Oncotarget

Vol 6, No 5

February 20, 2015

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About The Cover

Effects of MET aberrations on MCF-10A xenograft in hHGF transgenic mice. H&E for histological images from representative tumor from MET-WT: see Liu et al.

Table of Contents

Editorial

Hyperactivated endolysosomal trafficking in melanoma

Hyperactivated endolysosomal trafficking in melanoma

https://doi.org/10.18632/oncotarget.3141

Direna Alonso-Curbelo,  and Maria S. Soengas
2583-2584
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About-face on the metabolic side effects of rapamycin

About-face on the metabolic side effects of rapamycin

https://doi.org/10.18632/oncotarget.3354

Adam B. Salmon
2585-2586
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Antibiotics for cancer therapy

Antibiotics for cancer therapy

https://doi.org/10.18632/oncotarget.3388

Richard G. Pestell,  and Albert A. Rizvanov
2587-2588
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Reviews

Cancer associated fibroblasts in hematological malignancies

Cancer associated fibroblasts in hematological malignancies

https://doi.org/10.18632/oncotarget.2661

Lizzia Raffaghello, Angelo Vacca, Vito Pistoia,  and Domenico Ribatti
2589-2603
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Priority Research Papers

Functional consequence of the MET-T1010I polymorphism in breast cancer

Functional consequence of the MET-T1010I polymorphism in breast cancer

https://doi.org/10.18632/oncotarget.3094

Shuying Liu, Funda Meric-Bernstam, Napa Parinyanitikul, Bailiang Wang, Agda K. Eterovic, Xiaofeng Zheng, Mihai Gagea, Mariana Chavez-MacGregor, Naoto T. Ueno, Xiudong Lei, Wanding Zhou, Lakshmy Nair, Debu Tripathy, Powel H. Brown, Gabriel N. Hortobagyi, Ken Chen, John Mendelsohn, Gordon B. Mills,  and Ana M. Gonzalez-Angulo
2604-2614
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Tumor-targeting Salmonella typhimurium A1-R arrests growth of breast-cancer brain metastasis

Tumor-targeting Salmonella typhimurium A1-R arrests growth of breast-cancer brain metastasis

https://doi.org/10.18632/oncotarget.2811

Yong Zhang, Shinji Miwa, Nan Zhang, Robert M. Hoffman,  and Ming Zhao
2615-2622
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Identification of a new class of natural product MDM2 inhibitor: In vitro and in vivo anti-breast cancer activities and target validation

Identification of a new class of natural product MDM2 inhibitor: In vitro and in vivo anti-breast cancer activities and target validation

https://doi.org/10.18632/oncotarget.3098

Jiang-Jiang Qin, Wei Wang, Sukesh Voruganti, Hui Wang, Wei-Dong Zhang,  and Ruiwen Zhang
2623-2640
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Research Papers: Gerotarget (Focus on Aging)

Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells

Age and metabolic risk factors associated with oxidatively damaged DNA in human peripheral blood mononuclear cells

https://doi.org/10.18632/oncotarget.3202

Mille Løhr, Annie Jensen, Louise Eriksen, Morten Grønbæk, Steffen Loft,  and Peter Møller
2641-2653
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Research Papers

ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer

ERp57 modulates STAT3 activity in radioresistant laryngeal cancer cells and serves as a prognostic marker for laryngeal cancer

https://doi.org/10.18632/oncotarget.3042

Min Ho Choe, Joong Won Min, Hong Bae Jeon, Dong-Hyung Cho, Jeong Su Oh, Hyun Gyu Lee, Sang-Gu Hwang, Sungkwan An, Young-Hoon Han,  and Jae-Sung Kim
2654-2666
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Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia

Up-regulation of CDK9 kinase activity and Mcl-1 stability contributes to the acquired resistance to cyclin-dependent kinase inhibitors in leukemia

https://doi.org/10.18632/oncotarget.2096

Yuh-Ying Yeh, Rong Chen, Joshua Hessler, Emilia Mahoney, Amy M. Lehman, Nyla A. Heerema, Michael R. Grever, William Plunkett, John C. Byrd,  and Amy J. Johnson
2667-2679
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CBX7 and HMGA1b proteins act in opposite way on the regulation of the SPP1 gene expression

