Genes & Cancer

Volume 5: Issue 9-10, September 2014

pp303-374

Issue 9-10, September 2014

About the Cover

The cover for Genes & Cancer features figure 9E ("TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer") from Singha et al.

Research Perspective

Cutting the brakes and flooring the gas: how TMEPAI turns TGF-β into a tumor promoter

Magdalena A. Cichon , and Derek C. Radisky

Abstract |  PDF |  Full Text   p303 -305

Research Papers

Telomere dysfunction suppresses multiple endocrine neoplasia in mice

Ji-Hyeon  Lee , Miriam  Anver , Maria  Kost-Alimova , Alexei  Protopopov , Ronald A. DePinho , and Sushil G. Rane

Abstract |  PDF |  Full Text   p306 -319

TGF-β induced TMEPAI/PMEPA1 inhibits canonical Smad signaling through R-Smad sequestration and promotes non-canonical PI3K/Akt signaling by reducing PTEN in triple negative breast cancer

Prajjal K. Singha , Srilakshmi  Pandeswara , Hui  Geng , Rongpei  Lan , Manjeri A. Venkatachalam , and Pothana  Saikumar

Abstract |  PDF |  Full Text |  Supplementary Materials   p320 -336

Mirk kinase inhibition blocks the in vivo growth of pancreatic cancer cells

Xiaobing  Deng , and Eileen  Friedman

Abstract |  PDF |  Full Text |  Supplementary Materials   p337 -347

Generation of a mouse model of T-cell lymphoma based on chronic LPS challenge and TGF-β signaling disruption

Nina M. Muñoz , Lior H. Katz , Ji-Hyun  Shin , Young Jin Gi , Vipin Kumar Menon , Mihai  Gagea , Asif  Rashid , Jian  Chen , and Lopa  Mishra

Abstract |  PDF |  Full Text   p348 -352

miR-155 induced transcriptome changes in the MCF-7 breast cancer cell line leads to enhanced mitogen activated protein kinase signaling

Elizabeth C. Martin , Adrienne E. Krebs , Hope E. Burks , Steven  Elliott , Melody  Baddoo , Bridgette M. Collins-Burow , Erik K. Flemington , and Matthew E. Burow

Abstract |  PDF |  Full Text   p353 -364

The apoptosis associated tyrosine kinase gene is frequently hypermethylated in human cancer and is regulated by epigenetic mechanisms

Tanja  Haag , Christina E. Herkt , Sara K. Walesch , Antje M. Richter , and Reinhard H. Dammann

Abstract |  PDF |  Full Text   p365 -374