Oncotarget

Vol 6, No 9

March 30, 2015

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About The Cover

Correlation plot showing the heatmap with the Pearson’s correlation coefficient values for H4K12ac, BRD4, H3K27ac, H3K4me3, H2Bub1, GRO-seq, RNAPII and H3K27me3 on TSS and 3 kb downstream region of estrogen-upregulated genes. See Nagarajan et al.

Table of Contents

Editorial

Ghrelin receptor controls obesity by fat burning

Ghrelin receptor controls obesity by fat burning

https://doi.org/10.18632/oncotarget.3668

Yuxiang Sun
6470-6471
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Reviews

The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy

The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy

https://doi.org/10.18632/oncotarget.3052

Brock Humphries,  and Chengfeng Yang
6472-6498
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CARP-1 / CCAR1: A biphasic regulator of cancer cell growth and apoptosis

CARP-1 / CCAR1: A biphasic regulator of cancer cell growth and apoptosis

https://doi.org/10.18632/oncotarget.3376

Magesh Muthu, Vino T. Cheriyan,  and Arun K. Rishi
6499-6510
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Research Papers: Gerotarget (Focus on Aging)

Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium

Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium

https://doi.org/10.18632/oncotarget.2989

Júlia Santos, Fernanda Leitão-Correia, Maria João Sousa,  and Cecília Leão
6511-6523
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Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors

Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors

https://doi.org/10.18632/oncotarget.3002

Emanuela Corsini, Valentina Galbiati, Antonella Pinto, Annalisa Davin, Letizia Polito, Antonio Guaita,  and Marco Racchi
6524-6534
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Research Papers: Pathology

Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia

Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia

https://doi.org/10.18632/oncotarget.3163

Xiu-Xia Wang, Bao-Fa Sun, Jiao Jiao, Ze-Chen Chong, Yu-Shen Chen, Xiao-Li Wang, Yue Zhao, Yi-Ming Zhou,  and Da Li
6535-6543
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Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth

Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth

https://doi.org/10.18632/oncotarget.3446

Marco Pizzi, Francesco Piazza, Claudio Agostinelli, Fabio Fuligni, Pietro Benvenuti, Elisa Mandato, Alessandro Casellato, Massimo Rugge, Gianpietro Semenzato,  and Stefano A. Pileri
6544-6552
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Research Papers

Constitutive activation of the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma

Constitutive activation of the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma

https://doi.org/10.18632/oncotarget.2720

Enrico Derenzini, Claudio Agostinelli, Enrica Imbrogno, Ilaria Iacobucci, Beatrice Casadei, Elisa Brighenti, Simona Righi, Fabio Fuligni, Andrea Ghelli Luserna Di Rorà, Anna Ferrari, Giovanni Martinelli, Stefano Pileri,  and Pier Luigi Zinzani
6553-6569
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Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma

Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.3262

Wen Hu, Shi-Xun Lu, Min Li, Chao Zhang, Li-Li Liu, Jia Fu, Jie-Tian Jin, Rong-Zhen Luo, Chris Zhiyi Zhang,  and Jing-Ping Yun
6570-6583
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P-selectin-mediated platelet adhesion promotes tumor growth

P-selectin-mediated platelet adhesion promotes tumor growth

https://doi.org/10.18632/oncotarget.3164

Cuiling Qi, Bo Wei, Weijie Zhou, Yang Yang, Bin Li, Simei Guo, Jialin Li, Jie Ye, Jiangchao Li, Qianqian Zhang, Tian Lan, Xiaodong He, Liu Cao, Jia Zhou, Jianguo Geng,  and Lijing Wang
6584-6596
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Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia

Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia

https://doi.org/10.18632/oncotarget.3260

Alice Cani, Carolina Simioni, Alberto M. Martelli, Giorgio Zauli, Giovanna Tabellini, Simona Ultimo, James A. McCubrey, Silvano Capitani,  and Luca M. Neri
6597-6610
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Loss of p21Cip1/CDKN1A renders cancer cells susceptible to Polo-like kinase 1 inhibition

