Oncotarget

Vol 6, No 8

March 20, 2015

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C. novyi-NT induces a potent local host-inflammatory response in 060919 (G) and F98 (H, shown) bearing animal. See Staedtke et al.

Table of Contents

Editorial

Mitochondria fingerprint longevity in iPSCs

Mitochondria fingerprint longevity in iPSCs

https://doi.org/10.18632/oncotarget.3530

Andrea Masotti, Enrico Bertini,  and Claudia Compagnucci
5475-5746
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Reviews

Structural variation discovery in the cancer genome using next generation sequencing: Computational solutions and perspectives

Structural variation discovery in the cancer genome using next generation sequencing: Computational solutions and perspectives

https://doi.org/10.18632/oncotarget.3491

Biao Liu, Jeffrey M. Conroy, Carl D. Morrison, Adekunle O. Odunsi, Maochun Qin, Lei Wei, Donald L. Trump, Candace S. Johnson, Song Liu,  and Jianmin Wang
5477-5489
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Aberrant nuclear factor-kappa B activity in acute myeloid Leukemia: from molecular pathogenesis to therapeutic target

Aberrant nuclear factor-kappa B activity in acute myeloid Leukemia: from molecular pathogenesis to therapeutic target

https://doi.org/10.18632/oncotarget.3545

Jianbiao Zhou, Ying Qing Ching,  and Wee-Joo Chng
5490-5500
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Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery

Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery

https://doi.org/10.18632/oncotarget.3551

Lei-lei Fu, Mao Tian, Xiang Li, Jing-jing Li, Jian Huang, Liang Ouyang, Yonghui Zhang,  and Bo Liu
5501-5516
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Research Perspectives

Combination of carbon ion beam and gemcitabine causes irreparable DNA damage and death of radioresistant pancreatic cancer stem-like cells in vitro and in vivo

Combination of carbon ion beam and gemcitabine causes irreparable DNA damage and death of radioresistant pancreatic cancer stem-like cells in vitro and in vivo

https://doi.org/10.18632/oncotarget.3584

Sei Sai, Toshifumi Wakai, Guillaume Vares, Shigeru Yamada, Takehiko Kamijo, Tadashi Kamada,  and Toshiyuki Shirai
5517-5535
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Priority Research Papers

Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats

Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats

https://doi.org/10.18632/oncotarget.3627

Verena Staedtke, Ren-Yuan Bai, Weiyun Sun, Judy Huang, Kathleen Kazuko Kibler, Betty M. Tyler, Gary L. Gallia, Kenneth Kinzler, Bert Vogelstein, Shibin Zhou,  and Gregory J. Riggins
5536-5546
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Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression

Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression

https://doi.org/10.18632/oncotarget.2587

Fabio Valenti, Federica Ganci, Giulia Fontemaggi, Andrea Sacconi, Sabrina Strano, Giovanni Blandino,  and Silvia Di Agostino
5547-5566
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Research Papers

miR-17 inhibition enhances the formation of kidney cancer spheres with stem cell/ tumor initiating cell properties

miR-17 inhibition enhances the formation of kidney cancer spheres with stem cell/ tumor initiating cell properties

https://doi.org/10.18632/oncotarget.1901

Zsuzsanna Lichner, Carol Saleh, Venkateswaran Subramaniam, Annetta Seivwright, Gerald Joseph Prud’homme,  and George Makram Yousef
5567-5581
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Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety

Dihydroartemisinin and its derivative induce apoptosis in acute myeloid leukemia through Noxa-mediated pathway requiring iron and endoperoxide moiety

https://doi.org/10.18632/oncotarget.3336

Xuan Zhao, Hang Zhong, Rui Wang, Dan Liu, Samuel Waxman, Linxiang Zhao,  and Yongkui Jing
5582-5596
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Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma

Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma

https://doi.org/10.18632/oncotarget.3343

Jiayu Chen, Zijun Y. Xu-Monette, Lijuan Deng, Qi Shen, Ganiraju C. Manyam, Azahara Martinez-Lopez, Li Zhang, Santiago Montes-Moreno, Carlo Visco, Alexandar Tzankov, Lihui Yin, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W.L. Choi, J. Han van Krieken, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Xiaoying Zhao, Michael B. Møller, John P. Farnen, Jane N. Winter, Miguel A. Piris, Lan Pham,  and Ken H. Young
5597-5614
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical and biological significance of de novo CD5+ diffuse large B-cell lymphoma in Western countries

Clinical and biological significance of de novo CD5+ diffuse large B-cell lymphoma in Western countries

https://doi.org/10.18632/oncotarget.3479

Zijun Y. Xu-Monette, Meifeng Tu, Kausar J. Jabbar, Xin Cao, Alexandar Tzankov, Carlo Visco, Qingqing Cai, Santiago Montes-Moreno, Yuji An, Karen Dybkaer, April Chiu, Attilio Orazi, Youli Zu, Govind Bhagat, Kristy L. Richards, Eric D. Hsi, William W.L. Choi, J. Han van Krieken, Jooryung Huh, Maurilio Ponzoni, Andrés J.M. Ferreri, Xiaoying Zhao, Michael B. Møller, John P. Farnen, Jane N. Winter, Miguel A. Piris, Roberto N. Miranda, L. Jeffrey Medeiros,  and Ken H. Young
5615-5633
Abstract  |  PDF  |  HTML  |  Erratum  |  Supplementary Information  |  Order a Reprint

Clonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasis

Clonal expansion and linear genome evolution through breast cancer progression from pre-invasive stages to asynchronous metastasis

https://doi.org/10.18632/oncotarget.3111

Anne Bruun Krøigård, Martin Jakob Larsen, Anne-Vibeke Lænkholm, Ann S. Knoop, Jeanette D. Jensen, Martin Bak, Jan Mollenhauer, Torben A. Kruse,  and Mads Thomassen
5634-5649
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Knockdown of GALNT1 suppresses malignant phenotype of hepatocellular carcinoma by suppressing EGFR signaling

Knockdown of GALNT1 suppresses malignant phenotype of hepatocellular carcinoma by suppressing EGFR signaling

https://doi.org/10.18632/oncotarget.3117

Miao-Juei Huang, Rey-Heng Hu, Chih-Hsing Chou, Chia-Lang Hsu, Ya-Wen Liu, John Huang, Ji-Shiang Hung, I-Rue Lai, Hsueh-Fen Juan, Sung-Liang Yu, Yao-Ming Wu,  and Min-Chuan Huang
5650-5665
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Pseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular carcinoma

Pseudogene INTS6P1 regulates its cognate gene INTS6 through competitive binding of miR-17-5p in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.3290

Haoran Peng, Masaharu Ishida, Ling Li, Atsushi Saito, Atsushi Kamiya, James P. Hamilton, Rongdang Fu, Alexandru V. Olaru, Fangmei An, Irinel Popescu, Razvan Iacob, Simona Dima, Sorin T. Alexandrescu, Razvan Grigorie, Anca Nastase, Ioana Berindan-Neagoe, Ciprian Tomuleasa, Florin Graur, Florin Zaharia, Michael S. Torbenson, Esteban Mezey, Minqiang Lu,  and Florin M. Selaru
5666-5677
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer

Combining lapatinib and pertuzumab to overcome lapatinib resistance due to NRG1-mediated signalling in HER2-amplified breast cancer

https://doi.org/10.18632/oncotarget.3296

Wing-yin Leung, Ioannis Roxanis, Helen Sheldon, Francesca M. Buffa, Ji-Liang Li, Adrian L. Harris,  and Anthony Kong
5678-5694
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2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma

2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma

https://doi.org/10.18632/oncotarget.3299

Giada Poli, Elisabetta Ceni, Roberta Armignacco, Tonino Ercolino, Letizia Canu, Gianna Baroni, Gabriella Nesi, Andrea Galli, Massimo Mannelli,  and Michaela Luconi
5695-5706
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Cell-specific expression of artificial microRNAs targeting essential genes exhibit potent antitumor effect on hepatocellular carcinoma cells