CBX7 and HMGA1b proteins act in opposite way on the regulation of the SPP1 gene expression

https://doi.org/10.18632/oncotarget.2777

Romina Sepe, Umberto Formisano, Antonella Federico, Floriana Forzati, André Uchimura Bastos, Daniela D’ Angelo, Nunzio Antonio Cacciola, Alfredo Fusco,  and Pierlorenzo Pallante
2680-2692
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The translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against EBV-driven lymphoproliferative disease

The translation inhibitor silvestrol exhibits direct anti-tumor activity while preserving innate and adaptive immunity against EBV-driven lymphoproliferative disease

https://doi.org/10.18632/oncotarget.2098

John T. Patton, Mark E. Lustberg, Gerard Lozanski, Sabrina L. Garman, William H. Towns, Callie M. Drohan, Amy Lehman, Xiaoli Zhang, Brad Bolon, Li Pan, A. Douglas Kinghorn, Michael R. Grever, David M. Lucas,  and Robert A. Baiocchi
2693-2708
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A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma

A microRNA-1280/JAG2 network comprises a novel biological target in high-risk medulloblastoma

https://doi.org/10.18632/oncotarget.2779

Fengfei Wang, Marc Remke, Kruttika Bhat, Eric T. Wong, Shuang Zhou, Vijay Ramaswamy, Adrian Dubuc, Ekokobe Fonkem, Saeed Salem, Hongbing Zhang, Tze-chen Hsieh, Stephen T. O'Rourke, Lizi Wu, David W. Li, Cynthia Hawkins, Isaac S. Kohane, Joseph M. Wu, Min Wu, Michael D. Taylor,  and Erxi Wu
2709-2724
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The non glycanated endocan polypeptide slows tumor growth by inducing stromal inflammatory reaction

The non glycanated endocan polypeptide slows tumor growth by inducing stromal inflammatory reaction

https://doi.org/10.18632/oncotarget.2614

Hanane Yassine, Nathalie De Freitas Caires, Florence Depontieu, Arnaud Scherpereel, Ali Awad, Anne Tsicopoulos, Christophe Leboeuf, Anne Janin, Catherine Duez, Bogdan Grigoriu,  and Philippe Lassalle
2725-2735
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Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas

Upregulation of miR-328 and inhibition of CREB-DNA-binding activity are critical for resveratrol-mediated suppression of matrix metalloproteinase-2 and subsequent metastatic ability in human osteosarcomas

https://doi.org/10.18632/oncotarget.3088

Shun-Fa Yang, Wei-Jiunn Lee, Peng Tan, Chih-Hsin Tang, Michael Hsiao, Feng-Koo Hsieh,  and Ming-Hsien Chien
2736-2753
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Mutational spectrum of adult T-ALL

Mutational spectrum of adult T-ALL

https://doi.org/10.18632/oncotarget.2218

Martin Neumann, Sebastian Vosberg, Cornelia Schlee, Sandra Heesch, Stefan Schwartz, Nicola Gökbuget, Dieter Hoelzer, Alexander Graf, Stefan Krebs, Isabelle Bartram, Helmut Blum, Monika Brüggemann, Jochen Hecht, Stefan K. Bohlander, Philipp A. Greif,  and Claudia D. Baldus
2754-2766
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Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype

Reduction of miR-29c enhances pancreatic cancer cell migration and stem cell-like phenotype

https://doi.org/10.18632/oncotarget.3089

Jianxin Jiang, Chao Yu, Meiyuan Chen, Hao Zhang, Se Tian,  and Chengyi Sun
2767-2778
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Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells

Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells

https://doi.org/10.18632/oncotarget.2995

Rossella Loria, Giulia Bon, Valentina Perotti, Enzo Gallo, Ilaria Bersani, Paola Baldassari, Manuela Porru, Carlo Leonetti, Selene Di Carlo, Paolo Visca, Maria Felice Brizzi, Andrea Anichini, Roberta Mortarini,  and Rita Falcioni
2779-2793
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Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation

Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells - high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation

https://doi.org/10.18632/oncotarget.3056

Øystein Bruserud, Håkon Reikvam, Hanne Fredly, Jørn Skavland, Karen-Marie Hagen, Tuyen Thy van Hoang, Annette K. Brenner, Amir Kadi, Audrey Astori, Bjørn Tore Gjertsen,  and Frederic Pendino
2794-2811
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Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets

Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets

https://doi.org/10.18632/oncotarget.2802

Leonardo Mirandola, Jose A. Figueroa, Tam T. Phan, Fabio Grizzi, Minji Kim, Rakhshanda Layeequr Rahman, Marjorie R. Jenkins, Everardo Cobos, Cynthia Jumper, Raed Alalawi,  and Maurizio Chiriva-Internati
2812-2826
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Folate-mediated mitochondrial targeting with doxorubicin-polyrotaxane nanoparticles overcomes multidrug resistance

Folate-mediated mitochondrial targeting with doxorubicin-polyrotaxane nanoparticles overcomes multidrug resistance

https://doi.org/10.18632/oncotarget.3090

He Wang, Henghui Yin, Fengjiao Yan, Mingna Sun, Lingran Du, Wei Peng, Qiuli Li, Yinghong Feng,  and Yi Zhou
2827-2842
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MicroRNA 196B regulates FAS-mediated apoptosis in colorectal cancer cells

MicroRNA 196B regulates FAS-mediated apoptosis in colorectal cancer cells

https://doi.org/10.18632/oncotarget.3066

Ji-Su Mo, Khondoker Jahengir Alam, In-Hong Kang, Won Cheol Park, Geom-Seog Seo, Suck-Chei Choi, Hun-Soo Kim, Hyung-Bae Moon, Ki-Jung Yun,  and Soo-Cheon Chae
2843-2855
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Chronic inflammation-related DNA damage response: a driving force of gastric cardia carcinogenesis

Chronic inflammation-related DNA damage response: a driving force of gastric cardia carcinogenesis

https://doi.org/10.18632/oncotarget.3091

Runhua Lin, Dejun Xiao, Yi Guo, Dongping Tian, Hailong Yun, Donglin Chen,  and Min Su
2856-2864
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NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect

NCL1, a highly selective lysine-specific demethylase 1 inhibitor, suppresses prostate cancer without adverse effect

https://doi.org/10.18632/oncotarget.3067

Toshiki Etani, Takayoshi Suzuki, Taku Naiki, Aya Naiki-Ito, Ryosuke Ando, Keitaro Iida, Noriyasu Kawai, Keiichi Tozawa, Naoki Miyata, Kenjiro Kohri,  and Satoru Takahashi
2865-2878
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12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models

12/15 lipoxygenase regulation of colorectal tumorigenesis is determined by the relative tumor levels of its metabolite 12-HETE and 13-HODE in animal models

https://doi.org/10.18632/oncotarget.2994

Jian Chang, Li Jiang, Yinqiu Wang, Bing Yao, Shilin Yang, Bixiang Zhang,  and Ming-Zhi Zhang
2879-2888
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Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation

Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation

https://doi.org/10.18632/oncotarget.3068

Jonathan Vosper, Alessia Masuccio, Michael Kullmann, Christian Ploner, Stephan Geley,  and Ludger Hengst
2889-2902
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Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma

Clusterin facilitates metastasis by EIF3I/Akt/MMP13 signaling in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.3093

Cun Wang, Guangzhi Jin, Haojie Jin, Ning Wang, Qin Luo, Yurong Zhang, Dongmei Gao, Kai Jiang, Dishui Gu, Qiujing Shen, Xisong Huo, Fangyuan Hu, Tianxiang Ge, Fangyu Zhao, Wei Chu, Huiqun Shu, Ming Yao, Wenming Cong,  and Wenxin Qin
2903-2916
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Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation

Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation

https://doi.org/10.18632/oncotarget.2784

Jie Zhang, Pengxing He, Yong Xi, Meiyu Geng, Yi Chen,  and Jian Ding
2917-2927
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Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth

Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth

https://doi.org/10.18632/oncotarget.2758

Anthony M. Barsotti, Michael Ryskin, Wenyan Zhong, Wei-Guo Zhang, Andreas Giannakou, Christine Loreth, Veronica Diesl, Maximillian Follettie, Jonathan Golas, Michelle Lee, Timothy Nichols, Conglin Fan, Gang Li, Stephen Dann, Valeria R. Fantin, Kim Arndt, Dominique Verhelle,  and Robert A. Rollins
2928-2938
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Cathelicidin, an antimicrobial peptide produced by macrophages, promotes colon cancer by activating the Wnt/β-catenin pathway

Cathelicidin, an antimicrobial peptide produced by macrophages, promotes colon cancer by activating the Wnt/β-catenin pathway

https://doi.org/10.18632/oncotarget.2845

Dong Li, Wenfan Liu, Xuan Wang, Junlu Wu, Wenqiang Quan, Yiwen Yao, Robert Bals, Shurong Ji, Kaiyin Wu, Jia Guo,  and Haiying Wan
2939-2950
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Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression

Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression

https://doi.org/10.18632/oncotarget.3095

Shiyi Yu, Xiuxiu Cai, Chenxi Wu, Lele Wu, Yuzhi Wang, Yan Liu, Zhenghong Yu, Sheng Qin, Fei Ma, Jean Paul Thiery,  and Liming Chen
2951-2965
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy

miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy

https://doi.org/10.18632/oncotarget.3070

Animesh Bhattacharya, Ulf Schmitz, Yvonne Raatz, Madeleine Schönherr, Tina Kottek, Marianne Schauer, Sandra Franz, Anja Saalbach, Ulf Anderegg, Olaf Wolkenhauer, Dirk Schadendorf, Jan C. Simon, Thomas Magin, Julio Vera,  and Manfred Kunz
2966-2980
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Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration

Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration

https://doi.org/10.18632/oncotarget.3205

Timothy J. Zumwalt, Mildred Arnold, Ajay Goel,  and C. Richard Boland
2981-2991
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Transcriptional regulation of Sox2 by the retinoblastoma family of pocket proteins

Transcriptional regulation of Sox2 by the retinoblastoma family of pocket proteins

https://doi.org/10.18632/oncotarget.2996

Jéssica M. Vilas, Alba Ferreirós, Carmen Carneiro, Lluis Morey, Sabela Da Silva-Álvarez, Tânia Fernandes, María Abad, Luciano Di Croce, Tomás García-Caballero, Manuel Serrano, Carmen Rivas, Anxo Vidal,  and Manuel Collado
2992-3002
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TXNIP interaction with the Her-1/2 pathway contributes to overall survival in breast cancer

TXNIP interaction with the Her-1/2 pathway contributes to overall survival in breast cancer

https://doi.org/10.18632/oncotarget.3096

Weiwei Nie, Weisun Huang, Wenwen Zhang, Jing Xu, Wei Song, Yanru Wang, Aiyu Zhu, Jiayan Luo, Guichun Huang, Yucai Wang,  and Xiaoxiang Guan
3003-3012
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Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression

Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression

https://doi.org/10.18632/oncotarget.3072

R. Mitchell Baldwin, Nasim Haghandish, Manijeh Daneshmand, Shahrier Amin, Geneviève Paris, Theresa J. Falls, John C. Bell, Shahidul Islam,  and Jocelyn Côté
3013-3032
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Cyclin alterations in diverse cancers: Outcome and co-amplification network

Cyclin alterations in diverse cancers: Outcome and co-amplification network

https://doi.org/10.18632/oncotarget.2848

Maria Schwaederle, Gregory A. Daniels, David E. Piccioni, Paul T. Fanta, Richard B. Schwab, Kelly A. Shimabukuro, Barbara A. Parker,  and Razelle Kurzrock
3033-3042
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Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle

Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle

https://doi.org/10.18632/oncotarget.2812

Francesca Pretto, Carmen Ghilardi, Michele Moschetta, Andrea Bassi, Alessandra Rovida, Valentina Scarlato, Laura Talamini, Fabio Fiordaliso, Cinzia Bisighini, Giovanna Damia, Maria Rosa Bani, Rosanna Piccirillo,  and Raffaella Giavazzi
3043-3054
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Lovastatin enhances adenovirus-mediated TRAIL induced apoptosis by depleting cholesterol of lipid rafts and affecting CAR and death receptor expression of prostate cancer cells

Lovastatin enhances adenovirus-mediated TRAIL induced apoptosis by depleting cholesterol of lipid rafts and affecting CAR and death receptor expression of prostate cancer cells

https://doi.org/10.18632/oncotarget.3073

Youhong Liu, Lin Chen, Zhicheng Gong, Liangfang Shen, Chinghai Kao, Janet M. Hock, Lunquan Sun,  and Xiong Li
3055-3070
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Long-term treatment with imatinib results in profound mast cell deficiency in Ph+ chronic myeloid leukemia

Long-term treatment with imatinib results in profound mast cell deficiency in Ph+ chronic myeloid leukemia

https://doi.org/10.18632/oncotarget.3074

Sabine Cerny-Reiterer, Anja Rabenhorst, Gabriele Stefanzl, Susanne Herndlhofer, Gregor Hoermann, Leonhard Müllauer, Sigrid Baumgartner, Christine Beham-Schmid, Wolfgang R. Sperr, Christine Mannhalter, Heinz Sill, Werner Linkesch, Michel Arock, Karin Hartmann,  and Peter Valent
3071-3084
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Paracrine SDF-1α signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells

Paracrine SDF-1α signaling mediates the effects of PSCs on GEM chemoresistance through an IL-6 autocrine loop in pancreatic cancer cells

https://doi.org/10.18632/oncotarget.3099

Hui Zhang, Huanwen Wu, Jian Guan, Li Wang, Xinyu Ren, Xiaohua Shi, Zhiyong Liang,  and Tonghua Liu
3085-3097
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Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma

Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma

https://doi.org/10.18632/oncotarget.3075

Mohamed A.Y. Abdel Malek, Sajjeev Jagannathan, Ehsan Malek, Douaa M. Sayed, Sahar A. Elgammal, Hanan G. Abd El-Azeem, Nabila M. Thabet,  and James J. Driscoll
3098-3110
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Galectin-1 is overexpressed in CD133+ human lung adenocarcinoma cells and promotes their growth and invasiveness

Galectin-1 is overexpressed in CD133+ human lung adenocarcinoma cells and promotes their growth and invasiveness

https://doi.org/10.18632/oncotarget.3076

Xuefeng Zhou, Dan Li, Xianguo Wang, Bo Zhang, Hua Zhu,  and Jinping Zhao
3111-3122
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Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/β-catenin pathway

Slit2/Robo1 signaling promotes intestinal tumorigenesis through Src-mediated activation of the Wnt/β-catenin pathway

https://doi.org/10.18632/oncotarget.3060

Qian-Qian Zhang, Da-lei Zhou, Yan Lei, Li Zheng, Sheng-Xia Chen, Hong-Ju Gou, Qu-Liang Gu, Xiao-Dong He, Tian Lan, Cui-Ling Qi, Jiang-Chao Li, Yan-Qing Ding, Liang Qiao,  and Li-Jing Wang
3123-3135
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Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer

Top2a identifies and provides epigenetic rationale for novel combination therapeutic strategies for aggressive prostate cancer

https://doi.org/10.18632/oncotarget.3077

Jason S. Kirk, Kevin Schaarschuch, Zafardjan Dalimov, Elena Lasorsa, ShengYu Ku, Swathi Ramakrishnan, Qiang Hu, Gissou Azabdaftari, Jianmin Wang, Roberto Pili,  and Leigh Ellis
3136-3146
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors

Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors

https://doi.org/10.18632/oncotarget.3061

Zeyou Wang, Jing Yang, Gang Xu, Wei Wang, Changhong Liu, Honghui Yang, Zhibin Yu, Qianqian Lei, Lan Xiao, Jing Xiong, Liang Zeng, Juanjuan Xiang, Jian Ma, Guiyuan Li,  and Minghua Wu
3147-3164
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target

Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target

https://doi.org/10.18632/oncotarget.3078

Melanie F. Weingart, Jacquelyn J. Roth, Marianne Hutt-Cabezas, Tracy M. Busse, Harpreet Kaur, Antoinette Price, Rachael Maynard, Jeffrey Rubens, Isabella Taylor, Xing-gang Mao, Jingying Xu, Yasumichi Kuwahara, Sariah J. Allen, Anat Erdreich-Epstein, Bernard E. Weissman, Brent A. Orr, Charles G. Eberhart, Jaclyn A. Biegel,  and Eric H. Raabe
3165-3177
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Metformin inhibits tumor growth by regulating multiple miRNAs in human cholangiocarcinoma

Metformin inhibits tumor growth by regulating multiple miRNAs in human cholangiocarcinoma

https://doi.org/10.18632/oncotarget.3063

Xingming Jiang, Ning Ma, Dayong Wang, Fuyuan Li, Rongzhang He, Dongliang Li, Ruiqi Zhao, Qingxin Zhou, Yimin Wang, Fumin Zhang, Ming Wan, Pengcheng Kang, Xu Gao,  and Yunfu Cui
3178-3194
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines

Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines

https://doi.org/10.18632/oncotarget.3084

Vidya P. Ramamurthy, Senthilmurugan Ramalingam, Lalji Gediya, Andrew K. Kwegyir-Afful,  and Vincent C.O. Njar
3195-3210
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A

MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A

https://doi.org/10.18632/oncotarget.3085

Katsuya Ohta, Hiromitsu Hoshino, Jinhua Wang, Shigeshi Ono, Yuuki Iida, Keisuke Hata, Sharon K. Huang, Steven Colquhoun,  and Dave S. B. Hoon
3211-3224
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Genistein suppresses FLT4 and inhibits human colorectal cancer metastasis

Genistein suppresses FLT4 and inhibits human colorectal cancer metastasis

https://doi.org/10.18632/oncotarget.3064

Xiao Xiao, Zhiguo Liu, Rui Wang, Jiayin Wang, Song Zhang, Xiqiang Cai, Kaichun Wu, Raymond C. Bergan, Li Xu,  and Daiming Fan
3225-3239
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

KITENIN promotes glioma invasiveness and progression, associated with the induction of EMT and stemness markers

KITENIN promotes glioma invasiveness and progression, associated with the induction of EMT and stemness markers

https://doi.org/10.18632/oncotarget.3087

Kyung-Hwa Lee, Eun-Jung Ahn, Se-Jeong Oh, Ok Kim, Young-Eun Joo, Jeong-A Bae, Somy Yoon, Hyang-Hwa Ryu, Shin Jung, Kyung-Keun Kim, Jae-Hyuk Lee,  and Kyung-Sub Moon
3240-3253
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Dihydromyricetin prevents cardiotoxicity and enhances anticancer activity induced by adriamycin

Dihydromyricetin prevents cardiotoxicity and enhances anticancer activity induced by adriamycin

https://doi.org/10.18632/oncotarget.2410

Hong Zhu, Peihua Luo, Yingying Fu, Jincheng Wang, Jiabin Dai, Jinjin Shao, Xiaochun Yang, Linlin Chang, Qinjie Weng, Bo Yang,  and Qiaojun He
3254-3267
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells

MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells

https://doi.org/10.18632/oncotarget.3065

Qingling Yang, Yangyang Wang, Xiaohui Lu, Zunlan Zhao, Lihua Zhu, Sulian Chen, Qiong Wu, Changjie Chen,  and Zhiwei Wang
3268-3279
Abstract  |  PDF  |  HTML  |  Order a Reprint

Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer

Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer

https://doi.org/10.18632/oncotarget.2462

Dhruv Kumar, Dwijendra Gupta, Sharmila Shankar,  and Rakesh K. Srivastava
3280-3291
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MYC is a critical target of FBXW7

MYC is a critical target of FBXW7

https://doi.org/10.18632/oncotarget.3203

Mai Sato, Ruth Rodriguez-Barrueco, Jiyang Yu, Catherine Do, Jose M. Silva,  and Jean Gautier
3292-3305
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Overexpression of IFN-induced protein with tetratricopeptide repeats 3 (IFIT3) in pancreatic cancer: cellular “pseudoinflammation” contributing to an aggressive phenotype

Overexpression of IFN-induced protein with tetratricopeptide repeats 3 (IFIT3) in pancreatic cancer: cellular “pseudoinflammation” contributing to an aggressive phenotype

https://doi.org/10.18632/oncotarget.2494

Hanno Niess, Peter Camaj, Ruth Mair, Andrea Renner, Yue Zhao, Carsten Jäckel, Peter J. Nelson, Karl-Walter Jauch,  and Christiane J. Bruns
3306-3318
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In vivo treatment with epigenetic modulating agents induces transcriptional alterations associated with prognosis and immunomodulation in multiple myeloma

In vivo treatment with epigenetic modulating agents induces transcriptional alterations associated with prognosis and immunomodulation in multiple myeloma

https://doi.org/10.18632/oncotarget.3207

Ken Maes, Eva De Smedt, Alboukadel Kassambara, Dirk Hose, Anja Seckinger, Els Van Valckenborgh, Eline Menu, Bernard Klein, Karin Vanderkerken, Jérôme Moreaux,  and Elke De Bruyne
3319-3334
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer

Prognostic and therapeutic impact of RPN2-mediated tumor malignancy in non-small-cell lung cancer

https://doi.org/10.18632/oncotarget.2793

Yu Fujita, Shigehiro Yagishita, Fumitaka Takeshita, Yusuke Yamamoto, Kazuyoshi Kuwano,  and Takahiro Ochiya
3335-3345
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Differential expression and prognostic value of the chemokine receptor CXCR4 in bronchopulmonary neuroendocrine neoplasms