Loss of p21Cip1/CDKN1A renders cancer cells susceptible to Polo-like kinase 1 inhibition

https://doi.org/10.18632/oncotarget.2844

Nina-Naomi Kreis, Frank Louwen, Brigitte Zimmer,  and Juping Yuan
6611-6626
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Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin–NF-κB–HIF-1α pathway

Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin–NF-κB–HIF-1α pathway

https://doi.org/10.18632/oncotarget.3113

Lei Cao, Xiaoyu Fan, Wei Jing, Yingchao Liang, Rui Chen, Yingying Liu, Minhui Zhu, Rongjie Jia, Hao Wang, Xueguang Zhang, Yanyun Zhang, Xuyu Zhou, Jian Zhao,  and Yajun Guo
6627-6640
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The activity regulation of the mitotic centromere-associated kinesin by Polo-like kinase 1

The activity regulation of the mitotic centromere-associated kinesin by Polo-like kinase 1

https://doi.org/10.18632/oncotarget.2843

Andreas Ritter, Mourad Sanhaji, Kerstin Steinhäuser, Susanne Roth, Frank Louwen,  and Juping Yuan
6641-6655
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Elevated S100A6 (Calcyclin) enhances tumorigenesis and suppresses CXCL14-induced apoptosis in clear cell renal cell carcinoma

Elevated S100A6 (Calcyclin) enhances tumorigenesis and suppresses CXCL14-induced apoptosis in clear cell renal cell carcinoma

https://doi.org/10.18632/oncotarget.3169

Xiang-Jun Lyu, Hong-Zhao Li, Xin Ma, Xin-Tao Li, Yu Gao, Dong Ni, Dong-Lai Shen, Liang-You Gu, Bao-Jun Wang, Yu Zhang,  and Xu Zhang
6656-6669
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Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis

Fibrillin-1, induced by Aurora-A but inhibited by BRCA2, promotes ovarian cancer metastasis

https://doi.org/10.18632/oncotarget.3118

Ziliang Wang, Yang Liu, Lili Lu, Lina Yang, Sheng Yin, Yan Wang, Zihao Qi, Jiao Meng, Rongyu Zang,  and Gong Yang
6670-6683
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Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1

Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1

https://doi.org/10.18632/oncotarget.3246

Hui-Ping Lin, Ching-Yu Lin, Chieh Huo, Ping-Hsuan Hsiao, Liang-Cheng Su, Shih Sheng Jiang, Tzu-Min Chan, Chung-Ho Chang, Li-Tzong Chen, Hsing-Jien Kung, Horng-Dar Wang,  and Chih-Pin Chuu
6684-6707
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Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status

Disruption of BASIGIN decreases lactic acid export and sensitizes non-small cell lung cancer to biguanides independently of the LKB1 status

https://doi.org/10.18632/oncotarget.2862

Sara Granja, Ibtissam Marchiq, Renaud Le Floch, Conceição Souto Moura, Fátima Baltazar,  and Jacques Pouysségur
6708-6721
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Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia

Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia

https://doi.org/10.18632/oncotarget.3156

Alisa B. Lee-Sherick, Weihe Zhang, Kelly K. Menachof, Amanda A. Hill, Sean Rinella, Gregory Kirkpatrick, Lauren S. Page, Michael A. Stashko, Craig T. Jordan, Qi Wei, Jing Liu, Dehui Zhang, Deborah DeRyckere, Xiaodong Wang, Stephen Frye, H. Shelton Earp,  and Douglas K. Graham
6722-6736
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Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers

Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers

https://doi.org/10.18632/oncotarget.3253

Ye Zhang, Xiujuan Qu, Yuee Teng, Zhi Li, Ling Xu, Jing Liu, Yanju Ma, Yibo Fan, Ce Li, Shizhou Liu, Zhenning Wang, Xuejun Hu, Jingdong Zhang,  and Yunpeng Liu
6737-6748
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Inhibition of non-small cell lung cancer (NSCLC) growth by a novel small molecular inhibitor of EGFR