Cell-specific expression of artificial microRNAs targeting essential genes exhibit potent antitumor effect on hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.3302

Chenyu Mao, Hao Liu, Ping Chen, Jingjia Ye, Lisong Teng, Zhenyu Jia,  and Jiang Cao
5707-5719
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NPM/ALK mutants resistant to ASP3026 display variable sensitivity to alternative ALK inhibitors but succumb to the novel compound PF-06463922

NPM/ALK mutants resistant to ASP3026 display variable sensitivity to alternative ALK inhibitors but succumb to the novel compound PF-06463922

https://doi.org/10.18632/oncotarget.3122

Luca Mologni, Monica Ceccon, Alessandra Pirola, Giampaolo Chiriano, Rocco Piazza, Leonardo Scapozza,  and Carlo Gambacorti-Passerini
5720-5734
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Preclinical antitumor activity of ST7612AA1: a new oral thiol-based histone deacetylase (HDAC) inhibitor

Preclinical antitumor activity of ST7612AA1: a new oral thiol-based histone deacetylase (HDAC) inhibitor

https://doi.org/10.18632/oncotarget.3240

Loredana Vesci, Elena Bernasconi, Ferdinando Maria Milazzo, Rita De Santis, Eugenio Gaudio, Ivo Kwee, Andrea Rinaldi, Silvia Pace, Valeria Carollo, Giuseppe Giannini,  and Francesco Bertoni
5735-5748
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Myeloid differentiation primary response gene 88-leukotriene B4 receptor 2 cascade mediates lipopolysaccharide-potentiated invasiveness of breast cancer cells

Myeloid differentiation primary response gene 88-leukotriene B4 receptor 2 cascade mediates lipopolysaccharide-potentiated invasiveness of breast cancer cells

https://doi.org/10.18632/oncotarget.3304

Geun-Soo Park,  and Jae-Hong Kim
5749-5759
Abstract  |  PDF  |  HTML  |  Order a Reprint

Somatic microsatellite variability as a predictive marker for colorectal cancer and liver cancer progression

Somatic microsatellite variability as a predictive marker for colorectal cancer and liver cancer progression

https://doi.org/10.18632/oncotarget.3306

Zalman Vaksman,  and Harold R. Garner
5760-5771
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Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells

https://doi.org/10.18632/oncotarget.3308

Srustidhar Das, Satyanarayana Rachagani, Maria P. Torres-Gonzalez, Imayavaramban Lakshmanan, Prabin D. Majhi, Lynette M. Smith, Kay-Uwe Wagner,  and Surinder K. Batra
5772-5787
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

EBNA3C regulates p53 through induction of Aurora kinase B

EBNA3C regulates p53 through induction of Aurora kinase B

https://doi.org/10.18632/oncotarget.3310

Hem C. Jha, Karren Yang, Darine W. El-Naccache, Zhiguo Sun,  and Erle S. Robertson
5788-5803
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EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma

EBV-LMP1 targeted DNAzyme enhances radiosensitivity by inhibiting tumor angiogenesis via the JNKs/HIF-1 pathway in nasopharyngeal carcinoma

https://doi.org/10.18632/oncotarget.3331

Lifang Yang, Liyu Liu, Zhijie Xu, Weihua Liao, Deyun Feng, Xin Dong, San Xu, Lanbo Xiao, Jingchen Lu, Xiangjian Luo, Min Tang, Ann M. Bode, Zigang Dong, Lunquan Sun,  and Ya Cao
5804-5817
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Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation

Granzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation

https://doi.org/10.18632/oncotarget.3461

Huiru Wang, Qing Sun, Yanhong Wu, Lin Wang, Chunxia Zhou, Wenbo Ma, Youhui Zhang, Shengdian Wang,  and Shuren Zhang
5818-5831
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Afatinib increases sensitivity to radiation in non-small cell lung cancer cells with acquired EGFR T790M mutation