Differential expression and prognostic value of the chemokine receptor CXCR4 in bronchopulmonary neuroendocrine neoplasms

https://doi.org/10.18632/oncotarget.3242

Daniel Kaemmerer, Christiane Reimann, Elisa Specht, Ralph M. Wirtz, Manal Sayeg, Richard P. Baum, Stefan Schulz,  and Amelie Lupp
3346-3358
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma

Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma

https://doi.org/10.18632/oncotarget.3245

Roberto Jose Diaz, Brian Golbourn, Claudia Faria, Daniel Picard, David Shih, Denis Raynaud, Michael Leadly, Danielle MacKenzie, Melissa Bryant, Matthew Bebenek, Christian A. Smith, Michael D. Taylor, Annie Huang,  and James T. Rutka
3359-3374
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation

A Golgi-based KDELR-dependent signalling pathway controls extracellular matrix degradation

https://doi.org/10.18632/oncotarget.3270

Carmen Ruggiero, Giorgia Fragassi, Mauro Grossi, Benedetta Picciani, Rosaria Di Martino, Mirco Capitani, Roberto Buccione, Alberto Luini,  and Michele Sallese
3375-3393
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma

Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphoma

https://doi.org/10.18632/oncotarget.2583

Rosaria Chilà, Alessandra Basana, Monica Lupi, Federica Guffanti, Eugenio Gaudio, Andrea Rinaldi, Luciano Cascione, Valentina Restelli, Chiara Tarantelli, Francesco Bertoni, Giovanna Damia,  and Laura Carrassa
3394-3408
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis

FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis

https://doi.org/10.18632/oncotarget.2636

Catherine E. Waters, Joshua C. Saldivar, Zaynab A. Amin, Morgan S. Schrock,  and Kay Huebner
3409-3419
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Clinical Research Papers

Methylation of MGMT and ADAMTS14 in normal colon MUCOSA: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans

Methylation of MGMT and ADAMTS14 in normal colon MUCOSA: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans

https://doi.org/10.18632/oncotarget.2852

Sergio Alonso, Yuichi Dai, Kentaro Yamashita, Shina Horiuchi, Tomoko Dai, Akihiro Matsunaga, Rosa Sánchez-Muñoz, Cristina Bilbao-Sieyro, Juan Carlos Díaz-Chico, Andrei V. Chernov, Alex Y. Strongin,  and Manuel Perucho
3420-3431
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RMP predicts survival and adjuvant TACE response in hepatocellular carcinoma

RMP predicts survival and adjuvant TACE response in hepatocellular carcinoma

https://doi.org/10.18632/oncotarget.3092

Jian Zhang, Tian-Yi Jiang, Bei-Ge Jiang, Chun Yang, Ye-Xiong Tan, Ning Yang, Yu-Fei Pan, Zhi-Wen Ding, Guang-Zhen Yang, Meng-Chao Wu, Li-Wei Dong,  and Hong-Yang Wang
3432-3442
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Oncogenes and tumor suppressor genes in squamous cell carcinoma of the tongue in young patients

Oncogenes and tumor suppressor genes in squamous cell carcinoma of the tongue in young patients

https://doi.org/10.18632/oncotarget.2850

Andreas Knopf, Justine Lempart, Murat Bas, Julia Slotta-Huspenina, Naglaa Mansour,  and Marie Kristin Fritsche
3443-3451
Abstract  |  PDF  |  HTML  |  Order a Reprint

B7-H1 and B7-H3 are independent predictors of poor prognosis in patients with non-small cell lung cancer

B7-H1 and B7-H3 are independent predictors of poor prognosis in patients with non-small cell lung cancer

https://doi.org/10.18632/oncotarget.3097

Yixiang Mao, Wei Li, Kai Chen, Yufeng Xie, Qiang Liu, Min Yao, Weiming Duan, Xiumin Zhou, Rongrui Liang,  and Min Tao
3452-3461
Abstract  |  PDF  |  HTML  |  Order a Reprint

Potential impact of human papilloma virus on survival of basaloid squamous carcinoma of the head and neck

Potential impact of human papilloma virus on survival of basaloid squamous carcinoma of the head and neck

https://doi.org/10.18632/oncotarget.3062

Christian Jacobi, Isabelle Ayx, Kristin Fritsche, Guido Piontek, Dieter Hoffmann, Gregor Weirich,  and Andreas Knopf
3462-3470
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint


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