metastasis through AKT and NF-kB signaling and is associated with metastasis and poor prognosis in gastric cancer patients

https://doi.org/10.18632/oncotarget.3200

Jian Li, Zhijuan Deng, Zhu Wang, Dong Wang, Longjuan Zhang, Qiao Su, Yingrong Lai, Bin Li, Zexing Luo, Xu Chen, Yu Chen, Xiaohui Huang, Jieyi Ma, Wenjian Wang, Wen Li, Jiong Bi,  and Xinyuan Guan
8323-8338
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine

Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine

https://doi.org/10.18632/oncotarget.3234

Takahiro Kishikawa, Motoyuki Otsuka, Tan Poh Seng, Motoko Ohno, Xiaochen Sun, Takeshi Yoshikawa, Chikako Shibata, Akemi Takata, Kentaro Kojima, Kenji Takehana, Maki Ohishi, Sana Ota, Tomoyuki Noyama, Yuji Kondo, Masaya Sato, Tomoyoshi Soga, Yujin Hoshida,  and Kazuhiko Koike
8339-8352
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HOTAIR is a therapeutic target in glioblastoma

HOTAIR is a therapeutic target in glioblastoma

https://doi.org/10.18632/oncotarget.3229

Xuan Zhou, Yu Ren, Jing Zhang, Chuanbao Zhang, Kailiang Zhang, Lei Han, Lingping Kong, Jianwei Wei, Luyue Chen, Jingxuan Yang, Qixue Wang, Jianning Zhang, Yuqi Yang, Tao Jiang, Min Li,  and Chunsheng Kang
8353-8365
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Blood-brain barrier permeability of gefitinib in patients with brain metastases from non-small-cell lung cancer before and during whole brain radiation therapy

Blood-brain barrier permeability of gefitinib in patients with brain metastases from non-small-cell lung cancer before and during whole brain radiation therapy

https://doi.org/10.18632/oncotarget.3187

Yin-duo Zeng, Hai Liao, Tao Qin, Li Zhang, Wei-dong Wei, Jian-zhong Liang, Fei Xu, Xiao-xiao Dinglin, Shu-xiang Ma,  and Li-kun Chen
8366-8376
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of thymidylate synthase (TYMS) is associated with aggressive tumor features and early PSA recurrence in prostate cancer

Overexpression of thymidylate synthase (TYMS) is associated with aggressive tumor features and early PSA recurrence in prostate cancer

https://doi.org/10.18632/oncotarget.3107

Christoph Burdelski, Christian Strauss, Maria Christina Tsourlakis, Martina Kluth, Claudia Hube-Magg, Nathaniel Melling, Patrick Lebok, Sarah Minner, Christina Koop, Markus Graefen, Hans Heinzer, Corinna Wittmer, Till Krech, Guido Sauter, Waldemar Wilczak, Ronald Simon, Thorsten Schlomm,  and Stefan Steurer
8377-8387
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Role of ASXL1 and TP53 mutations in the molecular classification and prognosis of acute myeloid leukemias with myelodysplasia-related changes

Role of ASXL1 and TP53 mutations in the molecular classification and prognosis of acute myeloid leukemias with myelodysplasia-related changes

https://doi.org/10.18632/oncotarget.3460

Raynier Devillier, Véronique Mansat-De Mas, Veronique Gelsi-Boyer, Cecile Demur, Anne Murati, Jill Corre, Thomas Prebet, Sarah Bertoli, Mandy Brecqueville, Christine Arnoulet, Christian Recher, Norbert Vey, Marie-Joelle Mozziconacci, Eric Delabesse,  and Daniel Birnbaum
8388-8396
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Synchronous occurrence of gastrointestinal stromal tumors and other digestive tract malignancies in the elderly

Synchronous occurrence of gastrointestinal stromal tumors and other digestive tract malignancies in the elderly

https://doi.org/10.18632/oncotarget.3108

Chaoyong Shen, Haining Chen, Yuan Yin, Jiaju Chen, Luyin Han, Bo Zhang, Zhixin Chen,  and Jiaping Chen
8397-8406
Abstract  |  PDF  |  HTML  |  Order a Reprint

MLH1 V384D polymorphism associates with poor response to EGFR tyrosine kinase inhibitors in patients with EGFR L858R-positive lung adenocarcinoma

MLH1 V384D polymorphism associates with poor response to EGFR tyrosine kinase inhibitors in patients with EGFR L858R-positive lung adenocarcinoma

https://doi.org/10.18632/oncotarget.3511

Chao-Hua Chiu, Hsiang-Ling Ho, Howard Doong, Yi-Chen Yeh, Mei-Yu Chen, Teh-Ying Chou,  and Chun-Ming Tsai
8407-8417
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

11C-Methionine-PET: A novel and sensitive tool for monitoring of early response to treatment in multiple myeloma

11C-Methionine-PET: A novel and sensitive tool for monitoring of early response to treatment in multiple myeloma

https://doi.org/10.18632/oncotarget.3053

Katharina Lückerath, Constantin Lapa, Christa Albert, Ken Herrmann, Gerhard Jörg, Samuel Samnick, Herrmann Einsele, Stefan Knop,  and Andreas K. Buck
8418-8429
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


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