Afatinib increases sensitivity to radiation in non-small cell lung cancer cells with acquired EGFR T790M mutation

https://doi.org/10.18632/oncotarget.3332

Shirong Zhang, Xiaoliang Zheng, Haixiu Huang, Kan Wu, Bing Wang, Xufeng Chen,  and Shenglin Ma
5832-5845
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD133+ ovarian cancer stem-like cells promote non-stem cancer cell metastasis via CCL5 induced epithelial-mesenchymal transition

CD133+ ovarian cancer stem-like cells promote non-stem cancer cell metastasis via CCL5 induced epithelial-mesenchymal transition

https://doi.org/10.18632/oncotarget.3462

Haixia Long, Tong Xiang, Wei Qi, Jiani Huang, Junying Chen, Luhang He, Zhiqing Liang, Bo Guo, Yongsheng Li, Rongkai Xie,  and Bo Zhu
5846-5859
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ROS generation mediates the anti-cancer effects of WZ35 via activating JNK and ER stress apoptotic pathways in gastric cancer

ROS generation mediates the anti-cancer effects of WZ35 via activating JNK and ER stress apoptotic pathways in gastric cancer

https://doi.org/10.18632/oncotarget.3333

Peng Zou, Junru Zhang, Yiqun Xia, Karvannan Kanchana, Guilong Guo, Wenbo Chen, Yi Huang, Zhe Wang, Shulin Yang,  and Guang Liang
5860-5876
Abstract  |  PDF  |  HTML  |  Order a Reprint

DACH1 inhibits lung adenocarcinoma invasion and tumor growth by repressing CXCL5 signaling

DACH1 inhibits lung adenocarcinoma invasion and tumor growth by repressing CXCL5 signaling

https://doi.org/10.18632/oncotarget.3463

Na Han, Xun Yuan, Hua Wu, Hanxiao Xu, Qian Chu, Mingzhou Guo, Shiying Yu, Yuan Chen,  and Kongming Wu
5877-5888
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CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid

CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid

https://doi.org/10.18632/oncotarget.3334

Shi-Lin Xia, Mo-Li Wu, Hong Li, Jia-Hui Wang, Nan-Nan Chen, Xiao-Yan Chen, Qing-You Kong, Zheng Sun,  and Jia Liu
5889-5902
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Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer

Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer

https://doi.org/10.18632/oncotarget.3464

Óscar Aguilera, José Manuel González-Sancho, Sandra Zazo, Raúl Rincón, Agustín F. Fernández, Olga Tapia, Francesc Canals, Beatriz Morte, Vincenzo Calvanese, José L. Orgaz, Núria Niell, Susana Aguilar, José M. Freije, Osvaldo Graña, David G. Pisano, Aurea Borrero, Javier Martínez-Useros, Benilde Jiménez, Mario F. Fraga, Jesús García-Foncillas, Carlos López-Otín, Miguel Lafarga, Federico Rojo,  and Alberto Muñoz
5903-5917
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

New insights into the genetics of glioblastoma multiforme by familial exome sequencing

New insights into the genetics of glioblastoma multiforme by familial exome sequencing

https://doi.org/10.18632/oncotarget.2950

Christina Backes, Christian Harz, Ulrike Fischer, Jana Schmitt, Nicole Ludwig, Britt-Sabina Petersen, Sabine C. Mueller, Yoo-Jin Kim, Nadine M. Wolf, Hugo A. Katus, Benjamin Meder, Rhoikos Furtwängler, Andre Franke, Rainer Bohle, Wolfram Henn, Norbert Graf, Andreas Keller,  and Eckart Meese
5918-5931
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN

MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN

https://doi.org/10.18632/oncotarget.3465

Li-Juan Wang, Chen-Chen He, Xin Sui, Meng-Jiao Cai, Cong-Ya Zhou, Jin-Lu Ma, Lei Wu, Hao Wang, Su-Xia Han,  and Qing Zhu
5932-5946
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Discrete functions of GSK3α and GSK3β isoforms in prostate tumor growth and micrometastasis

