Genes & Cancer

Telomere length regulation through epidermal growth factor receptor signaling in cancer

Titto Augustine1, Radhashree Maitra1, Sanjay Goel1

1 Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA


Sanjay Goel, email:

Keywords: telomere length, EGFR pathways/signaling, colorectal cancer, biomarker identification, telomerase

Received: April 25, 2017 Accepted: June 05, 2017 Published: June 21, 2017


Length of the telomere (TL), a structure at the tip of chromosome that protects and ensures stability, is determined by multi-protein complexes such as telosome/shelterin and telomerase. Earlier studies from our laboratory show that longer TL has potential to be positive predictive biomarker of clinical outcome to anti-epidermal growth factor receptor (EGFR) monoclonal antibody therapy in patients with KRAS WT metastatic colorectal cancer. Although there is extensive literature suggesting the role of shelterin and telomerase, not much literature exists that describes the role of EGFR and KRAS pathway in regulating TL. This detailed review focuses on an insight into various components, including proteins, enzymes and transcription factors, interlinking between EGFR pathways and telomerase that regulate TL.

PII: 140