Oncotarget

Vol 6, No 3

January 30, 2015

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Effects of rapamycin on TTLshort ALL in vivo. See Hasan et al.

Table of Contents

Editorial

Circulating microRNAs in aging

Circulating microRNAs in aging

https://doi.org/10.18632/oncotarget.3175

Massimiliano Bonafè,  and Fabiola Olivieri
1340-1341
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Proteome-wide analysis of in situ aged fibroblasts

Proteome-wide analysis of in situ aged fibroblasts

https://doi.org/10.18632/oncotarget.3176

Daniel M. Waldera-Lupa,  and Kai Stühler
1342-1343
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Carcinoma-derived exosomes modify microenvironment

Carcinoma-derived exosomes modify microenvironment

https://doi.org/10.18632/oncotarget.3182

Norman J. Maitland
1344-1345
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Bladder cancer and the Notch pathway

Bladder cancer and the Notch pathway

https://doi.org/10.18632/oncotarget.3183

Pablo J. Fernandez-Marcos, Manuel Serrano,  and Antonio Maraver
1346-1347
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Reviews

Advances in targeted therapies and new promising targets in esophageal cancer

Advances in targeted therapies and new promising targets in esophageal cancer

https://doi.org/10.18632/oncotarget.2752

Abbes Belkhiri,  and Wael El-Rifai
1348-1358
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Targeting the tumor microenvironment to enhance antitumor immune responses

Targeting the tumor microenvironment to enhance antitumor immune responses

https://doi.org/10.18632/oncotarget.3204

Kevin Van der Jeught, Lukasz Bialkowski, Lidia Daszkiewicz, Katrijn Broos, Cleo Goyvaerts, Dries Renmans, Sandra Van Lint, Carlo Heirman, Kris Thielemans,  and Karine Breckpot
1359-1381
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Priority Research Papers

Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model

Targeting of hyperactivated mTOR signaling in high-risk acute lymphoblastic leukemia in a pre-clinical model

https://doi.org/10.18632/oncotarget.2842

Md. Nabiul Hasan, Manon Queudeville, Luca Trentin, Sarah Mirjam Eckhoff, Ilaria Bronzini, Chiara Palmi, Thomas Barth, Giovanni Cazzaniga, Geertruy te Kronnie, Klaus-Michael Debatin,  and Lüder Hinrich Meyer
1382-1395
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Research Papers: Gerotarget (Focus on Aging)

Amyloid accumulation is a late event in sporadic Alzheimer’s disease-like pathology in nontransgenic rats

Amyloid accumulation is a late event in sporadic Alzheimer’s disease-like pathology in nontransgenic rats

https://doi.org/10.18632/oncotarget.2751

Natalia A. Stefanova, Natalia A. Muraleva, Elena E. Korbolina, Elena Kiseleva, Kseniya Yi. Maksimova,  and Nataliya G. Kolosova
1396-1413
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Age-independent rise of inflammatory scores may contribute to accelerated aging in multi-morbidity

Age-independent rise of inflammatory scores may contribute to accelerated aging in multi-morbidity

https://doi.org/10.18632/oncotarget.2725

Maria Stepanova, Edgar Rodriguez, Aybike Birerdinc,  and Ancha Baranova
1414-1421
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Research Papers

Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas

Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas

https://doi.org/10.18632/oncotarget.2805

Angela Margarida Costa, Filipe Pinto, Olga Martinho, Maria José Oliveira, Peter Jordan,  and Rui Manuel Reis
1422-1434
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Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling

Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling

https://doi.org/10.18632/oncotarget.2935

Carlotta Giorgi, Massimo Bonora, Sonia Missiroli, Federica Poletti, Fabian Galindo Ramirez, Giampaolo Morciano, Claudia Morganti, Pier Paolo Pandolfi, Fabio Mammano,  and Paolo Pinton
1435-1445
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Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins

Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins

https://doi.org/10.18632/oncotarget.2735

Raed Rizkallah, Paratchata Batsomboon, Gregory B. Dudley,  and Myra M. Hurt
1446-1461
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By downregulating Ku80, hsa-miR-526b suppresses non-small cell lung cancer

By downregulating Ku80, hsa-miR-526b suppresses non-small cell lung cancer

https://doi.org/10.18632/oncotarget.2808

Zun-yi Zhang, Sheng-ling Fu, Su-qin Xu, Xiao Zhou, Xian-shen Liu, Yong-jian Xu, Jian-ping Zhao,  and Shuang Wei
1462-1477
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Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma

Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma

https://doi.org/10.18632/oncotarget.2756

Chi-Hao Chang, Po-Chao Chan, Jian-Ri Li, Chun-Jung Chen, Jeng-Jer Shieh, Yun-Ching Fu, Hong-Chen Chen,  and Ming-Ju Wu
1478-1489
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Overexpression of Nodal induces a metastatic phenotype in pancreatic cancer cells via the Smad2/3 pathway

Overexpression of Nodal induces a metastatic phenotype in pancreatic cancer cells via the Smad2/3 pathway

https://doi.org/10.18632/oncotarget.2686

Wanxing Duan, Rong Li, Jiguang Ma, Jianjun Lei, Qinhong Xu, Zhengdong Jiang, Ligang Nan, Xuqi Li, Zheng Wang, Xiongwei Huo, Liang Han, Zheng Wu, Erxi Wu,  and Qingyong Ma
1490-1506
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HS-543 induces apoptosis of Imatinib-resistant chronic myelogenous leukemia with T315I mutation

HS-543 induces apoptosis of Imatinib-resistant chronic myelogenous leukemia with T315I mutation

https://doi.org/10.18632/oncotarget.2837

Soo Jung Kim, Kyung Hee Jung, Hong Hua Yan, Mi Kwon Son, Zhenghuan Fang, Ye-Lim Ryu, Hyunseung Lee, Joo Han Lim, Jun-Kyu Suh, JinHee Kim, Soyoung Lee, Sungwoo Hong,  and Soon-Sun Hong
1507-1518
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Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis

Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis

https://doi.org/10.18632/oncotarget.2729

Chuan Bian Lim, Cecilia M. Prêle, Svetlana Baltic, Peter G. Arthur, Jenette Creaney, D. Neil Watkins, Philip J. Thompson,  and Steven E. Mutsaers
1519-1530
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Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway

Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway

https://doi.org/10.18632/oncotarget.2828

Vikas Bhardwaj, Jennifer M. Noto, Jinxiong Wei, Claudia Andl, Wael El-Rifai, Richard M. Peek,  and Alexander I. Zaika
1531-1543
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Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma

Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma

https://doi.org/10.18632/oncotarget.2838

Chunyan Li, Gang Meng, Lei Su, Aiping Chen, Mao Xia, Chun Xu, Decai Yu, Aiqin Jiang,  and Jiwu Wei
1544-1555
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Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells

Carnosic acid sensitized TRAIL-mediated apoptosis through down-regulation of c-FLIP and Bcl-2 expression at the post translational levels and CHOP-dependent up-regulation of DR5, Bim, and PUMA expression in human carcinoma caki cells

https://doi.org/10.18632/oncotarget.2727

Kyong-Jin Jung, Kyoung-Jin Min, Jae Hoon Bae,  and Taeg Kyu Kwon
1556-1568
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LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients

LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients

https://doi.org/10.18632/oncotarget.2807

Valeria Cazzaniga, Cristina Bugarin, Michela Bardini, Marco Giordan, Geertruy te Kronnie, Giuseppe Basso, Andrea Biondi, Grazia Fazio,  and Giovanni Cazzaniga
1569-1581
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Cyclosporine A and tacrolimus inhibit bladder cancer growth through down-regulation of NFATc1

Cyclosporine A and tacrolimus inhibit bladder cancer growth through down-regulation of NFATc1

https://doi.org/10.18632/oncotarget.2750

Takashi Kawahara, Eiji Kashiwagi, Hiroki Ide, Yi Li, Yichun Zheng, Yurina Miyamoto, George J. Netto, Hitoshi Ishiguro,  and Hiroshi Miyamoto
1582-1593
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MicroRNA regulation of molecular pathways as a generic mechanism and as a core disease phenotype

MicroRNA regulation of molecular pathways as a generic mechanism and as a core disease phenotype

https://doi.org/10.18632/oncotarget.2734

Rotem Ben-Hamo,  and Sol Efroni
1594-1604
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miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer

miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer

https://doi.org/10.18632/oncotarget.2748

Xiaoyu Zhang, Jie Tang, Xiaofei Zhi, Kunling Xie, Weizhi Wang, Zheng Li, Yi Zhu, Li Yang, Hao Xu,  and Zekuan Xu
1605-1617
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Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility

Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility

https://doi.org/10.18632/oncotarget.2730

Jian Wang, Ming Liu, Leilei Chen, Tim Hon Man Chan, Lingxi Jiang, Yun-Fei Yuan,  and Xin-Yuan Guan
1618-1630
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Stimulation of hERG1 channel activity promotes a calcium-dependent degradation of cyclin E2, but not cyclin E1, in breast cancer cells