Discrete functions of GSK3α and GSK3β isoforms in prostate tumor growth and micrometastasis

https://doi.org/10.18632/oncotarget.3335

Fei Gao, Ahmad Al-Azayzih,  and Payaningal R. Somanath
5947-5962
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Transforming growth factor-β pathway activity in glioblastoma

Transforming growth factor-β pathway activity in glioblastoma

https://doi.org/10.18632/oncotarget.3467

Karl Frei, Dorothee Gramatzki, Isabel Tritschler, Judith Johanna Schroeder, Larisa Espinoza, Elisabeth Jane Rushing,  and Michael Weller
5963-5977
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen

Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen

https://doi.org/10.18632/oncotarget.3468

Gaganpreet S. Tiwana, Remko Prevo, Francesca M. Buffa, Sheng Yu, Daniel V. Ebner, Alison Howarth, Lisa K. Folkes, Balam Budwal, Kwun-Ye Chu, Lisa Durrant, Ruth J. Muschel, W. Gillies McKenna,  and Geoff S. Higgins
5978-5989
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The over-expression of survivin enhances the chemotherapeutic efficacy of YM155 in human hepatocellular carcinoma

The over-expression of survivin enhances the chemotherapeutic efficacy of YM155 in human hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.3337

Hongping Xia, Jianxiang Chen, Ming Shi, Amudha Deivasigamani, London Lucien P.J. Ooi,  and Kam M. Hui
5990-6000
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway

Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway

https://doi.org/10.18632/oncotarget.3469

Fang Li, Liyuan Zhang, Wei Li, Jieqiong Deng, Jian Zheng, Mingxing An, Jiachun Lu,  and Yifeng Zhou
6001-6013
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells

miR-1236 down-regulates alpha-fetoprotein, thus causing PTEN accumulation, which inhibits the PI3K/Akt pathway and malignant phenotype in hepatoma cells

https://doi.org/10.18632/oncotarget.3338

Rui Gao, Chunli Cai, Jiancheng Gan, Xi Yang, Zeyu Shuang, Min Liu, Shengping Li,  and Hua Tang
6014-6028
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Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer

Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer

https://doi.org/10.18632/oncotarget.3472

Igor F. Tsigelny, Jennifer J. Wheler, Jerry P. Greenberg, Valentina L. Kouznetsova, David J. Stewart, Lyudmila Bazhenova,  and Razelle Kurzrock
6029-6039
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Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model

Initiation of esophageal squamous cell carcinoma (ESCC) in a murine 4-nitroquinoline-1-oxide and alcohol carcinogenesis model

https://doi.org/10.18632/oncotarget.3339

Kwame Osei-Sarfo, Alison M. Urvalek, Xiao-Han Tang, Theresa Scognamiglio,  and Lorraine J. Gudas
6040-6052
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The anti-tumor effect is enhanced by simultaneously targeting VEGF and PROK1 in colorectal cancer

The anti-tumor effect is enhanced by simultaneously targeting VEGF and PROK1 in colorectal cancer

https://doi.org/10.18632/oncotarget.3474

Takanori Goi, Toshiyuki Nakazawa, Yasuo Hirono,  and Akio Yamaguchi
6053-6061
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miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo

miR-372 inhibits p62 in head and neck squamous cell carcinoma in vitro and in vivo

https://doi.org/10.18632/oncotarget.3340

Li-Yin Yeh, Chung-Ji Liu, Yong-Kie Wong, Christine Chang, Shu-Chun Lin,  and Kuo-Wei Chang
6062-6075
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients

HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients

https://doi.org/10.18632/oncotarget.3475

Vaishali Pannu, Padmashree C.G. Rida, Angela Ogden, Ravi Chakra Turaga, Shashikiran Donthamsetty, Nathan J. Bowen, Katie Rudd, Meenakshi V. Gupta, Michelle D. Reid, Guilherme Cantuaria, Claire E. Walczak,  and Ritu Aneja
6076-6091
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-188-5p inhibits tumour growth and metastasis in prostate cancer by repressing LAPTM4B expression

miR-188-5p inhibits tumour growth and metastasis in prostate cancer by repressing LAPTM4B expression

https://doi.org/10.18632/oncotarget.3341

Hongtuan Zhang, Shiyong Qi, Tao Zhang, Andi Wang, Ranlu Liu, Jia Guo, Yuzhuo Wang,  and Yong Xu
6092-6104
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Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy

Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy

https://doi.org/10.18632/oncotarget.3368

Frédéric R. Santer, Holger H. H. Erb, Su Jung Oh, Florian Handle, Gertrud E. Feiersinger, Birgit Luef, Huajie Bu, Georg Schäfer, Christian Ploner, Martina Egger, Jayant K. Rane, Norman J. Maitland, Helmut Klocker, Iris E. Eder,  and Zoran Culig
6105-6122
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Up-regulation of C1GALT1 promotes breast cancer cell growth through MUC1-C signaling pathway

Up-regulation of C1GALT1 promotes breast cancer cell growth through MUC1-C signaling pathway

https://doi.org/10.18632/oncotarget.3045

Chih-Hsing Chou, Miao-Juei Huang, Chi-Hau Chen, Ming-Kwang Shyu, John Huang, Ji-Shiang Hung, Chiun-Sheng Huang,  and Min-Chuan Huang
6123-6135
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Hydrazinobenzoylcurcumin inhibits androgen receptor activity and growth of castration-resistant prostate cancer in mice

Hydrazinobenzoylcurcumin inhibits androgen receptor activity and growth of castration-resistant prostate cancer in mice

https://doi.org/10.18632/oncotarget.3346

Min Wu, Sahn-Ho Kim, Indrani Datta, Albert Levin, Gregory Dyson, Jing Li, Stephanie Kaypee, M. Mahadeva Swamy, Nilesh Gupta, Ho Jeong Kwon, Mani Menon, Tapas K. Kundu,  and G. Prem-Veer Reddy
6136-6150
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Gene expression profile predictive of response to chemotherapy in metastatic colorectal cancer

Gene expression profile predictive of response to chemotherapy in metastatic colorectal cancer

https://doi.org/10.18632/oncotarget.3152

Purificacion Estevez-Garcia, Fernando Rivera, Sonia Molina-Pinelo, Marta Benavent, Javier Gómez, Maria Luisa Limón, Maria Dolores Pastor, Julia Martinez-Perez, Luis Paz-Ares, Amancio Carnero,  and Rocio Garcia-Carbonero
6151-6159
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Elevated NIBP/TRAPPC9 mediates tumorigenesis of cancer cells through NFκB signaling

Elevated NIBP/TRAPPC9 mediates tumorigenesis of cancer cells through NFκB signaling

https://doi.org/10.18632/oncotarget.3349

Yonggang Zhang, Shu Liu, Hong Wang, Wensheng Yang, Fang Li, Fan Yang, Daohai Yu, Frederick V. Ramsey, George P. Tuszyski,  and Wenhui Hu
6160-6178
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Late-phase miRNA-controlled oncolytic adenovirus for selective killing of cancer cells

Late-phase miRNA-controlled oncolytic adenovirus for selective killing of cancer cells

https://doi.org/10.18632/oncotarget.3350

Xavier Bofill-De Ros, Eneko Villanueva,  and Cristina Fillat
6179-6190
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma

Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma

https://doi.org/10.18632/oncotarget.3356

Valentina E. Schneeberger, Yuan Ren, Noreen Luetteke, Qingling Huang, Liwei Chen, Harshani R. Lawrence, Nicholas J. Lawrence, Eric B. Haura, John M. Koomen, Domenico Coppola,  and Jie Wu
6191-6202
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Autophagy protects against dasatinib-induced hepatotoxicity via p38 signaling

Autophagy protects against dasatinib-induced hepatotoxicity via p38 signaling

https://doi.org/10.18632/oncotarget.3357

Xiaochun Yang, Jincheng Wang, Jiabin Dai, Jinjin Shao, Jian Ma, Chao Chen, Shenglin Ma, Qiaojun He, Peihua Luo,  and Bo Yang
6203-6217
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation

Targeting WISP1 to sensitize esophageal squamous cell carcinoma to irradiation

https://doi.org/10.18632/oncotarget.3358

Hongfang Zhang, Honglei Luo, Zhaoyang Hu, Jin Peng, Zhenzhen Jiang, Tao Song, Bo Wu, Jing Yue, Rongjing Zhou, Ruifei Xie, Tian Chen,  and Shixiu Wu
6218-6234
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Recurrent SKIL-activating rearrangements in ETS-negative prostate cancer

Recurrent SKIL-activating rearrangements in ETS-negative prostate cancer

https://doi.org/10.18632/oncotarget.3359

Matti Annala, Kati Kivinummi, Joonas Tuominen, Serdar Karakurt, Kirsi Granberg, Leena Latonen, Antti Ylipää, Liisa Sjöblom, Pekka Ruusuvuori, Outi Saramäki, Kirsi M. Kaukoniemi, Olli Yli-Harja, Robert L. Vessella, Teuvo L.J. Tammela, Wei Zhang, Tapio Visakorpi,  and Matti Nykter
6235-6250
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells

ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells

https://doi.org/10.18632/oncotarget.3360

Lekhana Bhandary, Rebecca A. Whipple, Michele I. Vitolo, Monica S. Charpentier, Amanda E. Boggs, Kristi R. Chakrabarti, Keyata N. Thompson,  and Stuart S. Martin
6251-6266
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Coexpression analysis of CD133 and CD44 identifies Proneural and Mesenchymal subtypes of glioblastoma multiforme

Coexpression analysis of CD133 and CD44 identifies Proneural and Mesenchymal subtypes of glioblastoma multiforme

https://doi.org/10.18632/oncotarget.3365

Daniel V. Brown, Paul M. Daniel, Giovanna M. D’Abaco, Andrew Gogos, Wayne Ng, Andrew P. Morokoff,  and Theo Mantamadiotis
6267-6280
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Function of phosphorylation of NF-kB p65 ser536 in prostate cancer oncogenesis

Function of phosphorylation of NF-kB p65 ser536 in prostate cancer oncogenesis

https://doi.org/10.18632/oncotarget.3366

Li Zhang, Longjiang Shao, Chad J. Creighton, Yiqun Zhang, Li Xin, Michael Ittmann,  and Jianghua Wang
6281-6294
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin

Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin

https://doi.org/10.18632/oncotarget.3370

Niramol Savaraj, Chunjing Wu, Ying-Ying Li, Medhi Wangpaichitr, Min You, John Bomalaski, Wei He, Macus Tien Kuo,  and Lynn G. Feun
6295-6309
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells

FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells

https://doi.org/10.18632/oncotarget.3355

Hui Yang, Xiaofei Lu, Ziming Liu, Lili Chen, Yunfei Xu, Yuli Wang, Guangwei Wei,  and Yuxin Chen
6310-6325
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells

Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells

https://doi.org/10.18632/oncotarget.3436

Zhi-Jie Hou, Xi Luo, Wei Zhang, Fei Peng, Bai Cui, Si-Jin Wu, Fei-Meng Zheng, Jie Xu, Ling-Zhi Xu, Zi-Jie Long, Xue-Ting Wang, Guo-Hui Li, Xian-Yao Wan, Yong-Liang Yang,  and Quentin Liu
6326-6340
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs

Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs

https://doi.org/10.18632/oncotarget.3437

Isabel Ben-Batalla, Miguel Cubas-Cordova, Florian Udonta, Mark Wroblewski, Jonas S. Waizenegger, Melanie Janning, Stefanie Sawall, Victoria Gensch, Lin Zhao, Iñigo Martinez-Zubiaurre, Kristoffer Riecken, Boris Fehse, Klaus Pantel, Carsten Bokemeyer,  and Sonja Loges
6341-6358
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MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation

MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation

https://doi.org/10.18632/oncotarget.3438

Jianxin Jiang, Yi Zhang, Yuting Guo, Chao Yu, Meiyuan Chen, Zhu Li, Se Tian,  and Chengyi Sun
6359-6372
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fatty acid binding protein 5 promotes metastatic potential of triple negative breast cancer cells through enhancing epidermal growth factor receptor stability

Fatty acid binding protein 5 promotes metastatic potential of triple negative breast cancer cells through enhancing epidermal growth factor receptor stability

https://doi.org/10.18632/oncotarget.3442

Catherine A. Powell, Mohd W. Nasser, Helong Zhao, Jacob C. Wochna, Xiaoli Zhang, Charles Shapiro, Konstantin Shilo,  and Ramesh K. Ganju
6373-6385
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel

Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel

https://doi.org/10.18632/oncotarget.3443

Jong Hyun Lee, Chulwon Kim, Gautam Sethi,  and Kwang Seok Ahn
6386-6405
Abstract  |  PDF  |  HTML  |  Order a Reprint

Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP

Piperlongumine selectively kills hepatocellular carcinoma cells and preferentially inhibits their invasion via ROS-ER-MAPKs-CHOP

https://doi.org/10.18632/oncotarget.3444

Yong Chen, Ju Mei Liu, Xin Xin Xiong, Xin Yao Qiu, Feng Pan, Di Liu, Shu Jue Lan, Si Jin, Shang Bin Yu,  and Xiao Qian Chen
6406-6421
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Variants in CDA and ABCB1 are predictors of capecitabine-related adverse reactions in colorectal cancer

Variants in CDA and ABCB1 are predictors of capecitabine-related adverse reactions in colorectal cancer

https://doi.org/10.18632/oncotarget.3289

Xandra García-González, Lucía Cortejoso, María I. García, Pilar García-Alfonso, Luis Robles, Cristina Grávalos, Eva González-Haba, Pellicer Marta, María Sanjurjo,  and Luis A. López-Fernández
6422-6430
Abstract  |  PDF  |  HTML  |  Order a Reprint

Drug metabolism and clearance system in tumor cells of patients with multiple myeloma

Drug metabolism and clearance system in tumor cells of patients with multiple myeloma

https://doi.org/10.18632/oncotarget.3237

Wafa Hassen, Alboukadel Kassambara, Thierry Reme, Surinder Sahota, Anja Seckinger, Laure Vincent, Guillaume Cartron, Jérôme Moreaux, Dirk Hose,  and Bernard Klein
6431-6447
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Efficacy and safety of decitabine in combination with G-CSF, low-dose cytarabine and aclarubicin in newly diagnosed elderly patients with acute myeloid leukemia

Efficacy and safety of decitabine in combination with G-CSF, low-dose cytarabine and aclarubicin in newly diagnosed elderly patients with acute myeloid leukemia

https://doi.org/10.18632/oncotarget.3361

Jianyong Li, Yaoyu Chen, Yu Zhu, Jianfeng Zhou, Yanli Xu, Yan Li, Kang Yu, Ling Pan, Jianmin Wang, Jiahua Ding, Jian Gu, Shanhua Zhou, Jinning Shi, Ming Hong, Ji Xu, Liangqin Pan, Limin Duan, Run Zhang, Sujiang Zhang, Huayuan Zhu, Hua Lu, Peng Liu, Hongxia Qiu, Hanxin Wu,  and Sixuan Qian
6448-6458
Abstract  |  PDF  |  HTML  |  Order a Reprint

Antibody response to BK polyomavirus as a prognostic biomarker and potential therapeutic target in prostate cancer

Antibody response to BK polyomavirus as a prognostic biomarker and potential therapeutic target in prostate cancer

https://doi.org/10.18632/oncotarget.3363

Xavier Etienne Keller, Piotr Kardas, Claudio Acevedo, Giovanni Sais, Cédric Poyet, Irina Banzola, Ashkan Mortezavi, Burkhardt Seifert, Tullio Sulser, Hans H. Hirsch,  and Maurizio Provenzano
6459-6469
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


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