Volume 2: Issue 5


Issue 5

About the Cover

The cover for the issue of Oncoscience features Figure 5 (“TALEN-mediated apc mutation in Xenopus tropicalis phenocopies Familial Adenomatous Polyposis”) from Nieuwenhuysen et al.


Expression of cancer stem cell biomarkers as a tool for a correct therapeutic approach to hepatocellular carcinoma


Maurizio  Romano, Francesco De Francesco, Giuseppe  Pirozzi, Enrico  Gringeri, Riccardo  Boetto, Marina Di Domenico, Barbara  Zavan, Giuseppe A. Ferraro, Umberto  Cillo

p 443-456

Abstract |  PDF |  Full Text

Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds


Ningning  Liu, Hongbiao  Huang, Q. Ping  Dou, Jinbao  Liu

p 457-466

Abstract |  PDF |  Full Text

Research Perspectives

The migration ability of stem cells can explain the existence of cancer of unknown primary site. Rethinking metastasis.


Miguel  López-Lázaro

p 467-475

PDF |  Full Text

Rapid and efficient transfer of the T cell aging marker CD57 from glioblastoma stem cells to CAR T cells


Xuekai  Zhu, Gabriele  Niedermann

p 476-482

PDF |  Full Text

Another small molecule in the oncometabolite mix: L-2-Hydroxyglutarate in kidney cancer


Eun-Hee  Shim, Sunil  Sudarshan

p 483-486

PDF |  Full Text

Research Papers

A meta-analysis to evaluate the cellular processes regulated by the interactome of endogenous and over-expressed estrogen receptor alpha


Joana  Simões, Francisco M. Amado, Rui  Vitorino, Luisa A. Helguero

p 487-496

Abstract |  PDF |  Full Text |  Supplementary Materials |  Supplementary Table

Uncovering potential downstream targets of oncogenic GRPR overexpression in prostate carcinomas harboring ETS rearrangements


Joana  Santos, Diana  Mesquita, João D. Barros-Silva, Carmen  Jerónimo, Rui  Henrique, António  Morais, Paula  Paulo, Manuel R. Teixeira

p 497-507

Abstract |  PDF |  Full Text |  Supplementary Materials

Methylation changes in the TFAP2E promoter region are associated with BRAF mutation and poorer overall & disease free survival in colorectal cancer


Andrew D. Beggs, Mark P. Dilworth, Enric  Domingo, Rachel  Midgley, David  Kerr, Ian PM. Tomlinson, Gary W. Middleton

p 508-516

Abstract |  PDF |  Full Text

Identification of artesunate as a specific activator of ferroptosis in pancreatic cancer cells


Nils  Eling, Lukas  Reuter, John  Hazin, Anne  Hamacher-Brady, Nathan R. Brady

p 517-532

Abstract |  PDF |  Full Text

Retrospective review of MET gene mutations


Maryam  Zenali, James  deKay, Zesheng  Liu, Stanley  Hamilton, Zhuang  Zuo, Xinyan  Lu, Rania  Bakkar, Gordon  Mills, Russell  Broaddus

p 533-541

Abstract |  PDF |  Full Text

A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX phosphorylation in human peripheral blood mononuclear cells


Christopher  J. Bakkenist, R. Kenneth  Czambel, Pamela A. Hershberger, Hussein  Tawbi, Jan H. Beumer, John C. Schmitz

p 542-554

Abstract |  PDF |  Full Text

TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis


Tom Van Nieuwenhuysen, Thomas  Naert, Hong Thi Tran, Griet Van Imschoot, Sarah  Geurs, Ellen  Sanders, David  Creytens, Frans Van Roy, Kris  Vleminckx

p 555-566

Abstract |  PDF |  Full Text