Inhibition of non-small cell lung cancer (NSCLC) growth by a novel small molecular inhibitor of EGFR

https://doi.org/10.18632/oncotarget.3155

Jinsong Li, Huayun Deng, Meichun Hu, Yuanzhang Fang, Amanda Vaughn, Xiaopan Cai, Leqin Xu, Wei Wan, Zhenxi Li, Shijie Chen, Xinghai Yang, Song Wu,  and Jianru Xiao
6749-6761
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Computational design, chemical synthesis, and biological evaluation of a novel ERK inhibitor (BL-EI001) with apoptosis-inducing mechanisms in breast cancer

Computational design, chemical synthesis, and biological evaluation of a novel ERK inhibitor (BL-EI001) with apoptosis-inducing mechanisms in breast cancer

https://doi.org/10.18632/oncotarget.3105

Bo Liu, Leilei Fu, Cui Zhang, Lan Zhang, Yonghui Zhang, Liang Ouyang, Gu He,  and Jian Huang
6762-6775
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Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells

Carbonic anhydrase XII is a new therapeutic target to overcome chemoresistance in cancer cells

https://doi.org/10.18632/oncotarget.2882

Joanna Kopecka, Ivana Campia, Andrea Jacobs, Andreas P. Frei, Dario Ghigo, Bernd Wollscheid,  and Chiara Riganti
6776-6793
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Snail and Slug collaborate on EMT and tumor metastasis through miR-101-mediated EZH2 axis in oral tongue squamous cell carcinoma

Snail and Slug collaborate on EMT and tumor metastasis through miR-101-mediated EZH2 axis in oral tongue squamous cell carcinoma

https://doi.org/10.18632/oncotarget.3180

Min Zheng, Ya-ping Jiang, Wei Chen, Kai-de Li, Xin Liu, Shi-yu Gao, Hao Feng, Sha-sha Wang, Jian Jiang, Xiang-rui Ma, Xiao Cen, Ya-jie Tang, Yu Chen, Yun-feng Lin, Ya-ling Tang,  and Xin-hua Liang
6797-6810
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The histidine-rich calcium binding protein (HRC) promotes tumor metastasis in hepatocellular carcinoma and is upregulated by SATB1

The histidine-rich calcium binding protein (HRC) promotes tumor metastasis in hepatocellular carcinoma and is upregulated by SATB1

https://doi.org/10.18632/oncotarget.3049

Jingmei Liu, Ping Han, Mengke Li, Wei Yan, Jin Liu, Jiqiao Liu, Jiayi He, Wei Tu, Yujia Xia, Zhenzhen Zhou, Jin Gong, Mei Liu, Qiang Ding,  and Dean Tian
6811-6824
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Transcriptome-wide identification and study of cancer-specific splicing events across multiple tumors

Transcriptome-wide identification and study of cancer-specific splicing events across multiple tumors

https://doi.org/10.18632/oncotarget.3145

Yihsuan S. Tsai, Daniel Dominguez, Shawn M. Gomez,  and Zefeng Wang
6825-6839
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Radiation-induced PGE2 sustains human glioma cells growth and survival through EGF signaling

Radiation-induced PGE2 sustains human glioma cells growth and survival through EGF signaling

https://doi.org/10.18632/oncotarget.3160

Emeline Brocard, Kristell Oizel, Lisenn Lalier, Claire Pecqueur, François Paris, François M. Vallette,  and Lisa Oliver
6840-6849
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

High expression of TACC3 in esophageal squamous cell carcinoma correlates with poor prognosis

High expression of TACC3 in esophageal squamous cell carcinoma correlates with poor prognosis

https://doi.org/10.18632/oncotarget.3190

Zhi-Liang Huang, Zhi-Rui Lin, Yi-Ren Xiao, Xun Cao, Lin-Chun Zhu, Mu-Sheng Zeng, Qian Zhong,  and Zhe-Sheng Wen
6850-6861
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Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase

Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase

https://doi.org/10.18632/oncotarget.3119

Jelani C. Zarif, Laura E. Lamb, Veronique S. Schulz, Eric A. Nollet,  and Cindy K. Miranti
6862-6876
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H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway

H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway

https://doi.org/10.18632/oncotarget.3124

Marion Cortier, Rahamata Boina-Ali, Cindy Racoeur, Catherine Paul, Eric Solary, Jean-François Jeannin,  and Ali Bettaieb
6877-6886
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G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma

G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma

https://doi.org/10.18632/oncotarget.3159

Shuli Liu, Dongxia Ye, Wenzheng Guo, Wenwen Yu, Yue He, Jingzhou Hu, Yanan Wang, Ling Zhang, Yueling Liao, Hongyong Song, Shuangshuang Zhong, Dongliang Xu, Huijing Yin, Beibei Sun, Xiaofei Wang, Jingyi Liu, Yadi Wu, Binhua P. Zhou, Zhiyuan Zhang,  and Jiong Deng
6887-6901
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo

https://doi.org/10.18632/oncotarget.3125

Bertal H. Aktas, Paula Bordelois, Selen Peker, Sophia Merajver,  and Jose A. Halperin
6902-6914
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer

JQ1 suppresses tumor growth through downregulating LDHA in ovarian cancer

https://doi.org/10.18632/oncotarget.3126

Haifeng Qiu, Amanda L. Jackson, Joshua E. Kilgore, Yan Zhong, Leo Li-Ying Chan, Paola A. Gehrig, Chunxiao Zhou,  and Victoria L. Bae-Jump
6915-6930
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The miR-491-3p/mTORC2/FOXO1 regulatory loop modulates chemo-sensitivity in human tongue cancer

The miR-491-3p/mTORC2/FOXO1 regulatory loop modulates chemo-sensitivity in human tongue cancer

https://doi.org/10.18632/oncotarget.3165

Guopei Zheng, Xiaoting Jia, Cong Peng, Yingen Deng, Jiang Yin, Zhijie Zhang, Nan Li, Min Deng, Xiaorong Liu, Hao Liu, Minying Lu, Chengkun Wang, Yixue Gu,  and Zhimin He
6931-6943
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DC120, a novel AKT inhibitor, preferentially suppresses nasopharyngeal carcinoma cancer stem-like cells by downregulating Sox2

DC120, a novel AKT inhibitor, preferentially suppresses nasopharyngeal carcinoma cancer stem-like cells by downregulating Sox2

https://doi.org/10.18632/oncotarget.3128

Juan Qin, Jiao Ji, Rong Deng, Jun Tang, Fen Yang, Gong-Kan Feng, Wen-Dan Chen, Xiao-Qi Wu, Xiao-Jun Qian, Ke Ding,  and Xiao-Feng Zhu
6944-6958
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ZBRK1, a novel tumor suppressor, activates VHL gene transcription through formation of a complex with VHL and p300 in renal cancer

ZBRK1, a novel tumor suppressor, activates VHL gene transcription through formation of a complex with VHL and p300 in renal cancer

https://doi.org/10.18632/oncotarget.3134

Ke Chen, Gan Yu, Kiranmai Gumireddy, Anping Li, Weimin Yao, Lu Gao, Shuliang Chen, Jun Hao, Ji Wang, Qihong Huang, Hua Xu,  and Zhangqun Ye
6959-6976
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Distinct anti-oncogenic effect of various microRNAs in different mouse models of liver cancer

Distinct anti-oncogenic effect of various microRNAs in different mouse models of liver cancer

https://doi.org/10.18632/oncotarget.3166

Junyan Tao, Junfang Ji, Xiaolei Li, Ning Ding, Heng Wu, Yan Liu, XinWei Wang, Diego F. Calvisi, Guisheng Song,  and Xin Chen
6977-6988
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Leukemia inhibitory factor receptor is a novel immunomarker in distinction of well-differentiated HCC from dysplastic nodules

Leukemia inhibitory factor receptor is a novel immunomarker in distinction of well-differentiated HCC from dysplastic nodules

https://doi.org/10.18632/oncotarget.3136

Qin Luo, Yurong Zhang, Ning Wang, Guangzhi Jin, Haojie Jin, Dishui Gu, Xuemei Tao, Xisong Huo, Tianxiang Ge, Wenming Cong, Cun Wang,  and Wenxin Qin
6989-6999
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells

The PDGF-D/miR-106a/Twist1 pathway orchestrates epithelial-mesenchymal transition in gemcitabine resistance hepatoma cells

https://doi.org/10.18632/oncotarget.3193

Rui Wang, Yumei Li, Yueyue Hou, Qingling Yang, Sulian Chen, Xi Wang, Zishu Wang, Yan Yang, Changjie Chen, Zhiwei Wang,  and Qiong Wu
7000-7010
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TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1

TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1

https://doi.org/10.18632/oncotarget.3137

Lian-Hong Zou, Zeng-Fu Shang, Wei Tan, Xiao-Dan Liu, Qin-Zhi Xu, Man Song, Yu Wang, Hua Guan, Shi-Meng Zhang, Lan Yu, Cai-Gao Zhong,  and Ping-Kun Zhou
7011-7022
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Gene amplification during differentiation of mammalian neural stem cells in vitro and in vivo

Gene amplification during differentiation of mammalian neural stem cells in vitro and in vivo

https://doi.org/10.18632/oncotarget.3248

Ulrike Fischer, Christina Backes, Abdulrahman Raslan, Andreas Keller, Carola Meier,  and Eckart Meese
7023-7039
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Treatment-induced cell cycle kinetics dictate tumor response to chemotherapy

Treatment-induced cell cycle kinetics dictate tumor response to chemotherapy

https://doi.org/10.18632/oncotarget.3140

Robin M. Hallett, Cheng Huang, Ali Motazedian, Stefanie Auf der Mauer, Gregory R. Pond, John A. Hassell, Robert E. Nordon,  and Jonathan S. Draper
7040-7052
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A direct plasma assay of circulating microRNA-210 of hypoxia can identify early systemic metastasis recurrence in melanoma patients

A direct plasma assay of circulating microRNA-210 of hypoxia can identify early systemic metastasis recurrence in melanoma patients

https://doi.org/10.18632/oncotarget.3142

Shigeshi Ono, Takashi Oyama, Stella Lam, Kelly Chong, Leland J. Foshag,  and Dave S.B. Hoon
7053-7064
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties

A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties

https://doi.org/10.18632/oncotarget.3178

Melissa R. Pitman, Jason A. Powell, Carl Coolen, Paul A.B. Moretti, Julia R. Zebol, Duyen H. Pham, John W. Finnie, Anthony S. Don, Lisa M. Ebert, Claudine S. Bonder, Briony L. Gliddon,  and Stuart M. Pitson
7065-7083
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Autophagy-based survival prognosis in human colorectal carcinoma

Autophagy-based survival prognosis in human colorectal carcinoma

https://doi.org/10.18632/oncotarget.3054

Maopeng Yang, Hong Zhao, Li Guo, Qingyuan Zhang, Ling Zhao, Shuping Bai, Minghui Zhang, Sanqi Xu, Fujing Wang, Xiaohong Wang,  and Bin Zhao
7084-7103
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Cytokeratin 5/6 fingerprinting in HER2-positive tumors identifies a poor prognosis and trastuzumab-resistant Basal-HER2 subtype of breast cancer

Cytokeratin 5/6 fingerprinting in HER2-positive tumors identifies a poor prognosis and trastuzumab-resistant Basal-HER2 subtype of breast cancer

https://doi.org/10.18632/oncotarget.3106

Begoña Martin-Castillo, Eugeni Lopez-Bonet, Maria Buxó, Joan Dorca, Francesc Tuca-Rodríguez, Miguel Alonso Ruano, Ramon Colomer,  and Javier A. Menendez
7104-7122
Abstract  |  PDF  |  HTML  |  Order a Reprint

Sumoylation of HDAC2 promotes NF-κB-dependent gene expression

Sumoylation of HDAC2 promotes NF-κB-dependent gene expression

https://doi.org/10.18632/oncotarget.3344

Tobias Wagner, Nicole Kiweler, Katharina Wolff, Shirley K. Knauer, André Brandl, Peter Hemmerich, Jan-Hermen Dannenberg, Thorsten Heinzel, Günter Schneider,  and Oliver H. Krämer
7123-7135
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion

https://doi.org/10.18632/oncotarget.3044

Long Chen, Baoshan Xu, Lei Liu, Chunxiao Liu, Yan Luo, Xin Chen, Mansoureh Barzegar, Jun Chung,  and Shile Huang
7136-7150
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High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases

High neuropeptide Y release associates with Ewing sarcoma bone dissemination - in vivo model of site-specific metastases

https://doi.org/10.18632/oncotarget.3345

Sung-Hyeok Hong, Jason U. Tilan, Susana Galli, Ewa Izycka-Swieszewska, Taylor Polk, Meredith Horton, Akanksha Mahajan, David Christian, Shari Jenkins, Rachel Acree, Katherine Connors, Phuong Ledo, Congyi Lu, Yi-Chien Lee, Olga Rodriguez, Jeffrey A. Toretsky, Chris Albanese,  and Joanna Kitlinska
7151-7165
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Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: Involvement of p53/FoxO3A axis

Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: Involvement of p53/FoxO3A axis

https://doi.org/10.18632/oncotarget.3347

Saroj Nepal, Mi Jin Kim, Jin Tae Hong, Sang Hyun Kim, Dong-Hwan Sohn, Sung Hee Lee, Kyung Song, Dong Young Choi, Eung Seok Lee,  and Pil-Hoon Park
7166-7181
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma

Extension of the in vivo half-life of endostatin and its improved anti-tumor activities upon fusion to a humanized antibody against tumor-associated glycoprotein 72 in a mouse model of human colorectal carcinoma

https://doi.org/10.18632/oncotarget.3121

Sang-Hyun Lee, In Cheul Jeung, Tae Woo Park, Kyungmin Lee, Dong Gwang Lee, Young-Lai Cho, Tae Sup Lee, Hee-Jun Na, Young-Jun Park, Hee Gu Lee, Mun Sik Jeong, Kwang-Hee Bae, Sang Chul Lee, Hyo Jin Lee, Young-Guen Kwon, Hyo Jeong Hong, Jang-Seong Kim,  and Jeong-Ki Min
7182-7194
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress-mediated survival of melanoma cells

Inhibition of PI3K/AKT/mTOR axis disrupts oxidative stress-mediated survival of melanoma cells

https://doi.org/10.18632/oncotarget.3131

Heather G. Hambright, Peng Meng, Addanki P. Kumar,  and Rita Ghosh
7195-7208
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis

Association of Fusobacterium species in pancreatic cancer tissues with molecular features and prognosis

https://doi.org/10.18632/oncotarget.3109

Kei Mitsuhashi, Katsuhiko Nosho, Yasutaka Sukawa, Yasutaka Matsunaga, Miki Ito, Hiroyoshi Kurihara, Shinichi Kanno, Hisayoshi Igarashi, Takafumi Naito, Yasushi Adachi, Mami Tachibana, Tokuma Tanuma, Hiroyuki Maguchi, Toshiya Shinohara, Tadashi Hasegawa, Masafumi Imamura, Yasutoshi Kimura, Koichi Hirata, Reo Maruyama, Hiromu Suzuki, Kohzoh Imai, Hiroyuki Yamamoto,  and Yasuhisa Shinomura
7209-7220
Abstract  |  PDF  |  HTML  |  Order a Reprint

Free ISG15 triggers an antitumor immune response against breast cancer: a new perspective

Free ISG15 triggers an antitumor immune response against breast cancer: a new perspective

https://doi.org/10.18632/oncotarget.3372

Julian Burks, Ryan E. Reed,  and Shyamal D. Desai
7221-7231
Abstract  |  PDF  |  HTML  |  Order a Reprint

Multiple mechanisms of MYCN dysregulation in Wilms tumour

Multiple mechanisms of MYCN dysregulation in Wilms tumour

https://doi.org/10.18632/oncotarget.3377

Richard D. Williams, Tasnim Chagtai, Marisa Alcaide-German, John Apps, Jenny Wegert, Sergey Popov, Gordan Vujanic, Harm van Tinteren, Marry M. van den Heuvel-Eibrink, Marcel Kool, Jan de Kraker, David Gisselsson, Norbert Graf, Manfred Gessler,  and Kathy Pritchard-Jones
7232-7243
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EGF-reduced Wnt5a transcription induces epithelial-mesenchymal transition via Arf6-ERK signaling in gastric cancer cells

