Identification of new miRNA biomarkers associated with HER2-positive breast cancers
Hossam Tashkandi1,2, Nirav Shah1,2, Yogin Patel1,2 and Hexin Chen1,2
1 Department of Biological Science, University of South Carolina, Columbia, SC, U.S.A
2 Center for Colon Cancer Research, University of South Carolina, Columbia, SC, U.S.A
Hexin Chen, email:
Keywords: microRNA, miRNA, biomarker, breast cancer, HER2
Received: July 30, 2015 Accepted: November 25, 2015 Published: December 02, 2015
Human epidermal growth factor receptor 2 (HER2) is overexpressed/amplified in ~30% breast cancers which are associated with poor prognosis. microRNAs are small non-coding RNA which play an important role in many physiological conditions including cancer. Here we screened and identified many miRNAs which are dysregulated by HER2 overexpression. In line with our quantitative PCR analysis data, in silico analysis of microRNA expression profiles of 1302 breast tumors revealed that miR-146a-5p is up-regulated and miR-181d and miR-195-5p are down-regulated in HER2-positive tumors. Furthermore, the expression levels of these microRNAs can significantly predict patient survival and thus potentially serve as new prognostic markers for HER2-positive breast cancer.