Oncotarget

Vol 6, No 7

March 10, 2015

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About The Cover

Because mitochondria evolved from bacteria that were originally engulfed by eukaryotic cells millions of years ago, many FDA-approved antibiotics target mitochondrial ribosomes, as a mild side-effect, which is well-tolerated. These four classes of drugs include: the erythromycins, chloramphenicol, the tetracyclines and glycylcyclines. In this issue of Oncotarget, Lamb et al., 2015 used these antibiotics as “investigational tools” to assess if mitochondrial biogenesis is required for the propagation of cancer stem cells, in 8 different cancer types. Based on their positive results, these FDA-approved antibiotics could be re-purposed for the treatment of cancer, to eradicate cancer stem cells, to prevent tumor recurrence and possibly treat metastatic disease. See Lamb et al.

Table of Contents

Editorial

Senescence versus apoptosis in chemotherapy

Senescence versus apoptosis in chemotherapy

https://doi.org/10.18632/oncotarget.3114

Stéphane Ansieau,  and Guillaume Collin
4551-4552
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Reviews

Molecular landscape of pancreatic cancer: implications for current clinical trials

Molecular landscape of pancreatic cancer: implications for current clinical trials

https://doi.org/10.18632/oncotarget.2972

Gregory M. Heestand,  and Razelle Kurzrock
4553-4561
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MicroRNA dysregulation in uveal melanoma: a new player enters the game

MicroRNA dysregulation in uveal melanoma: a new player enters the game

https://doi.org/10.18632/oncotarget.2923

Zheng Li, Xin Yu, Jianxiong Shen,  and Yang Jiang
4562-4568
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Priority Research Papers

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease

https://doi.org/10.18632/oncotarget.3174

Rebecca Lamb, Bela Ozsvari, Camilla L. Lisanti, Herbert B. Tanowitz, Anthony Howell, Ubaldo E. Martinez-Outschoorn, Federica Sotgia,  and Michael P. Lisanti
4569-4584
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Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction

Targeting tumor-initiating cells: Eliminating anabolic cancer stem cells with inhibitors of protein synthesis or by mimicking caloric restriction

https://doi.org/10.18632/oncotarget.3278

Rebecca Lamb, Hannah Harrison, Duncan L. Smith, Paul A. Townsend, Thomas Jackson, Bela Ozsvari, Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Anthony Howell, Michael P. Lisanti,  and Federica Sotgia
4585-4601
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Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells

Activating transcription factor 5 enhances radioresistance and malignancy in cancer cells

https://doi.org/10.18632/oncotarget.2912

Seiichiro Ishihara, Motoaki Yasuda, Akihiro Ishizu, Masayori Ishikawa, Hiroki Shirato,  and Hisashi Haga
4602-4614
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Research Papers

Norepinephrine promotes tumor microenvironment reactivity through β3-adrenoreceptors during melanoma progression

Norepinephrine promotes tumor microenvironment reactivity through β3-adrenoreceptors during melanoma progression

https://doi.org/10.18632/oncotarget.2652

Maura Calvani, Floriane Pelon, Giuseppina Comito, Maria Letizia Taddei, Silvia Moretti, Stefania Innocenti, Romina Nassini, Gianni Gerlini, Lorenzo Borgognoni, Franco Bambi, Elisa Giannoni, Luca Filippi,  and Paola Chiarugi
4615-4632
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The broad-spectrum anti-DNA virus agent cidofovir inhibits lung metastasis of virus-independent, FGF2-driven tumors

The broad-spectrum anti-DNA virus agent cidofovir inhibits lung metastasis of virus-independent, FGF2-driven tumors

https://doi.org/10.18632/oncotarget.3079

Sandra Liekens, Sam Noppen, Sofie Gijsbers, Rebecca Sienaert, Roberto Ronca, Chiara Tobia,  and Marco Presta
4633-4648
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The soybean-derived peptide lunasin inhibits non-small cell lung cancer cell proliferation by suppressing phosphorylation of the retinoblastoma protein

