Genes & Cancer

Volume 6: Issue 3-4, March 2015

pp82-181

Issue 3-4, March 2015

About the Cover

The cover for Genes & Cancer features figure S6 (“EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma”) from Fadul et al.

Editorials

Biguanides and targeted anti-cancer treatments

Elyse K. Hanly , Zbigniew  Darzynkiewicz , and Raj K. Tiwari

PDF   p82 -83

Reviews

Trop2 and its overexpression in cancers: regulation and clinical/ therapeutic implications

Anna  Shvartsur , and Benjamin  Bonavida

Abstract |  PDF |  Full Text   p84 -105

Research Papers

Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma

Honglin  Chen , James  Lee , Noelyn  Kljavin , Benjamin  Haley , Anneleen  Daemen , Leisa  Johnson , and Yuxin  Liang

Abstract |  PDF |  Full Text |  Supplementary Materials   p106 -118

Drug sensitivity profiling and molecular characteristics of cells from pleural effusions of patients with lung adenocarcinoma

Rita  Ötvös , Adam  Szulkin , Carl-Olof  Hiilerdal , Aytekin  Celep , Eviane  Yousef-Fadhel , Henriette  Skribek , Anders  Hjerpe , Laszlo  Szekely , and Katalin  Dobra

Abstract |  PDF |  Full Text |  Supplementary Materials   p119 -128

EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma

John  Fadul , Russell  Bell , Laura M. Hoffman , Mary C. Beckerle , Michael E. Engel , and Stephen L. Lessnick

Abstract |  PDF |  Full Text |  Supplementary Materials   p129 -143

Triptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma

Blake A. Jacobson , Esther Z. Chen , Shaogeng  Tang , Holly Sedgwick Belgum , Joel A. McCauley , Kristen A. Evenson , Ryan G. Etchison , Joe  Jay-Dixon , Manish R. Patel , Ahmad  Raza , Ashok K. Saluja , Jonathan  D’Cunha , and Robert A. Kratzke

Abstract |  PDF |  Full Text   p144 -152

Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer

Jennifer E. Yeh , Simion  Kreimer , Sarah R. Walker , Megan M. Emori , Hannah  Krystal , Andrea  Richardson , Alexer R. Ivanov , and David A. Frank

Abstract |  PDF |  Full Text |  Supplementary Materials   p153 -168

Suberoylanilide hydroxamic acid (SAHA) reverses chemoresistance in head and neck cancer cells by targeting cancer stem cells via the downregulation of nanog

Bhavna  Kumar , Arti  Yadav , James C. Lang , Theodoros N. Teknos , and Pawan  Kumar

Abstract |  PDF |  Full Text |  Supplementary Materials   p169 -181