The emerging roles of GPRC5A in diseases

Honglei Zhou1 and Isidore Rigoutsos1

1 Computational Medicine Center, Jefferson Alumni Hall, Thomas Jefferson University, Philadelphia, PA


Isidore Rigoutsos, email:

Keywords: GPRC5A, RAI3, tumor suppressor, oncogene, dual-behavior, cancer

Received: November 18, 2014 Accepted: November 24, 2014 Published: November 25, 2014


The ‘Retinoic Acid-Inducible G-protein-coupled receptors’ or RAIG are a group comprising the four orphan receptors GPRC5A, GPRC5B, GPRC5C and GPRC5D. As the name implies, their expression is induced by retinoic acid but beyond that very little is known about their function. In recent years, one member, GPRC5A, has been receiving increasing attention as it was shown to play important roles in human cancers. As a matter of fact, dysregulation of GPRC5A has been associated with several cancers including lung cancer, breast cancer, colorectal cancer, and pancreatic cancer. Here we review the current state of knowledge about the heterogeneity and evolution of GPRC5A, its regulation, its molecular functions, and its involvement in human disease.

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