The soybean-derived peptide lunasin inhibits non-small cell lung cancer cell proliferation by suppressing phosphorylation of the retinoblastoma protein

https://doi.org/10.18632/oncotarget.3080

Elizabeth J. McConnell, Bharat Devapatla, Kavitha Yaddanapudi,  and Keith R. Davis
4649-4662
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Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors

Radiotherapy combined with TLR7/8 activation induces strong immune responses against gastrointestinal tumors

https://doi.org/10.18632/oncotarget.3081

Sebastian Schölch, Conrad Rauber, Alexandra Tietz, Nuh N. Rahbari, Ulrich Bork, Thomas Schmidt, Christoph Kahlert, Uwe Haberkorn, Mark A. Tomai, Kenneth E. Lipson, Rafael Carretero, Jürgen Weitz, Moritz Koch,  and Peter E. Huber
4663-4676
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Small non-coding RNA deregulation in endometrial carcinogenesis

Small non-coding RNA deregulation in endometrial carcinogenesis

https://doi.org/10.18632/oncotarget.2911

Maria Ravo, Angela Cordella, Antonio Rinaldi, Giuseppina Bruno, Elena Alexandrova, Pasquale Saggese, Giovanni Nassa, Giorgio Giurato, Roberta Tarallo, Giovanna Marchese, Francesca Rizzo, Claudia Stellato, Rossella Biancardi, Jacopo Troisi, Attilio Di Spiezio Sardo, Fulvio Zullo, Alessandro Weisz,  and Maurizio Guida
4677-4691
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α-Radioimmunotherapy with 213Bi-anti-CD38 immunoconjugates is effective in a mouse model of human multiple myeloma

α-Radioimmunotherapy with 213Bi-anti-CD38 immunoconjugates is effective in a mouse model of human multiple myeloma

https://doi.org/10.18632/oncotarget.2986

Katharina Teiluf, Christof Seidl, Birgit Blechert, Florian C. Gaertner, Klaus-Peter Gilbertz, Vanesa Fernandez, Florian Bassermann, Jan Endell, Rainer Boxhammer, Stephane Leclair, Mario Vallon, Michaela Aichler, Annette Feuchtinger, Frank Bruchertseifer, Alfred Morgenstern,  and Markus Essler
4692-4703
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Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma

Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma

https://doi.org/10.18632/oncotarget.3082

Ziming Du, Malak Abedalthagafi, Ayal A. Aizer, Allison R. McHenry, Heather H. Sun, Mark-Anthony Bray, Omar Viramontes, Revaz Machaidze, Priscilla K. Brastianos, David A. Reardon, Ian F. Dunn, Gordon J. Freeman, Keith L. Ligon, Anne E. Carpenter, Brian M. Alexander, Nathalie Y. Agar, Scott J. Rodig, Elizabeth M. Bradshaw,  and Sandro Santagata
4704-4716
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Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer

Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer

https://doi.org/10.18632/oncotarget.3069

Qinhong Xu, Zheng Wang, Xin Chen, Wanxing Duan, Jianjun Lei, Liang Zong, Xuqi Li, Liang Sheng, Jiguang Ma, Liang Han, Wei Li, Lun Zhang, Kun Guo, Zhenhua Ma, Zheng Wu, Erxi Wu,  and Qingyong Ma
4717-4732
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CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression

CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression

https://doi.org/10.18632/oncotarget.2900

Qian Cheng, Fuwen Yuan, Fengmin Lu, Bo Zhang, Tianda Chen, Xiangmei Chen, Yuan Cheng, Na Li, Liwei Ma,  and Tanjun Tong
4733-4744
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The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells

The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells

https://doi.org/10.18632/oncotarget.2938

Ning Wei, Edward Chu, Shao-yu Wu, Peter Wipf,  and John C. Schmitz
4745-4756
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FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells

FAK activation is required for IGF1R-mediated regulation of EMT, migration, and invasion in mesenchymal triple negative breast cancer cells

https://doi.org/10.18632/oncotarget.3023

LaTonia Taliaferro-Smith, Elaine Oberlick, Tongrui Liu, Tanisha McGlothen, Tiffanie Alcaide, Rachel Tobin, Siobhan Donnelly, Rachel Commander, Erik Kline, Ganji Purnachandra Nagaraju, Lauren Havel, Adam Marcus, Rita Nahta,  and Ruth O'Regan
4757-4772
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The histone code reader SPIN1 controls RET signaling in liposarcoma

The histone code reader SPIN1 controls RET signaling in liposarcoma

https://doi.org/10.18632/oncotarget.3000

Henriette Franz, Holger Greschik, Dominica Willmann, Luka Ozretić, Cordula Annette Jilg, Eva Wardelmann, Manfred Jung, Reinhard Buettner,  and Roland Schüle
4773-4789
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PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma

PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma

https://doi.org/10.18632/oncotarget.2993

Jara Majuelos-Melguizo, María Isabel Rodríguez, Laura López-Jiménez, Jose M. Rodríguez-Vargas, Juan M. Martí Martín-Consuegra, Santiago Serrano-Sáenz, Julie Gavard, J. Mariano Ruiz de Almodóvar,  and F. Javier Oliver
4790-4803
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

p53 activates G1 checkpoint following DNA damage by doxorubicin during transient mitotic arrest

p53 activates G1 checkpoint following DNA damage by doxorubicin during transient mitotic arrest

https://doi.org/10.18632/oncotarget.3103

Sun-Yi Hyun,  and Young-Joo Jang
4804-4815
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In-silico identification and functional validation of allele-dependent AR enhancers

In-silico identification and functional validation of allele-dependent AR enhancers

https://doi.org/10.18632/oncotarget.3019

Sonia Garritano, Alessandro Romanel, Yari Ciribilli, Alessandra Bisio, Antoneta Gavoci, Alberto Inga,  and Francesca Demichelis
4816-4828
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: Involvement of protein kinase C-θ activation

Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: Involvement of protein kinase C-θ activation

https://doi.org/10.18632/oncotarget.3104

Tetsuyuki Takahashi, Hisanori Uehara, Hirohisa Ogawa, Hitomi Umemoto, Yoshimi Bando,  and Keisuke Izumi
4829-4844
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The IgH 3′ regulatory region governs μ chain transcription in mature B lymphocytes and the B cell fate

The IgH 3′ regulatory region governs μ chain transcription in mature B lymphocytes and the B cell fate

https://doi.org/10.18632/oncotarget.3010

Alexis Saintamand, Pauline Rouaud, Armand Garot, Faten Saad, Claire Carrion, Christelle Oblet, Michel Cogné, Eric Pinaud,  and Yves Denizot
4845-4852
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Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody

Aberrant expression of the embryonic transcription factor brachyury in human tumors detected with a novel rabbit monoclonal antibody

https://doi.org/10.18632/oncotarget.3086

Duane H. Hamilton, Romaine I. Fernando, Jeffrey Schlom,  and Claudia Palena
4853-4862
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HDAC1,2 inhibition impairs EZH2- and BBAP- mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma

HDAC1,2 inhibition impairs EZH2- and BBAP- mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma

https://doi.org/10.18632/oncotarget.3120

Danielle P. Johnson, Gabriella S. Spitz, Shweta Tharkar, Steven N. Quayle, Jeffrey R. Shearstone, Simon Jones, Maria E. McDowell, Hannah Wellman, Jessica K. Tyler, Bradley R. Cairns, Mahesh B. Chandrasekharan,  and Srividya Bhaskara
4863-4887
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression

The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression

https://doi.org/10.18632/oncotarget.2917

Xiaolu Zhang, Bingnan Li, Nick de Jonge, Magnus Björkholm,  and Dawei Xu
4888-4900
Abstract  |  PDF  |  HTML  |  Order a Reprint

High expression of N-myc (and STAT) interactor predicts poor prognosis and promotes tumor growth in human glioblastoma