EGF-reduced Wnt5a transcription induces epithelial-mesenchymal transition via Arf6-ERK signaling in gastric cancer cells

https://doi.org/10.18632/oncotarget.3133

Yujie Zhang, Jun Du, Jianchao Zheng, Jiaojing Liu, Rui Xu, Tian Shen, Yichao Zhu, Jun Chang, Hong Wang, Zhihong Zhang, Fanqing Meng, Yan Wang, Yongchang Chen, Yong Xu,  and Luo Gu
7244-7261
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Stratifying risk of recurrence in stage II colorectal cancer using deregulated stromal and epithelial microRNAs

Stratifying risk of recurrence in stage II colorectal cancer using deregulated stromal and epithelial microRNAs

https://doi.org/10.18632/oncotarget.3225

Marc D. Bullock, Karen Pickard, Richard Mitter, A. Emre Sayan, John N. Primrose, Cristina Ivan, George A. Calin, Gareth J. Thomas, Graham K. Packham,  and Alex H. Mirnezami
7262-7279
Abstract  |  PDF  |  HTML  |  Order a Reprint

Bee venom inhibits growth of human cervical tumors in mice

Bee venom inhibits growth of human cervical tumors in mice

https://doi.org/10.18632/oncotarget.3110

Hye Lim Lee, Sang Ho Park, Tae Myoung Kim, Yu Yeon Jung, Mi Hee Park, Sang Hyun Oh, Hye Seok Yun, Hyung Ok Jun, Hwan Soo Yoo, Sang-Bae Han, Ung Soo Lee, Joo Hee Yoon, Min Jong Song,  and Jin Tae Hong
7280-7292
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Plexin-B2 promotes invasive growth of malignant glioma

Plexin-B2 promotes invasive growth of malignant glioma

https://doi.org/10.18632/oncotarget.3421

Audrey P. Le, Yong Huang, Sandeep C. Pingle, Santosh Kesari, Huaien Wang, Raymund L. Yong, Hongyan Zou,  and Roland H. Friedel
7293-7304
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription

H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription

https://doi.org/10.18632/oncotarget.3439

Sankari Nagarajan, Eva Benito, Andre Fischer,  and Steven A. Johnsen
7305-7317
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genetic and clinical characteristics of primary and secondary glioblastoma is associated with differential molecular subtype distribution

Genetic and clinical characteristics of primary and secondary glioblastoma is associated with differential molecular subtype distribution

https://doi.org/10.18632/oncotarget.3440

Rui Li, Hailin Li, Wei Yan, Pei Yang, Zhaoshi Bao, Chuanbao Zhang, Tao Jiang,  and Yongping You
7318-7324
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway

microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway

https://doi.org/10.18632/oncotarget.2621

Jia Wang, Eagle S.H . Chu, Hai-Yong Chen, Kwan Man, Minnie Y.Y. Go, Xiao Ru Huang, Hui Yao Lan, Joseph J.Y. Sung,  and Jun Yu
7325-7338
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

The influence of marital status on stage at diagnosis and survival of patients with colorectal cancer

The influence of marital status on stage at diagnosis and survival of patients with colorectal cancer

https://doi.org/10.18632/oncotarget.3129

Qingguo Li, Lu Gan, Lei Liang, Xinxiang Li,  and Sanjun Cai
7339-7347
Abstract  |  PDF  |  HTML  |  Order a Reprint

ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients

ColoLipidGene: signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients

https://doi.org/10.18632/oncotarget.3130

Teodoro Vargas, Juan Moreno-Rubio, Jesús Herranz, Paloma Cejas, Susana Molina, Margarita González-Vallinas, Marta Mendiola, Emilio Burgos, Cristina Aguayo, Ana B. Custodio, Isidro Machado, David Ramos, Meritxell Gironella, Isabel Espinosa-Salinas, Ricardo Ramos, Roberto Martín-Hernández, Alberto Risueño, Javier De Las Rivas, Guillermo Reglero, Ricardo Yaya, Carlos Fernández-Martos, Jorge Aparicio, Joan Maurel, Jaime Feliu,  and Ana Ramírez de Molina
7348-7363
Abstract  |  PDF  |  HTML  |  Order a Reprint


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