Stimulation of hERG1 channel activity promotes a calcium-dependent degradation of cyclin E2, but not cyclin E1, in breast cancer cells

https://doi.org/10.18632/oncotarget.2829

Mathew Perez-Neut, Andrew Shum, Bruce D. Cuevas, Richard Miller,  and Saverio Gentile
1631-1639
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Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis

Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis

https://doi.org/10.18632/oncotarget.2746

Shaoqing Shi, Qiong Wang, Jennings Xu, Jun-Ho Jang, Mabel T. Padilla, Toru Nyunoya, Chengguo Xing, Lin Zhang,  and Yong Lin
1640-1651
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Claudin-1 enhances tumor proliferation and metastasis by regulating cell anoikis in gastric cancer

Claudin-1 enhances tumor proliferation and metastasis by regulating cell anoikis in gastric cancer

https://doi.org/10.18632/oncotarget.2936

Jie Huang, Li Zhang, Changyu He, Ying Qu, Jianfang Li, Jianian Zhang, Tao Du, Xuehua Chen, Yingyan Yu, Bingya Liu,  and Zhenggang Zhu
1652-1665
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Lateral inhibition of Notch signaling in neoplastic cells

Lateral inhibition of Notch signaling in neoplastic cells

https://doi.org/10.18632/oncotarget.2762

Kah Jing Lim, William D. Brandt, Jason A. Heth, Karin M. Muraszko, Xing Fan, Eli E. Bar,  and Charles G. Eberhart
1666-1677
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Altered radiation responses of breast cancer cells resistant to hormonal therapy

Altered radiation responses of breast cancer cells resistant to hormonal therapy

https://doi.org/10.18632/oncotarget.3188

Lidiya Luzhna, Anne E. Lykkesfeldt,  and Olga Kovalchuk
1678-1694
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Molecular architecture of the ErbB2 extracellular domain homodimer

Molecular architecture of the ErbB2 extracellular domain homodimer

https://doi.org/10.18632/oncotarget.2713

Shi Hu, Yuna Sun, Yanchun Meng, Xiaoze Wang, Weili Yang, Wenyan Fu, Huaizu Guo, Weizhu Qian, Sheng Hou, Bohua Li, Zihe Rao, Zhiyong Lou,  and Yajun Guo
1695-1706
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Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells

Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells

https://doi.org/10.18632/oncotarget.2738

Antonella Cusimano, Roberto Puleio, Natale D'Alessandro, Guido R. Loria, James A. McCubrey, Giuseppe Montalto,  and Melchiorre Cervello
1707-1722
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Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation

Epidermal growth factor-induced cyclooxygenase-2 enhances head and neck squamous cell carcinoma metastasis through fibronectin up-regulation

https://doi.org/10.18632/oncotarget.2783

Jinn-Yuan Hsu, Kwang-Yu Chang, Shang-Hung Chen, Chung-Ta Lee, Sheng-Tsung Chang, Hung-Chi Cheng, Wen-Chang Chang,  and Ben-Kuen Chen
1723-1739
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Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells

Down-regulation of miR-223 reverses epithelial-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells

https://doi.org/10.18632/oncotarget.2714

Jia Ma, Binbin Fang, Fanpeng Zeng, Cong Ma, Haijie Pang, Long Cheng, Ying Shi, Hui Wang, Bin Yin, Jun Xia,  and Zhiwei Wang
1740-1749
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Cisplatin-selected resistance is associated with increased motility and stem-like properties via activation of STAT3/Snail axis in atypical teratoid/rhabdoid tumor cells

Cisplatin-selected resistance is associated with increased motility and stem-like properties via activation of STAT3/Snail axis in atypical teratoid/rhabdoid tumor cells

https://doi.org/10.18632/oncotarget.2737

Wei-Hsiu Liu, Ming-Teh Chen, Mong-Lien Wang, Yi-Yen Lee, Guang-Yuh Chiou, Chian-Shiu Chien, Pin-I Huang, Yi-Wei Chen, Ming-Chao Huang, Shih-Hwa Chiou, Yang-Hsin Shih,  and Hsin-I Ma
1750-1768
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Two hits are better than one: synergistic anticancer activity of α-helical peptides and doxorubicin/epirubicin

Two hits are better than one: synergistic anticancer activity of α-helical peptides and doxorubicin/epirubicin

https://doi.org/10.18632/oncotarget.2754

Jing Zhao, Yibing Huang, Dong Liu,  and Yuxin Chen
1769-1778
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

The TLR7 agonist induces tumor regression both by promoting CD4+T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells

The TLR7 agonist induces tumor regression both by promoting CD4+T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells

https://doi.org/10.18632/oncotarget.2757

Chenchen Wang, Quan Zhou, Xiaofeng Wang, Xiongyan Wu, Xuehua Chen, Jianfang Li, Zhenggang Zhu, Bingya Liu,  and Liping Su
1779-1789
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Targeting VEGFR1- and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy

Targeting VEGFR1- and VEGFR2-expressing non-tumor cells is essential for esophageal cancer therapy

https://doi.org/10.18632/oncotarget.2781

Wen Wen Xu, Bin Li, Alfred KY Lam, Sai Wah Tsao, Simon YK Law, Kwok Wah Chan, Qiu Ju Yuan,  and Annie LM Cheung
1790-1805
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Identification of DEK as a potential therapeutic target for neuroendocrine prostate cancer

Identification of DEK as a potential therapeutic target for neuroendocrine prostate cancer

https://doi.org/10.18632/oncotarget.2809

Dong Lin, Xin Dong, Kendric Wang, Alexander W. Wyatt, Francesco Crea, Hui Xue, Yuwei Wang, Rebecca Wu, Robert H. Bell, Anne Haegert, Sonal Brahmbhatt, Antonio Hurtado-Coll, Peter W. Gout, Ladan Fazli, Martin E. Gleave, Colin C. Collins,  and Yuzhuo Wang
1806-1820
Abstract  |  PDF  |  HTML  |  Order a Reprint

The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis

The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis

https://doi.org/10.18632/oncotarget.2782

Jade Peres, Shaheen Mowla,  and Sharon Prince
1821-1833
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Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis

Mitochondrial translocation and interaction of cofilin and Drp1 are required for erucin-induced mitochondrial fission and apoptosis

https://doi.org/10.18632/oncotarget.2795

Guobing Li, Jing Zhou, Amit Budhraja, Xiaoye Hu, Yibiao Chen, Qi Cheng, Lei Liu, Ting Zhou, Ping Li, Ehu Liu,  and Ning Gao
1834-1849
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

RasGRP3 regulates the migration of glioma cells via interaction with Arp3

RasGRP3 regulates the migration of glioma cells via interaction with Arp3

https://doi.org/10.18632/oncotarget.2575

Hae Kyung Lee, Susan Finniss, Simona Cazacu, Cunli Xiang, Laila M. Poisson, Peter M. Blumberg,  and Chaya Brodie
1850-1864
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Clinical Research Papers

The identification of trans-associations between prostate cancer GWAS SNPs and RNA expression differences in tumor-adjacent stroma

The identification of trans-associations between prostate cancer GWAS SNPs and RNA expression differences in tumor-adjacent stroma

https://doi.org/10.18632/oncotarget.2763

Xin Chen, Michael McClelland, Zhenyu Jia, Farah Rahmatpanah, Anne Sawyers, Jeffrey Trent, David Duggan,  and Dan Mercola
1865-1873
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A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma

A serum microRNA signature associated with complete remission and progression after autologous stem-cell transplantation in patients with multiple myeloma

https://doi.org/10.18632/oncotarget.2761

Alfons Navarro, Tania Díaz, Natalia Tovar, Fabiola Pedrosa, Rut Tejero, María Teresa Cibeira, Laura Magnano, Laura Rosiñol, Mariano Monzó, Joan Bladé,  and Carlos Fernández de Larrea
1874-1883
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia

Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia

https://doi.org/10.18632/oncotarget.2753

Kati Kämpjärvi, Tiina M. Järvinen, Tuomas Heikkinen, Amy S. Ruppert, Leigha Senter, Kevin W. Hoag, Olli Dufva, Mika Kontro, Laura Rassenti, Erin Hertlein, Thomas J. Kipps, Kimmo Porkka, John C. Byrd, Albert de la Chapelle,  and Pia Vahteristo
1884-1888
Abstract  |  PDF  |  HTML  |  Supplementary Information  |  Order a Reprint

CD117+ cells in the circulation are predictive of advanced prostate cancer

CD117+ cells in the circulation are predictive of advanced prostate cancer

https://doi.org/10.18632/oncotarget.2796

Bethany A. Kerr, Ranko Miocinovic, Armine K. Smith, Xiaoxia Z. West, Katherine E. Watts, Amanda W. Alzayed, Joseph C. Klink, Maria C. Mir, Tiffany Sturey, Donna E. Hansel, Warren D. Heston, Andrew J. Stephenson, Eric A. Klein,  and Tatiana V. Byzova
1889-1897
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