High expression of N-myc (and STAT) interactor predicts poor prognosis and promotes tumor growth in human glioblastoma

https://doi.org/10.18632/oncotarget.3208

Delong Meng, Yuanyuan Chen, Dapeng Yun, Yingjie Zhao, Jingkun Wang, Tao Xu, Xiaoying Li, Yuqi Wang, Li Yuan, Ruochuan Sun, Xiao Song, Cong Huai, Lingna Hu, Song Yang, Taishan Min, Juxiang Chen, Hongyan Chen,  and Daru Lu
4901-4919
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-27a and miR-27a* contribute to metastatic properties of osteosarcoma cells

miR-27a and miR-27a* contribute to metastatic properties of osteosarcoma cells

https://doi.org/10.18632/oncotarget.3025

Zaidoun Salah, Rand Arafeh, Vadim Maximov, Marco Galasso, Saleh Khawaled, Samah Abou-Sharieha, Stefano Volinia, Kevin B. Jones, Carlo M. Croce,  and Rami I. Aqeilan
4920-4935
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Galectin-3 augments tumor initiating property and tumorigenicity of lung cancer through interaction with β-catenin

Galectin-3 augments tumor initiating property and tumorigenicity of lung cancer through interaction with β-catenin

https://doi.org/10.18632/oncotarget.3210

Ling-Yen Chung, Shye-Jye Tang, Yi-Ching Wu, Guang-Huan Sun, Huan-Yun Liu,  and Kuang-Hui Sun
4936-4952
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites

Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites

https://doi.org/10.18632/oncotarget.3211

Krishna C. Vallabhaneni, Patrice Penfornis, Santosh Dhule, Francois Guillonneau, Kristen V. Adams, Yin Yuan Mo, Rui Xu, Yiming Liu, Kounosuke Watabe, Mohan C. Vemuri,  and Radhika Pochampally
4953-4967
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Comprehensive analysis of targetable oncogenic mutations in chinese cervical cancers

Comprehensive analysis of targetable oncogenic mutations in chinese cervical cancers

https://doi.org/10.18632/oncotarget.3212

Libing Xiang, Jiajia Li, Wei Jiang, Xuxia Shen, Wentao Yang, Xiaohua Wu,  and Huijuan Yang
4968-4975
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo

Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo

https://doi.org/10.18632/oncotarget.3213

Han-Li Huang, Chieh-Yu Peng, Mei-Jung Lai, Chun-Han Chen, Hsueh-Yun Lee, Jing-Chi Wang, Jing-Ping Liou, Shiow-Lin Pan,  and Che-Ming Teng
4976-4991
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine

The heparan sulfate mimetic PG545 interferes with Wnt/β-catenin signaling and significantly suppresses pancreatic tumorigenesis alone and in combination with gemcitabine

https://doi.org/10.18632/oncotarget.3214

Deok-Beom Jung, Miyong Yun, Eun-Ok Kim, Jaekwang Kim, Bonglee Kim, Ji Hoon Jung, Enfeng Wang, Debabrata Mukhopadhyay, Edward Hammond, Keith Dredge, Viji Shridhar,  and Sung-Hoon Kim
4992-5004
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activating enhancer-binding protein-2α induces cyclooxygenase-2 expression and promotes nasopharyngeal carcinoma growth

Activating enhancer-binding protein-2α induces cyclooxygenase-2 expression and promotes nasopharyngeal carcinoma growth

https://doi.org/10.18632/oncotarget.3215

Dingbo Shi, Xiangsheng Xiao, Yun Tian, Lijun Qin, Fangyun Xie, Rui Sun, Jingshu Wang, Wenbin Li, Tianze Liu, Yao Xiao, Wendan Yu, Wei Guo, Yuqing Xiong, Huijuan Qiu, Tiebang Kang, Wenlin Huang, Chong Zhao,  and Wuguo Deng
5005-5021
Abstract  |  PDF  |  HTML  |  Order a Reprint

CXCR4 over-expression and survival in cancer: A system review and meta-analysis

CXCR4 over-expression and survival in cancer: A system review and meta-analysis

https://doi.org/10.18632/oncotarget.3217

Hongli Zhao, Liyuan Guo, Hong Zhao, Jiaxin Zhao, Hao Weng,  and Bin Zhao
5022-5040
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies

Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies

https://doi.org/10.18632/oncotarget.3238

Lorenzo Tortolina, David J. Duffy, Massimo Maffei, Nicoletta Castagnino, Aimée M. Carmody, Walter Kolch, Boris N. Kholodenko, Cristina De Ambrosi, Annalisa Barla, Elia M. Biganzoli, Alessio Nencioni, Franco Patrone, Alberto Ballestrero, Gabriele Zoppoli, Alessandro Verri,  and Silvio Parodi
5041-5058
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Novel HDAC inhibitors exhibit pre-clinical efficacy in lymphoma models and point to the importance of CDKN1A expression levels in mediating their anti-tumor response

Novel HDAC inhibitors exhibit pre-clinical efficacy in lymphoma models and point to the importance of CDKN1A expression levels in mediating their anti-tumor response

https://doi.org/10.18632/oncotarget.3239

Afua Adjeiwaa Mensah, Ivo Kwee, Eugenio Gaudio, Andrea Rinaldi, Maurilio Ponzoni, Luciano Cascione, Gianluca Fossati, Anastasios Stathis, Emanuele Zucca, Gianluca Caprini,  and Francesco Bertoni
5059-5071
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop

Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop

https://doi.org/10.18632/oncotarget.3241

Zhengyan Yang, Liang Guo, Dan Liu, Limin Sun, Hongyu Chen, Que Deng, Yanjun Liu, Ming Yu, Yuanfang Ma, Ning Guo,  and Ming Shi
5072-5087
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Fluoxetine, an antidepressant, suppresses glioblastoma by evoking AMPAR-mediated calcium-dependent apoptosis

Fluoxetine, an antidepressant, suppresses glioblastoma by evoking AMPAR-mediated calcium-dependent apoptosis

https://doi.org/10.18632/oncotarget.3243

Kao-Hui Liu, Shun-Tai Yang, Yen-Kuang Lin, Jia-Wei Lin, Yi-Hsuan Lee, Jia-Yi Wang, Chaur-Jong Hu, En-Yuan Lin, Shu-Mei Chen, Chee-Kin Then,  and Shing-Chuan Shen
5088-5101
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1

Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1

https://doi.org/10.18632/oncotarget.3244

Kazuyuki Matsushita, Kouichi Kitamura, Bahityar Rahmutulla, Nobuko Tanaka, Takayuki Ishige, Mamoru Satoh, Tyuji Hoshino, Satoru Miyagi, Takeshi Mori, Sakae Itoga, Hideaki Shimada, Takeshi Tomonaga, Minoru Kito, Yaeko Nakajima-Takagi, Shuji Kubo, Chiaki Nakaseko, Masahiko Hatano, Takashi Miki, Masafumi Matsuo, Masaki Fukuyo, Atsushi Kaneda, Atsushi Iwama,  and Fumio Nomura
5102-5117
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A melanoma subtype with intrinsic resistance to BRAF inhibition identified by receptor tyrosine kinases gene-driven classification

A melanoma subtype with intrinsic resistance to BRAF inhibition identified by receptor tyrosine kinases gene-driven classification

https://doi.org/10.18632/oncotarget.3007

Matteo Dugo, Gabriella Nicolini, Gabrina Tragni, Ilaria Bersani, Antonella Tomassetti, Valentina Colonna, Michele Del Vecchio, Filippo De Braud, Silvana Canevari, Andrea Anichini,  and Marialuisa Sensi
5118-5133
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors

Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors

https://doi.org/10.18632/oncotarget.3016

Xiao-jun Qian, Yun-tian Li, Yan Yu, Fen Yang, Rong Deng, Ji Ji, Lin Jiao, Xuan Li, Rui-Yan Wu, Wen-Dan Chen, Gong-Kan Feng,  and Xiao-Feng Zhu
5134-5146
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers

Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers

https://doi.org/10.18632/oncotarget.2881

Feng Li, Muthu K. Shanmugam, Kodappully Sivaraman Siveen, Fan Wang, Tina H. Ong, Ser Yue Loo, Mahadeva M.M. Swamy, Somnath Mandal, Alan Prem Kumar, Boon Cher Goh, Tapas Kundu, Kwang Seok Ahn, Ling Zhi Wang, Kam Man Hui,  and Gautam Sethi
5147-5163
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer

https://doi.org/10.18632/oncotarget.3286

Parthasarathy Seshacharyulu, Moorthy P. Ponnusamy, Satyanarayana Rachagani, Imayavaramban Lakshmanan, Dhanya Haridas, Ying Yan, Apar K. Ganti,  and Surinder K. Batra
5164-5181
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Activation of RAS family members confers resistance to ROS1 targeting drugs

Activation of RAS family members confers resistance to ROS1 targeting drugs

https://doi.org/10.18632/oncotarget.3311

Marilisa Cargnelutti, Simona Corso, Margherita Pergolizzi, Laurence Mévellec, Dara L. Aisner, Rafal Dziadziuszko, Marileila Varella-Garcia, Paolo M. Comoglio, Robert C. Doebele, Jorge Vialard,  and Silvia Giordano
5182-5194
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A novel cancer immunotherapy based on the combination of a synthetic carbohydrate-pulsed dendritic cell vaccine and glycoengineered cancer cells

A novel cancer immunotherapy based on the combination of a synthetic carbohydrate-pulsed dendritic cell vaccine and glycoengineered cancer cells

https://doi.org/10.18632/oncotarget.2908

Lei Qiu, Jie Li, Shichong Yu, Qianli Wang, Yinghua Li, Zhenlin Hu, Qiuye Wu, Zhongwu Guo,  and Junping Zhang
5195-5203
Abstract  |  PDF  |  HTML  |  Order a Reprint

MYCN-targeting miRNAs are predominantly downregulated during MYCN‑driven neuroblastoma tumor formation

MYCN-targeting miRNAs are predominantly downregulated during MYCN‑driven neuroblastoma tumor formation

https://doi.org/10.18632/oncotarget.2477

Anneleen Beckers, Gert Van Peer, Daniel R. Carter, Evelien Mets, Kristina Althoff, Belamy B. Cheung, Johannes H. Schulte, Pieter Mestdagh, Jo Vandesompele, Glenn M. Marshall, Katleen De Preter,  and Frank Speleman
5204-5216
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Specific and redundant activities of ETV1 and ETV4 in prostate cancer aggressiveness revealed by co-overexpression cellular contexts

Specific and redundant activities of ETV1 and ETV4 in prostate cancer aggressiveness revealed by co-overexpression cellular contexts

https://doi.org/10.18632/oncotarget.2847

Diana Mesquita, João D. Barros-Silva, Joana Santos, Rolf I. Skotheim, Ragnhild A. Lothe, Paula Paulo,  and Manuel R. Teixeira
5217-5236
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Allyl isothiocyanate induces replication-associated DNA damage response in NSCLC cells and sensitizes to ionizing radiation

Allyl isothiocyanate induces replication-associated DNA damage response in NSCLC cells and sensitizes to ionizing radiation

https://doi.org/10.18632/oncotarget.3026

Kaushlendra Tripathi, Usama K Hussein, Roja Anupalli, Reagan Barnett, Lavanya Bachaboina, Jennifer Scalici, Rodney P Rocconi, Laurie B Owen, Gary A Piazza,  and Komaraiah Palle
5237-5252
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Cancerous inhibitor of protein phosphatase 2A contributes to human papillomavirus oncoprotein E7-induced cell proliferation via E2F1

Cancerous inhibitor of protein phosphatase 2A contributes to human papillomavirus oncoprotein E7-induced cell proliferation via E2F1

https://doi.org/10.18632/oncotarget.2867

Weifang Zhang, Hanxiang Chen, Yan Chen, Juan Liu, Xiao Wang, Xiuping Yu, Jason J. Chen,  and Weiming Zhao
5253-5262
Abstract  |  PDF  |  HTML  |  Order a Reprint

Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90

Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90

https://doi.org/10.18632/oncotarget.3029

Xiaoping Song, Zhimin Zhao, Xin Qi, Shuai Tang, Qiang Wang, Tianjiao Zhu, Qianqun Gu, Ming Liu,  and Jing Li
5263-5274
Abstract  |  PDF  |  HTML  |  Order a Reprint

Phospho-TCTP as a therapeutic target of Dihydroartemisinin for aggressive breast cancer cells

Phospho-TCTP as a therapeutic target of Dihydroartemisinin for aggressive breast cancer cells

https://doi.org/10.18632/oncotarget.2971

Maria Lucibello, Sara Adanti, Ester Antelmi, Dario Dezi, Stefania Ciafrè, Maria Luisa Carcangiu, Manuela Zonfrillo, Giuseppe Nicotera, Lorenzo Sica, Filippo De Braud,  and Pasquale Pierimarchi
5275-5291
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Traditional Chinese medicine herbal mixture LQ arrests FUCCI-expressing HeLa cells in G0/G1 phase in 2D plastic, 2.5D Matrigel®, and 3D Gelfoam® culture visualized with FUCCI imaging

Traditional Chinese medicine herbal mixture LQ arrests FUCCI-expressing HeLa cells in G0/G1 phase in 2D plastic, 2.5D Matrigel®, and 3D Gelfoam® culture visualized with FUCCI imaging

https://doi.org/10.18632/oncotarget.2983

Lei Zhang, Chengyu Wu, Shuya Yano,  and Robert M. Hoffman
5292-5298
Abstract  |  PDF  |  HTML  |  Order a Reprint

High expression of inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) as a novel biomarker for worse prognosis in cytogenetically normal acute myeloid leukemia

High expression of inositol 1,4,5-trisphosphate receptor, type 2 (ITPR2) as a novel biomarker for worse prognosis in cytogenetically normal acute myeloid leukemia

https://doi.org/10.18632/oncotarget.3024

Jin-long Shi, Lin Fu,  and Wei-dong Wang
5299-5309
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migration

PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migration

https://doi.org/10.18632/oncotarget.2776

Gennaro Chiappetta, Teresa Valentino, Michela Vitiello, Rosa Pasquinelli, Mario Monaco, Giuseppe Palma, Romina Sepe, Antonio Luciano, Pierlorenzo Pallante, Dario Palmieri, Concetta Aiello, Domenica Rea, Simona Nunzia Losito, Claudio Arra, Alfredo Fusco,  and Monica Fedele
5310-5323
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Proteomic analysis of zoledronic-acid resistant prostate cancer cells unveils novel pathways characterizing an invasive phenotype

Proteomic analysis of zoledronic-acid resistant prostate cancer cells unveils novel pathways characterizing an invasive phenotype

https://doi.org/10.18632/oncotarget.2694

Milone Maria Rita, Pucci Biagio, Bifulco Katia, Iannelli Federica, Lombardi Rita, Chiara Ciardiello, Bruzzese Francesca, Carriero Maria Vincenza,  and Budillon Alfredo
5324-5341
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Induction of cellular prion protein (PrPc) under hypoxia inhibits apoptosis caused by TRAIL treatment

Induction of cellular prion protein (PrPc) under hypoxia inhibits apoptosis caused by TRAIL treatment

https://doi.org/10.18632/oncotarget.3028

Jin-Young Park, Jae-Kyo Jeong, Ju-Hee Lee, Ji-Hong Moon, Sung-Wook Kim, You-Jin Lee,  and Sang-Youel Park
5342-5353
Abstract  |  PDF  |  HTML  |  Order a Reprint

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells

https://doi.org/10.18632/oncotarget.3022

Sebastian Drube, Franziska Weber, Romy Loschinski, Mandy Beyer, Mandy Rothe, Anja Rabenhorst, Christiane Göpfert, Isabel Meininger, Michaela A. Diamanti, David Stegner, Norman Häfner, Martin Böttcher, Kirstin Reinecke, Thomas Herdegen, Florian R. Greten, Bernhard Nieswandt, Karin Hartmann, Oliver H. Krämer,  and Thomas Kamradt
5354-5368
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene

Global analysis of H3K4me3 and H3K27me3 profiles in glioblastoma stem cells and identification of SLC17A7 as a bivalent tumor suppressor gene

https://doi.org/10.18632/oncotarget.3030

Biaoyang Lin, Hwahyung Lee, Jae-Geun Yoon, Anup Madan, Elizabeth Wayner, Sanja Tonning, Parvinder Hothi, Brett Schroeder, Ilya Ulasov, Gregory Foltz, Leroy Hood,  and Charles Cobbs
5369-5381
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A new chemical inhibitor of angiogenesis and tumorigenesis that targets the VEGF signaling pathway upstream of Ras

A new chemical inhibitor of angiogenesis and tumorigenesis that targets the VEGF signaling pathway upstream of Ras

https://doi.org/10.18632/oncotarget.2979

Agnès Desroches-Castan, Delphine Quélard, Martine Demeunynck, Jean-François Constant, Chongling Dong, Michelle Keramidas, Jean-Luc Coll, Caroline Barette, Laurence Lafanechère,  and Jean-Jacques Feige
5382-5411
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Up-regulation of matrix metalloproteinases in a mouse model of chemically induced colitis-associated cancer: the role of microRNAs

Up-regulation of matrix metalloproteinases in a mouse model of chemically induced colitis-associated cancer: the role of microRNAs

https://doi.org/10.18632/oncotarget.3027

Feiyan Ai, Xuemei Zhang, Xiayu Li, Zailong Qin, Qiurong Ye, Li Tian, Anliu Tang, Nan Li, Guiyuan Li, Jian Ma,  and Shourong Shen
5412-5425
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Frequencies of SF3B1, NOTCH1, MYD88, BIRC3 and IGHV mutations and TP53 disruptions in Chinese with chronic lymphocytic leukemia: disparities with Europeans

Frequencies of SF3B1, NOTCH1, MYD88, BIRC3 and IGHV mutations and TP53 disruptions in Chinese with chronic lymphocytic leukemia: disparities with Europeans

https://doi.org/10.18632/oncotarget.3101

Yi Xia, Lei Fan, Li Wang, Robert Peter Gale, Man Wang, Tian Tian, Wei Wu, Liang Yu, Yao-Yu Chen, Wei Xu,  and Jian-Yong Li
5426-5434
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A three-protein signature and clinical outcome in esophageal squamous cell carcinoma

A three-protein signature and clinical outcome in esophageal squamous cell carcinoma

https://doi.org/10.18632/oncotarget.3102

Hui-Hui Cao, Shi-Yi Zhang, Jin-Hui Shen, Zhi-Yong Wu, Jian-Yi Wu, Shao-Hong Wang, En-Min Li,  and Li-Yan Xu
5435-5448
Abstract  |  PDF  |  HTML  |  Order a Reprint

Prognostic and predictive value of PDL1 expression in breast cancer

Prognostic and predictive value of PDL1 expression in breast cancer

https://doi.org/10.18632/oncotarget.3216

Renaud Sabatier, Pascal Finetti, Emilie Mamessier, José Adelaide, Max Chaffanet, Hamid Raza Ali, Patrice Viens, Carlos Caldas, Daniel Birnbaum,  and François Bertucci
5449-5464
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lung cancer in never-smoker Asian females is driven by oncogenic mutations, most often involving EGFR

Lung cancer in never-smoker Asian females is driven by oncogenic mutations, most often involving EGFR

https://doi.org/10.18632/oncotarget.2925

Sang Yun Ha, So-Jung Choi, Jong Ho Cho, Hye Joo Choi, Jinseon Lee, Kyungsoo Jung, Darry Irwin, Xiao Liu, Maruja E. Lira, Mao Mao, Hong Kwan Kim, Yong Soo Choi, Young Mog Shim, Woong Yang Park, Yoon-La Choi,  and Jhingook Kim
5465-5474
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


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